Asymptotically (anti) de Sitter Black Holes and Wormholes with a Self Interacting Scalar Field in Four Dimensions

The aim of this paper is to report on the existence of a wide variety of exact solutions, ranging from black holes to wormholes, when a conformally coupled scalar field with a self interacting potential containing a linear, a cubic and a quartic self interaction is taken as a source of the energy-momentum tensor, in the Einstein theory with a cosmological constant. Among all the solutions there are two particularly interesting. On the one hand, the spherically symmetric black holes when the cosmological constant is positive; they are shown to be everywhere regular, namely there is no singularity neither inside nor outside the event horizon. On the other hand, there are spherically symmetric and topological wormholes that connect two asymptotically (anti) de Sitter regions with a different value for the cosmological constant. The regular black holes and the wormholes are supported by everywhere regular scalar field configurations.Comment: Final versio

Early Permian marine carbonate sequences in Antofagasta, northern Chile

Se analizan las sucesiones carbonáticas de las formaciones Cerro El Árbol y Cerros de Cuevitas, en la Depresión central de Antofagasta, norte de Chile. Las mismas están caracterizadas por una asociación de invertebrados marinos compuesta, en general, por braquiópodos, bivalvos, gastrópodos, crinoideos y briozoos, siendo el braquiópodo Kochiproductus Dunbar el elemento dominante. La presencia de este género, de amplia distribución mundial en secuencias pérmicas, sería clave para encontrar la posible vinculación de esta región con las cuencas clásticas del centro oeste de Argentina. Si bien la fauna del norte de Chile presenta claras afinidades con aquellas de las cuencas de Bolivia y Perú, su composición no es exactamente equivalente, siendo además marcadamente menos diversa. El conocimiento taxonómico aquí alcanzado indica que esta fauna podría representar una asociación de mezcla, que combinaría los elementos típicamente tetianos que caracterizan a las cuencas del norte, con aquellos gondwánicos. En términos bioestratigráficos, esta asociación podría también ser considerada intermedia entre las faunas más antiguas del Carbonífero tardío-Pérmico temprano del centro oeste de Argentina y las más jóvenes del Pérmico de Bolivia y Perú.The carbonate successions of the Cerro El Árbol and Cerros de Cuevitas formations in the central region of Antofagasta are herein studied. These stratigraphic units are characterized by an invertebrate marine fossil assemblage integrated by brachiopods, bivalves, gastropods, crinoids and bryozoans, in which the brachiopod Kochiproductus Dunbar is the dominant component. This genus, widely known in the Permian sequences of the world, can be considered a key to understand the possible connection between northern Chile and the central western Argentinean basins. Although the fauna studied shows clear affinities with those from Bolivia and Perú, it is notably less diverse and its composition appears to be not exactly equivalent. The taxonomic knowledge reached, indicates that this fauna, particularly brachiopods and bivalves, would represent a mixed-assemblage. From a biostratigraphic perspective, the fauna of northern Chile could be considered intermediate between the oldest Late Carboniferous-Early Permian faunas of central western Argentinian basins and the younger ones from Bolivia and Perú.Fil: Cisterna, Gabriela Adriana. Universidad Nacional de la Rioja; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sterren, Andrea Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Niemeyer, Hans R.. Universidad catolica del Norte; Chil

