Effect of strontium and cooling rate upon eutectic temperatures of A319 aluminum alloy

DTA analysis was used to investigate the solidification reactions of alloy A319 with either 12 or 136 ppm of Sr added. Strontium does not affect primary solidification of (Al) dendrites but modifies the kinetics of the (Al)–Si eutectic. The effects of Sr level and of cooling rate on the characteristic temperatures for the (Al)–Si and other eutectic reactions are described

Dystroglycan Depletion Impairs Actin-Dependent Functions of Differentiated Kasumi-1 Cells

Background Dystroglycan has recently been characterised in blood tissue cells, as part of the dystrophin glycoprotein complex involved in the differentiation process of neutrophils. Purpose In the present study we have investigated the role of dystroglycan in the human promyelocytic leukemic cell line Kasumi-1 differentiated to macrophage-like cells. Methods We characterised the pattern expression and subcellular distribution of dystroglycans in non-differentiated and differentiated Kasumi-1 cells. Results Our results demonstrated by WB and flow cytometer assays that during the differentiation process to macrophages, dystroglycans were down-regulated; these results were confirmed with qRT-PCR assays. Additionally, depletion of dystroglycan by RNAi resulted in altered morphology and reduced properties of differentiated Kasumi-1 cells, including morphology, migration and phagocytic activities although secretion of IL-1β and expression of markers of differentiation are not altered. Conclusion Our findings strongly implicate dystroglycan as a key membrane adhesion protein involved in actin-based structures during the differentiation process in Kasumi-1 cells

An innovative quick solidifying technique for the forensic investigation of brain circulation using addition silicones

Post-mortem study of the brain is extremely relevant to medico-legal autopsies. However, it can be difficult to handle due to its fragility. This article presents a study on the development of an arterial solidifying technique that can be applied to analyze arterial circulation, consequently easing the handling and later diagnosis of diseases in this anatomical site. Vinylpolysiloxane silicone is introduced into the internal carotid arteries until it completely fills the arterial tree, creating a detailed model of the arterial's internal anatomy. This technique is fast, easy to apply and requires no previous tissue fixation. In addition, it allows for further toxicological and pathological tests. In conclusion, this technique represents a simple, sensitive and efficient method to employ in conventional autopsies, which can help in the diagnosis of death

Digging deeper into colonial palaeontological practices in modern day Mexico and Brazil

Scientific practices stemming from colonialism, whereby middle- and low-income countries supply data for high-income countries and the contributions of local expertise are devalued, are still prevalent today in the field of palaeontology. In response to these unjust practices, countries such as Mexico and Brazil adopted protective laws and regulations during the twentieth century to preserve their palaeontological heritage. However, scientific colonialism is still reflected in many publications describing fossil specimens recovered from these countries. Here, we present examples of ‘palaeontological colonialism’ from publications on Jurassic–Cretaceous fossils from NE Mexico and NE Brazil spanning the last three decades. Common issues that we identified in these publications are the absence of both fieldwork and export permit declarations and the lack of local experts among authorships. In Mexico, access to many fossil specimens is restricted on account of these specimens being housed in private collections, whereas a high number of studies on Brazilian fossils are based on specimens illegally reposited in foreign collections, particularly in Germany and Japan. Finally, we outline and discuss the wider academic and social impacts of these research practices, and propose exhaustive recommendations to scientists, journals, museums, research institutions and government and funding agencies in order to overcome these practices

