Ages of [Wo]Man

Ages of [Wo]Man, was written to fulfill the thesis requirements of a solo performance for the M.F.A in Acting at Louisiana State University (LSU) in May 2015. The purpose of this project is to write, produce and perform a solo performance, to be reproduced after my time here at LSU. This paper documents the conception of my work, adaptation of Shakespeare’s text, rehearsal process and production of this piece. It contains five chapters. Chapter 1 is comprised of an introduction and discussion of how I decided on the topic for my solo performance. Chapter 2 continues with a layout of the objectives for the piece, including accessibility of Shakespeare’s text to a modern audience, gender bending roles, celebrating life and aging. Chapter 3 is the process of writing the script and adapting Shakespeare’s text. In Chapter 4 I describe my acting and rehearsal process and finally, in Chapter 5, a conclusion on the experience

Inducing Slips of Action: Creating a Window Into Attention Failures

Many of our daily activities are achieved through goal-oriented routines which illustrates the adaptability and efficiency of information processing. Nevertheless, slips of action do occur. This study was designed to determine if slips of action can be induced in a well learned task and if so, how these slips affect specific indicators of task performance. Thirty (12 male) right-handed undergraduate participants were taught, with arrow cues, a sequence of dominant hand movements. Following this learning phase, a portion of the sequences were altered by either changing the spatial location of the arrow cue or by changing the actual movement goal. Results revealed that participants made numerous action slips which were most prevalent when the movement goal was altered. This suggests that participants were unable to disengage their expected movement plan and thus were vulnerable to errors. In addition to exploring the frequency of action slips we also looked at participants’ reaction and movement times on trials that preceded and followed errors and found that a speed-accuracy trade-off could not account for the slips. We also showed that frequency of slips on our task could reliably predict performance on the SART, a measure of inhibitory control, and the frequency of attention failures in daily living on the ARCES. Overall, the results of this study reveal that action slips can be induced by manipulating a well learned action routine and that the frequency of these induced slips reflects a participant’s tendency to commit action slips in everyday life

'Oops! I can't believe I did that!' Inducing Errors in a Routine Action Sequence

‘What was I thinking ?!?’ – No matter age, intelligence or social status, we all experience moments like these. Perhaps it is walking into a room and forgetting what you went there to do or maybe failing to add sugar to your coffee due to an interruption. Regardless, even though many of our daily activities are accomplished through routines that require very little conscious effort, errors of attention or slips of action do occur. This collection of studies was designed with three main questions in mind: 1) can action slips be induced in a laboratory-based task (Slip Induction Task; SIT), 2) how well do currently established theories of action slips explain the errors that are induced within the SIT, and 3) what insight can be gained about preventing such errors? The first experiment was developed to replicate previous findings regarding the effectiveness of the SIT, as well as to determine the extent to which SIT performance correlates with other measures of attention failure. The study discussed in Chapter 3 expands on those results by investigating the effects of healthy aging on slip induction and finds that while older adults were better able to avoid action slips, they appear to sacrifice speed for accurate performance. The goal of the subsequent study was to determine whether young adult participants would also enjoy increased accuracy if they completed the task at a slower pace. Finally, the study discussed in Chapter 5 looks at whether changing the goal of the SIT would alter participants’ ability to inhibit unexpected cue information

Cost-Sensitive Concurrent Planning Under Duration Uncertainty for Service-Level Agreements

This paper brings together work in stochastic modelling, using the process algebra PEPA, and work in automated planning. Stochastic modelling has been concerned with verification of system performance metrics for some time: given a model of a system, determining whether it will meet a service-level agreement (SLA). For example, whether a given sequence of transitions on a network will complete within 5 seconds 80% of the time. The problem of deciding how to reconfigure the system most cost-effectively when the SLA cannot be met has not been widely explored: it is currently solved manually. Inspired by this, we consider how planning can be used to automate the configuration of service-oriented systems. Configuring these stochastic systems presents new challenges to planning: building plans that meet SLAs, but also have low cost. To this end, we present a domain-independent planner for planning problems with action costs and stochastic durations, and show how this can be used to solve both traditional planning domains, and within the framework of configuring a larger process algebra model

Knowledge, Leadership and the Role of Spirituality: An Exploration of Principal as Spiritual Leader

Recent scholarship (Knapp, Copland, Honig, Plecki & Portin, 2010; Louis, Leithwood, Wahlstrom, Anderson et al., 2010) demonstrates the impact of school leadership on student success. Using the research model of the ISSPP (Day, 2010), a team of researchers utilized a dynamic approach to identify leadership practices and beliefs that could be attributed to rises in student achievement and diminishing achievement gaps. In this paper, we present a cross-case analysis of three elementary schools in the southeastern US. Our findings highlight one particular aspect of these practices and beliefs: spirituality

Lifestyle Intervention with or without Lay Volunteers to Prevent Type 2 Diabetes in People with Impaired Fasting Glucose and/or Nondiabetic Hyperglycemia:A Randomized Clinical Trial

