Pathogenicity of Bibersteinia trehalosi in bovine calves

Introduction - Bibersteinia trehalosi has been associated with respiratory disease in ruminants particularly in wild and domestic sheep. Recently, there has been an increased interest in B. trehalosi isolates obtained from diagnostic samples from bovine respiratory disease cases. This study evaluated the role of B. trehalosi in the bovine respiratory disease complex using an intra-tracheal inoculation model in calves. This study also evaluated the potential of haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) serum concentrations as a useful diagnostic tool in calves affected with B. trehalosi and M. haemolytica associated respiratory disease. Materials and Methods - Thirty-five cross-bred dairy steers were inoculated intra-tracheally with either leukotoxin negative or leukotoxin positive B. trehalosi, Mannheimia haemolytica, a combination of leukotoxin negative B. trehalosi and M. haemolytica, or negative control. Physical examinations were conducted and serum samples were collected throughout the study. Calves were euthanized and necropsies performed on day 10 of the study. Results - No significant differences were found between the groups of calves challenged with B. trehalosi alone or in conjunction with M. haemolytica and the negative control calves with respect to percent lung involvement, rectal temperature, respiratory or depression score, or serum Hp or Hp-MMP 9 concentration in this study. M. haemolytica inoculated calves, but not B. trehalosi inoculated calves had increased lung involvement compared to control calves. B. trehalosi was only cultured once from the lungs of inoculated calves at necropsy. Increases in serum Hp and Hp-MMP 9 concentrations for the M. haemolytica group became significantly different from other groups on day 7. The leukotoxin positive B. trehalosi group demonstrated increased serum Hp-MMP 9 concentrations on days 3-10 compared to pre-inoculation concentrations. Conclusions - Based on these findings B. trehalosi may not be a primary pathogen of respiratory disease in cattle. Culture of B. trehalosi from diagnostic submissions should not be immediately identified as a primary cause of respiratory disease. Serum Hp-MMP 9 concentration is a useful diagnostic tool for detecting early pulmonary inflammation in calves challenged with B. trehalosi and M. haemolytica. Serum Hp-MMP 9 may also be a useful tool in detecting subclinical pulmonary inflammation in challenged calves

Inigo Jones's library and the language of architectural classicism in England, 1580-1640

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Architecture and Planning, 1993.Vita.Includes bibliographical references (v. 2, leaves 330-351).Inigo Jones's collection of books is a unique and early survival of an architect's annotated library. The combination of standard sixteenth century Italian and French editions of classics, mathematical and scientific treatises, and specialized architectural books, comprised the library of a professional whose approach to his field was based on an understanding of practical humanism and the study of antique precedent. The library is the starting point for an investigation of the relationship of humanist learning and the creation in England of a classical architectural vocabulary. The forty~s ix books record in Jones's marginal annotations to the text and plates his interpretation of continental architecture and textual exegesis. For Jones, books were a crucial resource for the study of classical architecture as practiced in continental Europe; and necessary for an understanding of the intellectual precepts inherent in that architectural vocabulary. Jones's architectural self~education reflected and repeated the desire by patrons for a visible document of their humanist learning and aspirations. From the evidence of the marginal annotations by Jones, I discuss three central themes of the shift in architectural style in England during the period 1580 to 1640: the role of reading as an essential professional skill for the architect and its mnemonic function in design method; the use and significance of the orders as a system for representing ideas of personal and public decorum and learning; and Jones's use of the methods and resources of English antiquarians in his study of ancient architectural precedent. Each of these themes are located within the cultural and intellectual history of Renaissance England. The descriptive language created for architecture, and the images used to encourage its study, was the language of education and classical learning, and specifically, the language of books. The appropriation by Jones and his patrons of the Vitruvian notion of decorum- the distinction between the exterior of a building and its internal distribution- formed a central tenet of English classicism, in Jones's terms the creation of an architecture "masculine and unaffected." The library of Inigo Jones represented one of the architect's essential professional tools, a repository of ideas and models which could serve as an ever present resource and comparable to other professional collections created by those seeking advancement within the late Tudor and early Stuart court. An annotated and descriptive bibliography of the surviving volumes, and further likely titles, attests to Jones's wide~ranging interests and design acumen.by Christy Jo Anderson.Ph.D

