Forward with Active Clamp for space applications: clamp capacitor, dynamic specifications and EMI filter impact on the power stage design

The impact of the clamp capacitor design, the dynamic specifications and the EMI filter design on the power stage design of a 28V 50W Forward with Active Clamp converter for space applications is analyzed along this paper. Clamp capacitor is designed by considering the ECSS standards limitations for the semiconductors and saturation of the magnetic components, and considering the influence of the resonance between this capacitance and the magnetizing inductance on the input impedance of the converter. Dynamic specifications influence are analyzed. Additionally, the EMI filter design process is described. Singlestage and Multi-stage approaches are proposed. All these features make an increase of 2:4W losses and 1:6 higher area of the converter, compared with a preliminary design of the power stage, before considering these aspects

Comportamiento a la fatiga de un cobre refinado sin y con severa deformación mediante Presión en Canal Angular Constante

Se realizó una investigación con el fin de estudiar el efecto de la severa deformación plástica mediante Presión en Canal Angular Constante (ECAP) en un cobre refinado, sobre el comportamiento a la fatiga. Los especímenes se recocieron y la mitad de éstos se deformaron mediante 8 pases siguiendo la ruta Bc, obteniendo un tamaño de grano micrométrico. El Cu deformado severamente presentó un incremento en el esfuerzo de fluencia y esfuerzo a carga máxima. Los ensayos de fatiga se realizaron en una máquina de carga axial aplicando ciclos de esfuerzo fluctuante a frecuencia de 150 Hz. Se obtuvo un incremento en la vida a la fatiga. Mediante un estudio fractográfico se observó que las grietas de fatiga tienen sus inicios en la superficie libre de la probeta, con lo cual se puede concluir que el incremento en el comportamiento a la fatiga es debido a la severa deformación plástica. An investigation has been carried out in order to study the effect of severe plastic deformation by Equal Channel Angular Pressing (ECAP) in a refined copper on fatigue behavior. Specimens were annealed and half of them were deformed through 8 ECAP passes following the route Bc, obtaining an ultrafine grain size. The severely deformed Cu showed an increase in the yield stress and tensile strength. The fatigue tests were performed on an axial load machine applying fluctuating stress cycles at 150 Hz frequency. An increase in fatigue life was obtained. By fractographic study it was found that fatigue cracks have their beginnings in the free surface of the specimens, thus it can be concluded that the increase in the fatigue behavior is due to the severe plastic deformation

Proyecto eMadrid: metodologías educativas, ludificación y calidad

Esta comunicación presenta un conjunto de trabajos de investigación sobre metodologías docentes, ludificación y calidad realizados en el seno del proyecto eMadrid, de la Comunidad Autónoma de Madrid. En primer lugar se resumen los trabajos realizados en los dos primeros años del proyecto. Posteriormente se presentan las líneas de trabajo previstas para los dos años restantesEstos trabajos se han financiado parcialmente por el proyecto eMadrid (S2013/ICE-2715) de la Comunidad de Madrid, los proyectos FLEXOR (TIN2014-52129-R), RESET (TIN2014-53199-C3-1-R) e iProg (TIN2015-66731-C2-1-R) del Ministerio de Economía y Competitividad, y el proyecto “Adaptación de la metodología PhyMEL a la formación clínica mediante el uso de simuladores” financiado por la empresa Medical Simulato

Development and Testing of a New Instrument for Researching on Cancer Treatment Technologies Based on Magnetic Hyperthermia

(c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.A power electronics circuit allows the generation of high-frequency magnetic field that can be used to increase the temperature of cancer cells previously invaded with the magnetic nanoparticles. The circuit designed for this purpose is a high-frequency phase-shift inverter implemented with SiC devices and natural zero voltage switching. The inductive load has been optimized to increase as much as possible the magnetic field at the center of it considering the physical restrictions. Into this inductor, an adiabatic probe filled with nanoparticles is placed being the main objective to increase its temperature. The control of the inverter has been designed in such a way that it is easy to try waveforms different from the classical sine waves to see its effect on the temperature of the sample. Although the research is in one of the early stages, the first conclusions about the optimal frequency and field have been obtained showing that this technique could be a real option in the future.García, O.; Moreno-Arrones, N.; Cuesta, A.; Gutierrez, A.; Alou, P.; Oliver, J.; Cobos, J.... (2016). Development and Testing of a New Instrument for Researching on Cancer Treatment Technologies Based on Magnetic Hyperthermia. IEEE Journal of Emerging and Selected Topics in Power Electronics. 4(1):243-251. https://doi.org/10.1109/JESTPE.2015.2479092S2432514

