SSRI use and clinical outcomes in epithelial ovarian cancer

Selective serotonin reuptake inhibitor (SSRI) use is common among ovarian cancer patients. We examined the effect of SSRIs on survival and progression in ovarian cancer patients and effects of 5-HT on ovarian cancer cell (OCC) proliferation. Ovarian cancer patients from a 6-site study between 1994 and 2010 were included. Cox proportional hazards models were used for multivariate analysis. SSRI use was associated with decreased time to disease recurrence (HR 1.3, CI 1.0-1.6, p=0.03), but not overall survival (HR 1.1, CI 0.9-1.3, p=0.56). Compared to normal ovarian cells, most OCCs had elevated 5-HT2A receptor mRNA expression (up to 1600 fold greater expression). Clonogenic survival increased in cells treated with 10 uM (1.6 fold, p<0.001) and 20uM (1.9 fold, p=0.018) 5-HT. Mice receiving 5-HT injections had increases in tumor weight (p=0.07) and nodules (p=0.08) with increased Ki67 expression. Injections with sertraline doubled mean tumor weight in mice (p=0.16). 5-HT and sertraline both increased Ki67 expression in mouse tumors (p < 0.001). Patients using SSRIs had significantly decreased time to disease progression. It is possible that SSRIs alter serotonin levels in the tumor microenvironment, resulting in activation of proliferation pathways. Further characterization of serotonergic pathways in ovarian cancer is recommended to demonstrate safety of these medications

Does Industry-Driven Alcohol Marketing Influence Adolescent Drinking Behaviour? A Systematic Review.

AIM: To systematically review evidence on the influence of specific marketing components (Price, Promotion, Product attributes and Place of sale/availability) on key drinking outcomes (initiation, continuation, frequency and intensity) in young people aged 9–17. METHODS: MEDLINE, EMBASE, SCOPUS, PsychINFO, CINAHL and ProQuest were searched from inception to July 2015, supplemented with searches of Google Scholar, hand searches of key journals and backward and forward citation searches of reference lists of identified papers. RESULTS: Forty-eight papers covering 35 unique studies met inclusion criteria. Authors tended to report that greater exposure to alcohol marketing impacted on drinking initiation, continuation, frequency and intensity during adolescence. Nevertheless, 23 (66%) studies reported null results or negative associations, often in combination with positive associations, resulting in mixed findings within and across studies. Heterogeneity in study design, content and outcomes prevented estimation of effect sizes or exploration of variation between countries or age subgroups. The strength of the evidence base differed according to type of marketing exposure and drinking outcome studied, with support for an association between alcohol promotion (mainly advertising) and drinking outcomes in adolescence, whilst only two studies examined the relationship between alcohol price and the drinking behaviour of those under the age of 18. CONCLUSION: Despite the volume of work, evidence is inconclusive in all four areas of marketing but strongest for promotional activity. Future research with standardized measures is needed to build on this work and better inform interventions and policy responses

In Search of the High Road: Meaning and Evidence

This article is the first in a series to celebrate the 70th anniversary of the ILR Review. We will be highlighting important research themes that have been featured in the journal over its many years of publication. In this article, Paul Osterman reviews research on the quality of jobs and recent debates over “High Road” and “Low Road” approaches to employment practices. Scholars and policy advocates frequently utilize the distinction between High Road and Low Road firms as a framework for efforts to improve the quality of work in low-wage employers. This article assesses the logic and evidence that underlies this construct. The author provides a definition of the concept and examines the evidence behind the assumption that firms have a choice in how they design their employment policies. He then takes up the assertion that firms that adopt a High Road model can “do well by doing good” and adds precision to this claim by reviewing the evidence that a profit-maximizing firm would benefit from following the High Road path. The article concludes by suggesting a research agenda and providing a framework for policy that flows from the conclusions drawn from the existing research base

Construction kits or virtual worlds; management applications of E2E models

Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Journal of Marine Systems 109/110 (2013): 103-108, doi:10.1016/j.jmarsys.2011.10.016.We review briefly the diversity of modeling activity that comes under the rubric of end-to-end (E2E) models, but the focus of this paper – of joint concern to researchers and to managers - is on applications to management and decision making. The models and applications span a range from “construction kits” that identify particular management issues and use comparisons across ecosystems; to “virtual worlds” that immerse managers in the details of strategic evaluations for particular systems. The general conclusion is that “application” is not a straightforward transition from theory to practice but a complex interactive process.This review is based on the proceedings of a workshop, held at Woods Hole Oceanographic Institution, 19-22 April 2010, as part of CAMEO (Comparative Analysis of Marine Ecosystem Organization), a program supported jointly by NOAA (U.S. National Oceanic and Atmospheric Agency) and NSF (U.S. National Science Foundation)

