Preventive healthcare services receipt and primary care provider utilization among people who inject drugs

Introduction: People who inject drugs (PWID) face barriers to accessing primary care providers (PCPs) and preventive services, but are at increased risk for preventable infections Preventive services can be accessed through PCPs, or while hospitalized or at community organizations like syringe service programs (SSPs)https://knowledgeconnection.mainehealth.org/lambrew-retreat-2021/1041/thumbnail.jp

Characteristics of Inpatients with Opioid Use Disorder Seen by “IMAT” Consult Service from 7/2016 - 6/2017

Introduction: • For people with opioid use disorder (OUD), admission to the hospital can provide an opportunity to initiate substance use disorder (SUD) treatment and preventive care • In 2016, a multidisciplinary “IMAT” (integrated medication for addiction treatment) inpatient team was established to help treat patients with SU

Creencias de docentes acerca del bullying

Se analizaron las creencias de docentes de educación básica acerca del bullying, para lo cual se seleccionaron las tres escuelas secundarias públicas de Sonora donde se encontró la mayor frecuencia de reportes de bullying por los estudiantes en un estudio previo realizado por Valdés et al. (2013). Participaron 45 docentes de estas escuelas, 15 fueron entrevistados y el resto respondió una encuesta con preguntas abiertas. Los docentes definieron el bullying como violencia directa, que involucra a estudiantes u otros actores. Consideran de forma no sistémica la acción de los factores asociados al bullying y ubican en la familia y el contexto social la explicación del fenómeno. Desplazan la responsabilidad de las intervenciones hacia otros actores y consideran estrategias de intervención aisladas. Se concluye que las creencias de los docentes acerca del bullying reducen el margen de acción para que este problema reciba atención en el ámbito escolar.In this paper the results of an analysis on the beliefs held by basic-education teaching staff regarding bullying are analyzed; to carry out the analysis, the three public high schools with the highest incidence of ‘bullying’ by students in Sonora were selected; these results were from a previous study by Valdés et al., in 2013. From these schools, 15 teaching staff (from a total of 45) were interviewed; the remainder answered a survey with open questions. Teachers defined ‘bullying’ as direct violence involving students or other stakeholders. The staff considered the factors associated with bullying as non-systemic; in their opinion, the family and social context were the explanation for the phenomenon. They placed the responsibility for ‘bullying’ on other actors and considered the intervention strategies to be isolated. The conclusion is that the beliefs of teachers regarding ‘bullying’ reduce the scope for action against this problem within the educational environment

Association Between Primary Care Provider Status and Preventive Health Care Among People Who Inject Drugs

Introduction: People who inject drugs (PWID) are at increased risk for preventable, communicable infections, such as hepatitis B. Preventive care, such as hepatitis B vaccination, is often delivered through primary care providers (PCPs). However, PWID may not have access to PCPs and, therefore, may receive preventive care through other sites. We aimed to characterize PCP and preventive care use among PWID in Maine. Methods: This is a cross-sectional study of PWID hospitalized with infections associated with injection drug use in Maine from January 2019 to May 2020. Descriptive analyses were used to identify characteristics of participants, rates of screening, and vaccination of participants with and without PCPs. Logistic regression analyses were performed to explore the relationship between PCP status and delivery of preventive services for PWID. Hepatitis B vaccination was an outcome of interest. Results: Of 101 participants, 68 (67%) had a PCP. Overall rates of hepatitis C (93%) and HIV (85%) screening were high and did not differ based on PCP status. More participants with PCPs had previously received a hepatitis B vaccination (62% of those with PCPs, 33% of those without PCPs; P = .006). Only half of those with PCPs recalled receiving a hepatitis B vaccination through a PCP office. Having a PCP was predictive of having received the hepatitis B vaccination (adjusted odds ratio, 3.59; 95% CI, 1.27-7.58; P = .014). Conclusions: Many PWID in Maine engage with PCPs and preventive care. Results from this study call for enhanced delivery of preventive services and linkages to care for PWID

Inglês como meio de instrução para a internacionalização do currículo: motivos e expectativas dos professores

