Poor sleep quality associates with decreased functional and structural brain connectivity in normative aging: A MRI multimodal approach

Sleep is a ubiquitous phenomenon, essential to the organism homeostasis. Notwithstanding, there has been an increasing concern with its disruption, not only within the context of pathological conditions, such as neurologic and psychiatric diseases, but also in health. In fact, sleep complaints are becoming particularly common, especially in middle-aged and older adults, which may suggest an underlying susceptibility to sleep quality loss and/or its consequences. Thus, a whole-brain modeling approach to study the shifts in the system can cast broader light on sleep quality mechanisms and its associated morbidities. Following this line, we sought to determine the association between the standard self-reported measure of sleep quality, the Pittsburgh Sleep Quality Index (PSQI) and brain correlates in a normative aging cohort. To this purpose, 86 participants (age range 52-87 years) provided information regarding sociodemographic parameters, subjective sleep quality and associated psychological variables. A multimodal magnetic resonance imaging (MRI) approach was used, with whole-brain functional and structural connectomes being derived from resting-state functional connectivity (FC) and probabilistic white matter tractography (structural connectivity, SC). Brain regional volumes and white matter properties associations were also explored. Results show that poor sleep quality was associated with a decrease in FC and SC of distinct networks, overlapping in right superior temporal pole, left middle temporal and left inferior occipital regions. Age displayed important associations with volumetric changes in the cerebellum cortex and white matter, thalamus, hippocampus, right putamen, left supramarginal and left lingual regions. Overall, results suggest that not only the PSQI global score may act as a proxy of changes in FC/SC in middle-aged and older individuals, but also that the age-related regional volumetric changes may be associated to an adjustment of brain connectivity. These findings may also represent a step further in the comprehension of the role of sleep disturbance in disease, since the networks found share regions that have been shown to be affected in pathologies, such as depression and Alzheimer's disease.Financial support was provided by FEDER funds through the Operational Programme Competitiveness Factors-COMPETE and National Funds through FCT-Foundation for Science and Technology under the project POCI-01-0145-FEDER-007038, by the project NORTE-01-0145-FEDER-000013 [supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 (P2020) Partnership Agreement, through the European Regional Development Fund (FEDER)], by POCI-01-0145-FEDER-016428 [supported by the Operational Programme Competitiveness and Internationalization (COMPETE 2020) and the Regional Operational Program of Lisbon and National Funding through Portuguese Foundation for Science and Technology (FCT, Portugal)], and by the Portuguese North Regional Operational Programme [ON.2 – O Novo Norte, under the National Strategic Reference Framework (QREN), through FEDER]. The work was also developed under the scope of the projects SwitchBox (European Commission, FP7; contract HEALTH-F2-2010-259772) and TEMPO-Better mental health during aging based on temporal prediction of individual brain aging trajectories (Fundação Calouste Gulbenkian; Contract grant number P-139977). LA, TC, RM, PSM, and CP-N were supported by FCT PhD scholarships [SFRH/BD/101398/2014 to LA; SFRH/BD/90078/2012 to TC; PDE/BDE/113604/2015 from the PhD-iHES Programme to RM; PDE/BDE/113601/2015 to PSM; PD/BD/106050/2015 from the Inter-University Doctoral Programme in Aging and Chronic Disease (PhDOC) to CP-N] and AC by a scholarship from the project NORTE-08-5639-FSE-000041 (NORTE 2020; UMINHO/BD/51/2017). NCS was a recipient of a Research Assistantship by the through the FCT Investigator Programme 200∞ Ciência.info:eu-repo/semantics/publishedVersio

Water Peel-Off Transfer of Electronically Enhanced, Paper-Based Laser-Induced Graphene for Wearable Electronics

