Recollections of Tim Coen

The following interview was conducted with Tim Coen, the interviewee, and Renee Dube, the interviewer, for the Salve Regina Memory Project. It took place on Thursday, September 22nd, 2022, at Salve Regina University. Tim Coen served as the football coach for Salve Regina from 1992 to 1999. He finished his career at Salve with 53 wins, 12 losses, and an overall .815 winning percentage

Letselschade Raad draait voor slachtoffers de klok meer dan twintig jaar terug:Analyse van handreiking zorgschade

De Handreiking Zorgschade en de daarin op te nemen Financiële paragraaf zijn in strijd met het geldende recht en het solidariteitsbeginsel, en met het wetsvoorstel dat de aanloop ertoe was. Dat is de conclusie van deze vier auteurs, die beargumenteren dat de keuzevrijheid van het letselschadeslachtoffer geheel is verdwenen, dat de voorgestelde tarieven op verschillende manieren niet kloppen, en dat de menselijke factor ontbreekt. Ze beginnen met een bespreking van de financieringsmogelijkheden van zorgschade, de jurisprudentie rond zorgschade en het wetsvoorstel Zorg- en affectieschade uit 2014. Daarna belichten ze de uitgangspunten van de Handreiking en de tarieven van de concept Financiële paragraaf. Ze vinden dat er onder de Handreiking een juridische bodem moet worden gelegd, met betrokkenheid van vertegenwoordigers van slachtoffers. Anders zou de wetgever alsnog moeten ingrijpen

Letselschade Raad draait voor slachtoffers de klok meer dan twintig jaar terug:Analyse van handreiking zorgschade

De Handreiking Zorgschade en de daarin op te nemen Financiële paragraaf zijn in strijd met het geldende recht en het solidariteitsbeginsel, en met het wetsvoorstel dat de aanloop ertoe was. Dat is de conclusie van deze vier auteurs, die beargumenteren dat de keuzevrijheid van het letselschadeslachtoffer geheel is verdwenen, dat de voorgestelde tarieven op verschillende manieren niet kloppen, en dat de menselijke factor ontbreekt. Ze beginnen met een bespreking van de financieringsmogelijkheden van zorgschade, de jurisprudentie rond zorgschade en het wetsvoorstel Zorg- en affectieschade uit 2014. Daarna belichten ze de uitgangspunten van de Handreiking en de tarieven van de concept Financiële paragraaf. Ze vinden dat er onder de Handreiking een juridische bodem moet worden gelegd, met betrokkenheid van vertegenwoordigers van slachtoffers. Anders zou de wetgever alsnog moeten ingrijpen

Liberal market economies, business, and political finance: Britain under New Labour

The extent and nature of business financing of parties is an important feature of political finance. Britain’s transparent and permissive regulatory system provides an excellent opportunity to study business financing of parties. Business donations have been very important to the Conservative party over the last decade, and of only marginal importance to Labour. Unlike other Conservative contributors, business donors are more likely to contribute when the party is popular. In contrast to the previous period of Conservative government, the biggest British businesses tended to abstain from political finance under New Labour. However, their bias towards the Conservatives is affected by the party’s popularity and the closeness of an election. Britain shares the political importance of business financing of parties and its mixture of ideological and pragmatic motivations with other liberal market economies. However, in Britain the bias towards the right is much stronger and the role of big business more marginal

Protocol of the SOMNIA project : an observational study to create a neurophysiological database for advanced clinical sleep monitoring

