8 research outputs found
Plan de responsabilidad social empresarial Navitrans.
- Author
- Publication venue
- Universidad Nacional Abierta y a Distancia UNAD
- Publication date
- 18/07/2019
- Field of study
A continuación, se presenta el enlace del video que hace contextualización sobre Marketing Social y Marketing Corporativo e identificación del sector de la economía al cual pertenece la empresa Navitrans. Link video RSE vs. Marketing https://www.powtoon.com/online-presentation/fukfTSirMew/?mode=movie#/El presente trabajo consiste en Diseñar el plan de responsabilidad social empresarial para la empresa Navitrans, después de una serie de investigaciones y la orientación pertinente de directores y tutores del Diplomado De Profundización En Gerencia Estratégica Y Responsabilidad Social Empresarial, se logra realizar este a través de la evaluación de desempeño que ha tenido la empresa a nivel económico, social y ambiental, en el que mide su nivel de impacto y la prioridad de atención que se le debe dar. Para ello se justifica la importancia de la RSE y la implementación de un código de conducta en el que todos aportaron para su construcción y aprobación, teniendo como referencia el Modelo Benchmarking, en el que ofrece beneficios en los procesos.
Los Stakeholder juegan un papel importante en el diseño del plan de responsabilidad social empresarial ya que nos ayudan a identificar a las personas, grupos u organizaciones, que pueden afectar positiva o negativamente según las actividades y decisiones de la empresa, analizando la matriz de relaciones (influencia vs Impacto) de los actores internos y externos con el fin de informar la situación presentada a los interesados.
Lo anterior favoreció para la construcción del Plan De Responsabilidad Social Empresarial de Navitrans S.A.S, el cual aportará a su eficiencia, sostenibilidad y transparencia; adoptando políticas organizacionales que propicien y fomenten el balance económico, social y ambiental; atrayendo nuevos clientes y futuros socios que desarrollan oportunidades sociales de negocio.The current work consists of designing the responsibility plan for social work for the Navitrans business, after a series of investigations and the pertinent investigation of the directors and tutors of the diploma of deepening in strategic management and corporate social responsability it will be carried out through the evaluation of the economic, social and environmental performance company has had in that we measure the level of impact and the priority of attention that should be given. It justifies the importance of the RSE and the implementation of a code of conduct in that all contributed to its construction and approval having as a reference the Benchmarking Model in that it offers benefits in the processes.
The Stakeholders plays an important part in the responsibility plan for social work since it helps identify the people groups or organizations that can affect positively or negatively according to the activities and decisions of the business, analyzing the matrix of relationships (influence vs impact) of the internal and external actors with an end to inform the presented situation to those interested.
The anterior favored for the construction of the responsibility plan for social work of Navitrans S.A.S. Which contributes to its efficiency, sustainability and transparency; adapting organizational politics that create a suitable atmosphere for and promote the economic, social and environmental balance; attracting new clients and future partners that bring social opportunities to the business
Fortalecimiento del sentido de pertenencia en los colaboradores de la compañía Refinadora Nacional de Aceites y Grasas S.A a través de la aplicación de técnicas experienciales.
