975 research outputs found
Spotlight on Cardiovascular Scoring Systems in Covid-19: Severity Correlations in Real-world Setting
Objectives and Methods: the current understanding of the interplay between cardiovascular (CV) risk and Covid-19 is grossly inadequate. CV risk-prediction models are used to identify and treat high risk populations and to communicate risk effectively. These tools are unexplored in Covid-19. The main objective is to evaluate the association between CV scoring systems and chest X ray (CXR) examination (in terms of severity of lung involvement) in 50 Italian Covid-19 patients. Results only the Framingham Risk Score (FRS) was applicable to all patients. The Atherosclerotic Cardiovascular Disease Score (ASCVD) was applicable to half. 62% of patients were classified as high risk according to FRS and 41% according to ASCVD. Patients who died had all a higher FRS compared to survivors. They were all hypertensive. FRS≥30 patients had a 9.7 higher probability of dying compared to patients with a lower FRS. We found a strong correlation between CXR severity and FRS and ASCVD (P < 0.001). High CV risk patients had consolidations more frequently. CXR severity was significantly associated with hypertension and diabetes. 71% of hypertensive patients’ CXR and 88% of diabetic patients’ CXR had consolidations. Patients with diabetes or hypertension had 8 times greater risk of having consolidations. Conclusions: High CV risk correlates with more severe CXR pattern and death. Diabetes and hypertension are associated with more severe CXR. FRS offers more predictive utility and fits best to our cohort. These findings may have implications for clinical practice and for the identification of high-risk groups to be targeted for the vaccine precedence
Discovery of a Thirty-Degree Long Ultraviolet Arc in Ursa Major
Our view of the interstellar medium of the Milky Way and the universe beyond
is affected by the structure of the local environment in the Solar
neighborhood. Here, we present the discovery of a thirty-degree long arc of
ultraviolet emission with a thickness of only a few arcminutes: the Ursa Major
Arc. It consists of several arclets seen in the near- and far-ultraviolet bands
of the GALEX satellite. A two-degree section of the arc was first detected in
the H{\alpha} optical spectral line in 1997; additional sections were seen in
the optical by the team of amateur astronomers included in this work. This
direction of the sky is known for very low hydrogen column density and dust
extinction; many deep fields for extra-galactic and cosmological investigations
lie in this direction. Diffuse ultraviolet and optical interstellar emission
are often attributed to scattering of light by interstellar dust. The lack of
correlation between the Ursa Major Arc and thermal dust emission observed with
the Planck satellite, however, suggests that other emission mechanisms must be
at play. We discuss the origin of the Ursa Major Arc as the result of an
interstellar shock in the Solar neighborhood.Comment: Accepted by A&A on April 3, 202
The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study
Trigeminal input exerts acute and chronic effects on the brain, modulating cognitive functions. Here, new data from humans and animals suggest that these effects are caused by trigeminal influences on the Locus Coeruleus (LC). In humans subjects clenching with masseter asymmetric activity, occlusal correction improved cognition, alongside with reductions in pupil size and anisocoria, proxies of LC activity and asymmetry, respectively. Notably, reductions in pupil size at rest on the hypertonic side predicted cognitive improvements. In adult rats, a distal unilateral section of the trigeminal mandibular branch reduced, on the contralateral side, the expression of c-Fos (brainstem) and BDNF (brainstem, hippocampus, frontal cortex). This counterintuitive finding can be explained by the following model: teeth contact perception loss on the lesioned side results in an increased occlusal effort, which enhances afferent inputs from muscle spindles and posterior periodontal receptors, spared by the distal lesion. Such effort leads to a reduced engagement of the intact side, with a corresponding reduction in the afferent inputs to the LC and in c-Fos and BDNF gene expression. In conclusion, acute effects of malocclusion on performance seem mediated by the LC, which could also contribute to the chronic trophic dysfunction induced by loss of trigeminal input
SUDARE-VOICE variability-selection of Active Galaxies in the Chandra Deep Field South and the SERVS/SWIRE region
One of the most peculiar characteristics of Active Galactic Nuclei (AGN) is
their variability over all wavelengths. This property has been used in the past
to select AGN samples and is foreseen to be one of the detection techniques
applied in future multi-epoch surveys, complementing photometric and
spectroscopic methods.
In this paper, we aim to construct and characterise an AGN sample using a
multi-epoch dataset in the r band from the SUDARE-VOICE survey.
Our work makes use of the VST monitoring program of an area surrounding the
Chandra Deep Field South to select variable sources. We use data spanning a six
month period over an area of 2 square degrees, to identify AGN based on their
photometric variability.
The selected sample includes 175 AGN candidates with magnitude r < 23 mag. We
distinguish different classes of variable sources through their lightcurves, as
well as X-ray, spectroscopic, SED, optical and IR information overlapping with
our survey.
