Feasibility of improving risk stratification in the inherited cardiac conditions

Fatal ventricular arrhythmias can occur in patients with Hypertrophic Cardiomyopathy, Brugada Syndrome and rarely in patients with normal cardiac investigations. Despite very different pathogeneses, we hypothesised that a common electrophysiological substrate precipitates these arrhythmias and could be used as a marker for risk stratification. In Chapter 3 of this thesis, we found that fewer than half the cardiac arrest survivors with Brugada Syndrome would have been offered prophylactic defibrillators based on current risk scoring, highlighting the need for better risk stratification. Our group previously used a commercially available 252-electrode vest which constructs ventricular electrograms onto a CT image of the heart to show exercise related differences in high-risk patients. In Chapter 4, we applied this method to Brugada patients, but could not reproduce prior results. Further investigation revealed periodic changes in activation patterns after exercise that could explain this discrepancy. An alternative matrix approach was developed to overcome this problem. Exercise induced conduction heterogeneity differentiated Brugada patients from unaffected controls, but not those surviving cardiac arrest. However, if considered alongside spontaneous type 1 ECG and syncope, inducible conduction heterogeneity markedly improved identification of Brugada cardiac arrest survivors. In Chapter 5 the method was shown to differentiate idiopathic ventricular fibrillation patients from those fully recovered from acute ischaemic cardiac arrest, implying a permanent electrophysiological abnormality. In Chapter 8, we showed prolonged mean local activation times and activation-recovery intervals in hypertrophic cardiomyopathy cardiac arrest survivors compared to those without previous ventricular arrhythmia. These metrics were combined into both logistic regression and support vector machine models to strongly differentiate the groups. We concluded that electrophysiological changes could identify cardiac arrest survivors in various cardiac conditions, but a single factor common pathway was not established. Prospective studies are required to determine if using these parameters could enhance current risk stratification for sudden death.Open Acces

Restrictions on the position of exh

The grammatical approach to scalar implicatures attributes their introduction to a covert operator exh, which can be posited in various structural positions. By studying the interaction of scalar implicature calculation and the presuppositions of English also and again, we are able to pinpoint the structural position of exh. This diagnostic shows that some triggers of scalar implicature require exh to be adjoined as low as possible above them, whereas other triggers allow for more delayed adjunction of exh. We offer a concrete proposal for these behaviors in terms of syntactic feature-checking and show how it extends to cases involving ignorance inferences

Ricci flow of conformally compact metrics

In this paper we prove that given a smoothly conformally compact metric there is a short-time solution to the Ricci flow that remains smoothly conformally compact. We adapt recent results of Schn\"urer, Schulze and Simon to prove a stability result for conformally compact Einstein metrics sufficiently close to the hyperbolic metric.Comment: 26 pages, 2 figures. Version 2 includes stronger stability result and fixes several typo

Environmental Life-Cycle Analysis of Hybrid Solar Photovoltaic/Thermal Systems for Use in Hong Kong

While sheet-and-tube absorber is generally recommended for flat-plate photovoltaic/thermal (PV/T) collector design because of the simplicity and promising performance, the use of rectangular-channel absorber is also tested to be a good alternative. Before a new energy technology, like PV/T, is fully implemented, its environmental superiority over the competing options should be assessed, for instance, by evaluating its consumption levels throughout its production and service life. Although there have been a plenty of environmental life-cycle assessments on the domestic solar hot water systems and PV systems, the related works on hybrid solar PV/T systems have been very few. So far there is no reported work on the assessment of PV/T collector with channel-type absorber design. This paper reports an evaluation of the energy payback time and the greenhouse gas payback time of free-standing and building-integrated PV/T systems in Hong Kong. This is based on two case studies of PV/T collectors with modular channel-type aluminium absorbers. The results confirm the long-term environmental benefits of PV/T applications

