Glacier change along West Antarctica’s Marie Byrd Land Sector and links to inter-decadal atmosphere-ocean variability

Over the past 20 years satellite remote sensing has captured significant downwasting of glaciers that drain the West Antarctic Ice Sheet into the ocean, particularly across the Amundsen Sea Sector. Along the neighbouring Marie Byrd Land Sector, situated west of Thwaites Glacier to Ross Ice Shelf, glaciological change has been only sparsely monitored. Here, we use optical satellite imagery to track grounding-line migration along the Marie Byrd Land Sector between 2003 and 2015, and compare observed changes with ICESat and CryoSat-2-derived surface elevation and thickness change records. During the observational period, 33% of the grounding line underwent retreat, with no significant advance recorded over the remainder of the  ∼ 2200km long coastline. The greatest retreat rates were observed along the 650km-long Getz Ice Shelf, further west of which only minor retreat occurred. The relative glaciological stability west of Getz Ice Shelf can be attributed to a divergence of the Antarctic Circumpolar Current from the continental-shelf break at 135°W, coincident with a transition in the morphology of the continental shelf. Along Getz Ice Shelf, grounding-line retreat reduced by 68% during the CryoSat-2 era relative to earlier observations. Climate reanalysis data imply that wind-driven upwelling of Circumpolar Deep Water would have been reduced during this later period, suggesting that the observed slowdown was a response to reduced oceanic forcing. However, lack of comprehensive oceanographic and bathymetric information proximal to Getz Ice Shelf's grounding zone make it difficult to assess the role of intrinsic glacier dynamics, or more complex ice-sheet–ocean interactions, in moderating this slowdown. Collectively, our findings underscore the importance of spatial and inter-decadal variability in atmosphere and ocean interactions in moderating glaciological change around Antarctica

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumour evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes