127 research outputs found
Motivational interviewing and problem solving treatment to reduce type 2 diabetes and cardiovascular disease risk in real life: a randomized controlled trial
BACKGROUND: Intensive lifestyle interventions in well-controlled settings are effective in lowering the risk of chronic diseases such as type 2 diabetes (T2DM) and cardiovascular diseases (CVD), but there are still no effective lifestyle interventions for everyday practice. In the Hoorn Prevention Study we aimed to assess the effectiveness of a primary care based lifestyle intervention to reduce the estimated risk of developing T2DM and for CVD mortality, and to motivate changes in lifestyle behaviors. METHODS: The Hoorn Prevention Study is a parallel group randomized controlled trial, implemented in the region of West-Friesland, the Netherlands. 622 adults with ≥10% estimated risk of T2DM and/or CVD mortality were randomly assigned and monitored over a period of 12 months. The intervention group (n=314) received a theory-based lifestyle intervention based on an innovative combination of motivational interviewing and problem solving treatment, provided by trained practice nurses in 12 general practices. The control group (n=308) received existing health brochures. Primary outcomes was the estimated diabetes risk according to the formula of the Atherosclerosis Risk In Communities (ARIC) Study, and the estimated risk for CVD mortality according to the Systematic COronary Risk Evaluation (SCORE) formula. Secondary outcomes included lifestyle behavior (diet, physical activity and smoking). The research assistants, the principal investigator and the general practitioners were blinded to group assignment. Linear and logistic regression analysis was applied to examine the between-group differences in each outcome measure, adjusted for baseline values. RESULTS: 536 (86.2%) of the 622 participants (age 43.5 years) completed the 6-month follow-up, and 502 (81.2%) completed the 12-month follow-up. The mean baseline T2DM risk was 18.9% (SD 8.2) and the mean CVD mortality risk was 3.8% (SD 3.0). The intervention group participated in a median of 2 sessions. Intention-to-treat analyses showed no significant differences in outcomes between the two groups at 6 or 12-months follow-up. CONCLUSIONS: The lifestyle intervention was not more effective than health brochures in reducing risk scores for T2DM and CVD or improving lifestyle behavior in an at-risk population. TRIAL REGISTRATION: Current Controlled Trials: ISRCTN59358434
Pairing in spin polarized two-species fermionic mixtures with mass asymmetry
We discuss on the pairing mechanism of fermions with mismatch in their fermi
momenta due to a mass asymmetry. Using a variational ansatz for the ground
state we also discuss the BCS -BEC crossover of this system. It is shown that
the breached pairing solution with a single fermi surface is stable in the BEC
regime. We also include the temperatures effect on the fermion pairing within
an approximation that is valid for temperatures much below the critical
temperature.Comment: 8 pages and 6 figures, few typos corrected, version to appear in EPJ
Flow and critical velocity of an imbalanced Fermi gas through an optical potential
Optical lattices offer the possibility to investigate the superfluid
properties of both Bose condensates and Fermionic superfluid gases. When a
population imbalance is present in a Fermi mixture, this leads to frustration
of the pairing, and the superfluid properties will be affected. In this
contribution, the influence of imbalance on the flow of a Fermi superfluid
through an optical lattice is investigated. The flow through the lattice is
analysed by taking into account coupling between neighbouring layers of the
optical lattice up to second order in the interlayer tunneling amplitude for
single atoms. The critical velocity of flow through the lattice is shown to
decrease monotonically to zero as the imbalance is increased to 100%.
