Case Studies on Impediments to Exports in Small Transition Economies

This series of enterprise case studies grew out from a 1995-1996 research project at IIASA. It acknowledged the importance of export development for the recovery of the economies of Central and Eastern Europe following their deep transformational recession in 1990-1994. The main goal was a systematic empirical analysis of the different kinds of impediments to exports in various small East European countries. The project included the coordinated elaboration of country studies for seven small transitional economies (Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Romania, Slovakia and Slovenia) and the writing of three topical studies. The authors of the country studies and the author of the topical study on Russia were requested to base their work on 20 enterprise case studies each (eventually the Russian study was based on 10 cases). Before the start of the research a common scheme of the enterprise case studies was discussed and agreed upon with the authors. After completing their work the authors were asked to supplement a short version of their case studies to their main text. Eventually it was decided that, due to the length of the full text, two related publications would be arranged, one book made up of the country studies and topical studies, and another of the enterprise case studies. The book was published by Edward Elgar: Cooper, R. and Gács, J. (Eds.) (1997) Trade Growth in Transition Economies: Export Impediments for Central and Eastern Europe, Edward Elgar, Cheltenham, UK. The second publication is the present series of case studies

Case Studies on Impediments to Exports in Small Transition Economies

This series of enterprise case studies grew out from a 1995-1996 research project at IIASA. It acknowledged the importance of export development for the recovery of the economies of Central and Eastern Europe following their deep transformational recession in 1990-1994. The main goal was a systematic empirical analysis of the different kinds of impediments to exports in various small East European countries. The project included the coordinated elaboration of country studies for seven small transitional economies (Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Romania, Slovakia and Slovenia) and the writing of three topical studies. The authors of the country studies and the author of the topical study on Russia were requested to base their work on 20 enterprise case studies each (eventually the Russian study was based on 10 cases). Before the start of the research a common scheme of the enterprise case studies was discussed and agreed upon with the authors. After completing their work the authors were asked to supplement a short version of their case studies to their main text. Eventually it was decided that, due to the length of the full text, two related publications would be arranged, one book made up of the country studies and topical studies, and another of the enterprise case studies. The book was published by Edward Elgar: Cooper, R. and Gács, J. (Eds.) (1997) Trade Growth in Transition Economies: Export Impediments for Central and Eastern Europe, Edward Elgar, Cheltenham, UK. The second publication is the present series of case studies

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity