Co-creating social and sustainable innovation in makerspaces and fab labs. Lessons learnt from the SISCODE European project

“Making” and the Fourth Industrial Revolution have been extensively investigated in the last few years. Several pieces of research have been carried out on the topic of fab lab networks and makers movements; in many cases, these studies highlighted problems of their economic sustainability, stressing -however- their cultural-related role. Nowadays, it is evident that Makerspaces and Fab Labs do not only produce physical goods, but they also develop knowledge and relationships, which are expressed through physical productions and activities. The European Union has been particularly interested in the study and development of innovative ecosystems, which might serve as levers for sustainable growth, because of their focus on co-creation and the involvement of different groups of stakeholders. SISCODE Horizon 2020 project was developed according to this European requirement. Within the SISCODE project, a co-creation methodology for societal challenges was proposed and tested throughout ten pilot projects carried out by Living Labs, Science Museums and Makerspaces, and Fab Labs. In this paper, we are going to present the three pilot projects developed by three Makerspaces and Fab Labs (Polifactory (Milan), Maker (Copenhagen), and Fab Lab Barcelona) and discuss main insights on co-creation practices

Reconstruction of upper limb soft-tissue defects after sarcoma resection with free flaps: A systematic review

BACKGROUND AND OBJECTIVES: Upper limb preservation after soft tissue sarcoma (STS) surgical excision is now the accepted gold standard and it often requires reconstruction with free flaps. The purpose of this review is to summarize current literature on upper limb reconstruction with free flaps after STS resection.METHODS: A systematic review was performed in July 2019 in PubMed and MedLine Ovid databases according to the PRISMA guidelines.RESULTS: A total of 17 studies were included in the final analysis, with 132 patients. The most common diagnosis was Malignant Fibrous Histiocytoma. The most frequent timing of flap coverage was immediate. The success rate was almost always 100%. The length of follow-up was reported in 11 studies with a range of 2-187 months. The most commonly reported patient-centered outcome was the MSTS Score. Based on the evidence of the literature collected, we divided the upper limb into four parts (shoulder, elbow and arm, forearm and wrist, and hand) and described the most common and functional free flaps used for reconstruction after STS resection.CONCLUSIONS: Free flaps in the treatment of STS of the upper extremity have a good overall outcome, with a low postoperative complication rate. A wide array of free flaps is available for reconstruction, and the choice of flap is based on defect size, types of tissue required, postoperative functional goal, and surgeon preference. A greater degree of standardization is needed in the reporting of patient-centered outcomes to facilitate future comparative studies

Las fabulas como didactica de enseñanza en el area de comunicación en estudiantes del nivel primario de la institucion educativa No 20341 “Madre Teresa de Calcuta” Santa Maria-Huaura

objetivo: se encuentra orientada a la determinación del grado de influencia de la fábula como didáctica de enseñanza en el Área de Comunicación, como también es trascendental adoptar tácticas que conduzcan hacia el interés de los educandos en la etapa de aprendizaje y también de la enseñanza utilizando las fábulas como un modelo didáctico. La población de estudio lo conformó todos los educandos matriculados en el presente año de estudio correspondiente al nivel primario, toda vez que es una población pequeña, se empleara a toda la muestra de estudio. Dentro de las técnicas de investigación que se empleó, fueron dos cuestionarios dirigidos a los estudiantes para medir las variables de estudio: Las fábulas como didáctica de enseñanza y el Área de Comunicación. Los hallazgos logados se encuentran debidamente evidenciados mediante figuras como también tablas. Al culminar este propósito de estudio, se estableció que la fábula como didáctica en la enseñanza influye significativamente para que los estudiantes que han sido referidos correspondientes a la Entidad de Educación ”Madre Teresa de Calcuta” establecido en Santas María en la provincia de Huaura, se sugiere tomar en cuenta los indicadores que se señalan como hallazgo en este estudio con el interés de que los resultados tengan un mejor logro y que esto sirva como un aporte a otros investigadores y docentes de primaria que desarrollan asignaturas referente

Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials

Dose equivalence of antidepressants is critically important for clinical practice and for research. There are several methods to define and calculate dose equivalence but for antidepressants, only daily defined dose and consensus methods have been applied to date. The purpose of the present study is to examine dose equivalence of antidepressants by a less arbitrary and more systematic method

Comparative efficacy and acceptability of pharmacological treatments for insomnia in adults: a systematic review and network meta-analysis

This is the protocol for a review and there is no abstract. The objectives are as follows: 1) To compare individual pharmacological treatments for insomnia in adults in terms of: efficacy, measured as self-rated quality of sleep or satisfaction with sleep; and acceptability of treatment. 2) To generate a clinically-useful hierarchy of available pharmacological treatments for insomnia in adults, according to their efficacy and acceptability

Study protocol: the OxWell school survey investigating social, emotional and behavioural factors associated with mental health and well-being.