This research article presents the results of a research that aimed to analyze the motives and expectations of teachers from a public university in northwestern Mexico when participating in the internationalization of the curriculum through Englishmedium instruction (EMI). The analysis is based on the variables such as discipline, seniority, type of contract and frequency of teaching in English. A mixed methodology was employed to analyze quantitative and qualitative data, collected through a digital instrument addressed to a total of 42 teachers who were accredited to teach subjects in English, and 36 complete questionnaires were answered. The results allow us to conclude that most professors from all disciplines agree that their main reason for participating in internationalization through EMI is “to support institutional initiatives”; in contrast, “receiving economic incentives from institutional programs” was a reason for participation with marked differences according to discipline and type of contract. The qualitative analysis concludes the existence of positive conceptions around this type of education, as it is favorable for the university and a possible source of economic remuneration. Although teachers express an intrinsic motivation towards training and teaching in English, the lack of equal economic incentives could be a cause of limited teacher participation.Este artículo presenta los resultados de una investigación que se propuso analizar los motivos y las expectativas de docentes de una universidad pública en el noroeste de México al participar en la internacionalización del currículo mediante el uso de inglés como medio de instrucción (EMI por sus siglas en inglés), el análisis se basa a partir de las variables, atales como disciplina, antigüedad laboral, tipo de contratación y frecuencia de enseñanza en inglés. Se empleó una metodología mixta para analizar datos cuantitativos y cualitativos, recopilados mediante un instrumento digital dirigido a un total de 42 profesores que estaban acreditados para impartir asignaturas en inglés, y se obtuvieron 36 cuestionarios completos respondidos. Los resultados permiten concluir que la mayor parte de los profesores de todas las disciplinas están de acuerdo en que su principal motivo para participar en la internacionalización mediante uso de emi es “apoyar iniciativas institucionales”; en contraste, “recibir incentivos económicos por parte de programas institucionales” fue un motivo de participación con diferencias marcadas según la disciplina y el tipo de contratación. El análisis cualitativo concluye la existencia de concepciones positivas en torno a este tipo de enseñanza, por ser favorable para la universidad y como posible fuente de remuneración económica. Aunque los docentes manifiestan una motivación intrínseca hacia la formación y enseñanza en inglés, la falta de incentivos económicos igualitarios podría ser una causante de la participación limitada del docente.Este artigo apresenta os resultados de uma pesquisa que teve como objetivo analisar os motivos e expectativas de professores de uma universidade pública no noroeste do México ao participar da internacionalização do currículo através do uso do inglês como meio de instrução (EMI). A analise é baseada a partir das variáveis tais como disciplina, antiguidade, tipo de contrato e frequência de ensino em inglês. Para a análise de dados quantitativos e qualitativos, seguiu-se uma metodologia mista, coletados por meio de instrumento digital dirigido a um total de 42 professores credenciados para lecionar disciplinas em inglês, e foram respondidos 36 questionários preenchidos. Os resultados permitem concluir que a maioria dos docentes de todas as disciplinas concordam que sua principal razão para participar da internacionalização por meio do uso do emi é “apoiar iniciativas institucionais”; por outro lado, “receber incentivos econômicos de programas institucionais” foi um motivo de participação com diferenças marcantes conforme a disciplina e o tipo de contrato. A análise qualitativa conclui a existência de conceções positivas em torno dessa modalidade de ensino, por ser favorável à universidade e como possível fonte de remuneração econômica. Embora os professores expressem uma motivação intrínseca para a formação e ensino em inglês, a falta de incentivos econômicos iguais pode ser uma causa da participação limitada dos professores

Independent mobility of proteins and lipids in the plasma membrane of Escherichia coli

Biotechnology and Biological Sciences Research Council. Grant Number: BB/E009571, Oxford Centre for Integrative Systems Biology (OCISB), Engineering and Physical Science Research Council, Royal Society, Hertford College Oxfor

Paraneoplastic Autoimmunity in Thymus Tumors

Autoimmune phenomena are more frequent in thymic epithelial tumors (TET) than in any other human tumor. Mysthenia gravis (MG) is by far the most common autoimmune disease in thymoma patients. MG is characterized by muscle weakness due to autoantibodies against the acetylcholine receptor (AChR), and CD4 +AChR-specific T cells play a pivotal role for the production of these autoantibodies. About 10% of MG patients have a thymoma and, interestingly, only such thymomas exhibit an MG association that maintains thymuslike morphological and functional features with respect to the homing and differentiation of immature T cells. Since AChR protein is not expressed in thymomas, the specificity of the autoimmunity in thymoma-associated MG is thought to be determined by nonreceptor proteins with AChR epitopes. Such proteins are overexpressed in cortical-type MG-associated thymomas, and medullary thymomas express these proteins at barely detectable levels. Aside from this quantitative difference, the pathogenesis of anti-AChR autoimmunity might be qualitatively different in these thymoma subtypes. Our findings suggest that an antigen-specific abnormal Tcell selection by cortical-type TET may contribute to the pathogenesis of paraneoplastic MG. In contrast, an abnormal (intratumorous) activation of autoreactive T cells may be operative in medullary thymomas

SynBio2Easy – a biologist-friendly tool for batch operations on SBOL designs with Excel inputs

Practical delivery of Findable, Accessible, Reusable and Interoperable principles for research data management requires expertise, time resource, (meta)data standards and formats, software tools and public repositories. The Synthetic Biology Open Language (SBOL2) metadata standard enables FAIR sharing of the designs of synthetic biology constructs, notably in the repository of the SynBioHub platform. Large libraries of such constructs are increasingly easy to produce in practice, for example, in DNA foundries. However, manual curation of the equivalent libraries of designs remains cumbersome for a typical lab researcher, creating a barrier to data sharing. Here, we present a simple tool SynBio2Easy, which streamlines and automates operations on multiple Synthetic Biology Open Language (SBOL) designs using Microsoft Excel® tables as metadata inputs. The tool provides several utilities for manipulation of SBOL documents and interaction with SynBioHub: for example, generation of a library of plasmids based on an original design template, bulk deposition into SynBioHub, or annotation of existing SBOL component definitions with notes and authorship information. The tool was used to generate and deposit a collection of 3661 cyanobacterium Synechocystis plasmids into the public SynBioHub repository. In the process of developing the software and uploading these data, we evaluated some aspects of the SynBioHub platform and SBOL ecosystem, and we discuss proposals for improvement that could benefit the user community. With software such as SynBio2Easy, we aim to deliver a user-driven tooling to make FAIR a reality at all stages of the project lifecycle in synthetic biology research. Graphical Abstract [Image: see text

Сутність поняття "витрати основної діяльності промислового підприємства"

Розглянуто підходи науковців до визначення поняття "витрати основної діяльності промислового підприємства"