21 research outputs found
Relativistic Generalization of the Gamow Factor for Fermion Pair Production or Annihilation
In the production or annihilation of a pair of fermions, the initial-state or
final-state interactions often lead to significant effects on the reaction
cross sections. For Coulomb-type interactions, the Gamow factor has been
traditionally used to take into account these effects. However the Gamow factor
needs to be modified when the magnitude of the coupling constant or the
relative velocity of two particles increases. We obtain the relativistic
generalization of the Gamow factor in terms of the overlap of the Feynman
amplitude with the relativistic wave function of two fermions with an
attractive Coulomb-type interaction. An explicit form of the corrective factor
is presented for the spin-singlet S-wave state. While the corrective factor
approaches the Gamow factor in the non-relativistic limit, we found that the
Gamow factor significantly over-estimates the effects when the coupling
constant or the velocity is large.Comment: 16 pages, 4 figures in LaTe
Inclusive and Direct Photons in S + Au Central Collisions at 200A GeV/c
A hadron and string cascade model, JPCIAE, which is based on LUND string
model, PYTHIA event generator especially, is used to study both inclusive
photon production and direct photon production in 200A GeV S + Au central
collisions. The model takes into account the photon production from the
partonic QCD scattering process, the hadronic final-state interaction, and the
hadronic decay and deals with them consistently. The results of JPCIAE model
reproduce successfully both the WA93 data of low p_T inclusive photon
distribution and the WA80 data of transverse momentum dependent upper limit of
direct photon. The photon production from different decay channels is
investigated for both direct and inclusive photons. We have discussed the
effects of the partonic QCD scattering and the hadronic final-state interaction
on direct photon production as well.Comment: 6 pages with 5 figure
Simple Dip-Coating Process for the Synthesis of Small Diameter Single-Walled Carbon Nanotubes—Effect of Catalyst Composition and Catalyst Particle Size on Chirality and Diameter
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe
Measurement of jet fragmentation in Pb+Pb and collisions at TeV with the ATLAS detector at the LHC
Magnetocrystalline anisotropy and uniaxiality of MnAs/GaAs(100) films
We present an investigation of the magnetic behavior of epitaxial MnAs films grown on GaAs(100). We address the dependence of the magnetic moment, ferromagnetic transition temperature (T-c), and magnetocrystalline anisotropy constants on epitaxial conditions. From thorough structural and magnetic investigations, our findings indicate a more complex relationship between strain and magnetic properties in MnAs films than a simple stretch/compression of the unit cell axes. While a small increase is seen in the anisotropy constants, the enhancement of the magnetic moment at saturation is significant. Results of x-ray magnetic circular dichroism show a behavior of the spin and orbital moment that is consistent with a structural transition at T-c. In particular, we find that the ratio of the orbital to the spin moment shows a marked increase in the coexistence region of the ferromagnetic alpha- and paramagnetic beta-phases a result that is well in accord with the observed increase in the c/a ratio in the same temperature region. The ab initio density functional calculations reveal that the magnetic properties are more sensitive towards change in the ab-plane compared to change in the c-axis which is explained by the analysis of band structures. The effects of electron correlation in MnAs using ab initio dynamical mean field theory are also presented
Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies
Alveolar Rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer with about 80% of cases characterized by either a t(1;13)(p36;q14) or t(2;13)(q35;q14), which results in the formation of the fusion oncogenes PAX7-FOXO1 and PAX3-FOXO1, respectively. Since patients with fusion-positive ARMS (FP-RMS) have a poor prognosis and are treated with an aggressive therapeutic regimen, correct classification is of clinical importance. Detection of the translocation by different molecular methods is used for diagnostics, including fluorescence in situ hybridization and RT-PCR or NGS based approaches. Since these methods are complex and time consuming, we developed specific monoclonal antibodies (mAbs) directed to the junction region on the PAX3-FOXO1 fusion protein. Two mAbs, PFM.1 and PFM.2, were developed and able to immunoprecipitate in vitro-translated PAX3-FOXO1 and cellular PAX3-FOXO1 from FP-RMS cells. Furthermore, the mAbs recognized a 105 kDa band in PAX3-FOXO1-transfected cells and in FP-RMS cell lines. The mAbs did not recognize proteins in fusion-negative embryonal rhabdomyosarcoma cell lines, nor did they recognize PAX3 or FOXO1 alone when compared to anti-PAX3 and anti-FOXO1 antibodies. We next evaluated the ability of mAb PFM.2 to detect the fusion protein by immunohistochemistry. Both PAX3-FOXO1 and PAX7-FOXO1 were detected in HEK293 cells transfected with the corresponding cDNAs. Subsequently, we stained 26 primary tumor sections and a rhabdomyosarcoma tissue array and detected both fusion proteins with a positive predictive value of 100%, negative predictive value of 98%, specificity of 100% and a sensitivity of 91%. While tumors are stained homogenously in PAX3-FOXO1 cases, the staining pattern is heterogenous with scattered positive cells only in tumors expressing PAX7-FOXO1. No staining was observed in stromal cells, embryonal rhabdomyosarcoma, and fusion-negative rhabdomyosarcoma. These results demonstrate that mAbs specific for the chimeric oncoproteins PAX3-FOXO1 and PAX7-FOXO1 can be used efficiently for simple and fast subclassification of rhabdomyosarcoma in routine diagnostics via immunohistochemical detection
Simple Dip-Coating Process for the Synthesis of Small Diameter Single-Walled Carbon NanotubesEffect of Catalyst Composition and Catalyst Particle Size on Chirality and Diameter
We report on a dip-coating method to prepare catalyst
particles
(mixture of iron and cobalt) with a controlled diameter distribution
on silicon wafer substrates by changing the solution's concentration
and withdrawal velocity. The size and distribution of the prepared
catalyst particles were analyzed by atomic force microscopy. Carbon
nanotubes were grown by chemical vapor deposition on the substrates
with the prepared catalyst particles. By decreasing the catalyst particle
size to below 10 nm, the growth of carbon nanotubes can be tuned from
few-walled carbon nanotubes, with homogeneous diameter, to highly
pure single-walled carbon nanotubes. Analysis of the Raman radial
breathing modes, using three different Raman excitation wavelengths
(488, 633, and 785 nm), showed a relatively broad diameter distribution
(0.8–1.4 nm) of single-walled carbon nanotubes with different
chiralities. However, by changing the composition of the catalyst
particles while maintaining the growth parameters, the chiralities
of single-walled carbon nanotubes were reduced to mainly four different
types, (12, 1), (12, 0), (8, 5), and (7, 5), accounting for about
70% of all nanotubes