The Analysis of Influencing Factors of Trademark Strategy Implementation in Chinese Small and Middle Enterprises

It is an era of knowledge economy and globalization nowadays. Intellectual property has increasingly become a competitive weapon and strategic wealth of the company. Market competition has risen to brand competition. The well-known trademarks became the most valuable infinite asset of the enterprise. However, there is a widespread phenomenon that small and middle enterprises (SMEs) donot have their own trademark, which causes they just get a small part of the profits as well as low competitiveness. Through the SWOT analysis the article discusses important factors that influence the effectiveness of the implementation of the trademark strategy of SMEs, supporting SMEs to cultivate their own trademarks, building well-known trademarks and enhancing the core competitiveness of enterprises

Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes

YesAutophagy is the central cellular mechanism for delivering organelles and cytoplasm to lysosomes for degradation and recycling of their molecular components. To determine the contribution of autophagy to melanocyte (MC) biology, we inactivated the essential autophagy gene Atg7 specifically in MCs using the Cre-loxP system. This gene deletion efficiently suppressed a key step in autophagy, lipidation of microtubule-associated protein 1 light chain 3 beta (LC3), in MCs and induced slight hypopigmentation of the epidermis in mice. The melanin content of hair was decreased by 10–15% in mice with autophagy-deficient MC as compared with control animals. When cultured in vitro, MCs from mutant and control mice produced equal amounts of melanin per cell. However, Atg7-deficient MCs entered into premature growth arrest and accumulated reactive oxygen species (ROS) damage, ubiquitinated proteins, and the multi-functional adapter protein SQSTM1/p62. Moreover, nuclear factor erythroid 2–related factor 2 (Nrf2)–dependent expression of NAD(P)H dehydrogenase, quinone 1, and glutathione S-transferase Mu 1 was increased, indicating a contribution of autophagy to redox homeostasis in MCs. In summary, the results of our study suggest that Atg7-dependent autophagy is dispensable for melanogenesis but necessary for achieving the full proliferative capacity of MCs

A novel UEP scheme based upon rateless codes

In this paper, we propose a novel method suitable for unequal error protection(UEP) and unequal recovery time (URT) properties, namely the Duplicating-Expanding Window Fountain(D-EWF) codes. We implement duplicating windows and expanding windows techniques to improve the performance of both more important bits (MIB) and less important bits (LIB). We analyze the proposed method over binary erasure channels (BEC) by using asymptotic analysis. The D-EWF codes inherit the advantages of both EWF codes and the duplicating windows method. Therefore the UEP property of D-EWF codes is more obvious. Furthermore BER performance of LIB of D-EWF codes converges very fast. Compared with the previous UEP schemes, simulation results show that the D-EWF codes can provide better UEP performance

Research on the Relationship between Cutting Force and Machined Surface Quality in Micro Ball End-Milling of Potassium Dihydrogen Phosphate Crystal

Potassium dihydrogen phosphate (KDP or KH2PO4) crystal is widely used as terminal frequency converters in inertial confinement fusion (ICF). However, KDP crystal is a typical difficult-to-cut optical crystal with the characteristic of soft-brittle. In this work, the relationship between cutting force and processed surface quality in micro ball end-milling of KDP crystal with various depth of cut and spindle speed is studied by carried out the micro-milling experiments. Fast Fourier Transform (FFT) algorithm is used to diagnose the recorded cutting force. The periodic change of cutting force and the cutting force after filtering noises can be got through FFT analysis. Through calculating the correlation coefficients between the static component of thrust force and roughness value Ra of machined grooves, as well as the peak-valley (P-V) value of thrust force and dimensional error of machined grooves, the roughness value Ra and dimensional error of machined grooves would be predicted by monitoring the static component and P-V value of the thrust force, respectively. The relatively large spindle speed helps to reduce the roughness value Ra. The spindle speed with moderate value is recommended to reduce the dimensional error of machined groove because the dimensional error of machined groove will increase when the spindle speed is small enough (causing brittle cutting) or large enough (reducing cutting stability)

Research in minimum undeformed chip thickness and size effect in micro end-milling of potassium dihydrogen phosphate crystal