Importance:  Nearly half of the older adult population has diabetes or a high-risk intermediate glycemic category, but we still lack trial evidence for effective type 2 diabetes prevention interventions in most of the current high-risk glycemic categories. Objective:  To determine whether a group-based lifestyle intervention (with or without trained volunteers with type 2 diabetes) reduced the risk of progression to type 2 diabetes in populations with a high-risk glycemic category. Design, Setting, and Participants: The Norfolk Diabetes Prevention Study was a parallel, 3-arm, group-based, randomized clinical trial conducted with up to 46 months of follow-up from August 2011 to January 2019 at 135 primary care practices and 8 intervention sites in the East of England. We identified 141 973 people at increased risk of type 2 diabetes, screened 12 778 (9.0%), and randomized those with a high-risk glycemic category, which was either an elevated fasting plasma glucose level alone (≥110 and <126 mg/dL [to convert to millimoles per liter, multiply by 0.0555]) or an elevated glycated hemoglobin level (≥6.0% to <6.5%; nondiabetic hyperglycemia) with an elevated fasting plasma glucose level (≥100 to <110 mg/dL).Interventions A control arm receiving usual care (CON), a theory-based lifestyle intervention arm of 6 core and up to 15 maintenance sessions (INT), or the same intervention with support from diabetes prevention mentors, trained volunteers with type 2 diabetes (INT-DPM). Main Outcomes and Measures:  Type 2 diabetes incidence between arms.Results:  In this study, 1028 participants were randomized (INT, 424 [41.2%] [166 women (39.2%)]; INT-DPM, 426 [41.4%] [147 women (34.5%)]; CON, 178 [17.3%] [70 women (%39.3)]) between January 1, 2011, and February 24, 2017. The mean (SD) age was 65.3 (10.0) years, mean (SD) body mass index 31.2 (5) (calculated as weight in kilograms divided by height in meters squared), and mean (SD) follow-up 24.7 (13.4) months. A total of 156 participants progressed to type 2 diabetes, which comprised 39 of 171 receiving CON (22.8%), 55 of 403 receiving INT (13.7%), and 62 of 414 receiving INT-DPM (15.0%). There was no significant difference between the intervention arms in the primary outcome (odds ratio [OR], 1.14; 95% CI, 0.77-1.7; P = .51), but each intervention arm had significantly lower odds of type 2 diabetes (INT: OR, 0.54; 95% CI, 0.34-0.85; P = .01; INT-DPM: OR, 0.61; 95% CI, 0.39-0.96; P = .033; combined: OR, 0.57; 95% CI, 0.38-0.87; P = .01). The effect size was similar in all glycemic, age, and social deprivation groups, and intervention costs per participant were low at $153 (£122). Conclusions and Relevance:  The Norfolk Diabetes Prevention lifestyle intervention reduced the risk of type 2 diabetes in current high-risk glycemic categories. Enhancing the intervention with DPM did not further reduce diabetes risk. These translatable results are relevant for current diabetes prevention efforts

Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium

Extracellular RNAs (exRNAs) have been identified in all tested biofluids and have been associated with a variety of extracellular vesicles, ribonucleoprotein complexes and lipoprotein complexes. Much of the interest in exRNAs lies in the fact that they may serve as signalling molecules between cells, their potential to serve as biomarkers for prediction and diagnosis of disease and the possibility that exRNAs or the extracellular particles that carry them might be used for therapeutic purposes. Among the most significant bottlenecks to progress in this field is the lack of robust and standardized methods for collection and processing of biofluids, separation of different types of exRNA-containing particles and isolation and analysis of exRNAs. The Sample and Assay Standards Working Group of the Extracellular RNA Communication Consortium is a group of laboratories funded by the U.S. National Institutes of Health to develop such methods. In our first joint endeavour, we held a series of conference calls and in-person meetings to survey the methods used among our members, placed them in the context of the current literature and used our findings to identify areas in which the identification of robust methodologies would promote rapid advancements in the exRNA field

Effects of the Norfolk diabetes prevention lifestyle intervention (NDPS) on glycaemic control in screen-detected type 2 diabetes: a randomised controlled trial