The Experience of Forgiveness in Adults with Different Sacred Belief Systems

Forgiveness is the act of moving beyond shame, guilt, anger, or blame, and it has been linked to psychological well-being, prosocial behavior, and religion/spirituality (R/S). However, the research on why and how people forgive is inconsistent, as the concepts involved are complex and difficult to define and operationalize. The purpose of this interpretative phenomenological analysis (IPA) was to provide a better understanding of why and how people are cognitively and emotionally able to forgive and the role of R/S in that process. Goal orientation and cognitive restructuring theories were used as frameworks for understanding the forgiveness experience. First-person, semistructured interviews were conducted with 12 persons from 10 different sacred belief systems who had experienced forgiveness of a major transgression. Data were analyzed using the IPA process, and five themes emerged: what is forgiveness?; why forgive?; how to forgive; the relationship between self-forgiveness and forgiveness of others; and developing a forgiveness disposition. All participants described forgiveness as an effortful, transformative process. Their motivation to forgive was based on a learning goal orientation and benefits to personal well-being and relationships. Participants forgave through making supportive R/S and/or social connections, finding the courage to confront transgressions, and resolving issues with compassion and creativity. A model of forgiveness was proposed that researchers can apply to future research efforts, and that mental health providers, clergy, and other helping professionals can use with clients in therapeutic applications of healing from major transgressions

Functional Assessment as Strategy Assessment for Teaching Academics

Functional assessment of aggressive, aberrant, and challenging behavior has dominated the literature with relatively little attention given to the potential utility of functional assessment in academics. The purpose of this article is to advocate functional strategy assessment as a procedure for acquiring data to support the formulation of intervention hypotheses by school-based personnel with the aim of improving the academic performance of students with emotional and behavioral disorders. A functional strategy assessment model is presented, and two case illustrations are employed to demonstrate the feasibility of this assessment model for use by practitioners. Examples of both an individual and small group functional strategy assessment techniques are proffered as well as tips to the teacher-diagnostician

Defining the Genus Hydropsyche (Trichoptera:Hydropsychidae) Based on DNA and Morphological Evidence

In this paper, we review the history of Hydropsychinae genus-level classification and nomenclature and present new molecular evidence from mitochondrial cytochrome c oxidase subunit I (COI) and nuclear large subunit ribosomal ribonucleic acid (28S) markers supporting the monophyly of the genus Hydropsyche. Both molecular and morphological characters support a broad conservative definition of Hydropsyche. Caledopsyche, Hydatomanicus, and Occutanspsyche are synonymized with Hydropsyche. The following species groups are established: Hydropsyche bronta Group (generally corresponding with Ceratopsyche and Hydropsyche morosa and newae Groups), Hydropsyche colonica Group (generally corresponding with Orthopsyche), Hydropsyche instabilis Group (generally corresponding with Hydropsyche s.s.), and Hydropsyche naumanni Group (generally corresponding with Occutanspsyche). Molecular data recovered Hydromanicus as paraphyletic, and Cheumatopsyche and Potamyia as sister taxa. The genus names Plectropsyche and Streptopsyche are reinstated

Randomized Clinical Trial to Evaluate the Pathogenicity of Bibersteinia trehalosi in Respiratory Disease among Calves

Bibersteinia trehalosi causes respiratory disease in ruminants particularly in wild and domestic sheep. Recently, there has been an increased number of B. trehalosi isolates obtained from diagnostic samples from bovine respiratory disease cases. This study evaluated the role of B. trehalosi in bovine respiratory disease using an intra-tracheal inoculation model in calves. Thirty six cross bred 2–3 month old dairy calves were inoculated intra-tracheally with either leukotoxin negative B. trehalosi, leukotoxin positive B. trehalosi isolate, Mannheimia haemolytica, a combination of leukotoxin negative B. trehalosi and M. haemolytica or negative control. Calves were euthanized and necropsy performed on day 10 of study. B. trehalosi inoculated calves did not have increased lung involvement compared to control calves. Additionally, B. trehalosiwas only cultured once from the lungs of inoculated calves at necropsy. Based on these findings B. trehalosi may not be a primary pathogen of respiratory disease in cattle. Culture of B. trehalosifrom diagnostic submissions should not be immediately identified as a primary cause of respiratory disease