INTRODUCTION: Improving our understanding of the broad range of social, emotional and behavioural factors that contribute to mental health outcomes in adolescents will be greatly enhanced with diverse, representative population samples. We present a protocol for a repeated self-report survey assessing risk and protective factors for mental health and well-being in school pupils aged 8-18 years with different socioeconomic backgrounds in England. The survey will provide a comprehensive picture of mental health and associated risks at the community level to inform the development of primary and secondary prevention and treatment strategies in schools. METHODS AND ANALYSIS: This protocol is for a large-scale online repeated self-report survey, representative of children and adolescents aged 8-18 years attending schools or further education colleges in participating counties in England. The survey consists of around 300 questions, including validated measures of mental health and well-being, risk and protective factors, and care-seeking behaviour and preferences. Additional questions each year vary to address current events and novel hypotheses, developed by the research team, collaborators and stakeholders. Primary analyses will investigate current and changing risk and protective factors, care-seeking behaviour and attitudes to allowing linkage of their sensitive data to other databases for research, and will compare measures of mental health to measures of well-being. ETHICS AND DISSEMINATION: The study was approved by the University of Oxford Research Ethics Committee (Reference: R62366). Tailored data summaries will be provided to participating schools and stakeholders within 3 months of data collection. The main findings will be presented at scientific meetings, published in peer-reviewed journals and shared via digital and social media channels. At the end of the study, other researchers will be able to apply for access to anonymous data extracts

Downregulation of miRNA17-92 cluster marks Vγ9Vδ2 T cells from patients with rheumatoid arthritis

Background: We aimed to evaluate the phenotype, function, and microRNA (miRNA)17-92 cluster expression in Vγ9Vδ2 T-cell subsets and the correlation with immune response in rheumatoid arthritis (RA) patients. Methods: Peripheral blood from 10 early RA untreated patients and 10 healthy donors (HD) was obtained. Polyclonal Vγ9Vδ2 T-cell lines were generated and analysed by flow cytometry. Analysis of miRNA17-92 cluster expression was performed by real-time polymerase chain reaction (RT-PCR), and expression of mRNA target genes was also studied. Results: A remarkable change in the distribution of Vγ9Vδ2 T-cell functional subsets was observed in the peripheral blood of RA patients compared with HD, with an expansion of effector subsets and reduction of naive cells which was accompanied by modifications in proinflammatory cytokine expression. Vγ9Vδ2 T cells with a TEM (effector memory) phenotype and producing proinflammatory cytokines were correlated with disease activity score (DAS28). The comparison of miRNA expression among Vγ9Vδ2 T-cell subsets from RA patients and HD showed a lower level of miR-106a-5p and miR-20a-5p, and a higher level of miR-21a-5p, among Vγ9Vδ2 TEM cells, and a lower level of miR-19b-3p among Vγ9Vδ2 TCM (central memory) cells was also found. These differentially expressed miRNAs correlated with higher levels of expression of interleukin (IL)-8, IL-6, and PDCD4 genes. Conclusions: Our results provide evidence for a role of miR-106a, miR-19-3p, miR-20a, and miR-21a in the regulation of Vγ9Vδ2 T-cell function in RA patients and suggest the possibility that the miRNA17-92 family and Vγ9Vδ2 T cells contribute to the pathogenesis of RA

GLOSSÁRIO DE ELETROMECÂNICA EM LIBRAS

Por conta da grande deficiência comunicativa entre ouvintes e não-ouvintes nas empresas,foi desenvolvido, e estão sendo desenvolvidos, glossários de Libras em formato audiovisual,contendo sinais na área da Eletromecânica, usando como base os glossários já existentes,fazendo ajustes e modificações nos sinais utilizados, para que haja uma melhor utilização epraticidade, sendo desta maneira, sinais aceitos pela comunidade surda. O glossário serádivulgado para a mídia, aonde o projeto cumprirá seu papel, suprindo a incompatibilidadecomunicativa no ramo

Use of online cultural content for mental health and well-being during COVID-19 restrictions : cross-sectional survey

AIMS AND METHOD: To gain a deeper understanding of the use of online culture and its potential benefits to mental health and well-being, sociodemographic characteristics and self-reported data on usage, perceived mental health benefits and health status were collected in an online cross-sectional survey during COVID-19 restrictions in the UK in June-July 2020. RESULTS: In total, 1056 people completed the survey. A high proportion of participants reported finding online culture helpful for mental health; all but one of the benefits were associated with regular use and some with age. Reported benefits were wide-ranging and interconnected. Those aged under 25 years were less likely to be regular users of online culture or to have increased their use during lockdown. CLINICAL IMPLICATIONS: There may be benefits in targeting cultural resources for mental health to vulnerable groups such as young adults