12 research outputs found
Pubblica amministrazione e integrazione europea
No full textIstituto di Diritto Pubblico - Universita' di FirenzeConsiglio Nazionale delle Ricerche - Biblioteca Centrale -. P.le Aldo Moro, 7, Rome / CNR - Consiglio Nazionale delle RichercheSIGLEITItal
Le situazioni giuridiche soggettive
No full textIl contributo analizza le principali categorie e specie di diritti soggettivi individuali, nonchè i diritti di categoria, diffusi e collettivi. L'analisi ha poi ad oggetto i diritti procedimentali e processuali nei confronti della pubblica amministrazione, individuando al contempo gli obblighi dei cittadini europei e le situazioni giuridiche soggettive dei pubblici poteri della comunitÃ
europea. Si giunge per tale via a tracciare il difficile cammino delle situazioni giuridiche soggettive nazionali verso l’integrazione europea
Le situazioni giuridiche soggettive
No full textIl contributo analizza le principali categorie e specie di diritti soggettivi individuali, nonchè i diritti di categoria, diffusi e collettivi. L'analisi ha poi ad oggetto i diritti procedimentali e processuali nei confronti della pubblica amministrazione, individuando al contempo gli obblighi dei cittadini europei e le situazioni giuridiche soggettive dei pubblici poteri della comunitÃ
europea. Si giunge per tale via a tracciare il difficile cammino delle situazioni giuridiche soggettive nazionali verso l’integrazione europea
Intrinsic aggregation propensity of the CsgB nucleator protein is crucial for curli fiber formation
No full textFunctionally Significant Amino Acid Motifs of Heat Shock Proteins: Structural and Bioinformatics Analyses of Hsp60/Hsp10 in Five Classes of Chordata
No full textEpidemiology and outcome of Clostridium difficile infections in patients hospitalized in Internal Medicine: Findings from the nationwide FADOI-PRACTICE study
No full textBACKGROUND:
Clostridium difficile (CD) is a leading cause of diarrhoea among hospitalized patients. The objective of this study was to evaluate the rate, the optimal diagnostic work-up, and outcome of CD infections (CDI) in Internal Medicine (IM) wards in Italy.
METHODS:
PRACTICE is an observational prospective study, involving 40 IM Units and evaluating all consecutive patients hospitalized during a 4-month period. CDI were defined in case of diarrhoea when both enzyme immunoassay for GDH, and test for A/B toxin were positive. Patients with CDI were followed-up for recurrences for 4 weeks after the end of therapy.
RESULTS:
Among the 10,780 patients observed, 103 (0.96 %) showed CDI, at admission or during hospitalization. A positive history for CD, antibiotics in the previous 4 weeks, recent hospitalization, female gender and age were significantly associated with CDI (multivariable analysis). In-hospital mortality was 16.5 % in CD group vs 6.7 % in No-CD group (p < 0.001), whereas median length of hospital stay was 16 (IQR = 13) vs 8 (IQR = 8) days (p < 0.001) among patients with or without CDI, respectively. Rate of CD recurrences was 14.6 %. As a post-hoc evaluation, 23 out of 34 GDH+/Tox- samples were toxin positive, when analysed by molecular method (a real-time PCR assay). The overall CD incidence rate was 5.3/10,000 patient-days.
CONCLUSIONS:
Our results confirm the severity of CDI in medical wards, showing high in-hospital mortality, prolonged hospitalization and frequent short-term recurrences. Further, our survey supports a 2-3 step algorithm for CD diagnosis: EIA for detecting GDH, A and B toxin, followed by a molecular method in case of toxin-negative samples
Inhibition of Amyloid Fibrillation by Small Molecules and Nanomaterials: Strategic Development of Pharmaceuticals Against Amyloidosis
No full text