Funding Information: This work is funded by National Funds through FCT I.P., under the scope of the project UIDB/50025/2020-2023. The authors acknowledge the ERC AdG project DIGISMART ref 787410, EC project SYNERGY H2020-WIDESPREAF-2020-5, CSA, proposal number 952169, EC project EMERGE, No. 101008701, and project BEST - ALT20-03-0247-FEDER-113469 | LISBOA-01-0247-FEDER-113469. T.P. and R.C. acknowledge funding from FCT I.P. through the Ph.D. Grants DFA/BD/8606/2020 and UI/BD/151295/2021. The authors also want to thank Jonas Deuermeier for the help with XPS measurements and analysis. Publisher Copyright: © 2022 American Chemical Society.Laser-induced graphene (LIG) has gained preponderance in recent years, as a very attractive material for the fabrication and patterning of graphitic structures and electrodes, for multiple applications in electronics. Typically, polymeric substrates, such as polyimide, have been used as precursor materials, but other organic, more sustainable, and accessible precursor materials have emerged as viable alternatives, including cellulose substrates. However, these substrates have lacked the conductive and chemical properties achieved by conventional LIG precursor substrates and have not been translated into fully flexible, wearable scenarios. In this work, we expand the conductive properties of paper-based LIG, by boosting the graphitization potential of paper, through the introduction of external aromatic moieties and meticulous control of laser fluence. Colored wax printing over the paper substrates introduces aromatic chemical structures, allowing for the synthesis of LIG chemical structures with sheet resistances as low as 5 ω·sq-1, translating to an apparent conductivity as high as 28.2 S·cm-1. Regarding chemical properties, ID/IG ratios of 0.28 showcase low defect densities of LIG chemical structures and improve on previous reports on paper-based LIG, where sheet resistance has been limited to values around 30 ω·sq-1, with more defect dense and less crystalline chemical structures. With these improved properties, a simple transfer methodology was developed, based on a water-induced peel-off process that efficiently separates patterned LIG structures from the native paper substrates to conformable, flexible substrates, harnessing the multifunctional capabilities of LIG toward multiple applications in wearable electronics. Proof-of concept electrodes for electrochemical sensors, strain sensors, and in-plane microsupercapacitors were patterned, transferred, and characterized, using paper as a high-value LIG precursor for multiples scenarios in wearable technologies, for improved sustainability and accessibility of such applications.publishersversionpublishe

E. Globulus Vessel and Fibre Chemical Analysis

Hardwood species have a complex cellular structure consisting of fibres, vessel elements and parenchyma cells with different chemical compositions. However, the presence of vessels with significant dimensions in their structure is a recurrent problem in the operation of industrial UWF paper printing. Since the 1980s, vessel picking and ink refusal are problems that paper professionals have tried to solve, but solutions for these have not yet been fully found. If vessels are concentrated in a stream, they can be pre-treated (e.g., by mechanical refining) and reincorporated into the pulp. Other strategies aim at vessel enzymatic and/or chemical passivation and sheet surface chemical treatment, altering the vessel adhesion to the fibre network. This requires vessel concentration at laboratorial level for proper chemical studies, such as FE-SEM, μ-XPS, TOF-SIMS and μFTIR. The main objective of our experimental study was to examine bleached kraft pulp E. globulus vessel and fibre composition. For this we performed EDX and μ-FTIR analysis on both fibre and vessel elements, and obtained the carbohydrate composition, the total acids content, the hexenuronic acids content and the zeta potential. Keywords: E. globulus, vessel, EDX, μ-FTIR, sugar content, zeta potentia

Discrimination and surveillance of infectious severe acute respiratory syndrome Coronavirus 2 in wastewater using cell culture and RT-qPCR

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA has been extensively detected in raw wastewater in studies exploring wastewater-based epidemiology (WBE) for early warning purposes. Nonetheless, only a few limited studies investigated the presence of SARS-CoV-2 in treated wastewaters to determine the potential health risks across the water cycle. The detection of SARS-CoV-2 has been done mostly by RT-qPCR and ddPCR, which only provides information on the presence of nucleic acids rather than information on potential infectivity. In this study, we set to develop and evaluate the use of viability RT-qPCR for the selective discrimination and surveillance of infectious SARS-CoV-2 in secondary-treated wastewater. Enzymatic (nuclease) and viability dye (Reagent D) pretreatments were applied to infer infectivity through RT-qPCR using porcine epidemic diarrhea virus (PEDV) as a CoV surrogate. Infectivity tests were first performed on PEDV purified RNA, then on infectious and heat-inactivated PEDV, and finally on heat inactivated PEDV spiked in concentrated secondary-treated wastewater. The two viability RT-qPCR methods were then applied to 27 secondary-treated wastewater samples positive for SARS-CoV-2 RNA at the outlet of five large urban wastewater treatment plants in Portugal. Reagent D pretreatment showed similar behavior to cell culture for heat-inactivated PEDV and both viability RT-qPCR methods performed comparably to VERO E6 cell culture for SARS-CoV-2 present in secondary-treated wastewater, eliminating completely the RT-qPCR signal. Our study demonstrated the lack of infectious SARS-CoV-2 viral particles on secondary-treated wastewater through the application of two pretreatment methods for the rapid inference of infectivity through RT-qPCR, showing their potential application in environmental screening. This study addressed a knowledge gap on the public health risks of SARS-CoV-2 across the water cycle.info:eu-repo/semantics/publishedVersio

