Studies Directed Towards the Synthesis of Biologically Active Molecules

Indolizidine skeleton is one of the most important structural subunits present in numerous biologically active molecules. The polyhydroxy indolizidines are potent biologically active natural products and exhibit specific glycosidase inhibitory activities. Since glycosidases \ud are involved in a wide range of biological processes including those associated with a number of diseases and disorders, inhibitors of these enzymes constitute viable therapeutic targets for the treatment of various diseases and metabolic disorders such as cancer, diabetis, \ud obesity, viral and fungal infection, and lysosomal storage disorders.In addition, indolizidine skeleton is present in anti-cancer agents such as lepadiformine, serratine, tylophorine and crispine A, as well as in immunosuppressive agent FR901483 and antibacterialagent trolline

Studies Directed Towards the Synthesis of Biologically Active Molecules

Indolizidine skeleton is one of the most important structural subunits present in numerous biologically active molecules. The polyhydroxy indolizidines are potent biologically active natural products and exhibit specific glycosidase inhibitory activities. Since glycosidases are involved in a wide range of biological processes including those associated with a number of diseases and disorders, inhibitors of these enzymes constitute viable therapeutic targets for the treatment of various diseases and metabolic disorders such as cancer, diabetis, obesity, viral and fungal infection, and lysosomal storage disorders.In addition, indolizidine skeleton is present in anti-cancer agents such as lepadiformine, serratine, tylophorine and crispine A, as well as in immunosuppressive agent FR901483 and antibacterialagent trolline

A chemoselective oxidation of monosubstituted ethylene glycol: Facile synthesis of optically active α-hydroxy acids

A mild and efficient method for the synthesis of optically active α-hydroxy acids through chemoselective oxidation of monosubstituted ethylene glycols using the TEMPO-NaOCl reagent system is described. It is evident from our studies that the solvent, pH and reaction temperature are very crucial for the success of this oxidation. The versatility of this method has been demonstrated with a variety of aliphatic, aromatic and carbohydrate substrates bearing various functional groups

Geochemistry Data of the Nadergul Granodiorite of the Late Archean Hyderabad Granite Batholith, part of Eastern Dharwar Craton, India; Implications for Composition of the Lower Continental Crust.

The Nadergul granodiorite (NG), is a part of Hyderabad Granite Batholith (HGB), exposed at ground level covering an area of 6 km2. Field observational data suggests that the NG is involved in the magma mixing mingling process. Petrographical data shows holocrystaline, phaneritic, coarse grained, inequigranular, mesocratic characteristics, essentially consists of quartz, orthoclase, plagioclase and microcline. The common accessory minerals are hornblende, biotite, clinopyroxene, zircon, fluorite, apatite and opaque. The myrmekitic texture is the most common intergrowth texture which seems to be magmatic origin. Geochemical data suggest that the NG is metaluminous and show calc-alkaline trend. It is charecterised by SiO2 content ranging from 63.55 % to 64.54%, moderate alkali content (Na2O + K2O = 5.6%), relatively high MgO content ranging from 2.8 % to 3.5 %. The total CaO-Na2O-K2O content ranges from 9.5 % to10.4 %. The normalised REE patterns show LREEs enrichment with slight negative europium anomaly. The High Field Strength Elements such as Zr (67.3 to 114.3 ppm), Y (21.1 to 30.1 ppm), Nb (6.3 to 8.5 ppm) and Th (8.4 to 13.8 ppm) are relatively enriched. The granodiorite is I type, falls in the Volcanic Arc Granitoid (VAG) field in tectonic discrimination diagramTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Impact of COVID-19 and Lockdown on Health and Livelihoods of Transgender Individuals in Hyderabad, Telangana

To combat the coronavirus disease which claimed lot of lives globally, India went into a complete lockdown starting March 24, 2020. This study examines the impact of COVID-19 and lockdown on one of the vulnerable groups of populations, that is, transgender people’s livelihoods, health-seeking behavior along with their perceived health-care barriers, and accessibility to health-care services. A cross-sectional descriptive study with mixed methods approach for qualitative data was done in Hyderabad city. Eighty transgender participants identified through snowball sampling method were subjected to structured interviews and 30 among them were chosen randomly and were also subjected to in-depth semi-structured interviews. Data were analyzed using MS Excel and thematic analysis. The COVID-19 lockdown has affected target group’s livelihoods and their health-seeking behavior. The denial of treatment by the doctors and unavailability of health services are hindering their accessibility to health care. Violence/harassment, discrimination, discourtesy, maltreatment, and verbal and physical abuse are major barriers for health-care utilization by transgender individuals. An inclusive policy needs to be put in place for vulnerable groups like transgenders

Rhodium Carbenoid Initiated O–H Insertion/Aldol/Oxy-Cope Cascade for the Stereoselective Synthesis of Functionalized Oxacycles

A novel diazo-cascade approach has been developed for the synthesis of nine-membered oxacycles utilizing readily accessible β-hydroxy vinyl ketones and vinyl diazo esters. The Rh­(II)-catalyzed cascade reaction begins with carbene O–H insertion followed by an intramolecular aldol cyclization to provide a substituted tetrahydrofuran intermediate that undergoes an oxy-Cope rearrangement to provide functionalized nine-membered oxacycles with complete stereoselectivity

Synthesis of substituted hydantoins in low melting mixtures

A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting l-(+)-tartaric acid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ-unsaturated ketoacids and urea under environmentally benign and simple reaction conditions