- Author
- Publication venue
- Cali
- Publication date
- 01/01/2020
- Field of study
En la actualidad, es posible reconocer que a las organizaciones no solo les genera valor la producción, finanzas, tecnología o los recursos materiales sino también las personas que las integran (Rodríguez y Romo, 2013). En consecuencia, el talento humano que conforma la organización se considera parte importante de las fortalezas de la compañía, para la consecución de sus objetivos. Sin embargo, es una labor difícil encontrar personas que cuenten con el perfil profesional acorde al cargo y, que además sus intereses vayan en el mismo sentido con los objetivos de la empresa. Por esta razón, es importante que las organizaciones se encuentren interesadas en desarrollar en su equipo de trabajo, el sentido de pertenencia, con la intención de que este valor influya directamente en la motivación de los colaboradores y en la manera cómo perciben su rol en la organización (Rodríguez & Romo, 2013). Hagerty, Lynch-Sauer, Patusky, Bouwsema y Collier (1992) identifican como elementos esenciales para desarrollar el sentido de pertenencia la experiencia de sentirse valorado, necesitado y aceptado por otras personas, grupos o entornos; y la percepción por parte del sujeto de que sus características son similares o complementan a las de las personas que pertenecen al sistema, es decir, la experiencia de sentir que se ajusta o de ser congruente con otras personas, grupos o entornos a través de características compartidas o complementarias.Introducción. --
1.Caracterización de la organización. --
1.1.Nombre de la empresa. --
1.2.Tipo de organización. --
1.3.Ubicación. --
1.4.Logo. --
1.5.Misión. --
1.6.Visión. --
1.7.Valores. --
1.7.1.Compromiso. --
1.7.2.Trabajo en equipo. --
1.7.3.Respeto. --
1.7.4.Sostenibilidad. --
1.7.5.Transparencia. --
1.7.6.Competitividad. --
1.7.7.Lealtad. --
1.8.Caracterización de la población. --
2.Justificación. --
3.Planteamiento del problema. --
3.1.Pregunta problema. --
3.2.Arbol de problemas. --
4.Antecedentes. --
5.Marco teórico. --
6.Marco conceptual. -- 27
7.Objetivos. --
7.1.Objetivo general. --
7.2.Objetivos específicos. --
8.Propuesta de técnica grupal. --
8.1.La feria de los valores. --
8.1.1.Primer día. --
8.1.2.Segundo día. --
8.1.3.Tercer día. --
8.1.4.Cuarto día. --
8.1.5.Quinto día. --
8.1.6.Sexto día. --
9.Técnica de observación de la intervención grupal. --
10.Aspectos éticos. --
11.Conclusiones. --
Anexos. --
[email protected]@campusucc.edu.coisabella.cifuentesv@[email protected]@[email protected]
Primer Encuentro Internacional de Experiencias de Investigación en Ciencias Administrativas
- Author
- Acosta Molina Juan
- Agudelo Rivera Yuliana
- Amigó Raúl Guillermo
- Amézquita Pinzón Nicolás
- Arciniegas Vacares Javier
- Arjona Julio Yulieth Andrea
- Barbosa-Ramirez David-Hernando
- Benítez Perdomo Angelica Sofia
- Bernal Romero Edgar
- Camacho Cala Paula Vanessa
- Cano Mejía Vanessa
- Carranza Carranza Luisa Fernanda
- Castro Murcia Jorge Ivan
- Cerra Rojas Cristina María
- Cuesta Giraldo Daniel Eduardo
- Céspedes Junitico Monica Patricia
- Dueñas Infante Ingrid
- Frye Rocha Kevin
- Guix Mireia
- Gutiérrez Garzón Laura Alejandra
- Guzmán Prieto Humberto
- Halal Cardenas David
- Hernández Yesica
- Iwachita da Silva Luciana Iwachita da Silva
- Lizarazo Hoyos Andres
- López Santamaría Mónica
- Martínez Cárdenas Edgar Enrique
- Martínez Marín Nelson Andrés
- Martínez Quintero Geraldine Sofía
- Miranda Trujillo Viviana
- Pardo Pedraza Luis David
- Perea Sandoval Julio Alberto
- Pico García Harold David
- Pinzón Espitia Olga Lucía
- Pulgarin-Molina Sergio-Andres
- Pérez Ramírez Patricia
- Quintero C. Cristhian Alexis
- Rodríguez García Paula Andrea
- Rodríguez Modera Diego Alejandro
- Rodríguez Romero Carlos A.