Soil and native vegetation remnant in Campinas, SP, Brazil

O objetivo deste trabalho foi identificar atributos e classes de solos associados à ocorrência de remanescentes de cerrado e de floresta nativa em Campinas, SP, e identificar espécies indicadoras desses ambientes. Vinte e sete fragmentos de vegetação nativa foram estudados. Foi realizada a caracterização morfológica, classificação e coleta do solo para análises, bem como o levantamento florístico-fitossociológico do estrato arbóreo. A análise de correspondência canônica identificou as variáveis mais bem correlacionadas com a distribuição das espécies e identificou 15 variáveis que explicaram 31% da variância nos dois primeiros eixos. A classificação dos solos discriminou as fitofisionomias estudadas, Argissolos associados às matas e Latossolos aos cerrados, indício de que baixa fertilidade, baixa retenção de água e drenagem acentuada do solo favorecem o estabelecimento de cerrado. Parâmetro "n" da curva de retenção de água, densidade, H+Al, Ca, Al, K e Mg trocáveis, macroporos e matéria orgânica do solo foram os atributos dos solos mais efetivos nessa diferenciação fitofisionômica. A barreira química imposta pelo excesso de Al e deficiência de Ca no horizonte B e a baixa retenção de água nos solos sob cerrado favorecem as espécies Luehea grandiflora, Persea willdenovii, Xylopia aromatica e Erythroxylum daphnites, abundantes e exclusivamente encontradas nos fragmentos de cerrado.The objective of this work was to identify soil attributes and classes associated to the occurrence of forest and tropical savannah remnants in Campinas, SP, Brazil. Twenty seven native vegetation fragments were studied. Soil morphological, chemical, and physical characterization were carried out, along with floristic-phytosociological survey of the tree stratum. Canonic correspondence analysis identified variables better correlated with plant species distribution. Fifteen environment variables explained 31% of the variance of the first two axes. Soil classes at the Brazilian System of Soil Classification discriminated the studied vegetation: soils with argillic B horizons were more associated to forests, and soils with oxic B horizons, low fertility and good drainage were associated to tropical savannahs. Low fertility, low water retention and good drainage benefit cerrado vegetation establishment. Multivariate analysis identified n parameter of the water retention curve, bulk density, exchangeable H+Al, Ca, Al, K and Mg, macropores and soil organic matter as the most effective soil attributes to plant physiognomy differentiation. The chemical barrier imposed by excess aluminum and calcium deficiency, at B horizon, as well as low water retention in soils under savannah vegetation benefit Luehea grandiflora, Persea willdenovii, Xylopia aromatica and Erythroxylum daphnites, abundant and exclusive species on savannah fragments

Mineração de dados para inferência de relações solo-paisagem em mapeamentos digitais de solo

The objective of this work was to develop a methodology for digital soil mapping at a 1:100,000 scale by applying data mining techniques to preexisting relief descriptors and data from pedological and geological maps. A digital database was created from topographic and thematic maps, and allowed the generation of a digital elevation model (DEM) of the Dois Córregos (SP, Brazil) sheet (1:50,000 scale). The slope gradient, slope profile, contour profile, basin contributing area, and diagonal distance to drainage geomorphometric parameters were extracted from the DEM. The matrix which associated this georeferred data was analyzed by means of decision trees within the Weka machine-learning environment, and a model for soil mapping unit prediction was generated. The overall model accuracy increased from 54 to 61% when soil classes with no chances of being predicted were excluded. The association of data mining techniques with geographical information systems produced digital soil maps feasible to be used in studies requiring less detail than those made with the original reference soil maps.O objetivo deste trabalho foi desenvolver uma metodologia para mapeamento digital de solos na escala 1:100.000 com a aplicação de técnicas de mineração de dados a descritores de relevo e a dados de mapas geológico e pedológico preexistentes. Foi criada uma base de dados digitais a partir de cartas topográficas e temáticas, que permitiu elaboração do modelo digital de elevação (MDE) da folha Dois Córregos, SP (escala 1:50.000). A partir do MDE, foram calculados os parâmetros geomorfométricos declividade, curvaturas em planta e perfil, área de contribuição e distância diagonal de drenagem. A matriz que associou esses dados georreferenciados foi analisada por meio de árvores de decisão, no ambiente de aprendizado de máquina Weka, o que gerou um modelo de predição de unidades de mapeamento de solos. A acurácia geral do modelo aumentou de 54 para 61% com a eliminação das classes com probabilidade nula de ocorrência. A associação da mineração de dados com sistemas de informações geográficas permite a elaboração de mapas digitais passíveis de uso em estudos que requeiram menor detalhamento que aqueles realizados com o mapa original

