Global Light System for JEM-EUSO

The Global Light System (GLS) is a network of ground-based Xenon flash lamps and steered UV lasers to validate the key functions of the JEM-EUSO instrument. These functions include triggering efficiency, the accuracy of intrinsic luminosity measurements, and the reconstructed pointing direction accuracy. GLS units will generate benchmark optical signatures in the atmosphere with similar characteristics to the optical signals of cosmic ray EASs. The lasers will generate tracks and the flashers will generate point flashes. But unlike air showers, the number, energy, precise time, direction (lasers) can be specified. JEM-EUSO will reconstruct the pointing directions of the lasers and the energy of the lasers and flash lamps to monitor the detector's triggers, and accuracy of energy and direction reconstruction. 12 GLS units will be deployed at selected sites around the globe. The JEM-EUSO footprint will pass over a GLS unit on average once per (near) moonless night under clear conditions for appropriately selected sites. The 12 units will be supplemented by campaign style measurements with an airborne unit that will be flown over the open ocean at selected altitudes under JEM-EUSO. A GLS prototype in an airplane will support a high-altitude balloon flight in 2014 of a proto-type JEM-EUSO telescope. We will describe the concept and system design and report on the status of prototyping and the selection process for candidates sites

Testing of Large Diameter Fresnel Optics for Space Based Observations of Extensive Air Showers

The JEM-EUSO mission will detect extensive air showers produced by extreme energy cosmic rays. It operates from the ISS looking down on Earth's night time atmosphere to detect the nitrogen fluorescence and Cherenkov produce by the charged particles in the EAS. The JEM-EUSO science objectives require a large field of view, sensitivity to energies below 50 EeV, and must fit within available ISS resources. The JEM-EUSO optic module uses three large diameter, thin plastic lenses with Fresnel surfaces to meet the instrument requirements. A bread-board model of the optic has been manufactured and has undergone preliminary tests. We report the results of optical performance tests and evaluate the present capability to manufacture these optical elements

Extreme Universe Space Observatory (EUSO) Optics Module

A demonstration part will be manufactured in Japan on one of the large Toshiba machines with a diameter of 2.5 meters. This will be a flat PMMA disk that is cut between 0.5 and 1.25 meters radius. The cut should demonstrate manufacturing the most difficult parts of the 2.5 meter Fresnel pattern and the blazed grating on the diffractive surface. Optical simulations, validated with the subscale prototype, will be used to determine the limits on manufacturing errors (tolerances) that will result in optics that meet EUSO s requirements. There will be limits on surface roughness (or errors at high spatial frequency); radial and azimuthal slope errors (at lower spatial frequencies) and plunge cut depth errors in the blazed grating. The demonstration part will be measured to determine whether it was made within the allowable tolerances

Simulating ice core 10Be on the glacial–interglacial timescale

10Be ice core measurements are an important tool for paleoclimate research, e.g., allowing for the reconstruction of past solar activity or changes in the geomagnetic dipole field. However, especially on multi-millennial timescales, the share of production and climate-induced variations of respective 10Be ice core records is still up for debate. Here we present the first quantitative climatological model of the 10Be ice concentration up to the glacial–interglacial timescale. The model approach is composed of (i) a coarse resolution global atmospheric transport model and (ii) a local 10Be air–firn transfer model. Extensive global-scale observational data of short-lived radionuclides as well as new polar 10Be snow-pit measurements are used for model calibration and validation. Being specifically configured for 10Be in polar ice, this tool thus allows for a straightforward investigation of production- and non-production-related modulation of this nuclide. We find that the polar 10Be ice concentration does not immediately record the globally mixed cosmogenic production signal. Using geomagnetic modulation and revised Greenland snow accumulation rate changes as model input, we simulate the observed Greenland Summit (GRIP and GISP2) 10Be ice core records over the last 75 kyr (on the GICC05modelext timescale). We show that our basic model is capable of reproducing the largest portion of the observed 10Be changes. However, model–measurement differences exhibit multi-millennial trends (differences up to 87% in case of normalized to the Holocene records) which call for closer investigation. Focusing on the (12–37) b2k (before the year AD 2000) period, mean model–measurement differences of 30% cannot be attributed to production changes. However, unconsidered climate-induced changes could likely explain the model–measurement mismatch. In fact, the 10Be ice concentration is very sensitive to snow accumulation changes. Here the reconstructed Greenland Summit (GRIP) snow accumulation rate record would require revision of +28% to solely account for the (12–37) b2k model–measurement differences

Theoretical Study of Production of Light and Intermediate Mass Fragments from Interaction of GCR-LIKE Particles

