Strong Correlations in Actinide Redox Reactions

Reduction-oxidation (redox) reactions of the redox couples An(VI)/An(V), An(V)/An(IV), and An(IV)/An(III), where An is an element in the family of early actinides (U, Np, and Pu), as well as Am(VI)/Am(V) and Am(V)/Am(III), are modeled by combining density functional theory with a generalized Anderson impurity model that accounts for the strong correlations between the 5f electrons. Diagonalization of the Anderson impurity model yields improved estimates for the redox potentials and the propensity of the actinide complexes to disproportionate.Comment: 17 pages, 10 figure, 3 tables. Corrections and clarifications; this version has been accepted for publication in The Journal of Chemical Physic

A depth camera-based system for estimating cyclist-bike projected frontal area

A major component of total resistive force in cycling is aerodynamic drag. For speeds greater than ~14 m/s aerodynamic drag accounts for approximately 90% of total resistive force (Debraux et al., 2009: International Journal of Sports Medicine, 30, 266-272). Together with the air density, the coefficient of drag and the velocity of the cyclist-bike, an important determinant of aerodynamic drag is projected frontal area. Several techniques have been used to estimate the projected frontal area of a cyclist-bike, including the weighing of photographs and image digitising (Debraux et al., 2009). These techniques are similar as they involve extracting the cyclist-bike from a two-dimensional (2D) image and using scaling information from a plane of known dimensions. With the weighing photographs method this is done physically using sensitive weighing scales whereas image processing software is used for the image digitising technique. Both techniques require the collection of a calibration plane, involve considerable post-processing and cannot be performed in real time. We have developed a depth camera-based system for estimating cyclist-bike projected frontal area which addresses these issues. The depth camera algorithm works by creating a metrically scaled, three-dimensional point cloud of the cyclist-bike. The point cloud is projected on to a 2D representation of the scene and the area of the point cloud is calculated using a technique similar to ‘voxelization’; points in the cloud occupy spaces in a fine grid – the sum of the occupied grid spaces gives total area. The aim of this study was to investigate the agreement between our new method and the image digitising technique.After institutional ethics approval, eight regular cyclists volunteered to participate and provided written informed consent. Participants wore their normal cycling clothing and their bicycle was mounted on a stationary indoor trainer. The bicycle was positioned against a white background to help with the image digitising method. Participants placed their feet on the pedals and held the cranks parallel to the floor. A digital camera (Canon EOS 400D, 10.1 megapixel) and Kinect depth camera (Microsoft, Redmond, WA, USA) were mounted on tripods at a height of 1.1 m and positioned 5 m and 2.2 m in front of the participant, respectively. Similar to Debraux et al. (2009), participants adopted two positions on the bike: 1. Upright – upright torso with hands close to the stem and 2. Drops Position – hands on the drops. Three repeat captures were performed in each position, with the participant relaxing between each capture. The digitising method was performed as described by Debraux et al. (2009). Agreement between methods was assessed using limits of agreement (LOA - Bland and Altman, 1986: Lancet, 1, 307-310). A two-way repeated measures analysis of variance (method by position) was used to assess the effect of cyclist position on the systematic difference between measurement methods.There was no interaction between cyclist position and measurement method (p = 0.201) indicating that the same effect of cyclist position was observed using both measurement techniques. A significant main effect for cyclist position (p = 0.017) indicated that projected frontal area was smaller with hands on the drops (upright: 0.485 m2, drops: 0.434 m2). There was also a significant main effect for measurement method (p < 0.001) indicating a significantly smaller estimation of projected frontal area using the Kinect (Kinect: 0.416 m2, Image: 0.503 m2). A predominantly systematic difference between methods was also suggested by the LOA analysis (upright: 0.086 ± 0.029 m2, drops: 0.090 ± 0.033 m2).The aim of this study was to assess the agreement between a common method of estimating cyclist-bike frontal area and a new depth camera-based technique. The new technique estimated systematically smaller projected frontal area than the image digitisation method but there was relatively little random variation and the same effect of cyclist position was observed with both techniques. Which technique gives the most accurate estimate of projected frontal area is not clear as the image digitisation technique - to which the new technique was compared - has associated errors e.g. identification of the cyclist-bike outline and out-of-plane errors. However, it was apparent during testing that the depth camera-based system often failed to identify parts of the bike and this is most likely the cause of the difference between techniques. Regardless, the results of this study suggest that the new technique can be used to assess changes in projected frontal area – as the cyclist changes position, for example. Further, the new technique offers the possibility of analysing changes in projected frontal area in real time – there is no requirement for calibration or post-processing