Análise multicriterial na seleção de bacia hidrográfica para recuperação ambiental.

The Anhumas creek watershed, in the region of Campinas, São Paulo State, Brazil, is degraded also as a result of unplanned land use of its riparian zones, considered Permanent Preservation Areas (APP). Therefore, river flow is unstable, promoting frequent flood damages, besides the lack of several environmental functions of its APPs. Environmental recovery of a degraded area requires a comprehensive effort, often multidisciplinary. Multicriterial analysis is a tool which allows gathering a diversity of attributes of the studied subject, weighing and valuating them, helping in the decision making effort. This work aims to apply two methods of multicriteria analysis to optimize the selection of a watershed for an environmental recovery study of APPs in the Anhumas watershed. The Anhumas watershed was divided in 7 sub-basins aiming the selection of one of those to implement an environmental planning study and to establish and rank areas that should be prioritized for recovery. Thirteen environmental criteria were selected for application of multicriteria analysis using the methods of Compromise Programming (PC) and Cooperative Game Theory (CGT). Relevance of each criterion to the analysis was given by a questionnaire answered by specialists. Basin selection results showed no difference neither between PC and CGT nor between mean or mode used to standardize weights given by specialists. Multicriteria analysis was effective, but allowed enough flexibility for the decision maker (DM) to adjust undesired analysis distortions. After DM adjustments, the priority basins were ranked as basins 4 > 7 > 5 > 6 > 2 > 3 > 1. Important procedures when carrying out such an analysis were to avoid conceptual overlapping among different criteria, to implement appropriate value judgment for each criterion and to use decision maker expertise to supplement weights obtained with specialists.A bacia do ribeirão das Anhumas, na região de Campinas, SP, encontra-se com seus mananciais poluídos e assoreados em virtude de desmatamentos e do uso e ocupação irregulares das Áreas de Preservação Permanente (APP). Com essa falta de planejamento, o regime de vazão dos cursos d'água é alterado, promovendo enchentes sistemáticas, com prejuízos materiais, além de perda de várias funções ambientais dessas APP. A recuperação ambiental de uma área degradada como essa requer um esforço abrangente, muitas vezes muldisciplinar. A análise multicriterial é uma ferramenta que permite reunir características diversas, atribuir pesos e valores a estas, auxiliando na tomada de decisão. O objetivo deste trabalho foi aplicar dois métodos de análise multicriterial para otimização da seleção de uma sub-bacia hidrográfica para estudo de recuperação ambiental em APPs dentro da bacia do ribeirão das Anhumas. Dividiu-se a bacia do ribeirão das Anhumas em sete sub-bacias com o objetivo de selecionar uma delas como bacia-piloto para o planejamento e priorização para recuperação. Foram selecionados 13 critérios de natureza ambiental para aplicação da análise multicriterial. Usaram-se os métodos de análise multicriterial de Programação por Compromisso (PC) e o da Teoria dos Jogos Cooperativos (CGT). O uso dos dois métodos de análise multicriterial, PC e CGT, bem como o tratamento dos pesos atribuídos aos critérios pela média ou pela moda, não mostraram diferença significativa para seleção de bacias prioritárias. A análise multicriterial foi efetiva na seleção de bacias hidrográficas para recuperação de APPs, permitindo o uso de vários fatores no julgamento, com flexibilidade. Apesar dessa objetividade, a interferência do tomador de decisão se mostrou importante para corrigir distorções na análise. A ordenação das bacias prioritárias para recuperação de APPs, após interferência do tomador de decisão foi 4 > 7 > 5 > 6 > 2 > 3 > 1. Procedimentos complementares essenciais ao sucesso na análise multicriterial no contexto estudado foram evitar sobreposição conceitual de critérios, efetuar adequado julgamento de valor para os critérios e usar a experiência do tomador de decisão como complementar aos resultados obtidos com os especialistas

