1,530 research outputs found
Inventory Management with the Internet-Based Direct Channel in a Two-Echelon Supply Chain System
We present a two-echelon dual-channel inventory model in which stocks are kept in both the manufacturer warehouse (upper echelon) and the retail store (lower echelon), and the product is available in two supply channels: the traditional retail store and the web-based direct channel. The system receives stochastic demand from two customer segments: those who prefer the traditional retail store and those who prefer the web-based direct channel. Any order placed through the direct channel is fulfilled through direct delivery from the manufacturer warehouse. When a stockout occurs in either channel, customers are willing to shift the channel with a known probability. Customers who are unwilling to shift the channel result in lost sales. In order to develop operational measures of supply chain flexibility, we define a cost structure which captures two different operational cost factors: inventory holding costs and lost sales costs. Several insights are evident from the numerical experiments. We also examine the performance of two other possible channel strategies: retail-only and direct-only strategies. Simulation outcomes indicate that the dual-channel strategy outperforms the other two channel strategies in most cases, and the cost reductions realized by the flexibility of the dual-channel system could be very significant
Hawkes process modeling of COVID-19 with mobility leading indicators and spatial covariates
Hawkes processes are used in statistical modeling for event clustering and causal inference, while they also can be viewed as stochastic versions of popular compartmental models used in epidemiology. Here we show how to develop accurate models of COVID-19 transmission using Hawkes processes with spatial–temporal covariates. We model the conditional intensity of new COVID-19 cases and deaths in the U.S. at the county level, estimating the dynamic reproduction number of the virus within an EM algorithm through a regression on Google mobility indices and demographic covariates in the maximization step. We validate the approach on both short-term and long-term forecasting tasks, showing that the Hawkes process outperforms several models currently used to track the pandemic, including an ensemble approach and an SEIR-variant. We also investigate which covariates and mobility indices are most important for building forecasts of COVID-19 in the U.S
Self-interaction chromatography as a tool for optimizing conditions for membrane protein crystallization
The second virial coefficient, or B value, is a measurement of how well a protein interacts with itself in solution. These interactions can lead to protein crystallization or precipitation, depending on their strength, with a narrow range of B values (the `crystallization slot') being known to promote crystallization. A convenient method of determining the B value is by self-interaction chromatography. This paper describes how the light-harvesting complex 1-reaction centre core complex from Allochromatium vinosum yielded single straight-edged crystals after iterative cycles of self-interaction chromatography and crystallization. This process allowed the rapid screening of small molecules and detergents as crystallization additives. Here, a description is given of how self-interaction chromatography has been utilized to improve the crystallization conditions of a membrane protein
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Stretchable, Transparent, Ionic Conductors
Existing stretchable, transparent conductors are mostly electronic conductors. They limit the performance of interconnects, sensors, and actuators as components of stretchable electronics and soft machines. We describe a class of devices enabled by ionic conductors that are highly stretchable, fully transparent to light of all colors, and capable of operation at frequencies beyond 10 kilohertz and voltages above 10 kilovolts. We demonstrate a transparent actuator that can generate large strains and a transparent loudspeaker that produces sound over the entire audible range. The electromechanical transduction is achieved without electrochemical reaction. The ionic conductors have higher resistivity than many electronic conductors; however, when large stretchability and high transmittance are required, the ionic conductors have lower sheet resistance than all existing electronic conductors.Chemistry and Chemical BiologyEngineering and Applied SciencesOther Research Uni
X-ray Reflection By Photoionized Accretion Discs
We present the results of reflection calculations that treat the relevant
physics with a minimum of assumptions. The temperature and ionization structure
of the top five Thomson depths of an illuminated disc are calculated while also
demanding that the atmosphere is in hydrostatic equilibrium. In agreement with
Nayakshin, Kazanas & Kallman, we find that there is a rapid transition from hot
to cold material in the illuminated layer. However, the transition is usually
not sharp so that often we find a small but finite region in Thomson depth
where there is a stable temperature zone at T \sim 2 x 10^{6} K due to
photoelectric heating from recombining ions. As a result, the reflection
spectra often exhibit strong features from partially-ionized material,
including helium-like Fe K lines and edges. We find that due to the highly
ionized features in the spectra these models have difficulty correctly
parameterizing the new reflection spectra. There is evidence for a spurious
correlation in the ASCA energy range, where is the reflection
fraction for a power-law continuum of index , confirming the suggestion
of Done & Nayakshin that at least part of the R-Gamma correlation reported by
Zdziarski, Lubinski & Smith for Seyfert galaxies and X-ray binaries might be
due to ionization effects. Although many of the reflection spectra show strong
ionized features, these are not typically observed in most Seyfert and quasar
X-ray spectra.Comment: 16 pages, accepted by MNRAS, Fig. 8 is in colour Figures and tables
changed by a code update. Conclusions unchange
Simultaneous X-ray and Ultraviolet spectroscopy of the Seyfert galaxy NGC 5548. III. X-ray time variability
The Seyfert 1 galaxy NGC 5548 was observed for a week by Chandra using both
the HETGS and LETGS spectrometers. In this paper we study the time variability
of the continuum radiation. During our observation, the source showed a gradual
increase in flux over four days, followed by a rapid decrease and flattening of
the light curve afterwards. Superimposed upon these relatively slow variations
several short duration bursts or quasi-periodic oscillations occured with a
typical duration of several hours and separation between 0.6-0.9 days. The
bursts show a delay of the hard X-rays with respect to the soft X-rays of a few
hours. We interprete these bursts as due to a rotating, fluctuating hot spot at
approximately 10 gravitational radii; the time delay of the hard X-rays from
the bursts agree with the canonical picture of Inverse Compton scattering of
the soft accretion disk photons on a hot medium that is relatively close to the
central black hole.Comment: 6 pages, 7 figures, accepted for publication in Astronomy and
Astrophysic
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