BRACHIOPOD ASSEMBLAGES OF THE EURYDESMA FAUNA IN GLACIAL- DEGLACIAL SEQUENCES FROM ARGENTINA AND AUSTRALIA

The Eurydesma Fauna characterizes the Late Pennsylvanian-Permian glacial-postglacial sediments recorded in several Gondwanan basins during the Late Paleozoic Ice Age (LPIA). Brachiopods, as one the most significant components of this fauna, are herein analyzed along with the associated bivalves, in two key sections from western and eastern Gondwana (Bonete Formation in the Sauce Grande Basin, eastern Argentina, and the Wasp Head Formation in the southern Sydney Basin, eastern Australia). The preliminary quantitative analysis indicates a high compositional similarity in both regions but occupancy exhibits important differences: brachiopod-dominated faunas can be found in eastern Australia (Tomiopsis and Trigonotreta are the most frequent taxa), and bivalve-dominated faunas are characteristic in eastern Argentina, where the brachiopods are poorly represented with the genera Tivertonia and Tomiopsis. In this locality, the development of r-strategy taxa, such as the bivalve Eurydesma, during the end of a glacial episode would adversely affect brachiopods’ abundance. This is also consistent with previous studies that indicate that brachiopods already showed a decrease in importance in Pennsylvanian communities from Argentina. Relative abundances of brachiopods and bivalves in both localities may reflect differences in the regional environmental conditions but, unfortunately, eastern Argentina lacks younger records to compare the faunal turnover with that of the Australian sequences. Despite the ecological structural differences identified (i.e. brachiopod:bivalve ratio), the postglacial Eurydesma fauna flourished in western and eastern Gondwana and it is striking that two faunas located on the opposite margins of this paleocontinent show such high compositional similarity during the development of a global postglacial event. This is particularly significant considering that the type of the basins (i.e. restricted vs open basins), biological features, paleoenvironmental conditions directly related to glacial dynamics, and also the diachronism of the transgression, can be controlling the composition of this fauna

Short communication: Massive mortality in rabbits by maduramicin poisoning

[EN] A spontaneous outbreak of maduramicin intoxication in domestic rabbits (Oryctolagus cuniculus) is reported. It is believed that maduramicin incorporated as a coccidiostat into poultry pellet fed to rabbits was the cause, as up to 2.01 ppm was found in the samples and cardiopulmonary clinical signs in most of the rabbits was the common pattern. Findings here were consistent with the classic indications observed in ionophore toxicosis in different species, but little is known about the toxicity of maduramicin in rabbits.This study was partially supported by grants from CIC (Provincial Scientific Research Council), and SENASA (Argentina).Martino, P.; Parrado, E.; Sanguinetti, R.; Espinoza, C.; Debenedetti, R.; Di Benedetto, N.; Cisterna, C.... (2009). Short communication: Massive mortality in rabbits by maduramicin poisoning. World Rabbit Science. 17(1):45-48. https://doi.org/10.4995/wrs.2009.670454817

Muscleblind-like1 undergoes Ectopic relocation in the nuclei of skeletal muscles in myotonic dystrophy and sarcopenia.

Muscleblind-like 1 (MBNL1) is an alternative splicing factor involved in postnatal development of skeletal muscles and heart in humans and mice, and its deregulation is known to be pivotal in the onset and development of myotonic dystrophy (DM). In fact, in DM patients this protein is ectopically sequestered into intranuclear foci, thus compromising the regulation of the alternative splicing of several genes. However, despite the numerous biochemical and molecular studies, scarce attention has been paid to the intranuclear location of MBNL1 outside the foci, although previous data demonstrated that in DM patients various splicing and cleavage factors undergo an abnormal intranuclear distribution suggestive of impaired RNA processing. Interestingly, these nuclear alterations strongly remind those observed in sarcopenia i.e., the loss of muscle mass and function which physiologically occurs during ageing. On this basis, in the present investigation the ultrastructural localization of MBNL1 was analyzed in the myonuclei of skeletal muscles from healthy and DM patients as well as from adult and old (sarcopenic) mice, in the attempt to elucidate possible changes in its distribution and amount. Our data demonstrate that in both dystrophic and sarcopenic muscles MBNL1 undergoes intranuclear relocation, accumulating in its usual functional sites but also ectopically moving to domains which are usually devoid of this protein in healthy adults. This accumulation/delocalization could contribute to hamper the functionality of the whole splicing machinery, leading to a lower nuclear metabolic activity and, consequently, to a less efficient protein synthesis. Moreover, the similar nuclear alterations found in DM and sarcopenia may account for the similar muscle tissue features (myofibre atrophy, fiber size variability and centrally located nuclei), and, in general, for the aging-reminiscent phenotype observed in DM patients