Watershed Selection For Environmental Rehabilitation Using Multicriteria Analysis

A bacia do ribeir\ue3o das Anhumas, na regi\ue3o de Campinas, SP, encontra-se com seus mananciais polu\ueddos e assoreados em virtude de desmatamentos e do uso e ocupa\ue7\ue3o irregulares das \uc1reas de Preserva\ue7\ue3o Permanente (APP). Com essa falta de planejamento, o regime de vaz\ue3o dos cursos d'\ue1gua \ue9 alterado, promovendo enchentes sistem\ue1ticas, com preju\uedzos materiais, al\ue9m de perda de v\ue1rias fun\ue7\uf5es ambientais dessas APP. A recupera\ue7\ue3o ambiental de uma \ue1rea degradada como essa requer um esfor\ue7o abrangente, muitas vezes muldisciplinar. A an\ue1lise multicriterial \ue9 uma ferramenta que permite reunir caracter\uedsticas diversas, atribuir pesos e valores a estas, auxiliando na tomada de decis\ue3o. O objetivo deste trabalho foi aplicar dois m\ue9todos de an\ue1lise multicriterial para otimiza\ue7\ue3o da sele\ue7\ue3o de uma sub-bacia hidrogr\ue1fica para estudo de recupera\ue7\ue3o ambiental em APPs dentro da bacia do ribeir\ue3o das Anhumas. Dividiu-se a bacia do ribeir\ue3o das Anhumas em sete sub-bacias com o objetivo de selecionar uma delas como bacia-piloto para o planejamento e prioriza\ue7\ue3o para recupera\ue7\ue3o. Foram selecionados 13 crit\ue9rios de natureza ambiental para aplica\ue7\ue3o da an\ue1lise multicriterial. Usaram-se os m\ue9todos de an\ue1lise multicriterial de Programa\ue7\ue3o por Compromisso (PC) e o da Teoria dos Jogos Cooperativos (CGT). O uso dos dois m\ue9todos de an\ue1lise multicriterial, PC e CGT, bem como o tratamento dos pesos atribu\ueddos aos crit\ue9rios pela m\ue9dia ou pela moda, n\ue3o mostraram diferen\ue7a significativa para sele\ue7\ue3o de bacias priorit\ue1rias. A an\ue1lise multicriterial foi efetiva na sele\ue7\ue3o de bacias hidrogr\ue1ficas para recupera\ue7\ue3o de APPs, permitindo o uso de v\ue1rios fatores no julgamento, com flexibilidade. Apesar dessa objetividade, a interfer\ueancia do tomador de decis\ue3o se mostrou importante para corrigir distor\ue7\uf5es na an\ue1lise. A ordena\ue7\ue3o das bacias priorit\ue1rias para recupera\ue7\ue3o de APPs, ap\uf3s interfer\ueancia do tomador de decis\ue3o foi 4 > 7 > 5 > 6 > 2 > 3 > 1. Procedimentos complementares essenciais ao sucesso na an\ue1lise multicriterial no contexto estudado foram evitar sobreposi\ue7\ue3o conceitual de crit\ue9rios, efetuar adequado julgamento de valor para os crit\ue9rios e usar a experi\ueancia do tomador de decis\ue3o como complementar aos resultados obtidos com os especialistas.The Anhumas creek watershed, in the region of Campinas, S\ue3o Paulo State, Brazil, is degraded also as a result of unplanned land use of its riparian zones, considered Permanent Preservation Areas (APP). Therefore, river flow is unstable, promoting frequent flood damages, besides the lack of several environmental functions of its APPs. Environmental recovery of a degraded area requires a comprehensive effort, often multidisciplinary. Multicriterial analysis is a tool which allows gathering a diversity of attributes of the studied subject, weighing and valuating them, helping in the decision making effort. This work aims to apply two methods of multicriteria analysis to optimize the selection of a watershed for an environmental recovery study of APPs in the Anhumas watershed. The Anhumas watershed was divided in 7 sub-basins aiming the selection of one of those to implement an environmental planning study and to establish and rank areas that should be prioritized for recovery. Thirteen environmental criteria were selected for application of multicriteria analysis using the methods of Compromise Programming (PC) and Cooperative Game Theory (CGT). Relevance of each criterion to the analysis was given by a questionnaire answered by specialists. Basin selection results showed no difference neither between PC and CGT nor between mean or mode used to standardize weights given by specialists. Multicriteria analysis was effective, but allowed enough flexibility for the decision maker (DM) to adjust undesired analysis distortions. After DM adjustments, the priority basins were ranked as basins 4 > 7 > 5 > 6 > 2 > 3 > 1. Important procedures when carrying out such an analysis were to avoid conceptual overlapping among different criteria, to implement appropriate value judgment for each criterion and to use decision maker expertise to supplement weights obtained with specialists

