20 research outputs found
Pervasive gaps in Amazonian ecological research
Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4
While the increasing availability of global databases on ecological communities has advanced our knowledge
of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In
the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of
Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus
crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced
environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian
Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by
2050. This means that unless we take immediate action, we will not be able to establish their current status,
much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio
Pervasive gaps in Amazonian ecological research
Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost
Infecção primária cutânea aguda por Nocardia asteroides em paciente com lupus eritematoso sistêmico
Relatamos um caso de infecção primária cutânea aguda de origem traumática, causada por Nocardia asteroides, que manifestou-se como celulite em paciente com lupus eritematoso sistêmico. O diagnóstico foi feito pelo exame direto e cultivos do aspirado da lesão. São discutidas as formas clínicas das infecções por Nocardia que afetam a pele, relatadas no Rio Grande do Sul e no Uruguai.We report a case of acute primary cutaneous infection of traumatic origin caused by Nocardia asteroides, appeared as cellulitis in a patient with systemic lupus erythematosus. Diagnosis was established by direct examination and cultures from aspirate specimens. The clinical forms of Nocardia infections that affect the skin, reported in Rio Grande do Sul and Uruguay, are discussed
Autoimmune disease and multiple autoantibodies in 42 patients with RASopathies
The association of RASopathies [Noonan syndrome (NS) and Noonan-related syndromes] and autoimmune disorders has been reported sporadically. However, a concomitant evaluation of autoimmune diseases and an assessment of multiple autoantibodies in a large population of patients with molecularly confirmed RASopathy have not been performed. The clinical and laboratory features were analyzed in 42 RASopathy patients, the majority of whom had NS and five individuals had Noonan-related disorders. The following autoantibodies were measured: Anti-nuclear antibodies, anti-double stranded DNA, anti-SS-A/Ro, anti-SS-B/La, anti-Sm, anti-RNP, anti-Scl-70, anti-Jo-1, anti-ribosomal P, IgG and IgM anticardiolipin (aCL), thyroid, anti-smooth muscle, anti-endomysial (AE), anti-liver cytosolic protein type 1 (LC1), anti-parietal cell (APC), anti-mitochondrial (AM) antibodies, anti-liver-kidney microsome type 1 antibodies (LKM-1), and lupus anticoagulant. Six patients (14%) fulfilled the clinical criteria for autoimmune diseases [systemic lupus erythematous, polyendocrinopathy (autoimmune thyroiditis and celiac disease), primary antiphospholipid syndrome (PAPS), autoimmune hepatitis, vitiligo, and autoimmune thyroiditis]. Autoimmune antibodies were observed in 52% of the patients. Remarkably, three (7%) of the patients had specific gastrointestinal and liver autoantibodies without clinical findings. Autoimmune diseases and autoantibodies were frequently present in patients with RASopathies. Until a final conclusion of the real incidence of autoimmunity in Rasopathy is drawn, the physicians should be alerted to the possibility of this association and the need for a fast diagnosis, proper referral to a specialist and ultimately, adequate treatment. (c) 2012 Wiley Periodicals, Inc.FAPESP [07/59555-0, 08/50184-2]FAPESPCNPQ [301477/2009-4, 300248/2008-3, 300665/2009-1]CNPqFederico FoundationFederico Foundatio
Emergence of G12P[6] rotavirus strains among hospitalised children with acute gastroenteritis in Belém, Northern Brazil, following introduction of a rotavirus vaccine
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Species A rotavirus still remains a major cause of acute gastroenteritis in infants and young children. Globally, six genotypes (G1P[8], G2P[4], G3P[8], G4P[8], G9P[8] and G12P[8]) account for >90% of circulating strains; however, genotype G12 in combination with P[6] or P[9] has been detected at increasing rates. We sought to broaden our knowledge about the rotavirus strains circulating during the early post-vaccine-introduction period. Stool samples were obtained from children hospitalised for acute gastroenteritis in Belém, Northern Brazil, from May 2008 to May 2011 and examined by reverse transcription polymerase chain reaction and nucleotide sequencing. A total of 122 out of the original 1076 rotavirus strains were judged to be non-typeable in the first analysis and were therefore re-examined. G2P[4] was the most prevalent genotype (58.0%), followed by G1P[8] (16.9%), and G12P[6] (7.5%). G12P[6] strains were identified at similar rates during the first (2.5%) and second (3.9%) years, and the rate jumped to 15.6% in the third year. Analysis of VP7 sequences of the G12P[6] strains showed that they belonged to lineage III. In addition, co-circulating G12P[6] strains displaying long and short RNA patterns were found to belong to the Wa-like and DS-1-like constellation, respectively. Additional unusual circulating strains G12P[9] and G3P[9] were also identified. This hospital-based study showed a high prevalence of G12P[6] strains in the third year of surveillance. Our results highlight the need for continuous longitudinal monitoring of circulating rotavirus strains after introduction of rotavirus vaccines in Brazil and elsewhere
Julgamento moral sobre pena de morte e redução da maioridade penal Moral judgments on death penalty and reduction of criminal majority