QUIJOTE scientific results - VIII. Diffuse polarized foregrounds from component separation with QUIJOTE-MFI

We derive linearly polarized astrophysical component maps in the Northern Sky from the QUIJOTE-MFI data at 11 and 13?GHz in combination with the Wilkinson Microwave Anisotropy Probe K and Ka bands (23 and 33?GHz) and all Planck polarized channels (30-353-GHz), using the parametric component separation method B-SeCRET. The addition of QUIJOTE-MFI data significantly improves the parameter estimation of the low-frequency foregrounds, especially the estimation of the synchrotron spectral index, [beta]s. We present the first detailed ?s map of the Northern Celestial Hemisphere at a smoothing scale of 2°. We find statistically significant spatial variability across the sky. We obtain an average value of ?3.08 and a dispersion of 0.13, considering only pixels with reliable goodness of fit. The power-law model of the synchrotron emission provides a good fit to the data outside the Galactic plane but fails to track the complexity within this region. Moreover, when we assume a synchrotron model with uniform curvature, cs, we find a value of cs = ?0.0797 ± 0.0012. However, there is insufficient statistical significance to determine which model is favoured, either the power law or the power law with uniform curvature. Furthermore, we estimate the thermal dust spectral parameters in polarization. Our cosmic microwave background, synchrotron, and thermal dust maps are highly correlated with the corresponding products of the PR4 Planck release, although some large-scale differences are observed in the synchrotron emission. Finally, we find that the ?s estimation in the high signal-to-noise synchrotron emission areas is prior-independent, while, outside these regions, the prior governs the [beta]s estimation.We thank the staff of the Teide Observatory for invaluable assistance in the commissioning and operation of QUIJOTE. The QUIJOTE experiment is being developed by the Instituto de Astrofisica de Canarias (IAC), the Instituto de Fisica de Cantabria (IFCA), and the Universities of Cantabria, Manchester, and Cambridge. Partial financial support was provided by the Spanish Ministry of Science and Innovation under the projects AYA2007-68058-C03-01, AYA2007- 68058-C03-02, AYA2010-21766-C03-01, AYA2010-21766-C03-02, AYA2014-60438-P, ESP2015-70646-C2-1-R, AYA2017-84185-P, ESP2017-83921-C2-1-R, AYA2017-90675-REDC (co-funded with EU FEDER funds), PGC2018-101814-B-I00, PID2019-110610RBC21, PID2020-120514GB-I00, IACA13-3E-2336, IACA15-BE3707, EQC2018-004918-P, the Severo Ochoa Programs SEV-2015- 0548 and CEX2019-000920-S, the Maria de Maeztu Program MDM2017-0765, and by the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). We acknowledge support from the ACIISI, Consejeria de Economia, Conocimiento y Empleo del Gobierno de Canarias, and the European Regional Development Fund (ERDF) under grant with reference ProID2020010108. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 687312 (RADIOFOREGROUNDS). EdlH acknowledges financial support from the Concepcion´ Arenal Programme of the Universidad de Cantabria. DT acknowledges the support from the Chinese Academy of Sciences (CAS) President’s International Fellowship Initiative (PIFI) with grant no. 2020PM0042. FP acknowledges support from the Spanish State Research Agency (AEI) under grant number PID2019-105552RB-C43. The authors acknowledge the computer resources, technical expertise, and assistance provided by the Spanish Supercomputing Network (RES) node at Universidad de Cantabria. Some of the presented results are based on observations obtained with Planck (http://www.esa.int/Planck), an ESA science mission with instruments and contributions directly funded by ESA Member States, NASA, and Canada. We acknowledge the use of the Legacy Archive for Microwave Background Data Analysis (LAMBDA) and the Planck Legacy Archive (PLA). Support for LAMBDA is provided by the NASA Office of Space Science. Some of the results in this paper have been derived using the HEALPIX package (Gorski ´ et al. 2005), and the HEALPY (Zonca et al. 2019), NUMPY (Harris et al. 2020), EMCEE (ForemanMackey et al. 2013), and MATPLOTLIB (Hunter 2007) PYTHON packages