- Sanabria Mauricio
- Sierra Contreras Yessica Alejandra
- Talero Aldana Catalina
- Ujueta Marín Mario Esteban
- Valderrama Vargas Juan Felipe
- Vargas Mican Monica Yulieth
- Vargas Ramírez Ivan Rodrigo
- Vergara Varela Rafael
- Villamarín Cifuentes Gustavo Alberto
- Zerbo Cecilia
- Publication venue
- Universidad del Rosario. Escuela de Administración
- Publication date
- 13/11/2018
- Field of study
Este evento de investigación organizado por la Escuela de Administración de la Universidad del Rosario surgió como una iniciativa para fomentar la investigación formativa en áreas administrativas. El evento, al que asistieron 165 participantes, contó con dos conferencias centrales, 30 ponencias presentadas en 8 simposios y 7 posters. La participación de distintas universidades permitió un intercambio académico muy importante y formativo para los ponentes y asistentes en general, promoviendo el interés por la investigación en el campo de la administración, el cual fue el interés central de este encuentro. Este encuentro recibió el apoyo de las directivas de la Universidad del Rosario, la Señora vicerrectora Stephanie Lavaux, el Señor Decano de la Escuela de Administración, Dr. Alejandro Cheyne, ACBSP (Accreditation Council for Business Schools & Programs) y Asociación Colombiana de Facultades de Administración (ASCOLFA)
Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study) : Does nutrition really affect ICU mortality?
- Author
- Alanez-Saavedra Henry
- Alcazar-Espin M.d.l.N.
- Aldunate-Calvo S.
- Almanza-Lopez S.
- Almorin-Gonzalvez L.
- Andaluz-Ojeda David
- Andres-Gines L.
- Anguela-Calvet Laura
- Anton-Pascual J.L.
- Araujo-Aguilar P.
- Arbeloa C.S.
- Arjona-Diaz V.
- Barcelo-Castello M.
- Bautista-Redondo I.
- Bono M.P.
- Bordeje Mª Luisa
- Bordeje Mª Luisa
- Bueno-Vidales N.
- Calvo-Herranz E.
- Castor-Bekari S.
- Citores-Gonzalez R.
- Crespo-Gomez M.
- Cruz-Ramos A.
- De Frutos Fernando
- Diaz-Castellanos L.
- Dominguez-Fernandez M.I.
- Escobar-Ortiz J.
- Fernandez-Ortega J.F.
- Fernandez-Salvatierra L.
- Ferrer-Pereto C.
- Flecha-Viguera R.
- Flordelis-Lasierra José Luis
- Flordelis-Lasierra José Luis
- Fuente-O'Connor E.d.l.
- Fuster-Cabre M.
- Garcia-Fuentes C.
- Garcia-Gonzalez M.T.
- Gastaldo-Simeon R.
- Gero-Escapa M.
- Gimenez-Castellanos J.
- Gonzalez-Iglesias C.
- Gonzalez-Sanz M.
- Grau-Carmona T.
- Hacer-Puig Maria
- Hernandez-Duran Susana
- Higon-Cañigral A.
- Iglesias-Rodriguez R.
- Izura Gómez Marta
- Lage-Cendon L.
- Leon-Cinto C.
- Llorente-Ruiz B.
- Lluch-Candal C.
- Lopez-García E.
- Lopez-Luque E.
- Lorencio-Cardenas C.
- Lores-Obradors Africa
- Luna-Solis Stephani Maria
- López-Delgado Juan Carlos
- Macaya-Redin Laura
- Mampaso-Recio J.R.
- Manzano-Moratinos D.
- Marin-Corral Judith
- Marmol-Peis E.
- Martin-Luengo A.
- Martinez de Lagrán Itziar
- Martinez-Arroyo I.
- Martinez-Barrio E.
- Martinez-Carmona J.F.
- Martinez-Carmona J.F.
- Martinez-Diaz M.C.
- Martinez-Garcia P.
- Martinez-Valero C.
- Mateu-Campos L.
- Menor Fernández Eva Maria
- Millan-Taratiel P.
- Monge-Donaire D.
- Montejo-Gonzalez J.C.
- Montserrat-Ortiz N.
- Mor-Marco Esther
- Morales-Cifuentes M.
- Mudarra-Reche C.
- Muñoz De La Peña M.T.
- Muñoz-Del Río Gloria
- Navarro-Lacalle A.
- Navas-Moya E.
- Nieto-Martino B.
- Orejana-Martin M.
- Ortega-Ordiales A.
- Ortiz-Suñer A.
- Ossa-Echeverri S.
- Parra-Morais L.
- Perez-Quesada S.
- Philibert Viridiana
- Picornell-Noguera Marina
- Portugal-Rodriguez E.