Multidisciplinary Group Clinic Appointments: The Self-Management and Care of Heart Failure (SMAC-HF) Trial

Background—This trial tested the effects of multidisciplinary group clinic appointments on the primary outcome of time to first heart failure (HF) rehospitalization or death. Methods and Results—HF patients (n=198) were randomly assigned to standard care or standard care plus multidisciplinary group clinics. The group intervention consisted of 4 weekly clinic appointments and 1 booster clinic at month 6, where multidisciplinary professionals engaged patients in HF self-management skills. Data were collected prospectively for 12 months beginning after completion of the first 4 group clinic appointments (2 months post randomization). The intervention was associated with greater adherence to recommended vasodilators (P=0.04). The primary outcome (first HF-related hospitalization or death) was experienced by 22 (24%) in the intervention group and 30 (28%) in standard care. The total HF-related hospitalizations, including repeat hospitalizations after the first time, were 28 in the intervention group and 45 among those receiving standard care. The effects of treatment on rehospitalization varied significantly over time. From 2 to 7 months post randomization, there was a significantly longer hospitalization-free time in the intervention group (Cox proportional hazard ratio=0.45 (95% confidence interval, 0.21–0.98; P=0.04). No significant difference between groups was found from month 8 to 12 (hazard ratio=1.7; 95% confidence interval, 0.7–4.1). Conclusions—Multidisciplinary group clinic appointments were associated with greater adherence to selected HF medications and longer hospitalization-free survival during the time that the intervention was underway. Larger studies will be needed to confirm the benefits seen in this trial and identify methods to sustain these benefits

Colors of 2625 Quasars at 0<z<5 Measured in the Sloan Digital Sky Survey Photometric System

We present an empirical investigation of the colors of quasars in the Sloan Digital Sky Survey (SDSS) photometric system. The sample studied includes 2625 quasars with SDSS photometry. The quasars are distributed in a 2.5 degree wide stripe centered on the Celestial Equator covering $\sim529$ square degrees. Positions and SDSS magnitudes are given for the 898 quasars known prior to SDSS spectroscopic commissioning. New SDSS quasars represent an increase of over 200% in the number of known quasars in this area of the sky. The ensemble average of the observed colors of quasars in the SDSS passbands are well represented by a power-law continuum with $\alpha_{\nu} = -0.5$ ($f_{\nu} \propto \nu^{\alpha}$). However, the contributions of the $3000 {\rm \AA}$ bump and other strong emission lines have a significant effect upon the colors. The color-redshift relation exhibits considerable structure, which may be of use in determining photometric redshifts for quasars. The range of colors can be accounted for by a range in the optical spectral index with a distribution $\alpha_{\nu}=-0.5\pm0.65$ (95% confidence), but there is a red tail in the distribution. This tail may be a sign of internal reddening. Finally, we show that there is a continuum of properties between quasars and Seyfert galaxies and we test the validity of the traditional division between the two classes of AGN.Comment: 66 pages, 15 figures (3 color), accepted by A

Measurement of the Nucleon Structure Function F2 in the Nuclear Medium and Evaluation of its Moments

We report on the measurement of inclusive electron scattering off a carbon target performed with CLAS at Jefferson Laboratory. A combination of three different beam energies 1.161, 2.261 and 4.461 GeV allowed us to reach an invariant mass of the final-state hadronic system W~2.4 GeV with four-momentum transfers Q2 ranging from 0.2 to 5 GeV2. These data, together with previous measurements of the inclusive electron scattering off proton and deuteron, which cover a similar continuous two-dimensional region of Q2 and Bjorken variable x, permit the study of nuclear modifications of the nucleon structure. By using these, as well as other world data, we evaluated the F2 structure function and its moments. Using an OPE-based twist expansion, we studied the Q2-evolution of the moments, obtaining a separation of the leading-twist and the total higher-twist terms. The carbon-to-deuteron ratio of the leading-twist contributions to the F2 moments exhibits the well known EMC effect, compatible with that discovered previously in x-space. The total higher-twist term in the carbon nucleus appears, although with large systematic uncertainites, to be smaller with respect to the deuteron case for n<7, suggesting partial parton deconfinement in nuclear matter. We speculate that the spatial extension of the nucleon is changed when it is immersed in the nuclear medium.Comment: 37 pages, 15 figure