Exploraciones arqueológicas en la cuenca alta del río Samalá (Guatemala)

Sin resume

The Feynman effective classical potential in the Schr\"odinger formulation

New physical insight into the correspondence between path integral concepts and the Schr\"odinger formulation is gained by the analysis of the effective classical potential, that is defined within the Feynman path integral formulation of statistical mechanics. This potential is related to the quasi-static response of the equilibrium system to an external force. These findings allow for a comprehensive formulation of dynamical approximations based on this potential.Comment: 10 pages, 4 figure

Multidisciplinary teaching of Biotechnology and Omics sciences

In the last years, there was a great boom in the Omics fields that have developed as multidisciplinary sciences. They use laboratory techniques related to Biology and Chemistry but also Bioinformatics tools. However, the developmental progress of these disciplines has led that much of undergraduate studies related to Biology have curricula that become outdated. From this point of view, it is necessary to focus the students to the fundamentals and techniques of complementary disciplines that will be essentials for the understanding of the Omics sciences. In the present work, we have developed a new teaching approach for Biochemistry, Biology and Bioinformatics students. They formed interdisciplinary working groups. These groups have prepared and presented communications about different techniques or methods in Molecular Biology, Omics or Bioinformatics participating in a technical meeting. This learning strategy “I do and I learn” has enabled to the students a first contact with the scientific communication including the approach to the scientific literature to acquire technical knowledge. The cooperation between students from different disciplines has enriched their point of view and even has been used in some practical master’s works.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Informe preliminar sobre la cerámica de Las Victorias, Salcajá, Guatemala.

Sin resume

Core losses analysis of the LCL filter inductor for SiC-based inverter

The ability of SiC devices to switch at high speed allows increasing significantly the power density in both converters and passive components, reducing their required size. To mitigate harmonic injection form inverters into the grid, in order to comply with power quality standards, an accurate filter design is required. Given its excellent performance, an LCL filter is the configuration most suitable in grid-connected power converters. Several parameters must be considered when designing an effective LCL filter, and the inverter-side inductor assumes a special importance because of its relevance to suppress high frequency harmonic content at the inverter side. One of the most relevant issues to be considered in the process of designing the LCL filter is the evaluation of core losses in the inverter-side inductor, which will determine the final temperature of the inductor. This paper analyses the core losses of the inverter-side inductor of an LCL filter. The proposed method is based on the computation of the current harmonics generated by the inverter and on Steinmetz’s empirical equation. As a result, core losses calculated taking into account several carrier and sideband harmonics show good agreement with the experimental values. When current harmonics are estimated by simulation, as it is done in the proposed design procedure, results are less accurate, but precise enough for a design procedure

Short-term oleoyl-estrone treatment affects capacity to manage lipids in rat adipose tissue

Background: Short-term OE (oleoyl-estrone) treatment causes significant decreases in rat weight mainly due to adipose tissue loss. The aim of this work was to determine if OE treatment affects the expression of genes that regulate lipid metabolism in white adipose tissue. Results: Gene expression in adipose tissue from female treated rats (48 hours) was analysed by hybridization to cDNA arrays and levels of specific mRNAs were determined by real-time PCR. Treatment with OE decreased the expression of 232 genes and up-regulated 75 other genes in mesenteric white adipose tissue. The use of real-time PCR validate that, in mesenteric white adipose tissue, mRNA levels for Lipoprotein Lipase (LPL) were decreased by 52%, those of Fatty Acid Synthase (FAS) by 95%, those of Hormone Sensible Lipase (HSL) by 32%, those of Acetyl CoA Carboxylase (ACC) by 92%, those of Carnitine Palmitoyltransferase 1b (CPT1b) by 45%, and those of Fatty Acid Transport Protein 1 (FATP1) and Adipocyte Fatty Acid Binding Protein (FABP4) by 52% and 49%, respectively. Conversely, Tumour Necrosis Factor (TNF¿) values showed overexpression (198%). Conclusion: Short-term treatment with OE affects adipose tissue capacity to extract fatty acids from lipoproteins and to deal with fatty acid transport and metabolism

Complexes of Pd(II) and Pt(II) with 9-Aminoacridine: Reactions with DNA and Study of Their Antiproliferative Activity

Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)(μ-Cl)]2 · 2DMF was determined by X-ray diffraction. Two 9-acridine molecules in the imine form bind symmetrically to the metal ions in a bidentate fashion through the imine nitrogen atom and the C(1) atom of the aminoacridine closing a new five-membered ring. By reaction with phosphine or pyridine, the Cl bridges broke and compounds with general formulae [Pd(9AA)Cl(L)] (where L = PPh3 or py) were formed. A mononuclear complex of platinum of formulae [Pt(9AA)Cl(DMSO)] was also obtained by direct reaction of 9-aminoacridine and the complex [PtCl2(DMSO2]. The capacity of the compounds to modify the secondary and tertiary structures of DNA was evaluated by means of circular dichroism and electrophoretic mobility. Both palladium and platinum compounds proved active in the modification of both the secondary and tertiary DNA structures. AFM images showed noticeable modifications of the morphology of the plasmid pBR322 DNA by the compounds probably due to the intercalation of the complexes between base pairs of the DNA molecule. Finally, the palladium complex was tested for antiproliferative activity against three different human tumor cell lines. The results suggest that the palladium complex of formula [Pd(9AA)(μ-Cl)]2 has significant antiproliferative activity, although it is less active than cisplatin

Mineral content in semiarid grassland systems affected by community structure and soil characteristics

This work was supported by the European Union project nº 8001-CT90-0021.Mineral element concentrations in plants and their relationships with botanical composition and soil characteristics were analyzed over two consecutive years in herbage samples from semiarid grassland systems (central-western Spain) affected by a topographic gradient. There were not significant differences in the mineral concentration of the plant community between sampling years suggesting that factors other than those related to interannual climatic variation are more important in determining the mineral concentration of plant community in semiarid grasslands. A significant effect of slope position on aboveground biomass production, soil characteristics and plant tissue nutrient contents was found. As compared to the upper and middle zones, the lower zones of slope showed greater aboveground biomass production, a lower proportion of forbs, a higher proportion of grasses, higher concentrations of N, Ca, Mg and Na in botanical groups, and lower concentrations of P and K in botanical components. Stepwise multiple regression analysis showed that most of the variation in N, P, K, Ca, and Mg concentrations in the plant community along the slope can be explained by botanical composition and its specific mineral content. Several soil properties (organic matter, total N, total C, coarse sand) proved to be significantly correlated with the N, Ca, Mg, and Na concentrations of grasses, legumes and forbs, indicating an increase in plant tissue concentrations with increasing eutrophic status in soil from the upper to the lower zones of the slope. The P and K concentrations of legumes and forbs varied according to the phosphorus or potassium contents in soil, which decreased from the upper and middle to the lower zones. The results showed that the mineral concentrations of botanical components were dependent on soil characteristics in different ways.Peer reviewe