Spatio-temporal metrics that distinguish play outcomes: A pilot study

In team invasion sports, tactical behaviour can be examined using spatio-temporal data, i.e. the position of the players at a given time. A review of the spatio-temporal metrics used in team invasion sports performance analysis indicated that thousands of variations of metrics being used. Information about the distribution of metrics' individual effects can inform us of the best variable-selection method. The aim of this pilot study was to estimate the distribution of strong marginal effects of spatio-temporal metrics of field hockey plays. With institutional ethical approval, the Womens’ and Mens’ gold medal games from the EuroHockey 2015 field hockey tournament were recorded. Best, acceptable and worst-case outcomes for plays were described by 1,837 spatio-temporal metrics. Each metric's marginal effects were estimated using Cramér's V, Mutual Information and the I-score. Values for Cramér's V of 0.2 and 0.4 to mark the boundaries of small, moderate and large effects. Less than 1% of metrics show large effects with > 87% of all metrics showing small effects as per the Cramér's V thresholds. These large effect metrics where all within the 98th percentile of Mutual Information values and within the 96th percentile of the I-score values, which supports the Cramér's V distribution of marginal effects. Therefore, according to the recommendations of Tibshirani (1996), univariate variable-selection methods will be the most appropriate for selecting important metrics

Materials have driven the historical development of the Tennis Racket

© 2019 by the authors. The tennis racket has developed since the origins of Lawn Tennis in the 1870s. This study investigated how the tennis racket developed from 1874 to 2017, using measurements and material classifications for 525 samples. Racket measurements covered geometric, inertial and dynamic properties, and the number of strings. Rackets predating 1970 were mainly wooden, and typically characterised by head areas below 0.05 m2, masses over 350 g and natural frequencies below 120 Hz. Rackets from the 1970s were made from wood, metal and fibre-polymer composites, with most postdating 1980 made from fibre-polymer composites with a larger head, lower mass and higher natural frequency than their predecessors. Principal component analysis was used to reduce the dimensionality of the number of variables. Principal component one (PCA1) accounted for 35% of the variance in the measured racket properties, and was found to be significantly affected by material. Head width was best correlated with principal component one (r = 0.897, p < 0.001), followed by head length (r = 0.841, p < 0.001) and natural frequency (r = 0.813, p < 0.001). Early rackets were constrained by the limitations of wood, and the move to composites, which began in the 1970s, allowed this observed increase in head size and natural frequency. As material development has been a major driver of racket design in the past, we propose that new materials and manufacturing techniques, like additively manufactured composites, could further improve the tennis racket. The measurement techniques described here can be used to monitor developments in racket design

Clinical improvements following bilateral anterior capsulotomy in treatment-resistant depression

The purpose of this study was to evaluate a programme of lesion surgery carried out on patients with treatment-resistant depression (TRD). This was a retrospective study looking at clinical and psychometric data from 45 patients with TRD who had undergone bilateral stereotactic anterior capsulotomy surgery over a period of 15 years, with the approval of the Mental Health Act Commission (37 with unipolar depression and eight with bipolar disorder). The Beck Depression Inventory (BDI) before and after surgery was used as the primary outcome measure. The Montgomery–Asberg Depression Rating Scale was administered and cognitive aspects of executive and memory functions were also examined. We carried out a paired-samples t test on the outcome measures to determine any statistically significant change in the group as a consequence of surgery. Patients improved on the clinical measure of depression after surgery by −21.20 points on the BDI with a 52% change. There were no significant cognitive changes post-surgery. Six patients were followed up in 2013 by phone interview and reported a generally positive experience. No major surgical complications occurred. With the limitations of an uncontrolled, observational study, our data suggest that capsulotomy can be an effective treatment for otherwise TRD. Performance on neuropsychological tests did not deteriorate

Single view silhouette fitting techniques for estimating tennis racket position

Stereo camera systems have been used to track markers attached to a racket, allowing its position to be obtained in three-dimensional (3D) space. Typically, markers are manually selected on the image plane, but this can be time-consuming. A markerless system based on one stationary camera estimating 3D racket position data is desirable for research and play. The markerless method presented in this paper relies on a set of racket silhouette views in a common reference frame captured with a calibrated camera and a silhouette of a racket captured with a camera whose relative pose is outside the common reference frame. The aim of this paper is to provide validation of these single view fitting techniques to estimate the pose of a tennis racket. This includes the development of a calibration method to provide the relative pose of a stationary camera with respect to a racket. Mean static racket position was reconstructed to within ±2 mm. Computer generated camera poses and silhouette views of a full size racket model were used to demonstrate the potential of the method to estimate 3D racket position during a simplified serve scenario. From a camera distance of 14 m, 3D racket position was estimated providing a spatial accuracy of 1.9 ± 0.14 mm, similar to recent 3D video marker tracking studies of tennis

Upstaging nodal status in colorectal cancer using ex vivo fluorescence sentinel lymph node mapping: preliminary results

