Generalized Weyl solutions in d=5 Einstein-Gauss-Bonnet theory: the static black ring

We argue that the Weyl coordinates and the rod-structure employed to construct static axisymmetric solutions in higher dimensional Einstein gravity can be generalized to the Einstein-Gauss-Bonnet theory. As a concrete application of the general formalism, we present numerical evidence for the existence of static black ring solutions in Einstein-Gauss-Bonnet theory in five spacetime dimensions. They approach asymptotically the Minkowski background and are supported against collapse by a conical singularity in the form of a disk. An interesting feature of these solutions is that the Gauss-Bonnet term reduces the conical excess of the static black rings. Analogous to the Einstein-Gauss-Bonnet black strings, for a given mass the static black rings exist up to a maximal value of the Gauss-Bonnet coupling constant $\alpha'$. Moreover, in the limit of large ring radius, the suitably rescaled black ring maximal value of $\alpha'$ and the black string maximal value of $\alpha'$ agree.Comment: 43 pages, 14 figure

Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma

Multiple myeloma (MM) is a B cell malignancy characterized by the expansion of clonal plasmablast/plasma cells within the bone-marrow. It is well established that the bone-marrow microenvironment has a pivotal role in providing critical cytokines and cell–cell interactions to support the growth and survival of the MM tumor clone. The pathogenesis of MM is, however, only fragmentarily understood. Detailed genomic analysis reveals a heterogeneous and complex pattern of structural and numerical chromosomal aberrations. In this review we will discuss some of the recent results on the functional role and potential clinical use of the IGF-1R, one of the major mediators of growth and survival for MM. We will also describe some of our results on epigenetic gene silencing in MM, as it may indeed constitute a novel basis for the understanding of tumor initiation and maintenance in MM and thus may change the current view on treatment strategies for MM

The I4U Mega Fusion and Collaboration for NIST Speaker Recognition Evaluation 2016

The 2016 speaker recognition evaluation (SRE'16) is the latest edition in the series of benchmarking events conducted by the National Institute of Standards and Technology (NIST). I4U is a joint entry to SRE'16 as the result from the collaboration and active exchange of information among researchers from sixteen Institutes and Universities across 4 continents. The joint submission and several of its 32 sub-systems were among top-performing systems. A lot of efforts have been devoted to two major challenges, namely, unlabeled training data and dataset shift from Switchboard-Mixer to the new Call My Net dataset. This paper summarizes the lessons learned, presents our shared view from the sixteen research groups on recent advances, major paradigm shift, and common tool chain used in speaker recognition as we have witnessed in SRE'16. More importantly, we look into the intriguing question of fusing a large ensemble of sub-systems and the potential benefit of large-scale collaboration.Peer reviewe

Characterizing bird-keeping user-groups on Java reveals distinct behaviours, profiles and potential for change

Over 70 million cage‐birds are kept across 12 million households on the island of Java, Indonesia, fuelling serious concerns for the health of regional wild bird populations. Understanding the behaviours, preferences and demographic profiles of bird‐keepers will guide attempts to reduce demand for wild birds and hence the impact of trade on wild populations and their host ecosystems. We profile three songbird‐keeping user‐groups based on interviews of nearly one thousand people across Java: hobbyists, who own birds primarily as pets; contestants, who own birds to enter in singing contests; and breeders, who own birds to breed and train for resale or as a pastime. User‐groups diverged in their bird‐keeping habits and preferences. Hobbyists tended to own small numbers of inexpensive and typically native birds, while contestants and breeders owned larger numbers of often valuable birds. Hobbyists were far less likely to consider origin when buying a bird, owned a larger proportion of both potentially wild‐caught and globally threatened birds, but showed no preference for any taxon. By contrast, owning relatively large numbers of lovebirds Agapornis spp. and Zebra Doves Geopelia striata were key characteristics of contestants, while breeders owned the largest number of birds and species, in particular White‐rumped Shamas Kittacincla malabarica. Within a 2‐year period, user‐group membership was fluid, with much transitioning between non‐bird ownership and hobbyists, recruitment of non‐bird owners to contestants and movement both in and out of the breeder group. Our study provides behavioural change efforts with demographic and geographic profiles to target bird‐keepers, who tended to be more affluent and urban and to live in the eastern provinces. Among bird‐keepers, hobbyists tended to be middle‐aged and lived in the western provinces, contestants were younger urban bird‐keepers employed in business and breeders were commoner in the eastern provinces, reflecting the cultural importance of bird‐keeping among the Javanese. Efforts to increase the sustainability of bird‐keeping in Java should focus on emphasizing the importance of captive‐bred birds, in particular to hobbyists, the largest user‐group, whose bird‐keeping behaviour poses the biggest threat to wild bird populations, whilst also incentivizing legitimate breeding enterprises among contestants and breeders

