504 research outputs found
Adolescent Perceptions of Family Connectedness and School Belonging: Links with Self-Concept and Depressive Symptoms among Gifted African American and Hispanic Youth
Gifted minority students, particularly those who are African-American or Hispanic, often face significant barriers to their optimal psychosocial functioning and academic achievement. Lack of access to appropriate educational resources, reduced teacher expectations, under-identification and underrepresentation in gifted and talented programs, and outright discrimination all contribute to increased risk and reduced psychosocial and academic functioning among these youth. It is clear from the present results that sources of attachment are important for healthy functioning in gifted African American and Hispanic youth. Given the lack of presence of these students in gifted and talented programs nationwide, and the difficulty in retaining these students once enrolled, researchers and practitioners face increasing need to continue to strengthen the “family-school-community” link in order to enhance resiliency and reduce risk in gifted African American and Hispanic youth
Effects of driver familiarity and prolonged or intermittent right-side failure on level crossing safety
This paper investigates the adverse effects of familiarity and human factors issues associated with the reliability of low-cost warning devices at level crossings. The driving simulator study featured a repetitive, low workload, monotonous driving task in which there were no failures of the level crossing (control) or prolonged or intermittent right-side failures (where the device reverts to a safe failure mode). The results of the experiment provided mixed support for the familiarity hypothesis. Four of the 23 participants collided with the train when it first appeared on trial 10 but safety margins increased from the first train to the next presentation of a train (trial 12). Contrary to expectations, the safety margins decreased with repeated right-side failure only for the intermittent condition. The limited head movement data showed that participants in the prolonged failure condition were more likely to turn their head to check for trains in the right-side failure trials than in earlier trials where there was no signal and no train. Few control participants turned their head to check for trains when no signal was presented. This research highlights the need to consider repetitive tasks and workload in experimental design and accident investigation at railway level crossings
A new population of recently quenched elliptical galaxies in the SDSS
We use the Sloan Digital Sky Survey to investigate the properties of massive
elliptical galaxies in the local Universe (z\leq0.08) that have unusually blue
optical colors. Through careful inspection, we distinguish elliptical from
non-elliptical morphologies among a large sample of similarly blue galaxies
with high central light concentrations (c_r\geq2.6). These blue ellipticals
comprise 3.7 per cent of all c_r\geq2.6 galaxies with stellar masses between
10^10 and 10^11 h^{-2} {\rm M}_{\sun}. Using published fiber spectra
diagnostics, we identify a unique subset of 172 non-star-forming ellipticals
with distinctly blue urz colors and young (< 3 Gyr) light-weighted stellar
ages. These recently quenched ellipticals (RQEs) have a number density of
2.7-4.7\times 10^{-5}\,h^3\,{\rm Mpc}^{-3} and sufficient numbers above
2.5\times10^{10} h^{-2} {\rm M}_{\sun} to account for more than half of the
expected quiescent growth at late cosmic time assuming this phase lasts 0.5
Gyr. RQEs have properties that are consistent with a recent merger origin
(i.e., they are strong `first-generation' elliptical candidates), yet few
involved a starburst strong enough to produce an E+A signature. The preferred
environment of RQEs (90 per cent reside at the centers of < 3\times
10^{12}\,h^{-1}{\rm M}_{\sun} groups) agrees well with the `small group scale'
predicted for maximally efficient spiral merging onto their halo center and
rules out satellite-specific quenching processes. The high incidence of Seyfert
and LINER activity in RQEs and their plausible descendents may heat the
atmospheres of small host halos sufficiently to maintain quenching.Comment: 26 pages, 9 figures. Revised version; accepted for publication in
MNRA
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Energy embodied in household cookery: the missing part of a sustainable food system? Part 1: A method to survey and calculate representative recipes
This paper firstly reviews the current state of knowledge on sustainable cookery and the environmental impacts of the food consumption phase. It then uses the example of a dish of roast beef and Yorkshire pudding to explore energy use in food production and consumption. Part 1 of this paper conducts a meta-analysis of 33 roast beef and Yorkshire pudding recipes in order to create a representative recipe for analysis. Part 2 of this paper then uses life cycle assessment and energy use data is coupled with the representative recipe of roast beef and Yorkshire pudding, to calculate the embodied energy of the meal. Seven interventions are modelled to illustrate how sustainable cookery can play a role as part of a sustainable food system. Interventions show that sustainable cookery has the potential to reduce cookery related energy use by 18%, and integrating sustainable cookery within a sustainable food system has the potential to reduce the total energy use by 55%. Finally, the paper discusses the issue of how the adoption of the sustainable cookery agenda may help or hinder attempts to shift consumers towards sustainable diets
Regional and global contributions of air pollution to risk of death from COVID-19.
