Litho-sedimentological and morphodynamic characterization of the Pisa Province coastal area (northern Tuscany, Italy)

In this paper litho-sedimentological and morphodynamic maps of the coastal sector belonging to the Pisa Province are presented as an example of how increasing the accessibility to data on lithology, sedimentology, and morphodynamics may lead to a better approach to coastal management. The database used to build the maps includes an original rendering of remote sensing data (aerial imagery) and new field data (geologic survey), as well as data retrieved from the scientific literature (grain-size and past coastline positions). The maps show that the geometry of beach ridges is an indication of the evolution of the Arno River delta in the last 3000 years, highlighting the relationships between geological aspects and morphodynamic features. The maps represent the synthesis of different data available in the database, and they may be a useful support to coastal management as they are more easily understandable and straightforward than the database from which are created

Object oriented data analysis in ALEPH

This article describes the status of the ALPHA^{++} project of the ALEPH collaboration. The ALEPH data have been converted from Fortran data structures (BOS banks) into C^{++} objects and stored in a object oriented database (Objectivity/DB), using tools provided by the RD45 collaboration and the LHC^{++} software project at CERN. A description of the database setup and of a preliminary version of an object oriented analysis program is given.This article describes the status of the ALPHA^{++} project of the ALEPH collaboration. The ALEPH data have been converted from Fortran data structures (BOS banks) into C^{++} objects and stored in a object oriented database (Objectivity/DB), using tools provided by the RD45 collaboration and the LHC^{++} software project at CERN. A description of the database setup and of a preliminary version of an object oriented analysis program is given

New synthetic routes to Triazolo-benzodiazepine analogues:expanding the scope of the bump-and-hole approach for selective Bromo and Extra-Terminal (BET) bromodomain inhibition

We describe new synthetic routes developed toward a range of substituted analogues of bromo and extra-terminal (BET) bromodomain inhibitors I-BET762/JQ1 based on the triazolo-benzodiazepine scaffold. These new routes allow for the derivatization of the methoxyphenyl and chlorophenyl rings, in addition to the diazepine ternary center and the side chain methylene moiety. Substitution at the level of the side chain methylene afforded compounds targeting specifically and potently engineered BET bromodomains designed as part of a bump and hole approach. We further demonstrate that marked selectivity for the second over the first bromodomain can be achieved with an indole derivative that exploits differential interaction with an aspartate/histidine conservative substitution on the BC loop of BET bromodomains

Comparative analysis of tunisian sheep-like virus, bungowannah virus and border disease virus infection in the porcine host

Apart from the established pestivirus species Pestivirus A to Pestivirus K novel species emerged. Pigs represent not only hosts for porcine pestiviruses, but are also susceptible to bovine viral diarrhea virus, border disease virus (BDV) and other ruminant pestiviruses. The present study focused on the characterization of the ovine Tunisian sheep-like virus (TSV) as well as Bungowannah virus (BuPV) and BDV strain Frijters, which were isolated from pigs. For this purpose, we performed genetic characterization based on complete coding sequences, studies on virus replication in cell culture and in domestic pigs, and cross-neutralization assays using experimentally derived sera. TSV forms a distinct phylogenetic group more closely related to Pestivirus C (classical swine fever virus, CSFV) than to Pestivirus D (BDV). In contrast to BDV and BuPV, TSV replicates by far more efficiently on ovine than on porcine cells. Nevertheless, pigs were susceptible to TSV. As a consequence of close antigenic relatedness of TSV to CSFV, cross-reactivity was detected in CSFV-specific antibody assays. In conclusion, TSV is genetically closely related to CSFV and can replicate in domestic pigs. Due to close antigenic relatedness, field infections of pigs with TSV and other ruminant pestiviruses can interfere with serological diagnosis of classical swine fever

Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening

Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Despite the extensive efforts in targeting the ubiquitin system, very few E2 binders have currently been discovered. Herein we report the identification of a new allosteric pocket on Ube2T through a fragment screening using biophysical methods. Several fragments binding to this site inhibit ubiquitin conjugation in vitro

Convergence of the expansion of the Laplace-Borel integral in perturbative QCD improved by conformal mapping

The optimal conformal mapping of the Borel plane was recently used to accelerate the convergence of the perturbation expansions in QCD. In this work we discuss the relevance of the method for the calculation of the Laplace-Borel integral expressing formally the QCD Green functions. We define an optimal expansion of the Laplace-Borel integral in the principal value prescription and establish conditions under which the expansion is convergent.Comment: 10 pages, no figure

Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand

TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near gram scale in seven steps with notable improvements in the reported poor yielding last 2 steps enabling this key chemical probe compound to be available for researchers

QoS management and control for an all-IP WiMAX network architecture: Design, implementation and evaluation

The IEEE 802.16 standard provides a specification for a fixed and mobile broadband wireless access system, offering high data rate transmission of multimedia services with different Quality-of-Service (QoS) requirements through the air interface. The WiMAX Forum, going beyond the air interface, defined an end-to-end WiMAX network architecture, based on an all-IP platform in order to complete the standards required for a commercial rollout of WiMAX as broadband wireless access solution. As the WiMAX network architecture is only a functional specification, this paper focuses on an innovative solution for an end-to-end WiMAX network architecture offering in compliance with the WiMAX Forum specification. To our best knowledge, this is the first WiMAX architecture built by a research consortium globally and was performed within the framework of the European IST project WEIRD (WiMAX Extension to Isolated Research Data networks). One of the principal features of our architecture is support for end-to-end QoS achieved by the integration of resource control in the WiMAX wireless link and the resource management in the wired domains in the network core. In this paper we present the architectural design of these QoS features in the overall WiMAX all-IP framework and their functional as well as performance evaluation. The presented results can safely be considered as unique and timely for any WiMAX system integrator