O objetivo principal deste trabalho foi investigar o julgamento moral de estudantes do ensino médio e de licenciaturas sobre pena de morte e redução da maioridade penal. Para tanto, utilizou-se como suporte teórico e empírico a tipologia do desenvolvimento moral de Lawrence Kohlberg. Participaram deste estudo 200 estudantes que responderam, além de uma lista que solicitava informações de alguns dos seus dados biodemográficos, a questões relacionadas à pena de morte e à redução da maioridade penal. De um modo geral, os participantes opinaram favoravelmente pela pena de morte e pela redução da maioridade penal, e, em defesa de suas opiniões, utilizaram, sobretudo, argumentos típicos dos estágios hierarquicamente inferiores da tipologia kohlberguiana, havendo, contudo, algumas diferenças entre as respostas em função do grau de escolaridade. Esses resultados foram discutidos com base na teoria kohlberguiana e em estudos empíricos que tratam dos temas pena de morte e redução da maioridade penal.<br>The aim of this study was to investigate the moral judgments of students of high school and degrees on the death penalty and the reduction of criminal majority. Thus, it was used to support the theoretical and empirical typology of moral development of Lawrence Kohlberg. The study included 200 students who responded, beyond a list that requested information from some of their bio-demographic data, questions related to death penalty and reduction of criminal majority. In general, participants opined in favor of the death penalty and the reduction of criminal majority, and in defense of their views, used mainly typical arguments hierarchically lower stages of the Kohlberg's typology there, however, some differences between the responses according to level of schooling. These results were discussed taking into consideration the Kohlberg's theory and empirical studies dealing with the issues of death penalty and reduction of criminal majority
Acute primary cutaneous Nocardia asteroides infection in a patient with systemic lupus erythematosus. Case report Infecção primária cutânea aguda por Nocardia asteroides em paciente com lupus eritematoso sistêmico
We report a case of acute primary cutaneous infection of traumatic origin caused by Nocardia asteroides, appeared as cellulitis in a patient with systemic lupus erythematosus. Diagnosis was established by direct examination and cultures from aspirate specimens. The clinical forms of Nocardia infections that affect the skin, reported in Rio Grande do Sul and Uruguay, are discussed.<br>Relatamos um caso de infecção primária cutânea aguda de origem traumática, causada por Nocardia asteroides, que manifestou-se como celulite em paciente com lupus eritematoso sistêmico. O diagnóstico foi feito pelo exame direto e cultivos do aspirado da lesão. São discutidas as formas clínicas das infecções por Nocardia que afetam a pele, relatadas no Rio Grande do Sul e no Uruguai
Rotavirus antigenemia as a common event among children hospitalised for severe, acute gastroenteritis in Belém, northern Brazil
This study received financial support from the Evandro Chagas Institute (IEC),
Health Surveillance Secretariat, which supported the study team to perform
sample collection, analysis, interpretation of the data obtained and writing
the manuscript. The National Council for Scientific and Technological
Development (CNPq) provided financial support to purchase laboratory kits
for use in the analysis.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará State. Belém, PA, Brazil.Federal University of Pará State. Belém, PA, Brazil.Federal University of Pará State. Belém, PA, Brazil.Federal University of Pará State. Belém, PA, Brazil.Federal University of Pará State. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Background: Rotavirus antigenemia and RNAemia (the presence of rotavirus RNA in serum) have been commonly
identified among paediatric patients with acute gastroenteritis. In this study we examined the association between
rotavirus antigenemia and clinical features, and sought to determine the genotypes of rotaviruses detected in
paired stool and serum samples.
Methods: Paired stool and serum samples were obtained from children hospitalised for acute gastroenteritis in Belém,
Brazil, between June 2012 and June 2015. The 20-point Vesikari scoring system was used to assess the disease severity
upon a retrospective medical record review. Stool and serum samples were primarily screened for the presence of
rotavirus antigen using a commercial ELISA assay. The rotavirus isolates from stool and serum samples were genotyped
by using the classical reverse-transcriptase polymerase chain reaction (RT-PCR) and/or through nucleotide sequencing
of VP4 and VP7 genes. Viral load was estimated using real-time RT-PCR.
Results: In total rotavirus antigen was detected in 109 (24.2%) stool samples from 451 children, whereas antigenemia
occurred in 38.5% (42/109) of these patients. We demonstrated that patients positive for rotavirus RNA in paired stool
and serum samples were more likely to have a higher frequency of vomiting episodes in a 24-h period (p = 0.0035).
Our findings also suggested that children not vaccinated against rotavirus are more likely to develop antigenemia, as
compared to those given at least one vaccine dose (p = 0.0151). G12P [8] and G2P [4] genotypes were predominant
throughout the study period, accounting for 52.3% (57/109) and 27.5% (30/109) of the typed isolates, respectively. Ten
stool-serum pairs could be typed for VP4 and VP7 genes. Seven of these pairs showed concordant results with G2P [4]
genotype being detected in stool and serum samples, whereas discrepancies between genotypes (G2P [4]/G2P[NT]
and G12P [8]/G2P[NT]) were seen in three pairs.
Conclusions: Rotavirus antigenemia and RNAemia occur in a significant number of children hospitalised for acute
gastroenteritis in Belém, Brazil, and may contribute to a greater disease severity, particularly translated into a greater
number of vomiting episodes. This study documented a high concordance of genotypes detected in a subgroup of
paired stool and serum sample