A detailed analysis of the Gl 486 planetary system

Full list of authors: Caballero, J. A.; Gonzalez-Alvarez, E.; Brady, M.; Trifonov, T.; Ellis, T. G.; Dorn, C.; Cifuentes, C.; Molaverdikhani, K.; Bean, J. L.; Boyajian, T.; Rodriguez, E.; Sanz-Forcada, J.; Zapatero Osorio, M. R.; Abia, C.; Amado, P. J.; Anugu, N.; Bejar, V. J. S.; Davies, C. L.; Dreizler, S.; Dubois, F.; Ennis, J.; Espinoza, N.; Farrington, C. D.; Garcia Lopez, A.; Gardner, T.; Hatzes, A. P.; Henning, Th; Herrero, E.; Herrero-Cisneros, E.; Kaminski, A.; Kasper, D.; Klement, R.; Kraus, S.; Labdon, A.; Lanthermann, C.; Le Bouquin, J-B; Lopez Gonzalez, M. J.; Luque, R.; Mann, A. W.; Marfil, E.; Monnier, J. D.; Montes, D.; Morales, J. C.; Palle, E.; Pedraz, S.; Quirrenbach, A.; Reffert, S.; Reiners, A.; Ribas, I; Rodriguez-Lopez, C.; Schaefer, G.; Schweitzer, A.; Seifahrt, A.; Setterholm, B. R.; Shan, Y.; Shulyak, D.; Solano, E.; Sreenivas, K. R.; Stefansson, G.; Stuermer, J.; Tabernero, H. M.; Tal-Or, L.; ten Brummelaar, T.; Vanaverbeke, S.; von Braun, K.; Youngblood, A.; Zechmeister, M.- This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Context. The Gl 486 system consists of a very nearby, relatively bright, weakly active M3.5 V star at just 8 pc with a warm transiting rocky planet of about 1.3 R⊕ and 3.0 M⊕. It is ideal for both transmission and emission spectroscopy and for testing interior models of telluric planets. Aims. To prepare for future studies, we aim to thoroughly characterise the planetary system with new accurate and precise data collected with state-of-the-art photometers from space and spectrometers and interferometers from the ground. Methods. We collected light curves of seven new transits observed with the CHEOPS space mission and new radial velocities obtained with MAROON-X at the 8.1 m Gemini North telescope and CARMENES at the 3.5 m Calar Alto telescope, together with previously published spectroscopic and photometric data from the two spectrographs and TESS. We also performed near-infrared interferometric observations with the CHARA Array and new photometric monitoring with a suite of smaller telescopes (AstroLAB, LCOGT, OSN, TJO). This extraordinary and rich data set was the input for our comprehensive analysis. Results. From interferometry, we measure a limb-darkened disc angular size of the star Gl 486 at θLDD = 0.390 ± 0.018 mas. Together with a corrected Gaia EDR3 parallax, we obtain a stellar radius R* = 0.339 ± 0.015 R⊕. We also measure a stellar rotation period at Prot = 49.9 ± 5.5 days, an upper limit to its XUV (5-920 A) flux informed by new Hubble/STIS data, and, for the first time, a variety of element abundances (Fe, Mg, Si, V, Sr, Zr, Rb) and C/O ratio. Moreover, we imposed restrictive constraints on the presence of additional components, either stellar or sub-stellar, in the system. With the input stellar parameters and the radial-velocity and transit data, we determine the radius and mass of the planet Gl 486 b at Rp = 1.343−0.062+0.063 R⊕ and Mp = 3.00−0.12+0.13 M⊕, with relative uncertainties of the planet radius and mass of 4.7% and 4.2%, respectively. From the planet parameters and the stellar element abundances, we infer the most probable models of planet internal structure and composition, which are consistent with a relatively small metallic core with respect to the Earth, a deep silicate mantle, and a thin volatile upper layer. With all these ingredients, we outline prospects for Gl 486 b atmospheric studies, especially with forthcoming James Webb Space Telescope (Webb) observations. © J. A. Caballero et al. 2022.CARMENES is an instrument at the Centro Astronómico Hispano en Andalucía (CAHA) at Calar Alto (Almería, Spain), operated jointly by the Junta de Andalucía and the Instituto de Astrofísica de Andalucía (CSIC). CARMENES was funded by the Max-Planck-Gesellschaft (MPG), the Consejo Superior de Investigaciones Científicas (CSIC), the Ministerio de Economía y Competitividad (MINECO) and the European Regional Development Fund (ERDF) through projects FICTS-2011-02, ICTS-2017-07-CAHA-4, and CAHA16-CE-3978, and the members of the CARMENES Consortium (Max-Planck-Institut für Astronomie, Instituto de Astrofísica de Andalucía, Landessternwarte Königstuhl, Institut de Ciències de l’Espai, Institut für Astrophysik Göttingen, Universidad Complutense de Madrid, Thüringer Landessternwarte Tautenburg, Instituto de Astrofísica de Canarias, Hamburger Sternwarte, Centro de Astrobiología and Centro Astronómico Hispano-Alemán), with additional contributions by the MINECO, the Deutsche Forschungsgemeinschaft (DFG) through the Major Research Instrumentation Programme and Research Unit FOR2544 “Blue Planets around Red Stars”, the Klaus Tschira Stiftung, the states of Baden-Württemberg and Niedersachsen, and by the Junta de Andalucía. This work is based upon observations obtained with the Georgia State University (GSU) Center for High Angular Resolution Astronomy Array at Mount Wilson Observatory. The CHARA Array is supported by the National Science Foundation under Grant No. AST-1636624 and AST-2034336. Institutional support has been provided from the GSU College of Arts and Sciences and the GSU Office of the Vice President for Research and Economic Development. We would like to recognise the observing team, scientists, and support staff at the CHARA Array. Observation time for this work was generously allocated via discretionary time from CHARA Array director Theo ten Brumelaar and via NOIRLab community access program (proposals 2021A-0247 and 2021A-0141). MIRC-X received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant No. 639889), as well as from NASA (XRP NNX16AD43G) and NSF (AST 1909165). Data were partly collected with the 90 cm telescope at the Observatorio de Sierra Nevada operated by the Instituto de Astrofífica de Andalucía (IAA-CSIC). This work made use of observations from the Las Cumbres Observatory Global Telescope network. LCOGT observations were partially acquired via program number TAU2021A-015 of the Wise Observatory, Tel-Aviv University, Israel. We acknowledge financial support from the Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades and the ERDF through projects PID2019-109522GB-C5[1:4], PID2019-107061GB-C64, PID2019-110689RB-100, PGC2018-095317-B-C21, PGC2018-102108-B-I00, and the Centre of Excellence “Severo Ochoa” and “María de Maeztu” awards to the Instituto de Astrofísica de Canarias (CEX2019-000920-S), Instituto de Astrofísica de Andalucía (SEV-2017-0709), and Centro de Astrobiología (MDM-2017-0737), DFG through FOR2544 (KU 3625/2-1) and Germany’s Excellence Strategy to the Excellence Cluster ORIGINS (EXC-2094 - 390783311), European Research Council (Starting Grant 639889), Bulgarian National Science Fund through VIHREN-2021 (KP-06-DB/5), Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung / Fonds national suisse de la recherche scientifique (PZ00P2_174028), United Kingdom Science Technology and Facilities Council (630008203), NASA (80NSSC22K0117), National Science Foundation (2108465 and Graduate Research Fellowship DGE 1746045), Princeton University through the Henry Norris Russell Fellowship, Universidad La Laguna through the Margarita Salas Fellowship from the Spanish Ministerio de Universidades and under the EU Next Generation funds (UNI/551/2021-May 26), and the Generalitat de Catalunya (CERCA programme).Peer reviewe

