An "Ironclad Friend": Explaining Cambodia's Bandwagoning Policy towards China

In this article, drawing from both interviews and secondary sources, we examine why Cambodia welcomes the rise of China when other states appear to be less enthusiastic. Despite the alarm in the region at China's assertiveness, Cambodia, unlike some other nation states, has chosen to bandwagon with China. While some states in the region are pursuing a mixed strategy of economic engagement with China on the one hand and security alignment with the United States on the other (i.e. hedging), which allows such states to be on good terms with both the United States and China, Cambodia has embraced China almost exclusively. Situating the issue within the IR literature of bandwagoning, balancing, and hedging, this article presents four variables explaining the motivations behind Cambodia's bandwagoning policy towards China. Towards the end, we offer some suggestions for Cambodia to move forward

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

The transcription factor Nrf2 regulates expression of multiple cellular defence proteins through the antioxidant response element (ARE). Nrf2-deficient mice (Nrf2−/−) are highly susceptible to xenobiotic-mediated toxicity, but the precise molecular basis of enhanced toxicity is unknown. Oligonucleotide array studies suggest that a wide range of gene products is altered constitutively, however no equivalent proteomics analyses have been conducted. To define the range of Nrf2-regulated proteins at the constitutive level, protein expression profiling of livers from Nrf2−/− and wild type mice was conducted using both stable isotope labelling (iTRAQ) and gel electrophoresis methods. To establish a robust reproducible list of Nrf2-dependent proteins, three independent groups of mice were analysed. Correlative network analysis (MetaCore) identified two predominant groups of Nrf2-regulated proteins. As expected, one group comprised proteins involved in phase II drug metabolism, which were down-regulated in the absence of Nrf2. Surprisingly, the most profound changes were observed amongst proteins involved in the synthesis and metabolism of fatty acids and other lipids. Importantly, we show here for the first time, that the enzyme ATP-citrate lyase, responsible for acetyl-CoA production, is negatively regulated by Nrf2. This latter finding suggests that Nrf2 is a major regulator of cellular lipid disposition in the liver