Ciliotherapy: A Novel Intervention in Polycystic Kidney Disease

Background Ciliopathies are a group of diseases associated with abnormal structure or function of primary cilia. Ciliopathies include polycystic kidney disease (PKD), a pathology associated with vascular hypertension. We previously showed that cilia length regulates cilia function, and cilia function is required for nitric oxide (NO) biosynthesis in endothelial cells. Because patients with PKD show abnormal sensory cilia function, the aim of our current study was to search for a targeted therapy focused on primary cilia, which we refer to as ‘cilio-therapy’. Methods and Results In the present studies, our in vitro analyses refined fenoldopam as an equipotent and more specific dopa- minergic agonist to regulate cilia length and function

Ressenyes

Obra ressenyada: M. Dolors GARCIA RAMON; Mireia BAYLINA FERRÉ (eds.), El nuevo papel de las mujeres en el desarrollo rural. Vilassar de Mar: Oikos-Tau, 2000

A Programmable ANSI C Code Transformation Engine.

Source code transformations are a very effective method of parallelizing and improving the efficiency of programs. Unfortunately most compiler systems require implementing separate (sub-)programs for each transformation. This paper describes a different approach. We designed and implemented a fully programmable C code transformation engine. It can be programmed by means of a transformation language. This language was especially designed to be easy to use and flexible enough to express most of the common transformations that can be found in the mainstream compiler systems. In addition, it allows specification of more exotic, but highly desirable, transformations (like for example inter-procedural transformations). The program features a userfriendly graphical user interface, allowing interactive application of transformations. Its possible applications range from coarse-grain parallelism exploitation to optimizers for multimedia instruction sets

A Programmable ANSI C Code Transformation Engine.

Source code transformations are a very effective method of parallelizing and improving the efficiency of programs. Unfortunately most compiler systems require implementing separate (sub-)programs for each transformation. This paper describes a different approach. We designed and implemented a fully programmable C code transformation engine. It can be programmed by means of a transformation language. This language was especially designed to be easy to use and flexible enough to express most of the common transformations that can be found in the mainstream compiler systems. In addition, it allows specification of more exotic, but highly desirable, transformations (like for example inter-procedural transformations). The program features a userfriendly graphical user interface, allowing interactive application of transformations. Its possible applications range from coarse-grain parallelism exploitation to optimizers for multimedia instruction sets

Deserves a hearing? A case report of remitting tinnitus with N-acetyl cysteine

No Abstract

La comunicación del cambio de domicilio fiscal. La repercusión de las últimas sentencias del Tribunal Supremo en el ámbito local

En este trabajo se analiza la comunicación del cambio de domicilio fiscal como deber del obligado tributario, siguiendo la tendencia antiformalista que sostiene la jurisprudencia del Tribunal Supremo, e incidiendo en los problemas prácticos que plantea el incumplimiento de este deber a efectos de notificaciones