- Ramirez-Montero V.
- Revelo-Esquibel Pamela Alejandra
- Rio I.J.d.
- Rodriguez-Roldan J.M.
- Rodriguez-Serrano D.A.
- Rodríguez-Queraltó Oriol
- Rovira-Vallès Yáiza
- Ruiz-Izquierdo J.
- Ruiz-Miralles M.
- Salinas-Canovas Álvaro
- Sanchez-Ales L.
- Sanchez-Giron G.R.
- Sanchez-Miralles A.
- Serra-Paya Pau
- Server-Martinez A.
- Servia-Goixart L.
- Sistachs-Baquedano Maite
- Soldado-Olmo S.
- Tejada-Artigas A.
- Temprano-Vazquez S.
- Touceda-Bravo A.
- Trujillano-Cabello J.
- Universitat Autònoma de Barcelona
- Vaquerizo-Alonso C.
- Vera-Artazcoz Paula
- Vila-Garcia B.
- Yébenes-Reyes Juan Carlos
- Zamora-Elson M.
- Zapata-Rojas A.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The importance of artificial nutritional therapy is underrecognized, typically being considered an adjunctive rather than a primary therapy. We aimed to evaluate the influence of nutritional therapy on mortality in critically ill patients. Methods: This multicenter prospective observational study included adult patients needing artificial nutritional therapy for >48 h if they stayed in one of 38 participating intensive care units for ≥72 h between April and July 2018. Demographic data, comorbidities, diagnoses, nutritional status and therapy (type and details for ≤14 days), and outcomes were registered in a database. Confounders such as disease severity, patient type (e.g., medical, surgical or trauma), and type and duration of nutritional therapy were also included in a multivariate analysis, and hazard ratios (HRs) and 95% confidence intervals (95%CIs) were reported. We included 639 patients among whom 448 (70.1%) and 191 (29.9%) received enteral and parenteral nutrition, respectively. Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure Assessment (SOFA) scores (6.6 ± 3.3 vs 8.4 ± 3.7; P < 0.001); greater nutritional risk (Nutrition Risk in the Critically Ill [NUTRIC] score: 3.8 ± 2.1 vs 5.2 ± 1.7; P < 0.001); more vasopressor requirements (70.4% vs 83.5%; P=0.001); and more renal replacement therapy (12.2% vs 23.2%; P=0.001). Multivariate analysis showed that older age (HR: 1.023; 95% CI: 1.008-1.038; P=0.003), higher SOFA score (HR: 1.096; 95% CI: 1.036-1.160; P=0.001), higher NUTRIC score (HR: 1.136; 95% CI: 1.025-1.259; P=0.015), requiring parenteral nutrition after starting enteral nutrition (HR: 2.368; 95% CI: 1.168-4.798; P=0.017), and a higher mean Kcal/Kg/day intake (HR: 1.057; 95% CI: 1.015-1.101; P=0.008) were associated with mortality. By contrast, a higher mean protein intake protected against mortality (HR: 0.507; 95% CI: 0.263-0.977; P=0.042). Old age, higher organ failure scores, and greater nutritional risk appear to be associated with higher mortality. Patients who need parenteral nutrition after starting enteral nutrition may represent a high-risk subgroup for mortality due to illness severity and problems receiving appropriate nutritional therapy. Mean calorie and protein delivery also appeared to influence outcomes. ClinicaTrials.gov NCT: 03634943
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- Antolí Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart Mélodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- Blandinières Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cédric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller Kévin
- Boulanger Cécile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau Léa
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- Béziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- Coşkuner Taner
- Cruz Inés Marín
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera Martín Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca Pérez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-Agnès
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou Félix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- Domínguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival Céline
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- D’angio Mariella
- D’enfert Christophe
- D’ortenzio Eric
- Eberl Gérard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou Hélène
- Etienne Manuel
- Eto Shohei
- Euvrard Romain
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fallon Aoife
- Fartoukh Muriel
- Faure Morgane
- Fekkar Arnaud
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
- Fievet Nathalie
- Flaig Amandine
- Fleuren Lucas
- Flores Carlos
- Flores Carlos
- Florkin Benoit
- Fontes Magnus
- Foti Giuseppe
- Fouchard Julie
- Franco José Luis
- Franco José Luis
- Francois Bruno
- Frezouls Wahiba
- Froidure Antoine
- Fumadó Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- García Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
- Gaussem Pascale
- Gaymard Alexandre
- Gayretli Zeynep
- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
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- Tancevski Ivan
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- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
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- Tiberghien Pierre
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- Tolstrup Martin
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- Trouillet-Assant Sophie
- Troya Jesús
- Troya Jesús
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- Tserel Liina
- Tso Eugene
- Tsonas Anissa
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- Tubiana Sarah
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- Téoulé François
- Uddin K.