Background: Sentinel lymph node (SLN) mapping using near-infrared fluorescence (NIRF) imaging is a recent technique to improve nodal staging in several tumors. The presence of colorectal cancer (CRC) micro-metastases has recently been defined as N1 disease and no longer as N1mi, determining the need for adjuvant chemotherapy. In CRC, the reported rate of SLN micro-metastases detected by ultrastaging techniques is as high as 30%. The aim of this prospective study is to report the preliminary results of the sensitivity analysis of NIRF imaging for ex vivo SLN mapping and the research of micro-metastases in CRC, in patients with node-negative disease (NND). Material and methods: On the specimen of 22 CRC patients, 1 mL of ICG (5 mg/mL) was injected submucosally around the tumor to identify SLNs. NND SLNs were further investigated with ultrastaging techniques. Results: Three-hundred and sixty-three lymph nodes were retrieved (59 SLNs; mean per case: 2.7). The detection, sensitivity and false-negative rate were 100%, 100% and 0% respectively. Ultrastaging investigations showed no micro-metastases in the NND SLNs. Conclusions: The ex vivo SLN fluorescence-based detection in CRC was confirmed to be easy to perform and reliable. In this preliminary results report of an ongoing study, the SLN assay was congruent with the nodal status, as confirmed by histological investigations

Tumor-associated antigen human chorionic gonadotropin beta contains numerous antigenic determinants recognized by in vitro-induced CD8+ and CD4+ T lymphocytes.

The beta subunit of human chorionic gonadotropin (hCG beta) is markedly overexpressed by neoplastic cells of differing histological origin including those present in colon, breast, prostate and bladder tumors. We have previously shown that some patients with hCG beta-producing urothelial tumors have circulating T cells that proliferate in response to hCG beta. To make a comprehensive study of hCG beta as a potential target for cancer immunotherapy, we investigated whether hCG beta peptides could induce CD4+ or CD8+ T-cell responses in vitro. By stimulating peripheral blood mononuclear cells (PBMCs) from three donors with mixtures of overlapping 16-mer synthetic peptides analogous to portions of either the hCG beta 20-71 or the hCG beta 102-129 region, we established six CD4+ T-cell lines that proliferated specifically in response to five distinct determinants located within these two hCG beta regions. Three antigenic determinants (hCG beta 52-67, 106-121 and 114-125) were presented by HLA-DR molecules, while the two other antigenic determinants (hCG beta 48-63 and 56-67) were presented by HLA-DQ molecules. Interestingly, one T-cell line specific for peptide hCG beta 106-121 recognized hCG beta peptides comprising, at position 117, either an alanine or an aspartic acid residue, with the latter residue being present within the protein expressed by some tumor cells. In addition, three other hCG beta-derived peptides that exhibited HLA-A*0201 binding ability were able to stimulate CD8+ cytotoxic T cells from two HLA-A*0201 donors. These three immunogenic peptides corresponded to regions hCG beta 40-48, hCG beta 44-52 and hCG beta 75-84. Our results indicate that the tumor-associated antigen hCG beta possesses numerous antigenic determinants liable to stimulate CD4+ and CD8+ T lymphocytes, and might thus be an effective target antigen for the immunotherapy of hCG beta-producing tumors

Resting state fMRI entropy probes complexity of brain activity in adults with ADHD

In patients with attention deficit hyperactivity disorder (ADHD), quantitative neuroimaging techniques have revealed abnormalities in various brain regions, including the frontal cortex, striatum, cerebellum, and occipital cortex. Nonlinear signal processing techniques such as sample entropy have been used to probe the regularity of brain magnetoencephalography signals in patients with ADHD. In the present study, we extend this technique to analyse the complex output patterns of the 4 dimensional resting state functional magnetic resonance imaging signals in adult patients with ADHD. After adjusting for the effect of age, we found whole brain entropy differences (P=0.002) between groups and negative correlation (r=-0.45) between symptom scores and mean whole brain entropy values, indicating lower complexity in patients. In the regional analysis, patients showed reduced entropy in frontal and occipital regions bilaterally and a significant negative correlation between the symptom scores and the entropy maps at a family-wise error corrected cluster level of P<0.05 (P=0.001, initial threshold). Our findings support the hypothesis of abnormal frontal-striatal-cerebellar circuits in ADHD and the suggestion that sample entropy is a useful tool in revealing abnormalities in the brain dynamics of patients with psychiatric disorders

Creating drag and lift curves from soccer trajectories

Trajectory analysis is an alternative to using wind tunnels to measure a soccer balls aerodynamic properties. It has advantages over wind tunnel testing such as being more representative of game play. However, previous work has not presented a method that produces complete, speed -dependent drag and lift coefficients. Four high-speed cameras in stereo-calibrated pairs were used to measure the spatial co-ordinates for 29 separate soccer trajectories. Those trajectories span a range of launch speeds from 9.3 m/s to 29.9 m/s. That range encompasses low-speed laminar flow of air over a soccer ball, through the drag crises where air flow is both laminar and turbulent, and up to high-speed turbulent air flow. Results from trajectory analysis were combined to give speed-dependent drag and lift coefficient curves for the entire range of speeds found in the 29 trajectories. Average root mean square error between measured and modelled trajectory was 0.028 m horizontally and 0.034 m vertically. The drag and lift crises can be observed in the plots of drag and lift coefficients respectively