Introduction Polysomnography (PSG) is the primary tool for sleep monitoring and the diagnosis of sleep disorders. Recent advances in signal analysis make it possible to reveal more information from this rich data source. Furthermore, many innovative sleep monitoring techniques are being developed that are less obtrusive, easier to use over long time periods and in the home situation. Here, we describe the methods of the Sleep and Obstructive Sleep Apnoea Monitoring with Non-Invasive Applications (SOMNIA) project, yielding a database combining clinical PSG with advanced unobtrusive sleep monitoring modalities in a large cohort of patients with various sleep disorders. The SOMNIA database will facilitate the validation and assessment of the diagnostic value of the new techniques, as well as the development of additional indices and biomarkers derived from new and/or traditional sleep monitoring methods. Methods and analysis We aim to include at least 2100 subjects (both adults and children) with a variety of sleep disorders who undergo a PSG as part of standard clinical care in a dedicated sleep centre. Full-video PSG will be performed according to the standards of the American Academy of Sleep Medicine. Each recording will be supplemented with one or more new monitoring systems, including wrist-worn photoplethysmography and actigraphy, pressure sensing mattresses, multimicrophone recording of respiratory sounds including snoring, suprasternal pressure monitoring and multielectrode electromyography of the diaphragm

IL-1α Mediated Chorioamnionitis Induces Depletion of FoxP3+ Cells and Ileal Inflammation in the Ovine Fetal Gut

Endotoxin induced chorioamnionitis increases IL-1 and provokes an inflammatory response in the fetal ileum that interferes with intestinal maturation. In the present study, we tested in an ovine chorioamnionitis model whether IL-1 is a major cytokine driving the inflammatory response in the fetal ileum.Sheep bearing singleton fetuses received a single intraamniotic injection of recombinant ovine IL-1α at 7, 3 or 1 d before caesarian delivery at 125 days gestational age (term = 150 days).3 and 7 d after IL-1α administration, intestinal mRNA levels for IL-4, IL-10, IFN-γ and TNF-α were strongly elevated. Numbers of CD3+ and CD4+ T-lymphocytes and myeloidperoxidase+ cells were increased whereas FoxP3+ T-cells were detected at low frequency. This increased proinflammatory state was associated with ileal mucosal barrier loss as demonstrated by decreased levels of the intestinal fatty acid binding protein and disruption of the tight junctional protein ZO-1.Intraamniotic IL-1α causes an acute detrimental inflammatory response in the ileum, suggesting that induction of IL-1 is a critical element in the pathophysiological effects of endotoxin induced chorioamnionitis. A disturbed balance between T-effector and FoxP3+ cells may contribute to this process

Silicon pore optics mirror modules for inner and outer radii

Athena (Advanced Telescope for High Energy Astrophysics) is an x-ray observatory using a Silicon Pore Optics telescope and was selected as ESA's second L-class science mission for a launch in 2028. The x-ray telescope consists of several hundreds of mirror modules distributed over about 15-20 radial rings. The radius of curvature and the module sizes vary among the different radial positions of the rings resulting in different technical challenges for mirror modules for inner and outer radii. We present first results of demonstrating Silicon Pore Optics for the extreme radial positions of the Athena telescope. For the inner most radii (0.25 m) a new mirror plate design is shown which overcomes the challenges of larger curvatures, higher stress values and bigger plates. Preliminary designs for the mounting system and its mechanical properties are discussed for mirror modules covering all other radial positions up to the most outer radius of the Athena telescope

Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19

The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive pro-inflammatory immune response and profound lymphopenia. Inflammatory responses according to disease severity were explored by plasma cytokine measurements and proteomics analysis in 147 COVID-19 patients. Furthermore, peripheral blood mononuclear cell cytokine production assays and whole blood flow cytometry were performed. Results confirm a hyperinflammatory innate immune state, while highlighting hepatocyte growth factor and stem cell factor as potential biomarkers for disease severity. Clustering analysis reveals no specific inflammatory endotypes in COVID-19 patients. Functional assays reveal abrogated adaptive cytokine production (interferon-gamma, interleukin-17 and interleukin-22) and prominent T cell exhaustion in critically ill patients, whereas innate immune responses were intact or hyperresponsive. Collectively, this extensive analysis provides a comprehensive insight into the pathobiology of severe to critical COVID-19 and highlight potential biomarkers of disease severity

Report on the Workshop on Sustainable Software Sustainability 2019 (WOSSS19)

This report is based on the discussions and presentations that took place at the Workshop on Sustainable Software Sustainability (www.software.ac.uk/wosss19) in April 2019 (WOSSS19). It captures the state of the art for a range of Software Sustainability themes that were brought up by the organisers and attendees of the workshop