Ryanodine receptor 1 (RYR1) mutations in two patients with tubular aggregate myopathy

Two likely causative mutations in the RYR1 gene were identified in two patients with myopathy with tubular aggregates, but no evidence of cores or core-like pathology on muscle biopsy. These patients were clinically evaluated and underwent routine laboratory investigations, electrophysiologic tests, muscle biopsy and muscle magnetic resonance imaging (MRI). They reported stiffness of the muscles following sustained activity or cold exposure and had serum creatine kinase elevation. The identified RYR1 mutations (p.Thr2206Met or p.Gly2434Arg, in patient 1 and patient 2, respectively) were previously identified in individuals with malignant hyperthermia susceptibility and are reported as causative according to the European Malignant Hyperthermia Group rules. To our knowledge, these data represent the first identification of causative mutations in the RYR1 gene in patients with tubular aggregate myopathy and extend the spectrum of histological alterations caused by mutation in the RYR1 gene

DESCRIPCIÓN DE LOS GENOTIPOS DE C. TRACHOMATIS EN EL HOSPITAL DE BASURTO-BILBAO

Se describen las características genotípicas de los aislamientos de C. trachomatis en una consulta de infecciones de transmisión sexual (ITS) en Bilbao para valorar la posible introducción de la cepa cwCT, variante aislada en Suecia, en la población diana del hospital de Basurto-Bilbao

Streptococcus pneumoniae Coinfection Is Correlated with the Severity of H1N1 Pandemic Influenza

Initial reports in May 2009 of the novel influenza strain H1N1pdm estimated a case fatality rate (CFR) of 0.6%, similar to that of seasonal influenza. In July 2009, however, Argentina reported 3056 cases with 137 deaths, representing a CFR of 4.5%. Potential explanations for increased CFR included virus reassortment or genetic drift, or infection of a more vulnerable population. Virus genomic sequencing of 26 Argentinian samples representing both severe and mild disease indicated no evidence of reassortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence. Furthermore, no evidence was found for increased frequency of risk factors for H1N1pdm disease.We examined nasopharyngeal swab samples (NPS) from 199 cases of H1N1pdm infection from Argentina with MassTag PCR, testing for 33 additional microbial agents. The study population consisted of 199 H1N1pdm-infected subjects sampled between 23 June and 4 July 2009. Thirty-nine had severe disease defined as death (n = 20) or hospitalization (n = 19); 160 had mild disease. At least one additional agent of potential pathogenic importance was identified in 152 samples (76%), including Streptococcus pneumoniae (n = 62); Haemophilus influenzae (n = 104); human respiratory syncytial virus A (n = 11) and B (n = 1); human rhinovirus A (n = 1) and B (n = 4); human coronaviruses 229E (n = 1) and OC43 (n = 2); Klebsiella pneumoniae (n = 2); Acinetobacter baumannii (n = 2); Serratia marcescens (n = 1); and Staphylococcus aureus (n = 35) and methicillin-resistant S. aureus (MRSA, n = 6). The presence of S. pneumoniae was strongly correlated with severe disease. S. pneumoniae was present in 56.4% of severe cases versus 25% of mild cases; more than one-third of H1N1pdm NPS with S. pneumoniae were from subjects with severe disease (22 of 62 S. pneumoniae-positive NPS, p = 0.0004). In subjects 6 to 55 years of age, the adjusted odds ratio (OR) of severe disease in the presence of S. pneumoniae was 125.5 (95% confidence interval [CI], 16.95, 928.72; p<0.0001).The association of S. pneumoniae with morbidity and mortality is established in the current and previous influenza pandemics. However, this study is the first to demonstrate the prognostic significance of non-invasive antemortem diagnosis of S. pneumoniae infection and may provide insights into clinical management