Suitability of high-resolution seismic method to identifying petroleum reservoirs in Kansas--a geological perspective

Kansas has been a part of a stable craton since at least the beginning of the Paleozoic some 550 m. y. ago. The majority of the sedimentary rocks deposited during the last 550 m. y. are products of numerous inundations by shallow seas. Interspersed with these transgressions were periods of erosion, many coinciding with widespread uplift. The distribution of reservoir-quality rocks has been controlled by the varying structural and depositional settings in both time and space. The identification of these reservoirs begins with a knowledge of the geologic history as detailed by the vast subsurface information base, mainly wire line logs and completion records, that is available for Kansas. Seismic profiling has been and will continue to be used effectively to resolve structural traps. The trend in exploration in the midcontinent has been to strengthen the search for reservoirs associated with more subtle structures and difficult-to-find stratigraphic traps. Stratigraphic traps will become increasingly important, particularly within established production trends. The many unconformities in the midcontinent stratigraphic column afford numerous types of trapping geometry such as truncation beneath an unconformity, traps associated with buried valleys, discontinuous onlap onto erosion surfaces, and porosity pinchouts due to changes in original depositional conditions and diagenetic alteration. The most widespread petroleum accumulations in Kansas occur in structural and stratigraphic traps associated with the pre-Pennsylvanian unconformity. Production associated with the unconformity includes numerous lower Paleozoic pay zones which subcrop directly beneath the unconformity in the Sedgwick, Salina, and Anadarko basins; the Arbuckle production on the Central Kansas uplift; and numerous fields which payout from either conglomerates or weathered zones along the unconformity. Considerable production also occurs farther up-section with the Cherokee and Lansing-Kansas City groups, and down-section in the Viola Formation and Simpson Group. In order to demonstrate the potential use of the seismic method in defining subtle traps, synthetic seismograms were produced for selected strata in central Kansas. Critical attributes of reservoir rock and associated strata conducive to seismic stratigraphic processing include the thickness of a potential reservoir bed and its velocity and density contrast with adjacent strata. Thicker strata such as the Morrow and most lower Paleozoic formations may be more easily defined by seismic-stratigraphic methods. In contrast, the stratigraphy of the Pennsylvanian and Permian cyclothems may not be amenable to definition by seismic methods because these units contain heterogenous reservoirs interbedded with other thin strata of similar composition

Suitability of high-resolution seismic method to identifying petroleum reservoirs in Kansas--a geological perspective

Kansas has been a part of a stable craton since at least the beginning of the Paleozoic some 550 m. y. ago. The majority of the sedimentary rocks deposited during the last 550 m. y. are products of numerous inundations by shallow seas. Interspersed with these transgressions were periods of erosion, many coinciding with widespread uplift. The distribution of reservoir-quality rocks has been controlled by the varying structural and depositional settings in both time and space. The identification of these reservoirs begins with a knowledge of the geologic history as detailed by the vast subsurface information base, mainly wire line logs and completion records, that is available for Kansas. Seismic profiling has been and will continue to be used effectively to resolve structural traps. The trend in exploration in the midcontinent has been to strengthen the search for reservoirs associated with more subtle structures and difficult-to-find stratigraphic traps. Stratigraphic traps will become increasingly important, particularly within established production trends. The many unconformities in the midcontinent stratigraphic column afford numerous types of trapping geometry such as truncation beneath an unconformity, traps associated with buried valleys, discontinuous onlap onto erosion surfaces, and porosity pinchouts due to changes in original depositional conditions and diagenetic alteration. The most widespread petroleum accumulations in Kansas occur in structural and stratigraphic traps associated with the pre-Pennsylvanian unconformity. Production associated with the unconformity includes numerous lower Paleozoic pay zones which subcrop directly beneath the unconformity in the Sedgwick, Salina, and Anadarko basins; the Arbuckle production on the Central Kansas uplift; and numerous fields which payout from either conglomerates or weathered zones along the unconformity. Considerable production also occurs farther up-section with the Cherokee and Lansing-Kansas City groups, and down-section in the Viola Formation and Simpson Group. In order to demonstrate the potential use of the seismic method in defining subtle traps, synthetic seismograms were produced for selected strata in central Kansas. Critical attributes of reservoir rock and associated strata conducive to seismic stratigraphic processing include the thickness of a potential reservoir bed and its velocity and density contrast with adjacent strata. Thicker strata such as the Morrow and most lower Paleozoic formations may be more easily defined by seismic-stratigraphic methods. In contrast, the stratigraphy of the Pennsylvanian and Permian cyclothems may not be amenable to definition by seismic methods because these units contain heterogenous reservoirs interbedded with other thin strata of similar composition