- Uddin Mohammed
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- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- Antolí Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart Mélodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- Blandinières Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cédric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller Kévin
- Boulanger Cécile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau Léa
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- Béziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
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- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
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- Ikeda Fumiyo
- Imagawa Yusuke
- Imai Yuzuru
- Imbriano Carol
- Imoto Masaya
- Inman Denise M
- Inoki Ken
- Iovanna Juan
- Iozzo Renato V
- Ippolito Giuseppe
- Irazoqui Javier E
- Iribarren Pablo
- Ishaq Mohd
- Ishikawa Makoto
- Ishimwe Nestor
- Isidoro Ciro
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- Itakura Eisuke
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- Jackson William T
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- Jewell Jenna L
- Ji Jing
- Jia Lijun
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- Jiang Liwen
- Jiang Qing
- Jiang Richeng
- Jiang Teng
- Jiang Xuejun
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- Jin Li
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- Jin Meiyan
- Jin Si
- Jo Eun-Kyeong
- Joffre Carine
- Johansen Terje
- Johnson Gail VW
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- Jokitalo Eija
- Jolly Mohit Kumar
- Joosten Leo AB
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- Joseph Bertrand
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- Ju Dianwen
- Ju Jeong-Sun
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- Juarez Esmeralda
- Judith Delphine
- Juhasz Gabor
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- Just Steffen
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- Kain Renate
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- Kaminska Joanna
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- Kanamori Hiromitsu
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- Kang Chanhee
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- Kankanamalage Sachith Gallolu
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- Kroemer Guido
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- Lee Myung-Shik
- Lee Sang Yoon
- Lee Seung-Jae
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- Lee Yong-ho
- Lee Youngil
- Lefebvre Christophe
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- Leikin Sergey
- Leitinger Gerd
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- Li Zhiyuan
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- Lian Jiqin
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- Lin Yao-Xin
- Lin Yee-Shin
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- Liu Fang
- Liu Hao
- Liu Hsiao-Sheng
- Liu Hua-feng
- Liu Huifang
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- Liu Jing
- Liu Julia
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- Liu Yang
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- Maiani Emiliano
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- Marcucci Fabrizio
- Mardente Stefania
- Mareninova Olga A
- Margeta Marta
- Mari Muriel
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- Mariotto Sofia
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- Mishra Amit
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- Miyamoto Shigeki
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- Mizushima Noboru
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- Moura Andrea Felinto
- Moustaid-Moussa Naima
- Mrakovcic Maria
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- Murakawa Tomokazu
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- Nakagawa Ichiro
- Nakamura Ken
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- Nandi Shyam S
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- Napolitano Gennaro
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- Naveiras Olaia
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- Olivan Sara
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- Renga Giorgia
- Reue Karen
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- Varela-Nieto Isabel
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- Vasconcelos M Helena
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- Vega-Rubin-de-Celis Silvia
- VegaNaredo Ignacio
- Velasco Guillermo
- Velazquez Ariadna P
- Vellai Tibor
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- Verdier Mireille
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- Villarroya Francesc
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- Wang Yu
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- Xiao Hong-tao
- Xiao Jian
- Xiao Lan
- Xiao Shi
- Xiao Yin
- Xie Baoming
- Xie Chuan-Ming
- Xie Min
- Xie Yuxiang
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
- Yasui Takahiro
- Yazdankhah Meysam
- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
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- Yoshida Kiyotsugu
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- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field