3,809 research outputs found
Relationships between density and Young’s modulus with microporosity and physico-chemical properties of Wistar rat cortical bone from growth to senescence
The aim of this study is to assess density and elastic properties of Wistar rat cortical bone from growth to senescence and to correlate them with morphological and physico-chemical properties of bone. During growth (from 1 to 9 months), bone density and Young’s modulus were found to increase from 1659±85 to 2083±13 kg m−3 and from 8±0.8 to 19.6±0.7 GPa respectively. Bone microporosity was found to decrease from 8.1±0.7% to 3.3±0.7%. Physico-chemical investigations exhibited a mineralization of bone matrix and a maturation of apatite crystals, as protein content decreased from 21.4±0.2% to 17.6±0.6% and apatite crystal size and carbonate content increased (c-axis length: from 151 to 173 Å and CO3W%: from 4.1±0.3% to 6.1±0.2%). At adult age, all properties stabilized. During senescence, a slow decrease of mechanical properties was first observed (from 12 to 18 months, ρ=2089±14 to 2042±30 kg m−3 and E3=19.8 ±1.3 to 14.8±1.5 GPa), followed by a stabilization. Physico-chemical properties stabilized while microporosity increased slightly (from 3.3% to 4%) but not significantly (p>0.05). A multiple regression analysis showed that morphological and physico-chemical properties had significant effects on density regression model. Microporosity had a greater effect on Young’s modulus regression model than physico-chemical properties. This study showed that bone structure, mineralization and apatite maturation should be considered to improve the understanding of bone mechanical behaviour
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Mulsemedia: State of the art, perspectives, and challenges
Mulsemedia-multiple sensorial media-captures a wide variety of research efforts and applications. This article presents a historic perspective on mulsemedia work and reviews current developments in the area. These take place across the traditional multimedia spectrum-from virtual reality applications to computer games-as well as efforts in the arts, gastronomy, and therapy, to mention a few. We also describe standardization efforts, via the MPEG-V standard, and identify future developments and exciting challenges the community needs to overcome
Einstein-aether theory, violation of Lorentz invariance, and metric-affine gravity
We show that the Einstein-aether theory of Jacobson and Mattingly (J&M) can
be understood in the framework of the metric-affine (gauge theory of) gravity
(MAG). We achieve this by relating the aether vector field of J&M to certain
post-Riemannian nonmetricity pieces contained in an independent linear
connection of spacetime. Then, for the aether, a corresponding geometrical
curvature-square Lagrangian with a massive piece can be formulated
straightforwardly. We find an exact spherically symmetric solution of our
model.Comment: Revtex4, 38 pages, 1 figur
Cultural robotics : The culture of robotics and robotics in culture
Copyright 2013 Samani et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedIn this paper, we have investigated the concept of "Cultural Robotics" with regard to the evolution o social into cultural robots in the 21st Century. By defining the concept of culture, the potential development of culture between humans and robots is explored. Based on the cultural values of the robotics developers, and the learning ability of current robots, cultural attributes in this regard are in the process of being formed, which would define the new concept of cultural robotics. According to the importance of the embodiment of robots in the sense of presence, the influence of robots in communication culture is anticipated. The sustainability of robotics culture based on diversity for cultural communities for various acceptance modalities is explored in order to anticipate the creation of different attributes of culture between robot and humans in the futurePeer reviewe
Precise Black Hole Masses From Megamaser Disks: Black Hole-Bulge Relations at Low Mass
The black hole (BH)-bulge correlations have greatly influenced the last
decade of effort to understand galaxy evolution. Current knowledge of these
correlations is limited predominantly to high BH masses (M_BH> 10^8 M_sun) that
can be measured using direct stellar, gas, and maser kinematics. These objects,
however, do not represent the demographics of more typical L< L* galaxies. This
study transcends prior limitations to probe BHs that are an order of magnitude
lower in mass, using BH mass measurements derived from the dynamics of H_2O
megamasers in circumnuclear disks. The masers trace the Keplerian rotation of
circumnuclear molecular disks starting at radii of a few tenths of a pc from
the central BH. Modeling of the rotation curves, presented by Kuo et al.