Changes in activities of both photosystems and the regulatory effect of cyclic electron flow in field-grown cotton (Gossypium hirsutum L) under water deficit

To clarify the influence of water deficit on the functionality of the photosynthetic apparatus of cotton plants, leaf gas exchange, chlorophyll a fluorescence, and P700 redox state were examined in field-grown cotton Gossypium hirsutum L. cv. Xinluzao 45. In addition, we measured changes in the P515 signal and analyzed the activity of ATP synthase and the trans-thylakoid proton gradient (ΔpH). With increasing water deficit, the net CO2 assimilation rate (AN) and stomatal conductance (gs) significantly decreased, but the maximum quantum efficiency of PSII photochemistry (Fv/Fm) did not change. The photochemical activity of photosystem II (PSII) was reflected by the photochemical quenching coefficient (qP), quantum efficiency of photosystem II [Y(II)], and electron transport rate through PSII [ETR(II)], while the activity of photosystem I (PSI) was reflected by the quantum efficiency of photosystem I [Y(I)] and the electron transport rate through PSI [ETR(I)]. Both activities were maintained under mild water deficit, but were slightly decreased under moderate water deficit. Under moderate water deficit, cyclic electron flow (CEF), the fraction of absorbed light dissipated thermally via the ΔpH- and xanthophyll-regulated process [Y(NPQ)], and the fraction of P700 oxidized under a given set of conditions [Y(ND)] increased. Our results suggest that the activities of both photosystems are stable under mild water deficit and decrease only slightly under moderate water deficit. Moderate water deficit stimulates CEF, and the stimulation of CEF is essential for protecting PSI and PSII against photoinhibition.This study was financially supported by the National Natural Science Foundation of China (U1203283; 31260295) and by the Training Program for Outstanding Young College Teachers (Grant No. CZ027201)

Quantitative measurement of adhesion between polypropylene blends and paints by tensile mechanical testing

A tensile mechanical test suiable to measure the adhesion between brittle coatings and ductile substrates was applied to measure the adhesion of painted layers on polypropylene blends. The test involves the tensile deformation of the painted assembly, resulting in the periodic cracking of the brittle coating on the ductile substrate. The interfacial shear strength was determined by measuring the strength of the coating, the thickness of the coating, and the average width of paint fragment after the crack density reaches saturation. Apparent interfacial shear strength was obtained for different paints on the same kind of blend, which gave consistent results over the experimental strain rate range from 10 −4 to 10 −3 sec −1 . Interfacial delamination was studied by optical microscopy (OM) and transmission electron microscopy (TEM). The delamination was observed to mainly occur near the adhesion promoter and substrate interface.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34544/1/10741_ftp.pd

Carbon-nanotube-deposited long period fiber grating for continuous refractive index sensor applications

We present a carbon-nanotube-deposited long period fiber grating for refractive index sensing applications in liquid. Carbon nanotubes are deposited around the surface of a long period fiber grating to form the refractive index sensing element. The sensing mechanism relies mainly on the high refractive index properties of the carbon-nanotube thin film, which enhances the cladding mode of the long period fiber grating in order to have a significant interaction between the propagating light and the target medium. A sensitivity of 31 dB/RIU and 47 dB/RIU are obtained for the refractive index ranges of 1.33-1.38 and 1.38-1.42, respectively, which have not been demonstrated with normal long period fiber gratings as the sensing element. As the sensing mechanism is based on the change of the transmitted optical power, our proposed scheme can intrinsically solve the limitations of the free spectral range commonly seen in other reported schemes, and continuous and repeatable measurements can be obtained while only acquiring errors mainly from the power fluctuations from the light source. The fiber grating also does not require any further mechanical modification like etching or tapering, which allows the sensing element to have the advantage of mechanical strength for practical applications. The experimental results are consistent with the modeling of the sensing mechanism. © 2014 Elsevier B.V. All rights reserved

