6,437 research outputs found
Structure-based design of anti-cancer drugs: the use of biophysical techniques for screening and characterization of novel inhibitors of the initiation factor eIF4E
The Impact of the Revenue Reconciliation Act of 1993 on the Pricing Structure of Equity REITs
Tax legislation included in the Revenue Reconciliation Act of 1993 made large-scale investments in equity real estate investment trusts (REITs) more desirable to institutional investors. Other studies have observed an increased level of institutional ownership in REITs during the timeframe following passage of the act. Based on an analysis of equity REITs before and after passage of the Act, the present study finds that its passage coincided with a significant change in the role of unsystematic risk in the pricing of equity REITs.
Energy Dependence of Scattering Ground State Polar Molecules
We explore the total cross section of ground state polar molecules in an
electric field at various energies, focusing on RbCs and RbK. An external
electric field polarizes the molecules and induces strong dipolar interactions
leading to non-zero partial waves contributing to the scattering even as the
collision energy goes to zero. This results in the need to compute scattering
problems with many different values of total M to converge the total cross
section. An accurate and efficient approximate total cross section is
introduced and used to study the low field temperature dependence. To
understand the scattering of the polar molecules we compare a semi-classical
cross section with quantum unitarity limit. This comparison leads to the
ability to characterize the scattering based on the value of the electric field
and the collision energy.Comment: Accepted PRA, 10 pages, 5 figure
Computational design of low aspect ratio wing-winglet configurations for transonic wind-tunnel tests
A computational design has been performed for three different low aspect ratio wing planforms fitted with nonplanar winglets; one of the three planforms has been selected to be constructed as a wind tunnel model for testing in the NASA LaRC 7 x 10 High Speed Wind Tunnel. A design point of M = 0.8, CL approx = 0.3 was selected, for wings of aspect ratio equal to 2.2, and leading edge sweep angles of 45 and 50 deg. Winglet length is 15 percent of the wing semispan, with a cant angle of 15 deg, and a leading edge sweep of 50 deg. Winglet total area equals 2.25 percent of the wing reference area. This report summarizes the design process and the predicted transonic performance for each configuration
OCTS and SeaWiFS Bio-Optical Algorithm and Product Validation and Intercomparison in US Coastal Waters
The successful launch of the National Space Development Agency of Japan (NASDA) Ocean Color and Temperature Sensor (OCTS) in August 1996, and the launch of Orbital Science Corporation's (OSC) Sea-viewing Wide-Field-of-view Sensor (SeaWiFS) in August 1997 signaled the beginning of a new era for ocean color research and application. These data may be used to remotely evaluate 1) water quality, 2) transport of sediments and adhered pollutants, 3) primary production, upon which commercial shellfish and finfish populations depend for food, and 4) harmful algal blooms which pose a threat to public health and economies of affected areas. Several US government agencies have recently expressed interest in monitoring U.S. coastal waters using optical remote sensing. This renewed interest is broadly driven by 1) resource management concerns over the impact of coastward shifts in population and land use on the ecosystems of estuaries, wetlands, nearshore benthic environments and fisheries, 2) recognition of the need to understand short time scale global change due to urbanization of sensitive land-margin ecosystems, and 3) national security issues. Satellite ocean color sensors have the potential to furnish data at the appropriate time and space scales to evaluate and resolve these concerns and problems. In this draft technical memorandum, we outline our progress during the first year of our SIMBIOS project to evaluate ocean color bio-optical algorithms and products generated using OCTS and SeaWiFS data in coastal US waters
Long range scattering resonances in strong-field seeking states of polar molecules
We present first steps toward understanding the ultracold scattering
properties of polar molecules in strong electric field-seeking states. We have
found that the elastic cross section displays a quasi-regular set of potential
resonances as a function of the electric field, which potentially offers
intimate details about the inter-molecular interaction. We illustrate these
resonances in a ``toy'' model composed of pure dipoles, and in more physically
realistic systems. To analyze these resonances, we use a simple WKB
approximation to the eigenphase, which proves both reasonably accurate and
meaningful. A general treatment of the Stark effect and dipolar interactions is
also presented
Mapping parallel programs to heterogeneous CPU/GPU architectures using a Monte Carlo Tree Search
The single core processor, which has dominated for over 30 years, is now obsolete with recent trends increasing towards parallel systems, demanding a huge shift in programming techniques and practices. Moreover, we are rapidly moving towards an age where almost all programming will be targeting parallel systems. Parallel hardware is rapidly evolving, with large heterogeneous systems, typically comprising a mixture of CPUs and GPUs, becoming the mainstream. Additionally, with this increasing heterogeneity comes increasing complexity: not only does the programmer have to worry about where and how to express the parallelism, they must also express an efficient mapping of resources to the available system. This generally requires in-depth expert knowledge that most application programmers do not have. In this paper we describe a new technique that derives, automatically, optimal mappings for an application onto a heterogeneous architecture, using a Monte Carlo Tree Search algorithm. Our technique exploits high-level design patterns, targeting a set of well-specified parallel skeletons. We demonstrate that our MCTS on a convolution example obtained speedups that are within 5% of the speedups achieved by a hand-tuned version of the same application.Postprin
Moratória da soja na amazônia brasileira e governança ambiental: regulação através do Mercado ou regulação estatal?