What kind of impacts can artwork have on viewers? Establishing a taxonomy for aesthetic impacts

What kinds of impacts can visual art have on a viewer? To identify potential art impacts, we recruited five aesthetics experts from different academic disciplines: art history, neuroscience, philosophy, psychology, and theology. Together, the group curated a set of terms that corresponded to descriptive features (124 terms) and cognitive-affective impacts (69 terms) of artworks. Using these terms as prompts, participants (n = 899) were given one minute to generate words for each term related to how an artwork looked (descriptive features) or made them think or feel (cognitive-affective impacts). Using network psychometric approaches, we identified terms that were semantically similar based on participants’ responses and applied hierarchical exploratory graph analysis to map the relationships between the terms. Our analyses identified 17 descriptive dimensions which could be further reduced to 5, and 11 impact dimensions which could be further reduced to 4. The resulting taxonomy demonstrated overlap between the descriptive and impact networks as well as consistency with empirical evidence. This taxonomy could serve as the foundation to empirically evaluate art’s impacts on viewers

Can art promote understanding? A review of the psychology and neuroscience of aesthetic cognitivism

Aesthetic cognitivism refers to the proposition that art promotes knowledge and understanding. Despite its intuitive appeal, few empirical investigations have tested the validity of this philosophical claim. In our review, we outline prior arguments for and against aesthetic cognitivism. Then, with a focus on visual art, we discuss how empirical aesthetics and neuroscience can contribute to conversations about aesthetic cognitivism. We propose that engagement is necessary to acquire new knowledge and understanding, describe motivational states associated with learning, and posit who is most likely to experience these states to gain knowledge and understanding from art. Throughout the paper, we discuss how, when, and what knowledge derived from engagement might be measured and modeled. By grounding aesthetic cognitivism in empirical aesthetics, researchers can generate and test hypotheses about art’s role in promoting knowledge and understanding

What kind of impacts can artwork have on viewers? Establishing a taxonomy for aesthetic impacts

Aesthetic cognitivism is the philosophical position that art can advance knowledge and understanding. Operationalizing the claim of aesthetic cognitivism is necessary to put this philosophical view to test empirically. In pursuit of this goal, we recruited five aesthetics experts from different academic disciplines: art history, neuroscience, philosophy, psychology, and theology. Together, the group curated a set of terms that corresponded to descriptive features (124 terms) and cognitive-affective impacts (69 terms) of artworks. Using these terms as prompts, participants (n = 899) were given one minute to generate words for each term related to how an artwork looked (descriptive features) or made them think or feel (cognitive-affective impacts). Using network psychometric approaches, we identified terms that were semantically similar based on participants’ responses and applied hierarchical exploratory graph analysis to map the relationships between the terms. Our analyses identified 17 descriptive dimensions which could be further reduced to 5, and 11 impact dimensions which could be further reduced to 4. The resulting taxonomy demonstrated overlap between the descriptive and impact networks as well as consistency with previous reports. Terms directly relevant to aesthetic cognitivism were centrally positioned relative to other terms in the networks. This taxonomy could serve as the foundation to empirically evaluate aesthetic cognitivism’s claim

Can art promote understanding? A review of the psychology and neuroscience of aesthetic cognitivism

Art promotes knowledge and understanding. Philosophers have debated this proposition, which is referred to as aesthetic cognitivism. Despite its intuitive appeal, few empirical investigations have tested the validity of this claim. In our review, we outline philosophical arguments for and against aesthetic cognitivism. Then, we discuss how empirical aesthetics and neuroscience can contribute to conversations about aesthetic cognitivism, with a focus on visual art. We propose that engagement is necessary to acquire new knowledge and understanding, describe motivational states associated with engagement, and posit who is most likely to experience these states and engage with art. We conclude with a discussion on how aesthetic cognitivism might be measured and modeled. By grounding aesthetic cognitivism in empirical aesthetics, researchers can construct testable hypotheses about art’s role in promoting knowledge and understanding