Ionic and electronic properties of the topological insulator Bi2_2Te2_2Se investigated using β\beta-detected nuclear magnetic relaxation and resonance of 8^8Li

We report measurements on the high temperature ionic and low temperature electronic properties of the 3D topological insulator Bi$_2$Te$_2$Se using ion-implanted $^8$Li $\beta$-detected nuclear magnetic relaxation and resonance. With implantation energies in the range 5-28 keV, the probes penetrate beyond the expected range of the topological surface state, but are still within 250 nm of the surface. At temperatures above ~150 K, spin-lattice relaxation measurements reveal isolated $^8$Li$^{+}$ diffusion with an activation energy $E_{A} = 0.185(8)$ eV and attempt frequency $\tau_{0}^{-1} = 8(3) \times 10^{11}$ s$^{-1}$ for atomic site-to-site hopping. At lower temperature, we find a linear Korringa-like relaxation mechanism with a field dependent slope and intercept, which is accompanied by an anomalous field dependence to the resonance shift. We suggest that these may be related to a strong contribution from orbital currents or the magnetic freezeout of charge carriers in this heavily compensated semiconductor, but that conventional theories are unable to account for the extent of the field dependence. Conventional NMR of the stable host nuclei may help elucidate their origin.Comment: 17 pages, 12 figures, submitted to Phys. Rev.

Constraining Aerosol Optical Models Using Ground-Based, Collocated Particle Size and Mass Measurements in Variable Air Mass Regimes During the 7-SEAS/Dongsha Experiment

During the spring of 2010, NASA Goddard's COMMIT ground-based mobile laboratory was stationed on Dongsha Island off the southwest coast of Taiwan, in preparation for the upcoming 2012 7-SEAS field campaign. The measurement period offered a unique opportunity for conducting detailed investigations of the optical properties of aerosols associated with different air mass regimes including background maritime and those contaminated by anthropogenic air pollution and mineral dust. What appears to be the first time for this region, a shortwave optical closure experiment for both scattering and absorption was attempted over a 12-day period during which aerosols exhibited the most change. Constraints to the optical model included combined SMPS and APS number concentration data for a continuum of fine and coarse-mode particle sizes up to PM2.5. We also take advantage of an IMPROVE chemical sampler to help constrain aerosol composition and mass partitioning of key elemental species including sea-salt, particulate organic matter, soil, non sea-salt sulphate, nitrate, and elemental carbon. Our results demonstrate that the observed aerosol scattering and absorption for these diverse air masses are reasonably captured by the model, where peak aerosol events and transitions between key aerosols types are evident. Signatures of heavy polluted aerosol composed mostly of ammonium and non sea-salt sulphate mixed with some dust with transitions to background sea-salt conditions are apparent in the absorption data, which is particularly reassuring owing to the large variability in the imaginary component of the refractive indices. Extinctive features at significantly smaller time scales than the one-day sample period of IMPROVE are more difficult to reproduce, as this requires further knowledge concerning the source apportionment of major chemical components in the model. Consistency between the measured and modeled optical parameters serves as an important link for advancing remote sensing and climate research studies in dynamic aerosol-rich environments like Dongsha

Entropy of Kaluza-Klein Black Hole from Kerr/CFT Correspondence

We extend the recently proposed Kerr/CFT correspondence to examine the dual conformal field theory of Kaluza-Klein black hole. For the extremal Kaluza-Klein black hole, the central charge and temperature of the dual conformal field are calculated, and the microscopic entropy calculated by using Cardy formula agrees with the Bekenstein-Hawking entropy of extremal Kaluza-Klein black hole. For the non-extremal case, we investigate the hidden conformal symmetry of Kaluza-Klein black hole by studying the near-region wave equation of a neutral massless scalar field, and find the left and right temperatures of dual conformal field theory. Furthermore, the entropy of non-extremal Kaluza-Klein black hole is reproduced by using Cardy formula.Comment: 13pages, no figure, published versio