Alguns argumentam que o fim do desmatamento da Amazônia está próximo. Com a maior integração global de mercados e de sistemas de produção, há um aumento da pressão sobre a agricultura e a pecuária para produzir de modo social e ecologicamente correto. A moratória da soja, declarada em 2006, e seu propalado sucesso, é tido por alguns como um primeiro exemplo dosbenefícios que podem advir da regulação pelo mercado. Este artigo, baseado numa metodologia histórica e documental, e também em dados de pesquisa de campo em Vilhena, Rondônia, contesta tal designação da moratória da soja como exemplo de regulação via mercado. O sucesso da moratória também vem do estabelecimento de territórios e da tecnologia para monitorá-los, baseados em instituições estatais, fundadas ao longo da história brasileira, como aquelas do Estado Novo, de Vargas. Se, na verdade, a moratória da soja é um sucesso, foram os mercados e um forte estado nacional territorial que, em primeiro lugar, permitiram que ela ocorresse
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2
Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and hypertension. However, the disorder is usually incompletely corrected by suppression of cortisol, suggesting additional and irreversible changes, perhaps in the kidney. To examine this further, we produced mice with targeted disruption of the 11β-HSD2 gene. Homozygous mutant mice (11β-HSD2(–/–)) appear normal at birth, but ∼50% show motor weakness and die within 48 hours. Both male and female survivors are fertile but exhibit hypokalemia, hypotonic polyuria, and apparent mineralocorticoid activity of corticosterone. Young adult 11β-HSD2(–/–) mice are markedly hypertensive, with a mean arterial blood pressure of 146 ± 2 mmHg, compared with 121 ± 2 mmHg in wild-type controls and 114 ± 4 mmHg in heterozygotes. The epithelium of the distal tubule of the nephron shows striking hypertrophy and hyperplasia. These histological changes do not readily reverse with mineralocorticoid receptor antagonism in adulthood. Thus, 11β-HSD2(–/–) mice demonstrate the major features of SAME, providing a unique rodent model to study the molecular mechanisms of kidney resetting leading to hypertension. J. Clin. Invest. 103:683–689 (1999
A UV to Mid-IR Study of AGN Selection
We classify the spectral energy distributions (SEDs) of 431,038 sources in
the 9 sq. deg Bootes field of the NOAO Deep Wide-Field Survey (NDWFS). There
are up to 17 bands of data available per source, including ultraviolet (GALEX),
optical (NDWFS), near-IR (NEWFIRM), and mid-infrared (IRAC/MIPS) data, as well
as spectroscopic redshifts for ~20,000 objects, primarily from the AGN and
Galaxy Evolution Survey (AGES). We fit galaxy, AGN, stellar, and brown dwarf
templates to the observed SEDs, which yield spectral classes for the Galactic
sources and photometric redshifts and galaxy/AGN luminosities for the
extragalactic sources. The photometric redshift precision of the galaxy and AGN
samples are sigma/(1+z)=0.040 and sigma/(1+z)=0.169, respectively, with the
worst 5% outliers excluded. Based on the reduced chi-squared of the SED fit for
each SED model, we are able to distinguish between Galactic and extragalactic
sources for sources brighter than I=23.5. We compare the SED fits for a
galaxy-only model and a galaxy+AGN model. Using known X-ray and spectroscopic
AGN samples, we confirm that SED fitting can be successfully used as a method
to identify large populations of AGN, including spatially resolved AGN with
significant contributions from the host galaxy and objects with the emission
line ratios of "composite" spectra. We also use our results to compare to the
X-ray, mid-IR, optical color and emission line ratio selection techniques. For
an F-ratio threshold of F>10 we find 16,266 AGN candidates brighter than I=23.5
and a surface density of ~1900 AGN per deg^2.Comment: Submitted to ApJ, 35 pages, 17 figures, 2 table
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