AIMS: The risk of mortality from the coronavirus disease that emerged in 2019 (COVID-19) is increased by comorbidity from cardiovascular and pulmonary diseases. Air pollution also causes excess mortality from these conditions. Analysis of the first severe acute respiratory syndrome coronavirus (SARS-CoV-1) outcomes in 2003, and preliminary investigations of those for SARS-CoV-2 since 2019, provide evidence that the incidence and severity are related to ambient air pollution. We estimated the fraction of COVID-19 mortality that is attributable to the long-term exposure to ambient fine particulate air pollution. METHODS AND RESULTS: We characterized global exposure to fine particulates based on satellite data, and calculated the anthropogenic fraction with an atmospheric chemistry model. The degree to which air pollution influences COVID-19 mortality was derived from epidemiological data in the USA and China. We estimate that particulate air pollution contributed ∼15% (95% confidence interval 7-33%) to COVID-19 mortality worldwide, 27% (13 - 46%) in East Asia, 19% (8-41%) in Europe, and 17% (6-39%) in North America. Globally, ∼50-60% of the attributable, anthropogenic fraction is related to fossil fuel use, up to 70-80% in Europe, West Asia, and North America. CONCLUSION: Our results suggest that air pollution is an important cofactor increasing the risk of mortality from COVID-19. This provides extra motivation for combining ambitious policies to reduce air pollution with measures to control the transmission of COVID-19
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Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by destruction of bone and cartilage, which is mediated, in part, by synovial fibroblasts. Matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes responsible for matrix degradation. Macrophage migration inhibitory factor (MIF) is a cytokine that induces the production of a large number of proinflammatory molecules and has an important role in the pathogenesis of RA by promoting inflammation and angiogenesis. In the present study, we determined the role of MIF in RA synovial fibroblast MMP production and the underlying signaling mechanisms. We found that MIF induces RA synovial fibroblast MMP-2 expression in a time-dependent and concentration-dependent manner. To elucidate the role of MIF in MMP-2 production, we produced zymosan-induced arthritis (ZIA) in MIF gene-deficient and wild-type mice. We found that MMP-2 protein levels were significantly decreased in MIF gene-deficient compared with wild-type mice joint homogenates. The expression of MMP-2 in ZIA was evaluated by immunohistochemistry (IHC). IHC revealed that MMP-2 is highly expressed in wild-type compared with MIF gene-deficient mice ZIA joints. Interestingly, synovial lining cells, endothelial cells, and sublining nonlymphoid mononuclear cells expressed MMP-2 in the ZIA synovium. Consistent with these results, in methylated BSA (mBSA) antigen-induced arthritis (AIA), a model of RA, enhanced MMP-2 expression was also observed in wild-type compared with MIF gene-deficient mice joints. To elucidate the signaling mechanisms in MIF-induced MMP-2 upregulation, RA synovial fibroblasts were stimulated with MIF in the presence of signaling inhibitors. We found that MIF-induced RA synovial fibroblast MMP-2 upregulation required the protein kinase C (PKC), c-jun N-terminal kinase (JNK), and Src signaling pathways. We studied the expression of MMP-2 in the presence of PKC isoform-specific inhibitors and found that the PKCδ inhibitor rottlerin inhibits MIF-induced RA synovial fibroblast MMP-2 production. Consistent with these results, MIF induced phosphorylation of JNK, PKCδ, and c-jun. These results indicate a potential novel role for MIF in tissue destruction in RA
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