A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis

Lactobacilli with probiotic features play an essential role in maintaining a balanced vaginal microbiota and their administration has been suggested for the treatment and prevention of vaginal dysbiosis. The present study was aimed to in vitro and in vivo investigate the probiotic potential of the Lacticaseibacillus rhamnosus TOM 22.8 strain, isolated from the vaginal ecosystem of a healthy woman. For this purpose, safety and functional properties were in depth evaluated. The strain exhibited a broad spectrum of antagonistic activity against vaginal pathogens; adhesion capacity to both the vaginal VK2/E6E7 and the intestinal Caco-2 cells; anti-inflammatory and antioxidant activities, suggesting its promising probiotic features. In addition, an in vivo pilot-study was planned. Based on both clinical and microbiological parameters, the oral or vaginal strain administration, determined a significant pathogens reduction after 10 days of administration and a maintenance of eubiosis up to 30 days after the end of the treatment. Therefore, the L. rhamnosus TOM 22.8 strain can be proposed as valuable oral and/or vaginal treatment for vaginal dysbiosis

Optimal propagating fronts using Hamilton-Jacobi equations

The optimal handling of level sets associated to the solution of Hamilton-Jacobi equations such as the normal flow equation is investigated. The goal is to find the normal velocity minimizing a suitable cost functional that accounts for a desired behavior of level sets over time. Sufficient conditions of optimality are derived that require the solution of a system of nonlinear Hamilton-Jacobi equations. Since finding analytic solutions is difficult in general, the use of numerical methods to obtain approximate solutions is addressed by dealing with some case studies in two and three dimensions

Prospects of light sterile neutrino oscillation and CP violation searches at the Fermilab Short Baseline Neutrino Facility

We investigate the ability of the short baseline neutrino (SBN) experimental program at Fermilab to test the globally-allowed (3 þ N) sterile neutrino oscillation parameter space. We explicitly consider the globally-allowed parameter space for the (3 þ 1), (3 þ 2), and (3 þ 3) sterile neutrino oscillation scenarios. We find that SBN can probe with 5σ sensitivity more than 85%, 95% and 55% of the parameter space currently allowed at 99% confidence level for the (3 þ 1), (3 þ 2) and (3 þ 3) scenarios, respectively, with the (3 þ N) allowed space used in these studies closely resembling that of previous studies [J. M. Conrad, C. M. Ignarra, G. Karagiorgi, M. H. Shaevitz, and J. Spitz, Adv. High Energy Phys. 2013, 1 (2013).], calculated using the same methodology. In the case of the (3 þ 2) and (3 þ 3) scenarios, CP-violating phases appear in the oscillation probability terms, leading to observable differences in the appearance probabilities of neutrinos and antineutrinos. We explore SBN’s sensitivity to those phases for the (3 þ 2) scenario through the currently planned neutrino beam running, and investigate potential improvements through additional antineutrino beam running. We show that, if antineutrino exposure is considered, for maximal values of the (3 þ 2) CP-violating phase ϕ54, SBN could be the first experiment to directly observe ∼2σ hints of CP violation associated with an extended lepton sector

Current surgical concepts and indications in the management of the short bowel state: A call for the use of multidisciplinary intestinal rehabilitation programs

The mainstay of management for short bowel syndrome (SBS) is to promote access to the best quality of care provided by the intestinal rehabilitation program (IRP) in specialized centres. When treating SBS patients, the main goal is to minimize disease-associated complications, as well as achieve enteral autonomy. Surgical strategies should be selected cautiously upon the actual state of the bowel with respect to what it is clinically relevant for that specific patient. To this aim, a personalized and multidisciplinary approach for such a complex syndrome is needed

Foliated quantum error-correcting codes

We show how to construct a large class of quantum error-correcting codes, known as Calderbank-Steane-Shor codes, from highly entangled cluster states. This becomes a primitive in a protocol that foliates a series of such cluster states into a much larger cluster state, implementing foliated quantum error correction. We exemplify this construction with several familiar quantum error-correction codes and propose a generic method for decoding foliated codes. We numerically evaluate the error-correction performance of a family of finite-rate Calderbank-Steane-Shor codes known as turbo codes, finding that they perform well over moderate depth foliations. Foliated codes have applications for quantum repeaters and fault-tolerant measurement-based quantum computation

Universal topological phase of 2D stabilizer codes

Two topological phases are equivalent if they are connected by a local unitary transformation. In this sense, classifying topological phases amounts to classifying long-range entanglement patterns. We show that all 2D topological stabilizer codes are equivalent to several copies of one universal phase: Kitaev's topological code. Error correction benefits from the corresponding local mappings.Comment: 4 pages, 3 figure

Evaluation of DyScO(x) as an alternative blocking dielectric in TANOS memories with Si(3)N(4) or Si-rich SiN charge trapping layers

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Deep brain stimulation of globus pallidus internus and subthalamic nucleus in Parkinson’s disease: a multicenter, retrospective study of efficacy and safety

BackgroundDeep brain stimulation (DBS) is an established therapeutic option in advanced Parkinson's disease (PD). Literature data and recent guidelines remain inconclusive about the best choice as a target between the subthalamic nucleus (STN) and the globus pallidus internus (GPi).Materials and methodsWe retrospectively reviewed the clinical efficacy outcomes of 48 DBS-implanted patients (33 STN-DBS and 15 GPi-DBS) at a short- (<1 year from the surgery) and long-term (2-5 years) follow-up. Also, clinical safety outcomes, including postoperative surgical complications and severe side effects, were collected.ResultsWe found no difference between STN-DBS and GPi-DBS in improving motor symptoms at short-term evaluation. However, STN-DBS achieved a more prominent reduction in oral therapy (l-dopa equivalent daily dose, P = .02). By contrast, GPi-DBS was superior in ameliorating motor fluctuations and dyskinesia (MDS-UPDRS IV, P < .001) as well as motor experiences of daily living (MDS-UPDRS II, P = .03). The greater efficacy of GPi-DBS on motor fluctuations and experiences of daily living was also present at the long-term follow-up. We observed five serious adverse events, including two suicides, all among STN-DBS patients.ConclusionBoth STN-DBS and GPi-DBS are effective in improving motor symptoms severity and complications, but GPi-DBS has a greater impact on motor fluctuations and motor experiences of daily living. These results suggest that the two targets should be considered equivalent in motor efficacy, with GPi-DBS as a valuable option in patients with prominent motor complications. The occurrence of suicides in STN-treated patients claims further attention in target selection