No abstract availabl

Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism [preprint]

DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The sliding clamp needs to be actively opened and installed onto DNA by a clamp loader ATPase of the AAA+ family. The human clamp loader Replication Factor C (RFC) and sliding clamp PCNA are both essential and play critical roles in several diseases. Despite decades of study, no structure of human RFC has been resolved. Here, we report the structure of human RFC bound to PCNA by cryo-EM to an overall resolution of ~3.4 Å. The active sites of RFC are fully bound to ATP analogs, which is expected to induce opening of the sliding clamp. However, we observe the complex in a conformation prior to PCNA opening, with the clamp loader ATPase modules forming an over-twisted spiral that is incapable of binding DNA or hydrolyzing ATP. The autoinhibited conformation observed here has many similarities to a previous yeast RFC:PCNA crystal structure, suggesting that eukaryotic clamp loaders adopt a similar autoinhibited state early on in clamp loading. Our results point to a ‘Limited Change/Induced Fit’ mechanism in which the clamp first opens, followed by DNA binding inducing opening of the loader to release auto-inhibition. The proposed change from an over-twisted to an active conformation reveals a novel regulatory mechanism for AAA+ ATPases. Finally, our structural analysis of disease mutations leads to a mechanistic explanation for the role of RFC in human health

Astrophysics and Technical Study of a Solar Neutrino Spacecraft

We report on our study of the design of a neutrino detector, shielding and veto array needed to operate a neutrino detector in space close to the Sun. This study also took into account the expected rates of Galactic gamma and cosmic rays in addition to the particles from the Sun.These preliminary studies show that we can devise a detector such that a small signal of neutrino interactions can be extracted from a large random number of events from the background sources using a double timing method from the conversion electron produced in the neutrino interaction and a secondary delayed signal from the nuclear excited state produced from the initial neutrino interaction; in our case the conversion of Ga 69 or 71 into Ge 69 or 71, but this method could apply to other nuclei with large neutrino cross sections such as Ir 115. Although these types of events need to be above 0.405 megaelectronvolt (MeV) neutrino energy and are only 66 percent of all conversion neutrino interactions on Gallium, this is a small price to pay for an increase of 10,000 by going close to the Sun to enhance the neutrino rate over the background combatorical fake-signal events. The conclusion of this Phase-1 study is very positive in that we can get the backgrounds less than 20 percent fake signals, and in addition to this we have devised another shielding method that makes the Galactic gamma-ray rate a hundred fold less which will make further improvements over these initial estimates. Although these studies are very encouraging it suggests that the next step is a NIAC Phase-II to actually build a test device,measuring basic principles such as light attention within the scintillator with high dopants and to take data in the lab with a cosmic-ray test stand and triggered X-ray source for comparison with simulated expected performance of the detector. This would be the perfect lead into a future proposal beyond a NIAC (NASA Innovative Advanced Concepts) Phase-II for a test flight of a small one-pint detector in orbit of the detector concept beyond Earth outside of the radiation belts

Optimising access to best practice primary health care: a systematic review

Ensuring that Australians have access to health care is an integral component of Australian health care policy. Growing awareness of the importance of primary health care (PHC) in delivering equitable and cost-effective care is creating interest in better understanding and addressing access to best practice PHC. This review examines evidence from the published literature on potential interventions to enhance access to ‘best practice’.The research reported in this paper is a project of the Australian Primary Health Care Research Institute which is supported by a grant from the Australian Government Department of Health and Ageing under the Primary Health Care Research Evaluation and Development Strategy

Geant4 Simulation of Air Showers using Thinning Method

No abstract availabl

Detecting ultra-high energy cosmic rays from space with unprecedented acceptance: objectives and design of the JEM-EUSO mission

The Extreme Universe Space Observatory on the Japanese Experiment Module (JEM-EUSO) of the Interna- tional Space Station (ISS) is the first mission that will study from space Ultra High-Energy Cosmic Rays (UHECR). JEM-EUSO will observe Extensive Air Showers (EAS) pro- duced by UHECRs traversing the Earth's atmosphere from above. For each event, the detector will make accurate mea- surements of the energy, arrival direction and nature of the primary particle using a target volume far greater than what is achievable from ground. The corresponding increase in statistics will help to clarify the origin and sources of UHE- CRs as well as the environment traversed during production and propagation. Possibly this will bring new light onto par- ticle physics mechanisms operating at energies well beyond those achievable by man-made accelerators. The spectrum of scientific goals of the JEM-EUSO mission includes as ex- ploratory objectives the detection of high-energy gamma ray