Targeting tumor initiating cells through inhibition of cancer testis antigens and notch signaling : A hypothesis

Tumor initiating cells (TICs) differ from normal stem cells (SCs) in their ability to initiate tumorigenesis, invasive growth, metastasis and the acquisition of chemo and/or radio-resistance. Over the past years, several studies have indicated the potential role of the Notch system as a key regulator of cellular stemness and tumor development. Furthermore, the expression of cancer testis antigens (CTA) in TICs, and their role in SC differentiation and biology, has become an important area of investigation. Here, we propose a model in which CTA expression and Notch signaling interacts to maintain the sustainability of self-replicating tumor populations, ultimately leading to the development of metastasis, drug resistance and cancer progression. We hypothesize that Notch-CTA interactions in TICs offer a novel opportunity for meaningful therapeutic interventions in cancer

The QUIJOTE experiment: project status and first scientific results

We present the current status of the QUIJOTE (Q-U-I JOint TEnerife) experiment, a new polarimeter with the aim of characterizing the polarization of the Cosmic Microwave Background, and other galactic or extra-galactic physical processes that emit in microwaves in the frequency range 10–42 GHz, and at large angular scales (around 1 degree resolution). The experiment has been designed to reach the required sensitivity to detect a primordial gravitational wave component in the CMB, provided its tensor-to-scalar ratio is larger than r ∼ 0.05. The project consists of two telescopes and three instruments which will survey a large sky area from the Teide Observatory to provide I, Q and U maps of high sensitivity. The first QUIJOTE instrument, known as Multi-Frequency Instrument (MFI), has been surveying the northern sky in four individual frequencies between 10 and 20 GHz since November 2012, providing data with an average sensitivity of 80 µK beam−1 in Q and U in a region of 20, 000 square-degrees. The second instrument, or Thirty-GHz Instrument (TGI), is currently undergoing the commissioning phase, and the third instrument, or Forty-GHz Instrument (FGI), is in the final fabrication phase. Finally, we describe the first scientific results obtained with the MFI. Some specific regions, mainly along the Galactic plane, have been surveyed to a deeper depth, reaching sensitivities of around 40 µK beam−1. We present new upper limits on the polarization of the anomalous dust emission, resulting from these data, in the Perseus molecular complex and in the W43 molecular complex

Planck 2018 results. IV. Diffuse component separation

We present full-sky maps of the cosmic microwave background (CMB) and polarized synchrotron and thermal dust emission, derived from the third set of Planck frequency maps. These products have significantly lower contamination from instrumental systematic effects than previous versions. The methodologies used to derive these maps follow closely those described in earlier papers, adopting four methods (Commander, NILC, SEVEM, and SMICA) to extract the CMB component, as well as three methods (Commander, GNILC, and SMICA) to extract astrophysical components. Our revised CMB temperature maps agree with corresponding products in the Planck 2015 delivery, whereas the polarization maps exhibit significantly lower large-scale power, reflecting the improved data processing described in companion papers; however, the noise properties of the resulting data products are complicated, and the best available end-to-end simulations exhibit relative biases with respect to the data at the few percent level. Using these maps, we are for the first time able to fit the spectral index of thermal dust independently over 3 degree regions. We derive a conservative estimate of the mean spectral index of polarized thermal dust emission of beta_d = 1.55 +/- 0.05, where the uncertainty marginalizes both over all known systematic uncertainties and different estimation techniques. For polarized synchrotron emission, we find a mean spectral index of beta_s = -3.1 +/- 0.1, consistent with previously reported measurements. We note that the current data processing does not allow for construction of unbiased single-bolometer maps, and this limits our ability to extract CO emission and correlated components. The foreground results for intensity derived in this paper therefore do not supersede corresponding Planck 2015 products. For polarization the new results supersede the corresponding 2015 products in all respects