Noradrenaline effects on social behaviour, intergroup relations, and moral decisions

Recent research has begun to elucidate the neural basis of higher order social concepts, such as the mechanisms involved in intergroup relations, and moral judgments. Most theories have concentrated on higher order emotions, such as guilt, shame, or empathy, as core mechanisms. Accordingly, psychopharmacological and neurobiological studies have investigated the effects of manipulating serotonin or oxytocin activity on moral and social decisions and attitudes. However, recently it has been determined that changes in more basic emotions, such as fear and anger, might also have a significant role in social and moral cognition. This article summarizes psychopharmacological and fMRI research on the role of noradrenaline in higher order social cognition suggesting that indeed noradrenergic mediated affective changes might play key – and probably causal – role in certain social attitudes and moral judgments. Social judgments may also be directly influenced by numerous neurotransmitter manipulations but these effects could be mediated by modulation of basic emotions which appear to play an essential role in the formation of social concepts and moral behaviour

Collecting development data with mobile phones: Key considerations from a review of the evidence

Growth in mobile phone access and ownership presents an opportunity to collect more data, more frequently, from more people, and for less money. There are multiple ways to collect data with mobile phones (SMS, voice calls, etc.), each with particular strengths and weaknesses. n The best mode of data collection depends on the characteristics of the target population (e.g. literacy, network access, acceptability of using mobile phones, etc.) and of the data to be collected (e.g. quantitative vs. qualitative, number of questions, sensitivity of information, etc)

Immunological Control of Polyoma Virus Oncogenesis in Mice

Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized with polyoma virus; none developed tumours. Similar results were obtained in mice deliberately infected with polyoma virus but not with leprosy organisms. Passive transfer of antibody before but not after virus inoculation prevented tumour formation in immunosuppressed recipients. Virus infection in thymectomized, lethally irradiated and bone marrow reconstituted mice resulted in only a very low incidence of tumours. These results emphasize the role of immunological surveillance in preventing polyoma tumour formation under natural conditions

Delivering Optimal Care to People with Cognitive Impairment in Parkinson’s Disease: A Qualitative Study of Patient, Caregiver, and Professional Perspectives

Background: Cognitive impairment is common in Parkinson’s disease (PD) and associated with lower quality of life. Cognitive impairment in PD manifests differently to other dementia pathologies. Provision of optimal care requires knowledge about the support needs of this population. // Methods: Eleven people with PD and cognitive impairment (PwP), 10 family caregivers, and 27 healthcare professionals were purposively sampled from across the United Kingdom. Semistructured interviews were conducted in 2019–2021, audio-recorded, transcribed, and analysed using reflexive thematic analysis. // Results: Cognitive impairment in PD conveyed increased complexity for clinical management and healthcare interactions, the latter driven by multifactorial communication difficulties. Techniques that helped included slow, simple, and single messages, avoiding topic switching. Information and emotional support needs were often unmet, particularly for caregivers. Diagnostic pathways were inconsistent and awareness of cognitive impairment in PD was poor, both contributing to underdiagnosis. Many felt that PwP and cognitive impairment fell through service gaps, resulting from disjointed, nonspecific, and underresourced services. Personalised care was advocated through tailoring to individual needs of PwP and caregivers facilitated by flexibility, time and continuity within services, and supporting self-management. // Conclusions: This study highlights unmet need for people with this complex condition. Clinicians should adapt their approach and communication techniques for this population and provide tailored information and support to both PwP and caregivers. Services need to be more streamlined and collaborative, providing more time and flexibility. There is a need for wider awareness and deeper understanding of this condition and its differences from other types of dementia

Should We Be Screening for and Treating Periodontal Disease in Individuals Who Are at Risk of Rheumatoid Arthritis?

There is increasing evidence supporting an association between periodontal disease (PD) and rheumatoid arthritis (RA), both mechanistically and clinically. Trials have shown that treating PD in people with RA may improve RA disease activity. Patients with musculoskeletal symptoms without arthritis, who test positive for cyclic-citrullinated protein antibodies, are at risk of RA (CCP+ at-risk), with seropositivity preceding arthritis onset by months or years. Importantly, there is evidence to suggest that periodontal inflammation may precede joint inflammation in CCP+ at-risk and, therefore, this could be a trigger for RA. There has been increased research interest in RA prevention and the phenotyping of the pre-RA disease phase. This review will examine the merits of identifying individuals who are CCP+ at-risk and performing screening for PD. In addition, we discuss how PD should be treated once identified. Finally, the review will consider future research needed to advance our understanding of this disease association