We find that 12% of the sample (21/175) is represented by SN. Of the
remaining sources, 4% (6/154) are stars, while 66% (102/154) are likely AGNs
based on the available diagnostics. We estimate an upper limit to the
contamination of the variability selected AGN sample of about 34%, but we point
out that restricting the analysis to the sources with available
multi-wavelength ancillary information, the purity of our sample is close to
80% (102 AGN out of 128 non-SN sources with multi-wavelength diagnostics). Our
work thus confirms the efficiency of the variability selection method in
agreement with our previous work on the COSMOS field; in addition we show that
the variability approach is roughly consistent with the infrared selection.Comment: Published in A & A, 15 pages, 6 figure
Global phase time and path integral for the Kantowski--Sachs anisotropic univers
The action functional of the anisotropic Kantowski--Sachs cosmological model
is turned into that of an ordinary gauge system. Then a global phase time is
identified for the model by imposing canonical gauge conditions, and the
quantum transition amplitude is obtained by means of the usual path integral
procedure of Fadeev and Popov.Comment: 11 page
The VOICE Survey : VST Optical Imaging of the CDFS and ES1 Fields
IndexaciĂłn: Scopus.We present the VST Optical Imaging of the CDFS and ES1 Fields (VOICE) Survey, a VST INAF Guaranteed Time program designed to provide optical coverage of two 4 deg2 cosmic windows in the Southern hemisphere. VOICE provides the first, multi-band deep optical imaging of these sky regions, thus complementing and enhancing the rich legacy of longer-wavelength surveys with VISTA, Spitzer, Herschel and ATCA available in these areas and paving the way for upcoming observations with facilities such as the LSST, MeerKAT and the SKA. VOICE exploits VST's OmegaCAM optical imaging capabilities and completes the reduction of WFI data available within the ES1 fields as part of the ESO-Spitzer Imaging Extragalactic Survey (ESIS) program providing ugri and uBVR coverage of 4 and 4 deg2 areas within the CDFS and ES1 field respectively. We present the survey's science rationale and observing strategy, the data reduction and multi-wavelength data fusion pipeline. Survey data products and their future updates will be released at http://www.mattiavaccari.net/voice/ and on CDS/VizieR.https://pos.sissa.it/275/026/pd
Optically variable active galactic nuclei in the 3 yr VST survey of the COSMOS field
The analysis of the variability of active galactic nuclei (AGNs) at different
wavelengths and the study of possible correlations among different spectral
windows are nowadays a major field of inquiry. Optical variability has been
largely used to identify AGNs in multivisit surveys. The strength of a
selection based on optical variability lies in the chance to analyze data from
surveys of large sky areas by ground-based telescopes. However the
effectiveness of optical variability selection, with respect to other
multiwavelength techniques, has been poorly studied down to the depth expected
from next generation surveys. Here we present the results of our r-band
analysis of a sample of 299 optically variable AGN candidates in the VST survey
of the COSMOS field, counting 54 visits spread over three observing seasons
spanning > 3 yr. This dataset is > 3 times larger in size than the one
presented in our previous analysis (De Cicco et al. 2015), and the observing
baseline is ~8 times longer. We push towards deeper magnitudes (r(AB) ~23.5
mag) compared to past studies; we make wide use of ancillary multiwavelength
catalogs in order to confirm the nature of our AGN candidates, and constrain
the accuracy of the method based on spectroscopic and photometric diagnostics.
We also perform tests aimed at assessing the relevance of dense sampling in
view of future wide-field surveys. We demonstrate that the method allows the
selection of high-purity (> 86%) samples. We take advantage of the longer
observing baseline to achieve great improvement in the completeness of our
sample with respect to X-ray and spectroscopically confirmed samples of AGNs
(59%, vs. ~15% in our previous work), as well as in the completeness of
unobscured and obscured AGNs. The effectiveness of the method confirms the
importance to develop future, more refined techniques for the automated
analysis of larger datasets.Comment: 21 pages, 10 figures; accepted for publication in A&
Pressure-induced amorphization and polyamorphism in one-dimensional single crystal TiO2 nanomaterials
The structural phase transitions of single crystal TiO2-B nanoribbons were
investigated in-situ at high-pressure using the synchrotron X-ray diffraction
and the Raman scattering. Our results have shown a pressure-induced
amorphization (PIA) occurred in TiO2-B nanoribbons upon compression, resulting
in a high density amorphous (HDA) form related to the baddeleyite structure.
Upon decompression, the HDA form transforms to a low density amorphous (LDA)
form while the samples still maintain their pristine nanoribbon shape. HRTEM
imaging reveals that the LDA phase has an {\alpha}-PbO2 structure with short
range order. We propose a homogeneous nucleation mechanism to explain the
pressure-induced amorphous phase transitions in the TiO2-B nanoribbons. Our
study demonstrates for the first time that PIA and polyamorphism occurred in
the one-dimensional (1D) TiO2 nanomaterials and provides a new method for
preparing 1D amorphous nanomaterials from crystalline nanomaterials.Comment: 4 figure
Climate Change and Childhood Respiratory Health: A Call to Action for Paediatricians
Climate change (CC) is one of the main contributors to health emergencies worldwide. CC appears to be closely interrelated with air pollution, as some pollutants like carbon dioxide (CO2), nitrogen oxides (NOx) and black carbon are naturally occurring greenhouse gases. Air pollution may enhance the allergenicity of some plants and, also, has an adverse effect on respiratory health. Children are a uniquely vulnerable group that suffers disproportionately from CC burden. The increasing global warming related to CC has a big impact on plants' lifecycles, with earlier and longer pollen seasons, as well as higher pollen production, putting children affected by asthma and allergic rhinitis at risk for exacerbations. Extreme weather events may play a role too, not only in the exacerbations of allergic respiratory diseases but, also, in favouring respiratory infections. Even though paediatricians are already seeing the impacts of CC on their patients, their knowledge about CC-related health outcomes with specific regards to children's respiratory health is incomplete. This advocates for paediatricians' increased awareness and a better understanding of the CC impact on children's respiratory health. Having a special responsibility for children, paediatricians should actively be involved in policies aimed to protect the next generation from CC-related adverse health effects. Hence, there is an urgent need for them to take action and successfully educate families about CC issues. This paper aims at reviewing the evidence of CC-related environmental factors such as temperature, humidity, rainfall and extreme events on respiratory allergic diseases and respiratory infections in children and proposing specific actionable items for paediatricians to deal with CC-related health issues in their clinical practice
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