Latino Communities in the United States: Place-Making in the Pre-World War II, Postwar, and Contemporary City

Scholarship on Latino communities in the United States has yet to catch up with the rapid growth of this ethnic population in the country. Understanding the Latino urban experience and developing plans to better respond to both the needs of Latino communities and their integration within society is not only relevant, but also urgently necessary. Using the city of Los Angeles as a main lens, in addition to a general look at the urban Southwest, we contribute to the scholarship on the subject with a review of literature on Latino communities. We structure the review as an assessment of the various challenges and opportunities for urban Latinos in the pre-war, postwar, and contemporary city. Focusing on space, culture, economy, and governance, we chart the various roles both the private and public sectors play in meeting these challenges. Our reading of the literature shows that particular government actions in the economic and governance domains in the past had positive impacts on Latino integration, and we call for a similar effort today in addressing contemporary challenges. We conclude by suggesting that future planning scholarship on Latino communities engage the wider urban studies literature, focus on emerging forms of urbanization, and call on planners to sustain increased academic and practical interest in the topic

The contribution of social tourism to sustainable tourism: a case study of seasonally adjusted programmes in Spain

Recent policy from the European Union has attempted to justify social tourism initiatives on the basis that they lead to a more sustainable tourism industry. However, the majority of latest research in the field has been focused on the benefits for participants, with the addition of some evidence on the economic impacts of such programmes on destinations, which have pointed towards sustainability outcomes including: a longer tourism season, more even spread of demand, and longer periods of employment for tourism workers. Yet there is a lack of direct evidence linking such programme to these outcomes. This paper aimed to explore this important disconnect between policy assumptions and evidence-based outcomes through an analysis of the deseasonalising effects of the Spanish social tourism programme for older people. The research found that this programme does have an effect on the seasonal nature of employment and economic activity in most regions studied, but that the huge volume of demand from international tourists in the high seasons masks the quantitative effects in the regions with the highest seasonal concentration of international tourists. Recommendations for policy and practice in sustainable tourism are made that are transferable to many countries and regions that adopt social tourism programmes

SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome

The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n = 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥ 7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the final multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age ≥ 70 years, SpO2, neutrophils > 7.5 × 103/µL, lactate dehydrogenase ≥ 300 U/L, and C-reactive protein ≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome