Correlation of the International Prostate Symptom Score bother question with the Benign Prostatic Hyperplasia Impact Index in a clinical practice setting

To evaluate the association between the International Prostate Symptom Score (IPSS) bother question (BQ) and a validated disease-specific quality-of-life questionnaire, the Benign Prostatic Hyperplasia (BPH) Impact Index (BPH-II), using the BPH Registry and Patient Survey database. PATIENTS AND METHODS The BPH Registry and Patient Survey is a multicentre, longitudinal, observational database of management practices and patient outcomes in a population of patients with BPH in the USA, managed with watchful waiting or pharmacotherapy. Men enrolled in the BPH Registry who completed the IPSS BQ and the four-item BPH-II at enrolment were identified. The association between the IPSS BQ score and the BPH Impact Index was assessed using Spearman rank correlation. RESULTS At baseline (enrolment visit), 6439 men (mean age 66 years) completed the IPSS BQ and the BPH-II. The mean (sd) score of the IPSS BQ was 2.5 (1.4) and of the BPH-II was 2.8 (2.8). Based on responses to the BPH-II, at least half the men reported that their urinary symptoms were associated with physical discomfort, worry about their health, and bothersomeness. The IPSS BQ score was significantly correlated ( P  < 0.001) with the BPH-II ( r  = 0.68) and each of its four questions (physical discomfort, r  = 0.52; worry about health, r  = 0.53; bothersomeness of trouble with urination, r  = 0.67; and time kept from usual activities, r  = 0.44). CONCLUSIONS The IPSS BQ score has a strong and positive correlation with the BPH-II among men enrolled in the BPH Registry. The IPSS BQ is a convenient tool for assessing disease-specific quality of life when determining treatment strategies and evaluating treatment outcomes in men with BPH.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72931/1/j.1464-410X.2008.07574.x.pd

Co-existence of lipid and gas emboli in experimental decompression sickness

Coexistence of lipid and gas emboli in experimental decompression sickness, and lung tissue sectioning data on overcompressed dogs treated with dextran and hepari

Histopathological evidence for pulmonary emboli in experimental decompression sickness diagnosed by radioisotopic lung scanning

Histopathological evidence for pulmonary emboli in experimental decompression sickness diagnosed by radioisotopic lung scannin

Extending the Ehresmann-Schein-Nambooripad Theorem

We extend the `join-premorphisms' part of the Ehresmann-Schein-Nambooripad Theorem to the case of two-sided restriction semigroups and inductive categories, following on from a result of Lawson (1991) for the `morphisms' part. However, it is so-called `meet-premorphisms' which have proved useful in recent years in the study of partial actions. We therefore obtain an Ehresmann-Schein-Nambooripad-type theorem for meet-premorphisms in the case of two-sided restriction semigroups and inductive categories. As a corollary, we obtain such a theorem in the inverse case.Comment: 23 pages; final section on Szendrei expansions removed; further reordering of materia

Renal Lymph Oxygen Tension During Graded Renal Ischemia

Renal lymph oxygen tension in dogs during graded renal ischemi

A theory for game theories

International audienceGame semantics is a valuable source of fully abstract models of programming languages or proof theories based on categories of so-called games and strategies. However, there are many variants of this technique, whose interrelationships largely remain to be elucidated. This raises the question: what is a category of games and strategies? Our central idea, taken from the first author's PhD thesis, is that positions and moves in a game should be morphisms in a base category: playing move m in position f consists in factoring f through m, the new position being the other factor. Accordingly, we provide a general construction which, from a selection of "legal moves" in an almost arbitrary category, produces a category of games and strategies, together with subcategories of deterministic and winning strategies. As our running example, we instantiate our construction to obtain the standard category of Hyland-Ong games subject to the switching condition. The extension of our framework to games without the switching condition is handled in the first author's PhD thesis

Classical Structures Based on Unitaries

Starting from the observation that distinct notions of copying have arisen in different categorical fields (logic and computation, contrasted with quantum mechanics) this paper addresses the question of when, or whether, they may coincide. Provided all definitions are strict in the categorical sense, we show that this can never be the case. However, allowing for the defining axioms to be taken up to canonical isomorphism, a close connection between the classical structures of categorical quantum mechanics, and the categorical property of self-similarity familiar from logical and computational models becomes apparent. The required canonical isomorphisms are non-trivial, and mix both typed (multi-object) and untyped (single-object) tensors and structural isomorphisms; we give coherence results that justify this approach. We then give a class of examples where distinct self-similar structures at an object determine distinct matrix representations of arrows, in the same way as classical structures determine matrix representations in Hilbert space. We also give analogues of familiar notions from linear algebra in this setting such as changes of basis, and diagonalisation.Comment: 24 pages,7 diagram

Sodium cationization can disrupt the intramolecular hydrogen bond that mediates the sunscreen activity of oxybenzone

A key decay pathway by which organic sunscreen molecules dissipate harmful UV energy involves excited-state hydrogen atom transfer between proximal enol and keto functional groups. Structural modifications of this molecular architecture have the potential to block ultrafast decay processes, and hence promote direct excited-state molecular dissociation, profoundly affecting the efficiency of an organic sunscreen. Herein, we investigate the binding of alkali metal cations to a prototype organic sunscreen molecule, oxybenzone, using IR characterization. Mass-selective IR action spectroscopy was conducted at the free electron laser for infrared experiments, FELIX (600-1800 cm-1), on complexes of Na+, K+ and Rb+ bound to oxybenzone. The IR spectra reveal that K+ and Rb+ adopt binding positions away from the key OH intermolecular hydrogen bond, while the smaller Na+ cation binds directly between the keto and enol oxygens, thus breaking the intramolecular hydrogen bond. UV laser photodissociation spectroscopy was also performed on the series of complexes, with the Na+ complex displaying a distinctive electronic spectrum compared to those of K+ and Rb+, in line with the IR spectroscopy results. TD-DFT calculations reveal that the origin of the changes in the electronic spectra can be linked to rupture of the intramolecular bond in the sodium cationized complex. The implications of our results for the performance of sunscreens in mixtures and environments with high concentrations of metal cations are discussed

Quantum Speedup and Categorical Distributivity

This paper studies one of the best known quantum algorithms - Shor's factorisation algorithm - via categorical distributivity. A key aim of the paper is to provide a minimal set of categorical requirements for key parts of the algorithm, in order to establish the most general setting in which the required operations may be performed efficiently. We demonstrate that Laplaza's theory of coherence for distributivity provides a purely categorical proof of the operational equivalence of two quantum circuits, with the notable property that one is exponentially more efficient than the other. This equivalence also exists in a wide range of categories. When applied to the category of finite dimensional Hilbert spaces, we recover the usual efficient implementation of the quantum oracles at the heart of both Shor's algorithm and quantum period-finding generally; however, it is also applicable in a much wider range of settings.Comment: 17 pages, 11 Figure