(2010), yields BH masses with exquisite precision. We present stellar velocity
dispersion measurements for a sample of nine megamaser disk galaxies based on
long-slit observations using the B&C spectrograph on the Dupont telescope and
the DIS spectrograph on the 3.5m telescope at Apache Point. We also perform
bulge-to-disk decomposition of a subset of five of these galaxies with SDSS
imaging. The maser galaxies as a group fall below the M_BH-sigma* relation
defined by elliptical galaxies. We show, now with very precise BH mass
measurements, that the low-scatter power-law relation between M_BH and sigma*
seen in elliptical galaxies is not universal. The elliptical galaxy M_BH-sigma*
relation cannot be used to derive the BH mass function at low mass or the
zeropoint for active BH masses. The processes (perhaps BH self-regulation or
minor merging) that operate at higher mass have not effectively established an
M_BH-sigma* relation in this low-mass regime.Comment: 21 pages, 14 figures, accepted for publication in the Astrophysical
Journa
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes
Telomeres are maintained by three DNA-binding proteins (telomeric repeat binding factor 1 [TRF1], TRF2, and protector of telomeres 1 [POT1]) and several associated factors. One factor, TRF1-interacting protein 2 (TIN2), binds TRF1 and TRF2 directly and POT1 indirectly. Along with two other proteins, TPP1 and hRap1, these form a soluble complex that may be the core telomere maintenance complex. It is not clear whether subcomplexes also exist in vivo. We provide evidence for two TIN2 subcomplexes with distinct functions in human cells. We isolated these two TIN2 subcomplexes from nuclear lysates of unperturbed cells and cells expressing TIN2 mutants TIN2-13 and TIN2-15C, which cannot bind TRF2 or TRF1, respectively. In cells with wild-type p53 function, TIN2-15C was more potent than TIN2-13 in causing telomere uncapping and eventual growth arrest. In cells lacking p53 function, TIN2-15C was more potent than TIN2-13 in causing telomere dysfunction and cell death. Our findings suggest that distinct TIN2 complexes exist and that TIN2-15C–sensitive subcomplexes are particularly important for cell survival in the absence of functional p53
The prismatic Sigma 3 (10-10) twin bounday in alpha-Al2O3 investigated by density functional theory and transmission electron microscopy
The microscopic structure of a prismatic twin
boundary in \aal2o3 is characterized theoretically by ab-initio
local-density-functional theory, and experimentally by spatial-resolution
electron energy-loss spectroscopy in a scanning transmission electron
microscope (STEM), measuring energy-loss near-edge structures (ELNES) of the
oxygen -ionization edge. Theoretically, two distinct microscopic variants
for this twin interface with low interface energies are derived and analysed.
Experimentally, it is demonstrated that the spatial and energetical resolutions
of present high-performance STEM instruments are insufficient to discriminate
the subtle differences of the two proposed interface variants. It is predicted
that for the currently developed next generation of analytical electron
microscopes the prismatic twin interface will provide a promising benchmark
case to demonstrate the achievement of ELNES with spatial resolution of
individual atom columns
Distinct Gene Expression Profiles in Immortalized Human Urothelial Cells Exposed to Inorganic Arsenite and Its Methylated Trivalent Metabolites
Inorganic arsenic is an environmental carcinogen. The generation of toxic trivalent methylated metabolites complicates the study of arsenic-mediated carcinogenesis. This study systematically evaluated the effect of chronic treatment with sodium arsenite (iAs(III)), monomethylarsonous acid (MMA(III)), and dimethylarsinous acid (DMA(III)) on immortalized human uroepithelial cells (SV-HUC-1 cells) using cDNA microarray. After exposure for 25 passages to iAs(III) (0.5 μM), MMA(III) (0.05, 0.1, or 0.2 μM), or DMA(III) (0.2 or 0.5 μM), significant compound-specific morphologic changes were observed. A set of 114 genes (5.7% of the examined genes) was differentially expressed in one or more sets of arsenical-treated cells compared with untreated controls. Expression analysis showed that exposure of cells to DMA(III) resulted in a gene profile different from that in cells exposed to iAs(III) or MMA(III), and that the iAs(III)-induced gene profile was closest to that in the tumorigenic HUC-1–derived 3-methylcholanthrene–induced tumorigenic cell line MC-SV-HUC T2, which was derived from SV-HUC-1 cells by methylcholanthrene treatment. Of the genes affected by all three arsenicals, only one, that coding for interleukin-1 receptor, type II, showed enhanced expression, a finding confirmed by the reduced increase in NF-κB (nuclear factor kappa B) activity seen in response to interleukin-1β in iAs(III)-exposed cells. The expression of 11 genes was suppressed by all three arsenicals. 5-Aza-deoxycytidine partially restored the transcription of several suppressed genes, showing that epigenetic DNA methylation was probably involved in arsenical-induced gene repression. Our data demonstrate that chronic exposure to iAs(III), MMA(III), or DMA(III) has different epigenetic effects on urothelial cells and represses NF-κB activity
The Sigma 13 (10-14) twin in alpha-Al2O3: A model for a general grain boundary
The atomistic structure and energetics of the Sigma 13 (10-14)[1-210]
symmetrical tilt grain boundary in alpha-Al2O3 are studied by first-principles
calculations based on the local-density-functional theory with a mixed-basis
pseudopotential method. Three configurations, stable with respect to
intergranular cleavage, are identified: one Al-terminated glide-mirror twin
boundary, and two O-terminated twin boundaries, with glide-mirror and two-fold
screw-rotation symmetries, respectively. Their relative energetics as a
function of axial grain separation are described, and the local electronic
structure and bonding are analysed. The Al-terminated variant is predicted to
be the most stable one, confirming previous empirical calculations, but in
contrast with high-resolution transmission electron microscopy observations on
high-purity diffusion-bonded bicrystals, which resulted in an O-terminated
structure.
An explanation of this discrepancy is proposed, based on the different
relative energetics of the internal interfaces with respect to the free
surfaces
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