Reference Ontologies to Support the Development of New Product-Service Lifecycle Systems

In competitive and time sensitive market places, organisations are tasked with providing Product Lifecycle Management (PLM) approaches to achieve and maintain competitive advantage, react to change and understand the balance of possible options when making decisions on complex multi-faceted problems, Global Production Networks (GPN) in one such domain in which this applies. When designing and configuring GPN to develop, manufacture and deliver product-service provision, information requirements that affect decision making become more complex. The application of reference ontologies to a domain and its related information requirements can enhance and accelerate the development of new product-service lifecycle systems with a view towards the seamless interchange of information or interoperability between systems and domains. This paper present preliminary results for the capture and modelling of end-user information and an initial higher level reference core ontology for the development of reference ontologies to ameliorate product-service lifecycle management for GPNPalmer, C.; Urwin, E.; Pinazo-Sanchez, J.; Sánchez Cid, F.; Pajkovska-Goceva, S.; Young, R. (2014). Reference Ontologies to Support the Development of New Product-Service Lifecycle Systems. En Advances in Production Management Systems: Innovative and Knowledge-Based. Springer Verlag. 642-649. doi:10.1007/978-3-662-44736-9_78S642649Vandermerwe, S., Rada, J.: Servitization of business: adding value by adding services. European Management Journal 6(4), 314–324 (1988)Coe, N.M., Dicken, P., Hess, M.: Global production networks: realizing the potential. Economic Geography Research Group, Working Paper Series No. 05.07 (2007)Young, R.I.M., Gunendran, A.G., Chungoora, N., Harding, J.A., Case, K.: Enabling interoperable manufacturing knowledge sharing in PLM. In: Proceedings of the Sixth Interna-tional Conference on Product Life Cycle Management PLM 2009, University of Bath, Bath, UK, July 6-8, pp. 130–138. Inderscience Enterprises Ltd., Switzerland (2009)Chungoora, N., Young, R.I.M.: The configuration of design and manufacture know-ledge models from a heavyweight ontological foundation. International Journal of Production Research 49(15), 4701–4725 (2011)Chungoora, N., Cutting-Decelle, A.-F., Young, R.I.M., Gunendran, G., Usman, Z., Harding, J.A., Case, K.: Towards the ontology-based consolidation of production-centric standards. International Journal of Production Research 51(2), 327–345 (2013a)Hastilow, N.: An Ontological Approach to Manufacturing Systems Interoperability in Dynamic Change Environments. PhD Thesis. School of Mechanical and Manufacturing Engineering, Loughborough University, UK (2013)Highfleet Ontology Library Reference. Highfleet Inc., Baltimore (2014)International Standards Society, ISO/IEC 15288:2008 Systems and Software Engineering – System lifecycle processes. ISO, Genève (2008)Banathy, B.H.: A systems view of education: Concepts and principles for effective practice. Educational Technology (1992)OMG, 2012 OMG unified modeling language (OMG UML), superstructure and infrastructure version 2.4.1 (2012), http://www.omg.org/spec/UML/2.4.1/ (accessed May 9, 2014)Mizoguchi, R., Kozaki, K., Kitamura, Y.: Ontological analyses of roles. In: 2012 Federated Conference on Computer Science and Information Systems (FedCSIS), pp. 489–496. IEEE (September 2012)FIPS PUBs: Integration definition for function modelling (IDEF0). Federal information processing standards publication, 183 (1993)POP* Revised framework Work package – A1.8, Athena European integrated project no. 507849 public deliverable (2006

Validating GIC modeling in the Spanish power grid by differential magnetometry

series of experiences and recommendations are presented concerning the derivation of geomagnetically induced currents (GIC) by use of the differential magnetometry method (DMM) under power lines. This indirect technique, intended to obtain observations to validate GIC models, is an alternative to measuring the current flow in the transformer neutrals. It is a non-intrusive and autonomous technique, as the procedure does not depend on the grid operator. In contrast, the selection of suitable sites devoid of human interferences, the need for power to supply the magnetometer, the data acquisition and transmission system, along with the choice of the appropriate instrumentation are difficulties that make not just any site suitable for installation and often require costly solutions. We focus on the methodology followed to estimate the GIC flowing in several transmission lines of the Spanish power grid with the aim of validating our GIC models, and we share our experience on the installation of the measuring points. Uncertainty inherent in the DMM is assessed, showing that noise is the main handicap, although it can be minimized with appropriate filtering. According to such experience, on some occasions only total DC currents above a significant fraction of 1 A give magnetic signatures well above the noise level, so this figure can roughly be considered as the threshold limit for detection. The low solar activity, combined with the mid-latitude condition of Spain, limited the significance of available recorded data, but we can already report and analyze the results for several minor geomagnetic storms

