Data mining via ILP: The application of progol to a

As far as this author is aware, this is the first paper to describe the application of Progol to enantioseparations. A scheme is proposed for data mining a relational database of published enantioseparations using Progol. The application of the scheme is described and a preliminary assessment of the usefulness of the resulting generalisations is made using their accuracy, size, ease of interpretation and chemical justification

Deviation of Atmospheric Mixing from Maximal and Structure in the Leptonic Flavor Sector

I attempt to quantify how far from maximal one should expect the atmospheric mixing angle to be given a neutrino mass-matrix that leads, at zeroth order, to a nu_3 mass-eigenstate that is 0% nu_e, 50% nu_mu, and 50% nu_tau. This is done by assuming that the solar mass-squared difference is induced by an "anarchical" first order perturbation, an approach than can naturally lead to experimentally allowed values for all oscillation parameters. In particular, both |cos 2theta_atm| (the measure for the deviation of atmospheric mixing from maximal) and |U_e3| are of order sqrt(Delta m^2_sol/Delta m^2_atm) in the case of a normal neutrino mass-hierarchy, or of order Delta m^2_sol/Delta m^2_atm in the case of an inverted one. Hence, if any of the textures analyzed here has anything to do with reality, next-generation neutrino experiments can see a nonzero cos 2theta_atm in the case of a normal mass-hierarchy, while in the case of an inverted mass-hierarchy only neutrino factories should be able to see a deviation of sin^2 2theta_atm from 1.Comment: 12 pages, no figures, references and acknowledgments adde

Additional Nucleon Current Contributions to Neutrinoless Double Beta Decay

We have examined the importance of momentum dependent induced nucleon currents such as weak-magnetism and pseudoscalar couplings to the amplitude of neutrinoless double beta decay in the mechanisms of light and heavy Majorana neutrino as well as in that of Majoron emission. Such effects are expected to occur in all nuclear models in the direction of reducing the light neutrino matrix elements by about 30%. To test this we have performed a calculation of the nuclear matrix elements of the experimentally interesting nuclei A = 76, 82, 96, 100, 116, 128, 130, 136 and 150 within the pn-RQRPA. We have found that indeed such corrections vary somewhat from nucleus to nucleus, but in all cases they are greater than 25 percent. In the case of heavy neutrino the effect is much larger (a factor of 3). Combining out results with the best presently available experimental limits on the half-life of the neutrinoless double beta decay we have extracted new limits on the effective neutrino mass (light and heavy) and the effective Majoron coupling constant.Comment: 31 pages, RevTex, 3 Postscript figures, submitted to Phys. Rev.

Leptogenesis and Neutrino Oscillations Within A Predictive G(224)/SO(10)-Framework

A framework based on an effective symmetry that is either G(224)= SU(2)_L x SU(2)_R xSU(4)^c or SO(10) has been proposed (a few years ago) that successfully describes the masses and mixings of all fermions including neutrinos, with seven predictions, in good accord with the data. Baryogenesis via leptogenesis is considered within this framework by allowing for natural phases (~ 1/20-1/2) in the entries of the Dirac and Majorana mass-matrices. It is shown that the framework leads quite naturally, for both thermal as well as non-thermal leptogenesis, to the desired magnitude for the baryon asymmetry. This result is obtained in full accord with the observed features of the atmospheric and solar neutrino oscillations, as well as with those of the quark and charged lepton masses and mixings, and the gravitino-constraint. Hereby one obtains a unified description of fermion masses, neutrino oscillations and baryogenesis (via leptogenesis) within a single predictive framework.Comment: Efficiency factor updated, some clarifications and new references added. 19 page

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Feasibility of /sup 81/Br(nu,e/sup -/)/sup 81/Kr solar neutrino experiment

Several ingenious solutions have been offered for the solar neutrino problem - a defect in the solar model, the appearance of a new type of neutrino physics, the sun is no longer burning, etc. The range of these proffered solutions stresses the need for a new experiment to study the sun. The modern pulsed laser now makes possible a new solar neutrino test which examines an independent neutrino source in the sun. A recently proposed experiment would use the reaction /sup 81/Br(nu,e/sup -/)/sup 81/Kr to measure the flux of /sup 7/Be neutrinos from the sun. When /sup 7/Be decays by electron capture to make /sup 7/Li, a neutrino is emitted at 0.862 MeV and the flux of these on the earth is about 4 x 10/sup 9/ cm/sup -2/ s/sup -1/, according to the standard model. Therefore, an experiment based on /sup 81/Br(nu,e/sup -/)/sup 81/Kr which is sensitive to these lower energy neutrinos would be of fundamental importance. To first order, the chlorine experiment detects the /sup 8/B neutrinos while bromine detects the much more abundant /sup 7/Be neutrino source. In practice, the proposed bromine experiment would be very similar to the chlorine radiochemical experiment, except that /sup 81/Kr with a half-life of 2 x 10/sup 5/ years cannot be counted by decay methods. With an experiment of about the same volume as the chlorine experiment (380 m/sup 3/) filled with CH/sub 2/Br/sub 2/, the model predicts about 2 atoms of /sup 81/Kr per day. The bromine experiment depends entirely on the RIS method, implemented with pulsed lasers, for its success. 10 refs., 3 figs