© 2017 Elsevier Ltd Micro-milling is a promising approach to repair the micro-defects on the surface of potassium dihydrogen phosphate (KDP) crystal. However, KDP crystal is difficult to machine due to its properties of soft-brittle and easy deliquescence. This study investigates the minimum undeformed chip thickness hm and the size effect in micro end-milling of KDP crystal by comprehensively analyzing cutting force, specific cutting force and machined surface quality. A model of the chip formation, which is capable of connecting the minimum undeformed chip thickness, the undeformed chip thickness and the periodicity of cutting force together, is developed to predict the value of minimum undeformed chip thickness. The normalized minimum undeformed chip thickness λe in terms of the ratio of the minimum undeformed chip thickness to the cutting edge radius re, is estimated to be 0.43 ≤ λe ≤ 0.48. The significantly non-proportional increase of specific cutting force indicates the existence of size effects when the ratio of feed per tooth to cutting edge radius ft/re is less than 0.7. The machined surface quality also reflects severe size effect by the phenomenon that the micro cracks and brittle pits appear on the groove base, and the value of surface roughness Ra is large when the ratio ft/re is less than 0.5. Furthermore, the surface quality deteriorates and the brittle cutting appears when the ratio ft/re is much larger than 1 which seems similar to macro-milling. The perfect machined surface with almost no ploughing effect and brittle cutting is achieved at a ratio ft/re of 0.7. Therefore, a feed per tooth, slightly larger than the minimum undeformed chip thickness but smaller than cutting edge radius, is recommended for micro-milling of KDP crystal or soft-brittle crystal.status: publishe

IKULDAS: An Improved <i>k</i>NN-Based UHF RFID Indoor Localization Algorithm for Directional Radiation Scenario

Ultra high frequency radio frequency identification (UHF RFID)-based indoor localization technology has been a competitive candidate for context-awareness services. Previous works mainly utilize a simplified Friis transmission equation for simulating/rectifying received signal strength indicator (RSSI) values, in which the directional radiation of tag antenna and reader antenna was not fully considered, leading to unfavorable performance degradation. Moreover, a k-nearest neighbor (kNN) algorithm is widely used in existing systems, whereas the selection of an appropriate k value remains a critical issue. To solve such problems, this paper presents an improved kNN-based indoor localization algorithm for a directional radiation scenario, IKULDAS. Based on the gain features of dipole antenna and patch antenna, a novel RSSI estimation model is first established. By introducing the inclination angle and rotation angle to characterize the antenna postures, the gains of tag antenna and reader antenna referring to direct path and reflection paths are re-expressed. Then, three strategies are proposed and embedded into typical kNN for improving the localization performance. In IKULDAS, the optimal single fixed rotation angle is introduced for filtering a superior measurement and an NJW-based algorithm is advised for extracting nearest-neighbor reference tags. Furthermore, a dynamic mapping mechanism is proposed to accelerate the tracking process. Simulation results show that IKULDAS achieves a higher positioning accuracy and lower time consumption compared to other typical algorithms

Safety and efficacy of Pimecrolimus in atopic dermatitis among Chinese infants: a sub-group analysis of a five-year open-label study

Introduction Atopic dermatitis (AD) exhibits difference in immune polarization between Caucasians and Asian races due to which an evaluation of the efficacy and safety of Pimecrolimus (PIM) in Asian population is called for. The current study addresses the need via a sub-group analysis of the PETITE study (NCT00120523) to evaluate the safety and efficacy of PIM in Chinese infants. Materials and methods Patients with AD (≥3 months–<12 months of age) were randomized in a 1:1 ratio to either PIM 1% cream or topical corticosteroids (TCS). The primary endpoint was safety. The secondary endpoint was efficacy. Results 120 patients were randomized to either PIM 1% or TCS (n = 61 for PIM, n = 59 for TCS). The most often reported adverse events were reported by similar proportions of patients treated with PIM or TCS. There was a progressive increase in overall IGA treatment success in infants treated with PIM (82.9%, p < .05, 95% CI: 70.4, 95.3) after 26 weeks which was comparable to the TCS group (88.5%, p < .05, 95% CI: 79.8, 97.1). Conclusion PIM showed an early and sustained efficacy in the Chinese sub-population with a substantial corticosteroid-sparing effect in patients with AD