Surveillance of Climate-smart Agriculture for Nutrition (SCAN): Innovations for monitoring climate, agriculture and nutrition at scale

Climate change will affect the ability to deliver not only the quantity but also the type and quality of food necessary for nutritious diets. Global and regional 'climate-smart agriculture' initiatives offer an opportunity to mitigate climate impacts and improve nutrition outcomes at scale. The Surveillance of Climate-smart Agriculture for Nutrition (SCAN) project develops new way to acquire, integrate and analyze data to determine what is climate-smart and nutrition-sensitive

Effects of working memory on naturally occurring cravings

This is the author accepted manuscriptElaborated Intrusion (EI) theory posits a key role for visuospatial working memory (WM) in craving. In line with the predictions of EI theory, several studies have found that WM and craving show mutually interfering effects - for example, performance of visuospatial WM tasks has been found to attenuate naturally occurring cravings. However, the extent to which these effects are driven specifically by visuospatial processing remains unclear. We conducted two experiments to investigate the effects of WM on naturally occurring cravings in more detail. In experiment 1, we examined whether such effects are driven specifically by visuospatial WM processes or can also be induced by a verbal WM task. Subjective craving ratings were attenuated equally by performance of visuospatial and verbal WM tasks, suggesting that craving is not dependent specifically on visuospatial processing. In experiment 2, we examined whether effects of visuospatial WM on craving could be driven by simple distraction. Naturally occurring cravings were attenuated in a control condition with minimal WM demands (watching a video). However, the magnitude of attenuation was significantly greater in a visuospatial WM condition. Taken together, these findings highlight a key role for WM in the attenuation of naturally occurring craving, but do not support the hypothesis that such effects are dependent specifically on visuospatial processing

Language intermediaries and local agency: peacebuilding, translation/interpreting and political disempowerment in 'mature' post-Dayton Bosnia-Herzegovina

The peace negotiations that ended the 1992–95 war in Bosnia-Herzegovina established a constitutional system of ethnic power-sharing that satisfied its signatories (the presidents of Serbia, Croatia and Bosnia) enough for war to cease and provided for international military and civilian peacebuilding to play a significant role in post-conflict Bosnia’s governance and economy. This indefinite peacebuilding mission, still ongoing in a downsized form, depended – like any other form of intervention where foreigners work across linguistic boundaries – on interlinguistic mediation by locally-recruited translators/interpreters, an aspect of knowledge production that even current peace and conflict research into peacebuilding’s micropolitics often neglects. On an individual level, locally-recruited interpreters’ frequently-overlooked agency was integral to peacebuilding practice. Yet theorising their agency must also acknowledge the macrosocial level, where the post-war constitutional system has often been argued to have stripped Bosnians of political agency, since it foreclosed political participation as anything but an ethnic subject corresponding to the three institutionalised ethnic identities (Bosniak, Croat or Serb). The entrenched and growing disconnect between political elites and the public, expressed through social protest in 2014, foregrounds the problem of agency and dis/empowerment in Bosnian society more sharply than research on the politics of translation/interpreting and peacebuilding in Bosnia before 2014 took into account, yet reveals further articulations of how international peacebuilding and domestic political contestation were intertwined

Vertex Operators for Closed Superstrings

We construct an iterative procedure to compute the vertex operators of the closed superstring in the covariant formalism given a solution of IIA/IIB supergravity. The manifest supersymmetry allows us to construct vertex operators for any generic background in presence of Ramond-Ramond (RR) fields. We extend the procedure to all massive states of open and closed superstrings and we identify two new nilpotent charges which are used to impose the gauge fixing on the physical states. We solve iteratively the equations of the vertex for linear x-dependent RR field strengths. This vertex plays a role in studying non-constant C-deformations of superspace. Finally, we construct an action for the free massless sector of closed strings, and we propose a form for the kinetic term for closed string field theory in the pure spinor formalism.Comment: TeX, harvmac, amssym.tex, 41 pp; references adde

Origin of Pure Spinor Superstring

The pure spinor formalism for the superstring, initiated by N. Berkovits, is derived at the fully quantum level starting from a fundamental reparametrization invariant and super-Poincare invariant worldsheet action. It is a simple extension of the Green-Schwarz action with doubled spinor degrees of freedom with a compensating local supersymmetry on top of the conventional kappa-symmetry. Equivalence to the Green-Schwarz formalism is manifest from the outset. The use of free fields in the pure spinor formalism is justified from the first principle. The basic idea works also for the superparticle in 11 dimensions.Comment: 21 pages, no figure; v2: refs. adde