Hot Halos and Galactic Glasses

We initiate a systematic study of the state space of non-extremal, stationary black hole bound states in four-dimensional N = 2 supergravity. Specifically, we show that an exponential multitude of classically stable "halo" bound states can be formed between large finite temperature D4-D0 black hole cores and much smaller, arbitrarily charged black holes at the same temperature. We map out in full the regions of existence for thermodynamically stable and metastable bound states in terms of the core's charges and temperature, as well as the region of stability of the core itself. Several features of these systems, such as a macroscopic configurational entropy and exponential relaxation timescales, are similar to those of the extended family of glasses. We draw parallels between the two with a view toward understanding complex systems in fundamental physics.Comment: 29 pages, 5 figures, v2: typos corrected, references adde

Behavior in behavioral strategy : capturing, measuring, analyzing

Measuring behavior requires research methods that can capture observed outcomes and expose underlying processes and mechanisms. In this chapter, we present a toolbox of instruments and techniques we designed experimental tasks to simulate decision environments and capture behavior. We deployed protocol analysis and text analysis to examine the underlying cognitive processes. In combination, these can simultaneously grasp antecedents, outcomes, processes, and mechanisms. We applied them to collect rich behavioral data on two key topics in strategic management: the exploration–exploitation trade-off and strategic risk-taking. This mix of methods is particularly useful in describing actual behavior as it is, not as it should be, replacing assumptions with data and offering a finer-grained perspective of strategic decision-making

Discovery of Molecular Markers to Discriminate Corneal Endothelial Cells in the Human Body

The corneal endothelium is a monolayer of hexagonal corneal endothelial cells (CECs) on the inner surface of the cornea. CECs are critical in maintaining corneal transparency through their barrier and pump functions. CECs in vivo have a limited capacity in proliferation, and loss of a significant number of CECs results in corneal edema called bullous keratopathy which can lead to severe visual loss. Corneal transplantation is the most effective method to treat corneal endothelial dysfunction, where it suffers from donor shortage. Therefore, regeneration of CECs from other cell types attracts increasing interests, and specific markers of CECs are crucial to identify actual CECs. However, the currently used markers are far from satisfactory because of their non-specific expression in other cell types. Here, we explored molecular markers to discriminate CECs from other cell types in the human body by integrating the published RNA-seq data of CECs and the FANTOM5 atlas representing diverse range of cell types based on expression patterns. We identified five genes, CLRN1, MRGPRX3, HTR1D, GRIP1 and ZP4 as novel markers of CECs, and the specificities of these genes were successfully confirmed by independent experiments at both the RNA and protein levels. Notably none of them have been documented in the context of CEC function. These markers could be useful for the purification of actual CECs, and also available for the evaluation of the products derived from other cell types. Our results demonstrate an effective approach to identify molecular markers for CECs and open the door for the regeneration of CECs in vitro

Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group

This Policy Review presents the International Myeloma Working Group's clinical practice recommendations for the treatment of relapsed and refractory multiple myeloma. Based on the results of phase 2 and phase 3 trials, these recommendations are proposed for the treatment of patients with relapsed and refractory disease who have received one previous line of therapy, and for patients with relapsed and refractory multiple myeloma who have received two or more previous lines of therapy. These recommendations integrate the issue of drug access in both low-income and middle-income countries and in high-income countries to help guide real-world practice and thus improve patient outcomes