Closed-form analytical expressions are given for the tunneling contribution to
the action and for the critical velocity as a function of the binding energy of
pairs in the (quasi) two-dimensional Fermi superfluid and as a function of the
imbalance.Comment: 8 pages, 1 figure, contribution for the QFS 2007 conferenc
Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice
Pneumoviruses such as pneumonia virus of mice (PVM), bovine respiratory syncytial virus (bRSV) or human (h)RSV are closely related pneumoviruses that cause severe respiratory disease in their respective hosts. It is well-known that T-cell responses are essential in pneumovirus clearance, but pneumovirus-specific T-cell responses also are important mediators of severe immunopathology. In this study we determined whether memory- or pre-existing, transferred virus-specific CD8 + T-cells provide protection against PVM-induced disease. We show that during infection with a sublethal dose of PVM, both natural killer (NK) cells and CD8 + T-cells expand relatively late. Induction of CD8 + T-cell memory against a single CD8 + T-cell epitope, by dendritic cell (DC)-peptide immunization, leads to partial protection against PVM challenge and prevents Th2 differentiation of PVM-induced CD4 T-cells. In addition, adoptively transferred PVM-specific CD8 + T-cells, covering the entire PVM-specific CD8 + T-cell repertoire, provide partial protection from PVM-induced disease. From these data we infer that antigen-specific memory CD8 + T-cells offer significant protection to PVM-induced disease. Thus, CD8 + T-cells, despite being a major cause of PVM-associated pathology during primary infection, may offer promising targets of a protective pneumovirus vaccine
Fermionic superfluidity: From high Tc superconductors to ultracold Fermi gases
We present a pairing fluctuation theory which self-consistently incorporates
finite momentum pair excitations in the context of BCS--Bose-Einstein
condensation (BEC) crossover, and we apply this theory to high
superconductors and ultracold Fermi gases. There are strong similarities
between Fermi gases in the unitary regime and high Tc superconductors. Here we
address key issues of common interest, especially the pseudogap. In the Fermi
gases we summarize recent experiments including various phase diagrams (with
and without population imbalance), as well as evidence for a pseudogap in
thermodynamic and other experiments.Comment: Expanded version, invited talk at the 5th International Conference on
Complex Matter -- Stripes 2006, 6 pages, 6 figure
Multilayered feed forward Artificial Neural Network model to predict the average summer-monsoon rainfall in India
In the present research, possibility of predicting average summer-monsoon
rainfall over India has been analyzed through Artificial Neural Network models.
In formulating the Artificial Neural Network based predictive model, three
layered networks have been constructed with sigmoid non-linearity. The models
under study are different in the number of hidden neurons. After a thorough
training and test procedure, neural net with three nodes in the hidden layer is
found to be the best predictive model.Comment: 19 pages, 1 table, 3 figure
Thermodynamic Measurements in a Strongly Interacting Fermi Gas
We conduct a series of measurements on the thermodynamic properties of an
optically-trapped strongly interacting Fermi gas, including the energy ,
entropy , and sound velocity . Our model-independent measurements of
and enable a precision study of the finite temperature thermodynamics. The
data are directly compared to several recent predictions. The
temperature in both the superfluid and normal fluid regime is obtained from the
fundamental thermodynamic relation by parameterizing
the data. Our data are also used to experimentally calibrate the
endpoint temperatures obtained for adiabatic sweeps of the magnetic field
between the ideal and strongly interacting regimes. This enables the first
experimental calibration of the temperature scale used in experiments on
fermionic pair condensation. Our calibration shows that the ideal gas
temperature measured for the onset of pair condensation corresponds closely to
the critical temperature estimated in the strongly interacting regime from the
fits to our data. The results are in very good agreement with recent
predictions. Finally, using universal thermodynamic relations, we estimate the
chemical potential and heat capacity of the trapped gas from the data.Comment: 29 pages, 12 figures. To appear in JLTP online, and in the January,
2009 volum
Detector Description and Performance for the First Coincidence Observations between LIGO and GEO
For 17 days in August and September 2002, the LIGO and GEO interferometer
gravitational wave detectors were operated in coincidence to produce their
first data for scientific analysis. Although the detectors were still far from
their design sensitivity levels, the data can be used to place better upper
limits on the flux of gravitational waves incident on the earth than previous
direct measurements. This paper describes the instruments and the data in some
detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial
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