This is the final version. Available on open access from BMC via the DOI in this recordAvailability of data and materials: The dataset used in this publication is available from the corresponding author on reasonable request.Background The purpose of this trial was to test if the Norfolk Diabetes Prevention Study (NDPS) lifestyle intervention, recently shown to reduce the incidence of type 2 diabetes in high-risk groups, also improved glycaemic control in people with newly diagnosed screen-detected type 2 diabetes. Methods We screened 12,778 participants at high risk of type 2 diabetes using a fasting plasma glucose and glycosylated haemoglobin (HbA1c). People with screen-detected type 2 diabetes were randomised in a parallel, three-arm, controlled trial with up to 46 months of follow-up, with a control arm (CON), a group-based lifestyle intervention of 6 core and up to 15 maintenance sessions (INT), or the same intervention with additional support from volunteers with type 2 diabetes trained to co-deliver the lifestyle intervention (INT-DPM). The pre-specified primary end point was mean HbA1c compared between groups at 12 months. Results We randomised 432 participants (CON 149; INT 142; INT-DPM 141) with a mean (SD) age of 63.5 (10.0) years, body mass index (BMI) of 32.4 (6.4) kg/m2, and HbA1c of 52.5 (10.2) mmol/mol. The primary outcome of mean HbA1c at 12 months (CON 48.5 (9.1) mmol/mol, INT 46.5 (8.1) mmol/mol, and INT-DPM 45.6 (6.0) mmol/mol) was significantly lower in the INT-DPM arm compared to CON (adjusted difference −2.57 mmol/mol; 95% CI −4.5, −0.6; p = 0.007) but not significantly different between the INT-DPM and INT arms (−0.55 mmol/mol; 95% CI −2.46, 1.35; p = 0.57), or INT vs CON arms (−2.14 mmol/mol; 95% CI −4.33, 0.05; p = 0.07). Subgroup analyses showed the intervention had greater effect in participants  65 years old; p = 0.007). The use of oral hypoglycaemic medication was associated with a significantly lower mean HbA1c but only within the INT-DPM arm compared to CON (−7.0 mmol/mol; 95% CI −11.5, −2.5; p = 0.003). Conclusion The NDPS lifestyle intervention significantly improved glycaemic control after 12 months in people with screen-detected type 2 diabetes when supported by trained peer mentors with type 2 diabetes, particularly those receiving oral hypoglycaemics and those under 65 years old. The effect size was modest, however, and not sustained at 24 months. Trial registration ISRCTN34805606. Retrospectively registered 14.4.16National Institute for Health Research (NIHR

Refining and optimising a behavioural intervention to support endocrine therapy adherence (ROSETA) in UK women with breast cancer : protocol for a pilot fractional factorial trial

Introduction Women with breast cancer who do not adhere to adjuvant endocrine therapy (AET) have increased risks of mortality and recurrence. There are multiple barriers to AET adherence, including medication side-effects, beliefs about medication, memory and psychological distress. We developed four intervention components, each targeting a different barrier. This pilot trial is part of the preparation phase of the Multiphase Optimisation Strategy, and aims to establish key trial parameters, establish intervention component adherence, establish availability and feasibility of outcome and process data, estimate variability in planned outcome measures and estimate cost of developing and delivering each intervention component. Methods and analysis The four intervention components are as follows: short message service text reminders (target: memory); a written information leaflet (target: medication beliefs); a guided self-help Acceptance and Commitment Therapy programme (target: psychological flexibility to reduce distress) and a self-management website (target: side-effect management). To evaluate the feasibility of recruitment, acceptability of the intervention components and the availability of outcome data, we will conduct a multisite, exploratory pilot trial using a 2 4-1 fractional factorial design, with a nested process evaluation. We will randomise 80 women with early-stage breast cancer who have been prescribed AET to one of eight experimental conditions. This will determine the combination of intervention components they receive, ranging from zero to four, with all conditions receiving usual care. Key outcomes of interest include medication adherence and quality of life. Progression to the optimisation phase will be based on predefined criteria for consent rates, patient adherence to intervention components and availability of medication adherence data. Ethics and dissemination The study was reviewed by the Wales Research Authority Research Ethics Committee 3 (21/WA/0322). Written informed consent will be obtained from all patients before randomisation. The results of this trial will be disseminated in a peer-reviewed journal. Trial registration number ISRTCN10487576

Beliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study

Introduction Uptake of preventive therapies for breast cancer is low. We examined whether women at increased risk of breast cancer can be categorized into groups with similar medication beliefs, and whether belief group membership was prospectively associated with uptake of preventive therapy. Patients and Methods Women (n = 732) attending an appointment to discuss breast cancer risk were approached; 408 (55.7%) completed the Beliefs About Medicines and the Perceived Sensitivity to Medicines questionnaires. Uptake of tamoxifen at 3 months was reported in 258 (63.2%). The optimal number of belief groups were identified using latent profile analysis. Results Uptake of tamoxifen was 14.7% (38/258). One in 5 women (19.4%; 78/402) reported a strong need for tamoxifen. The model fit statistics supported a 2-group model. Both groups held weak beliefs about their need for tamoxifen for current and future health. Group 2 (38%; 154/406 of the sample) reported stronger concerns about tamoxifen and medicines in general, and stronger perceived sensitivity to the negative effects of medicines compared with group 1 (62%; 252/406). Women with low necessity and lower concerns (group 1) were more likely to initiate tamoxifen (18.3%; 33/180) than those with low necessity and higher concerns (group 2) (6.4%; 5/78). After adjusting for demographic and clinical factors, the odds ratio was 3.37 (95% confidence interval, 1.08-10.51; P = .036). Conclusion Uptake of breast cancer preventive therapy was low. A subgroup of women reported low need for preventive therapy and strong medication concerns. These women were less likely to initiate tamoxifen. Medication beliefs are targets for supporting informed decision-making