Microbially-Mediated Fluorescent Organic Matter Transformations in the Deep Ocean. Do the chemical precursors matter?

Original research paperThe refractory nature of marine dissolved organic matter (DOM) increases while it travels from surface waters to the deep ocean. This resistant fraction is in part composed of fluorescent humic-like material, which is relatively difficult to metabolize by deep water prokaryotes, and it can also be generated by microbial activity. It has been recently argued that microbial production of new fluorescent DOM (FDOM) requires the presence of humic precursors in the surrounding environment. In order to experimentally test how the chemical quality of the available organic compounds influences the production of new FDOM, three experiments were performed with bathypelagic Atlantic waters. Microbial communities were incubated in three treatments which differed in the quality of the organic compounds added: (i) glucose and acetate; (ii) glucose, acetate, essential amino acids, and humic acids; and (iii) humic acids alone. The response of the prokaryotes and the production of FDOM were simultaneously monitored. Prokaryotic abundance was highest in treatments where labile compounds were added. The rate of humic-like fluorescence production, scaled to prokaryotic abundance, varied depending on the quality of the additions. The precursor compounds affected the generation of new humic-like FDOM, and the cell-specific production of this material was higher in the incubations amended with humic precursors. Furthermore, we observed that the protein-like fluorescence decreased only when fresh amino acids were added. These findings contribute to the understanding of FDOM variability in deep waters and provide valuable information for studies where fluorescent compounds are used in order to track water masses and/or microbial processes.Spanish Ministry of Economy and Competitivity, CSIC, ESF and Danish Research Council for Independent ResearchVersión del edito

Intercultural communication between long-stay immigrants and Catalan Primary Care Nurses : a qualitative approach to rebalancing power

There is a gap between the preferences of immigrant patients and their experiences with intercultural communication. This study aims to explore the experiences and perspectives of long-stay immigrants on intercultural communication in encounters with primary care (PC) nurses. Participants were selected by purposive sampling at the Maresme Primary Care Center. A focus group and five in-depth interviews with long-stay immigrants from eight countries were carried out. Data collection was guided by a script previously validated by a group of experts. We conducted a qualitative analysis following Charmaz's approach, and data saturation was reached with 11 patients (one focus group and five interviews). Long-stay immigrants would like closer and more personalized communication exchanges with greater humanity, as well as polite and respectful manners as they perceive signs of an asymmetrical care relationship. Those who had negative communication experiences tried to justify some of the behaviors as a result of having free access to public health services. This is one of the few existing studies from the point of view of long-stay immigrants. Achieving effective intercultural communication requires a process of self-reflection, awareness-raising and commitment, both on a personal and institutional level, to eliminate the asymmetry in the nurse-patient relationship. Nurses should be trained in person-centered intercultural communication

Understanding factors that influence the decision to be vaccinated against influenza and pertussis in pregnancy : A qualitative study