The genetic structure and mating system of Acrocomia aculeata (Arecaceae)

Acrocomia aculeata is a perennial, fruit-producing palm tree, native to tropical forests. Its fruits have spurred interest because of their significant potential for use in the cosmetic industry and as feedstock for biofuel. In the present study, the genetic structure and mating system in Acrocomia aculeata were analyzed, using eight nuclear micro-satellite loci and samples from São Paulo and Minas Gerais states, Brazil. By means of Bayesian analysis, these populations were clustered into two or three groups. A high multilocus outcrossing rate suggests that outcrosses were predominant, although a certain degree of biparental inbreeding also occurred. Thus, although monoecious and self-compatible, there is every indication that A. aculeata bears a mixed reproductive system, with a predominance of outcrossing. Given the genetic structure revealed hereby, future conservation strategies and germplasm collecting should be focussed on sampling and preserving individuals from different clusters

Paper-based laser-induced graphene for sustainable and flexible microsupercapacitor applications

Funding Information: Open access funding provided by FCT|FCCN (b-on). This work was financed by national funds from Fundação para a Ciência e a Tecnologia (FCT), I.P., in the scope of the projects LA/P/0037/2020, UIDP/50025/2020, and UIDB/50025/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication–i3N and by FEDER funds through the COMPETE 2020 Program and National Funds through Portuguese Foundation for Science and Technology under projects POCI-01–0145-FEDER-007688, UID/CTM/50025 and by ERC AdG grant from the project DIGISMART (ERC-AdG-2017, GA 787410). J.C. would like to acknowledge FCT/MCTES for his present research contract with reference CEECIND/00880/2018. R.C. acknowledges funding from i3N-FCT I.P. through the PhD Grant UI/BD/151295/2021. S. S. and T. P. also acknowledge the funding from National Foundation for Science and Technology, through the PhD Grants SFRH/BD/149751/2019 and 2020.08606.BD, respectively. Publisher Copyright: © 2022, The Author(s).Laser-induced graphene (LIG) is as a promising material for flexible microsupercapacitors (MSCs) due to its simple and cost-effective processing. However, LIG-MSC research and production has been centered on non-sustainable polymeric substrates, such as polyimide. In this work, it is presented a cost-effective, reproducible, and robust approach for the preparation of LIG structures via a one-step laser direct writing on chromatography paper. The developed strategy relies on soaking the paper in a 0.1 M sodium tetraborate solution (borax) prior to the laser processing. Borax acts as a fire-retardant agent, thus allowing the laser processing of sensitive substrates that other way would be easily destroyed under the high-energy beam. LIG on paper exhibiting low sheet resistance (30 Ω sq−1) and improved electrode/electrolyte interface was obtained by the proposed method. When used as microsupercapacitor electrodes, this laser-induced graphene resulted in specific capacitances of 4.6 mF cm−2 (0.015 mA cm−2). Furthermore, the devices exhibit excellent cycling stability (> 10,000 cycles at 0.5 mA cm−2) and good mechanical properties. By connecting the devices in series and parallel, it was also possible to control the voltage and energy delivered by the system. Thus, paper-based LIG-MSC can be used as energy storage devices for flexible, low-cost, and portable electronics. Additionally, due to their flexible design and architecture, they can be easily adapted to other circuits and applications with different power requirements. Graphical Abstract: [Figure not available: see fulltext.]publishersversionpublishe