110: Non-invasive coronary flow reserve predicts response to exercise in asymptomatic severe aortic stenosis

In patients (pts) with asymptomatic aortic stenosis (AS), exercise stress echocardiography (ESE) provides additional prognostic information beyond baseline. The coronary flow reserve (CFR) is impaired in AS but its link with exertion is missing in this setting. We hypothesize that CFR could predict exercise capacity and an abnormal exercise test in AS.Methodsnon-invasive CFR and symptom limited semi-supine exercise stress echocardiography (ESE) were performed the same morning in 20 consecutive pts with asymptomatic isolated severe AS (mean age 69±12 years, 30% women, mean aortic valve area 0.8±0.1cm2;, mean LVEF 70±6%). CFR was performed in the distal part of the left anterior descending artery using intravenous adenosine infusion (140μg/kg/min over 2min). An abnormal ESE was defined as onset of symptoms at less than 80% of maximum predicted workload, ECG ST-segment depression ≥2mm during exercise, rise of systolic blood pressure < 20mmHg or fall in blood pressure, complex ventricular arrhythmia.Resultswhen compared to pts with normal ESE, pts with an abnormal ESE (n=9) were older, had higher left atrial volume index (all, ≤0.05), and lower CFR (2.1±0.3 vs. 2.9±0.7, ≤0.01), whereas resting hemodynamic variables assessing AS severity were not significantly different between subgroups. Furthermore, CFR was significantly correlated to age, the change of transvalvular pressure gradient and LVEF with exercise, workload (in watts), and exercise duration (all, p<0.05). After adjusting for age, and sex, CFR remained significantly correlated to exercise duration and workload (all, p<0.05). Using a ROC curve analysis, a CFR < 2.17 was the best cut-off to predict an abnormal ESE with a sensitivity of 67%, a specificity of 90% (AUC=0.8, p<0.01).ConclusionIn pts with asymptomatic severe AS, non-invasive CFR is correlated to exercise duration and workload, and a low CFR predicts an abnormal ESE with a good accuracy

Copernicus Sentinel-2 Collection-1: A Consistent Dataset of Multispectral Imagery with enhanced Quality

The Copernicus Sentinel-2 satellite mission, with its Sentinel-2A and Sentinel-2B units, offers since several years now a massive quantitative and qualitative resource for the Earth Observation community. Since the launch of Sentinel-2A in 2015, and Sentinel-2B in 2017, many lessons have been learnt leading to continuous improvements of the radiometric and the geometric performances. However, the current archive is composed of heterogenous processing baselines with inconsistent product formats and uneven data quality, which limits its use for multi-temporal monitoring applications. To overcome this limitation, the Copernicus program has undertaken a complete reprocessing with the latest processing baseline (05.00). It concerns the L1C (Top-OfAtmosphere reflectance) and L2A (Surface Reflectance) products. This paper recalls the features of Collection-1 products and gives an overview of the first validation results

Time series noise of Copernicus Sentinel-2 operational L2A-Products of year 2022

Copernicus Sentinel-2 is the main European land surface observing mission. It serves for observation of land-cover change and deriving biophysical variables related to agriculture and forestry, monitors coastal and inland waters and is useful for risk and disaster mapping. Data quality of the provided data products is a critical point for all these applications. The Sentinel-2 mission consists of a constellation of two polar orbiting satellite units. Both Sentinel-2A and Sentinel-2B are equipped with an identical optical imaging sensor MSI (Multi-Spectral Instrument) which samples 13 spectral bands: four bands at 10 m in the Visible Near Infrared (VNIR) region, six bands at 20 m and three bands at 60 m spatial resolution in the VNIR to Shortwave Infrared (SWIR) region. Sentinel-2 Level-2A (L2A) data contain Bottom-of-Atmosphere (BOA) surface reflectance products together with Aerosol Optical Thickness (AOT), Integrated Water Vapour (WV) and Scene Classification (SCL) maps. They are generated with Sen2Cor which is the operational atmospheric correction processor that removes the effect of the atmosphere from Top-of-Atmosphere Level-1C data. ESA started the complete reprocessing of the Sentinel-2 data archive named Collection-1 which is tagged with the processing baseline (PB) 5.00. The previous processing baseline PB 4.00 has equivalent evolutions and is very close to the PB 5.00 of Collection-1. Operational L2A products with PB 4.00 were generated from end of January 2022 to beginning of December 2022. In this presentation we propose to study surface reflectance time series smoothness, for several test sites, using L2A products from year 2022. The smoothness of that time series is used as an indicator of data quality of the reprocessed products. Test sites are selected representing different climate zones with different AOT retrieval performance 0.03 ≤ RMSDAOT ≤ 0.20 and different WV retrieval performance 0.12 g/cm2 ≤ RMSDWV ≤ 0.40 g/cm2

The Athena X-ray Integral Field Unit (X-IFU)

The X-ray Integral Field Unit (X-IFU) is the high resolution X-ray spectrometer of the ESA Athena X-ray observatory. Over a field of view of 5' equivalent diameter, it will deliver X-ray spectra from 0.2 to 12 keV with a spectral resolution of 2.5 eV up to 7 keV on similar to 5 '' pixels. The X-IFU is based on a large format array of super-conducting molybdenum-gold Transition Edge Sensors cooled at similar to 90 mK, each coupled with an absorber made of gold and bismuth with a pitch of 249 mu m. A cryogenic anti-coincidence detector located underneath the prime TES array enables the non X-ray background to be reduced. A bath temperature of similar to 50 mK is obtained by a series of mechanical coolers combining 15K Pulse Tubes, 4K and 2K Joule-Thomson coolers which pre-cool a sub Kelvin cooler made of a He-3 sorption cooler coupled with an Adiabatic Demagnetization Refrigerator. Frequency domain multiplexing enables to read out 40 pixels in one single channel. A photon interacting with an absorber leads to a current pulse, amplified by the readout electronics and whose shape is reconstructed on board to recover its energy with high accuracy. The defocusing capability offered by the Athena movable mirror assembly enables the X-IFU to observe the brightest X-ray sources of the sky (up to Crab-like intensities) by spreading the telescope point spread function over hundreds of pixels. Thus the X-IFU delivers low pile-up, high throughput (> 50%), and typically 10 eV spectral resolution at 1 Crab intensities, i.e. a factor of 10 or more better than Silicon based X-ray detectors. In this paper, the current X-IFU baseline is presented, together with an assessment of its anticipated performance in terms of spectral resolution, background, and count rate capability. The X-IFU baseline configuration will be subject to a preliminary requirement review that is scheduled at the end of 2018. The X-IFU will be provided by an international consortium led by France, the Netherlands and Italy, with further ESA member state contributions from Belgium, Czech Republic, Finland, Germany, Ireland, Poland, Spain, Switzerland and contributions from Japan and the United States.Peer reviewe

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR&nbsp;=&nbsp;2.05, 95%CI&nbsp;=&nbsp;1.39–3.02, p&nbsp;&lt;&nbsp;0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR&nbsp;=&nbsp;0.42, 95%CI&nbsp;=&nbsp;0.18–0.99, p&nbsp;=&nbsp;0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Déficits exécutifs chez des enfants atteints d’un Trouble Développemental des Coordinations/Dyspraxie

International audienc