The Effect of Anterior Tooth Position on Trumpet Performance Quality

poster abstractObjective: Music teachers contend that the arrangement of anterior teeth affects trumpet performance by influencing the embouchure. Since there is little quantitative data to support this claim, the purpose of this study was to determine whether trumpet performance skills are associated with the malalignment of anterior teeth. Methods: Following IRB approval, 70 trumpet students (55M:15F; aged 20-38.9 yrs.) from 11 universities were consented to complete a survey concerning dental history and trumpet playing habits. The students were asked to play a scripted performance skill test (flexibility, range, endurance, and articulation exercises) on their instrument in a soundproof music practice room while being audio and video recorded. A threedimensional (3D) cone beam computerized tomograph (CBCT) was taken of each student the same day as the skill test. Following reliability studies, overjet, overbite, and degree of anterior tooth irregularity (Little’s Index) were measured on the 3D CBCT. Nonparametric correlations, accepting p0.8). Significant (p<0.05), but weak (r<0.30) associations were found only between Little’s Index of the mandibular anterior dentition and the performance skills: flexibility (exercises a, c and avg) and articulation (double tongue). No other associations were significant. Conclusions: University trumpet students with mandibular anterior teeth that are smoothly aligned have significantly better performance skills than those with misaligned mandibular anterior teeth; however, the association is weak

Thermo-mechanical behavior of titanium beryllide pebble beds at elevated temperatures

The thermomechanical behavior of titanium beryllide pebble beds was investigated experimentally at temperatures between 200 and 500°C in helium atmosphere at atmospheric pressure. The pebbles consist of a mixture of TiBe12 and Ti2Be17 titanate beryllide phases and a small residual amount of Be phase, denominated as Be-7.7Ti. Like previous experiments at ambient temperature [1], the pebble beds were compressed uniaxially up to 4.5MPa and the effective thermal conductivity k was measured using the hot wire technique. Compared to ambient temperature, the stress-strain curves do not differ significantly in investigated temperature range. Because the thermal conductivity of solid TiBe12 is fairly constant in a wide temperature range [2], k increases moderately with increasing temperature because of the increasing thermal conductivity of helium. Compared to beryllium pebble beds, the k of the Be-7.7Ti pebble beds increases again much lesser because of the significantly smaller thermal conductivity of the solid material and the mechanically harder behavior resulting in smaller contact surfaces

Lateral and Axial Capacity of Monopiles for Offshore Wind Turbines

Offshore wind has enormous worldwide potential to generate increasing amounts of clean, renewable energy. Monopile foundations are considered to be viable in supporting larger offshore wind turbines in shallow to medium depth waters. In this paper, the lateral and axial response of monopiles installed in undrained clays of varying shear strength and stiffness is investigated using three-dimensional finite element analysis. A combination of axial and lateral loads expected at an offshore wind farm located in a water depth of 30 m has been used in the analysis. Numerically derived monopile axial capacities will be compared to those calculated using an established method in the literature. In addition, the lateral monopile capacity will be determined at ultimate limit state and compared to that at the serviceability limit state. Through a parametric study, it will be shown that with the exception of extremely high axial loads that border on monopile axial capacities, variation in axial loads does not have a significant effect on the ultimate lateral capacity and lateral displacement of monopiles. © 2013 Indian Geotechnical Society

Evaluation of droplet size spectra for agricultural pesticide applications using water sensitive paper and image analysis techniques

This study aims to evaluate the average droplet size and range of droplet size, which affects agricultural pesticide quality using image analysis techniques. In the study droplet diameters was measured by using 26 x 76 mm water sensitive paper produced by Ciba-Geigy with a little sprayer. A Nikon D300s camera body and a 105-mm macro lens were used for capturing images. Image J software was used for image evaluations, and Microsoft Excel software was used for evaluation of numerical data. At the end of the study, number median diameter (NMD) was calculated as 75 µm, diameter surface (ds) was calculated as 31 µm, volume median diameter (VMD) was calculated as 300 µm, Sauter diameter (dv/s) was calculated as 37 µm, and VMD/NMD was found 4.00 from evaluations. © by PSP

A comparative in vitro evaluation of two different magnetic devices detecting the stability of osseo-integrated implants

Geckili O, Bilhan H, Cilingir A, Mumcu E, Bural C. A comparative in vitro evaluation of two different magnetic devices detecting the stability of osseo-integrated implants. J Periodont Res 2012; 47: 508513. (c) 2012 John Wiley & Sons A/S Background and Objective: It is unknown whether the resonance frequency analysis (RFA) measurements made by two different magnetic resonance frequency analysers are comparable. This in vitro study was designed to compare the RFA measurements made by the two magnetic resonance frequency analysers and to evaluate the intra- and interobserver reliability of the magnetic devices. Material and Methods: Thirty-two implants were placed in four cow ribs. The RFA value of each implant was measured by five different examiners. The measurements were repeated five times, in both the buccal and mesial directions, for each implant at 2 h intervals, and the averages of registered implant stability quotient (ISQ) units were recorded as the buccal ISQ value and the mesial ISQ value for every implant. Results: No statistically significant differences (p > 0.05) were observed between the RFA measurements made by the two magnetic devices. The intra-observer reliability of both devices was excellent, whereas the interobserver reliability of the devices was poor. Conclusion: The results of the RFA measurements of both tested devices overlap. Although both devices show excellent intra-observer reliability, there are variations between the measurements of different examiners

Curcumin induces DNA damage by mediating homologous recombination mechanism in triple negative breast cancer

PMID = 3157335

Синтез, транспортные и ионофорные свойства БИС-а аминометилфосфиноксидов и фосфорилированных азаподантов: автореферат диссертации на соискание ученой степени к.х.н.: специальность 02.00.08

Curcumin has a therapeutic potential activity through modulation of different signaling pathways in various types of cancer. However, the relationship between the efficacy of curcumin and the homologous recombination (HR) mechanism which plays important roles in the repair of double strand DNA (dsDNA) breaks remains uncertain. Herein, we explored curcumin-dependent dsDNA breaks and the association of curcumin with HR mechanism in triple negative breast cancer (TNBC). The cytotoxic and therapeutic activity of curcumin on HCC1937 (BRCA1 mutant), MDA-MB-231 (BRCA1 wild type) TNBC and HUVEC control cell lines were assessed. Then, the expression level and subcellular localization of H2AX, PARP1, BRCA1 and RAD51 were detected by RT-PCR and immunofluorescence analysis. Furthermore, ultrastructural changes of cell death were observed by TEM. Our findings for the first time demonstrated that curcumin?s therapeutic activity was more pronounced in HCC1937 cells through the suppression of HR mechanism and the induction of dsDNA breaks. Consequently, curcumin based therapy could benefit in patients with TNBC particularly especially in women with a BRCA1 mutation