Catalytic constructive deoxygenation of lignin-derived phenols: new C-C bond formation processes from imidazole-sulfonates and ether cleavage reactions

Funding: UK Engineering and Physical Sciences Research Council (EPSRC)As part of a programme aimed at exploiting lignin as a chemical feedstock for less oxygenated fine chemicals, several catalytic C-C bond forming reactions utilising guaiacol imidazole sulfonate are demonstrated. These include the cross-coupling of a Grignard, a non-toxic cyanide source, a benzoxazole, and nitromethane. A modified Meyers reaction is used to accomplish a second constructive deoxygenation on a benzoxazole functionalised anisole.Publisher PDFPeer reviewe

An electrically powered binary star?

We propose a model for stellar binary systems consisting of a magnetic and a non-magnetic white-dwarf pair which is powered principally by electrical energy. In our model the luminosity is caused by resistive heating of the stellar atmospheres due to induced currents driven within the binary. This process is reminiscent of the Jupiter-Io system, but greatly increased in power because of the larger companion and stronger magnetic field of the primary. Electrical power is an alternative stellar luminosity source, following on from nuclear fusion and accretion. We find that this source of heating is sufficient to account for the observed X-ray luminosity of the 9.5-min binary RX J1914+24, and provides an explanation for its puzzling characteristics.Comment: accepted by MNRA

Mesolithic and later activity at North Barr River, Morvern

At North Barr River, Morvern, inspection of forestry planting mounds on a raised beach terrace identified a chipped stone assemblage associated with upcast deposits containing charcoal. An archaeological evaluation of the site, funded by Forestry Commission Scotland, sought to better understand the extent and character of this Mesolithic and later prehistoric lithic scatter. The lithic assemblage is predominantly debitage with some microliths and scrapers. The range of raw materials including flint, Rùm bloodstone and baked mudstone highlights wider regional networks. Other elements, including a barbed and tanged arrowhead, belong to later depositional episodes. Two mid-second millennium bc radiocarbon dates were obtained from soil associated with some lithics recovered from a mixed soil beneath colluvial deposits. The chronology of a putative stone bank or revetment is uncertain but the arrangement of stone may also date to the second millennium bc

Less hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethers

The authors thanks the EPSRC for funding in the initial stages of this work from EP/J018139/1 and from the DTG.The challenging reaction of unactivated ortho-substituted aromatic ethers with Grignard reagents has been found to be most effectively catalysed using nickel complexes of less sterically hindered ligands. Air stable, cheap, commercially available [NiCl2(PnBu3)2] stands out as an improved catalyst for this type of transformation. The improved results with this catalyst even extend to some couplings of a more activated substrate when examined at higher temperatures and at catalyst loadings down to 0.1 mol%. Unusual induction periods in these latter reactions have been related to the by-product magnesium salts acting as co-catalysts.PostprintPeer reviewe

Familiarization, Reliability, and Evaluation of a Multiple Sprint Running Test Using Self-Selected Recovery Periods

The aims of the present study were to investigate the process of self-selected recovery in a multiple sprint test with a view to using self-selected recovery time as a means of reliably quantifying an individual's ability to resist fatigue in this type of exercise. Twenty physically active exercise science students (means ± SD for age, height, body mass, body fat, and V̇O2max of the subjects were 21 ± 2 yr, 1.79 ± 0.09 m, 83.7 ± 10.8 kg, 16.6 ± 3.9%, and 52.7 ± 7.2 ml·kg−1·min−1, respectively) completed 4 trials of a 12 × 30 m multiple sprint running test under the instruction that they should allow sufficient recovery time between sprints to enable maximal sprint performance to be maintained throughout each trial. Mean recovery times across the 4 trials were 73.9 ± 24.7, 82.3 ± 23.8, 77.6 ± 19.1, and 77.5 ± 13.9 seconds, respectively, with variability across the first 3 trials considered evidence of learning effects. Test-retest reliability across trials 3 to 4 revealed a good level of reliability as evidenced by a coefficient of variation of 11.1% (95% likely range: 8.0-18.1%) and an intraclass correlation coefficient of 0.76 (95% likely range: 0.40-0.91). Despite no change in sprint performance throughout the trials, ratings of perceived exertion increased progressively and significantly (p < 0.001) from a value of 10 ± 2 after sprint 3 to 14 ± 2 after sprint 12. The correlation between relative V̇O2max and mean recovery time was 0.14 (95% likely range: −0.37-0.58). The results of the present study show that after the completion of 2 familiarization trials, the ability to maintain sprinting performance in a series of repeated sprints can be self-regulated by an athlete to a high degree of accuracy without the need for external timepieces