Acord transformatiu CRUE-CSICAims and Objectives: To identify how pregnant women perceive pertussis and influenza and the factors that influence their decision to be vaccinated. Background: Suffering from influenza during pregnancy increases complications in the pregnant woman, foetus and newborn. Pertussis in children under six months of age causes severe complications. Maternal vaccination against influenza and pertussis is effective and safe. However, vaccination rates are insufficient. Design: We conducted a qualitative descriptive study, using semi-structured interviews. This research adheres to the COREQ guidelines and checklist. Methods: We carried out 18 semi-structured face-to-face interviews with pregnant women, using intentional sampling and thematic analysis. Results: We identified an overarching theme, 'factors that influenced participants' decision to be vaccinated or not', which was composed of four subthemes that were in turn made up of 12 categories. The factors that influenced participants' decision to be vaccinated against influenza and pertussis were related to their knowledge of and their perception of risk for these diseases. Participants perceived the risk of pertussis to be greater, and they focused their concern on the newborn. The recommendations and convictions of nurse-midwives were the most important factors encouraging vaccination. Participants trusted their nurse-midwives and most reported that they would have been vaccinated if their midwife had recommended it. Other factors were linked to lack of information, fear and concerns about economic interests. Conclusions: The convictions and actions of the nurse-midwife in recommending vaccination to pregnant women are decisive. Strategies to improve vaccination rates should be directed to helping health professionals understand how their practice affects the final decision of pregnant women. Relevance to clinical practice: Understanding the factors that limit vaccination rates among pregnant women provides valuable information to nurse-midwives that can help to improve vaccination strategies and practices. Increased maternal vaccination rates would reduce morbidity and mortality among pregnant women and newborns

FCNC Top Quark Decays in Extra Dimensions

The flavor changing neutral top quark decay t -> c X is computed, where X is a neutral standard model particle, in a extended model with a single extra dimension. The cases for the photon, X= \gamma$, and a Standard Model Higgs boson, X = H, are analyzed in detail in a non-linear$R_\xi gauge. We find that the branching ratios can be enhanced by the dynamics originated in the extra dimension. In the limit where 1/R >> ->, we have found Br(t -> c \gamma) \simeq 10^{-10} for 1/R = 0.5 TeV. For the decay t -> c H, we have found Br(t -> cH) \simeq 10^{-10} for a low Higgs mass value. The branching ratios go to zero when 1/R -> \infty.Comment: Accepted to be published in the Europ. Phys. Jour. C; 16 pages, 2 figure

Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

We report the synthesis and biological evaluation of a series of 7-aryl-1,2,4-triazolo[4,3-c]pyridines with mGlu(2) positive allosteric modulator (PAM) activity and affinity. Besides traditional in vitro parameters of potency and affinity, kinetic parameters k(on), k(off) and residence time (RT) were determined. The PAMs showed various kinetic profiles; k(on) values ranged over 2 orders of magnitude, whereas RT values were within a 10-fold range. Association rate constant k(on) was linearly correlated to affinity. Evaluation of a short, medium, and long RT compound in a label-free assay indicated a correlation between RT and functional effect. The effects of long RT compound 9 on sleep-wake states indicated long RT was translated into sustained inhibition of rapid eye movement (REM) in vivo. These results show that affinity-only driven selection would have resulted in mGlu(2) PAMs with high values for k(on) but not necessarily optimized RT, which is key to predicting optimal efficacy in vivo

Wind-induced changes in the dynamics of fluorescent organic matter in the coastal NW Mediterranean

Original research paperMarine biogeochemistry dynamics in coastal marine areas is strongly influenced by episodic events such as rain, intense winds, river discharges and anthropogenic activities. We evaluated in this study the importance of these forcing events on modulating seasonal changes in the marine biogeochemistry of the northwestern coast of the Mediterranean Sea, based on data gathered from a fixed coastal sampling station in the area. A 4-year (2011–2014) monthly sampling at four depths (0.5 m, 20 m, 50 m and 80 m) was performed to examine the time variability of several oceanographic variables: seawater temperature, salinity, inorganic nutrient concentrations (NO3−, PO43 − and SiO2), chlorophyll a (Chl a), dissolved organic carbon (DOC) and fluorescent dissolved organic matter (FDOM). FDOM dynamics was predominantly influenced by upwelling events and mixing processes, driven by strong and characteristic wind episodes. SW wind episodes favored the upwelling of deeper and denser waters into the shallower shelf, providing a surplus of autochthonous humic-like material and inorganic nutrients, whereas northerlies favored the homogenization of the whole shelf water column by cooling and evaporation. These different wind-induced processes (deep water intrusion or mixing), reported along the four sampled years, determined a high interannual environmental variability in comparison with other Mediterranean sampling sites. Graphical abstract Image 1 Download : Download high-res image (344KB)Download : Download full-size imageECOSER (CTM2011-15937-E), DOREMI (CTM2012-342949), SUAVE (CTM2014/ 23456/1) and ANIMA (CTM2015-65720) from the Spanish Ministerio de Economía y Competitividad (MINECO) and the Grup de Recerca Consolidat 2014SGR1179 and 2014SGR1029 financed by the Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) from the Generalitat de Catalunya; (JAEPre_2011_00923) from the Agencia Estatal Consejo Su perior de Investigaciones Científicas (CSIC) and the project FERMIO (MINECO, CTM2014-57334-JIN) co-financed with FEDER fundsVersión del editor3,25

Progressive transformation of a flux rope to an ICME

The solar wind conditions at one astronomical unit (AU) can be strongly disturbed by the interplanetary coronal mass ejections (ICMEs). A subset, called magnetic clouds (MCs), is formed by twisted flux ropes that transport an important amount of magnetic flux and helicity which is released in CMEs. At 1 AU from the Sun, the magnetic structure of MCs is generally modeled neglecting their expansion during the spacecraft crossing. However, in some cases, MCs present a significant expansion. We present here an analysis of the huge and significantly expanding MC observed by the Wind spacecraft during 9 and 10 November, 2004. After determining an approximated orientation for the flux rope using the minimum variance method, we precise the orientation of the cloud axis relating its front and rear magnetic discontinuities using a direct method. This method takes into account the conservation of the azimuthal magnetic flux between the in- and out-bound branches, and is valid for a finite impact parameter (i.e., not necessarily a small distance between the spacecraft trajectory and the cloud axis). Moreover, using the direct method, we find that the ICME is formed by a flux rope (MC) followed by an extended coherent magnetic region. These observations are interpreted considering the existence of a previous larger flux rope, which partially reconnected with its environment in the front. These findings imply that the ejected flux rope is progressively peeled by reconnection and transformed to the observed ICME (with a remnant flux rope in the front part).Comment: Solar Physics (in press

Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort

BACKGROUND: Heritability estimates have revealed an important contribution of SNP variants for most common traits; however, SNP analysis by single-trait genome-wide association studies (GWAS) has failed to uncover their impact. In this study, we applied a multitrait GWAS approach to discover additional factor of the missing heritability of human anthropometric variation. METHODS: We analysed 205 traits, including diseases identified at baseline in the GCAT cohort (Genomes For Life- Cohort study of the Genomes of Catalonia) (n=4988), a Mediterranean adult population-based cohort study from the south of Europe. We estimated SNP heritability contribution and single-trait GWAS for all traits from 15 million SNP variants. Then, we applied a multitrait-related approach to study genome-wide association to anthropometric measures in a two-stage meta-analysis with the UK Biobank cohort (n=336 107). RESULTS: Heritability estimates (eg, skin colour, alcohol consumption, smoking habit, body mass index, educational level or height) revealed an important contribution of SNP variants, ranging from 18% to 77%. Single-trait analysis identified 1785 SNPs with genome-wide significance threshold. From these, several previously reported single-trait hits were confirmed in our sample with LINC01432 (p=1.9×10-9) variants associated with male baldness, LDLR variants with hyperlipidaemia (ICD-9:272) (p=9.4×10-10) and variants in IRF4 (p=2.8×10-57), SLC45A2 (p=2.2×10-130), HERC2 (p=2.8×10-176), OCA2 (p=2.4×10-121) and MC1R (p=7.7×10-22) associated with hair, eye and skin colour, freckling, tanning capacity and sun burning sensitivity and the Fitzpatrick phototype score, all highly correlated cross-phenotypes. Multitrait meta-analysis of anthropometric variation validated 27 loci in a two-stage meta-analysis with a large British ancestry cohort, six of which are newly reported here (p value threshold <5×10-9) at ZRANB2-AS2, PIK3R1, EPHA7, MAD1L1, CACUL1 and MAP3K9. CONCLUSION: Considering multiple-related genetic phenotypes improve associated genome signal detection. These results indicate the potential value of data-driven multivariate phenotyping for genetic studies in large population-based cohorts to contribute to knowledge of complex traits