Variations and Determinants of Hospital Costs for Acute Stroke in China

BACKGROUND: The burden of stroke is high and increasing in China. We modelled variations in, and predictors of, the costs of hospital care for patients with acute stroke in China. METHODS AND FINDINGS: Baseline characteristics and hospital costs for 5,255 patients were collected using the prospective register-based ChinaQUEST study, conducted in 48 Level 3 and 14 Level 2 hospitals in China during 2006-2007. Ordinary least squares estimation was used to determine factors associated with hospital costs. Overall mean cost of hospitalisation was 11,216 Chinese Yuan Renminbi (CNY) (≈US$1,602) per patient, which equates to more than half the average annual wage in China. Variations in cost were largely attributable to stroke severity and length of hospital stay (LOS). Model forecasts showed that reducing LOS from the mean of 20 days for Level 3 and 18 days for Level 2 hospitals to a duration of 1 week, which is common among Western countries, afforded cost reductions of 49% and 19%, respectively. Other lesser determinants varied by hospital level: in Level 3 hospitals, health insurance and the occurrence of in-hospital complications were each associated with 10% and 18% increases in cost, respectively, whilst treatment in a teaching hospital was associated with approximately 39% decrease in cost on average. For Level 2 hospitals, stroke due to intracerebral haemorrhage was associated with a 19% greater cost than for ischaemic stroke. CONCLUSIONS: Changes to hospital policies to standardise resource use and reduce the variation in LOS could attenuate costs and improve efficiencies for acute stroke management in China. The success of these strategies will be enhanced by broader policy initiatives currently underway to reform hospital reimbursement systems

Full characterization of vibrational coherence in a porphyrin chromophore by two-dimensional electronic spectroscopy

In this work we present experimental and calculated two-dimensional electronic spectra for a 5,15-bisalkynyl porphyrin chromophore. The lowest energy electronic Qy transition couples mainly to a single 380 cm–1 vibrational mode. The two-dimensional electronic spectra reveal diagonal and cross peaks which oscillate as a function of population time. We analyze both the amplitude and phase distribution of this main vibronic transition as a function of excitation and detection frequencies. Even though Feynman diagrams provide a good indication of where the amplitude of the oscillating components are located in the excitation-detection plane, other factors also affect this distribution. Specifically, the oscillation corresponding to each Feynman diagram is expected to have a phase that is a function of excitation and detection frequencies. Therefore, the overall phase of the experimentally observed oscillation will reflect this phase dependence. Another consequence is that the overall oscillation amplitude can show interference patterns resulting from overlapping contributions from neighboring Feynman diagrams. These observations are consistently reproduced through simulations based on third order perturbation theory coupled to a spectral density described by a Brownian oscillator model

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR)

Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt metal ion of the corrin ring from Co(II) to Co(I) before adenosylation can take place. A corrin reductase (CobR) enzyme has been identified as the likely agent to catalyse this reduction of the metal ion. Herein, we reveal how Brucella melitensis CobR binds its coenzyme FAD (flavin dinucleotide) and we also show that the enzyme can bind a corrin substrate consistent with its role in reduction of the cobalt of the corrin ring. Stopped-flow kinetics and EPR reveal a mechanistic asymmetry in CobR dimer that provides a potential link between the two electron reduction by NADH to the single electron reduction of Co(II) to Co(I)

The state of peer-to-peer network simulators

Networking research often relies on simulation in order to test and evaluate new ideas. An important requirement of this process is that results must be reproducible so that other researchers can replicate, validate and extend existing work. We look at the landscape of simulators for research in peer-to-peer (P2P) networks by conducting a survey of a combined total of over 280 papers from before and after 2007 (the year of the last survey in this area), and comment on the large quantity of research using bespoke, closed-source simulators. We propose a set of criteria that P2P simulators should meet, and poll the P2P research community for their agreement. We aim to drive the community towards performing their experiments on simulators that allow for others to validate their results

Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fractionation in patients with locoregionally advanced nasopharyngeal carcinoma

© 2014 American Cancer Society. BACKGROUND A current recommendation for locoregionally advanced nasopharyngeal carcinoma (NPC) is conventional fractionated radiotherapy with concurrent cisplatin plus adjuvant cisplatin and fluorouracil (PF). In this randomized trial, the authors evaluated the potential therapeutic benefit from changing to an induction-concurrent chemotherapy sequence, replacing fluorouracil with oral capecitabine, and/or using accelerated rather than conventional radiotherapy fractionation. METHODS Patients with stage III through IVB, nonkeratinizing NPC were randomly allocated to 1 of 6 treatment arms. The protocol was amended in 2009 to permit confining randomization to the conventional fractionation arms. The primary endpoint was progression-free survival. Secondary endpoints included overall survival and safety. RESULTS In total, 803 patients were accrued, and 706 patients were randomly allocated to all 6 treatment arms. Comparisons of induction PF versus adjuvant PF did not indicate a significant improvement. Unadjusted comparisons of induction cisplatin and capecitabine (PX) versus adjuvant PF indicated a favorable trend in progression-free survival for the conventional fractionation arm (P = .045); analyses that were adjusted for other significant factors and fractionation reflected a significant reduction in the hazards of disease progression (hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.36-0.80) and death (HR, 0.42; 95% CI, 0.25-0.70). Unadjusted comparisons of induction sequences versus adjuvant sequences did not reach statistical significance, but adjusted comparisons indicated favorable improvements by induction sequence. Comparisons of induction PX versus induction PF revealed fewer toxicities (neutropenia and electrolyte disturbance), unadjusted comparisons of efficacy were statistically insignificant, but adjusted analyses indicated that induction PX had a lower hazard of death (HR, 0.57; 95% CI, 0.34-0.97). Changing the fractionation from conventional to accelerated did not achieve any benefit but incurred higher toxicities (acute mucositis and dehydration). CONCLUSIONS Preliminary results indicate that the benefit of changing to an induction-concurrent sequence remains uncertain; replacing fluorouracil with oral capecitabine warrants further validation in view of its convenience, favorable toxicity profile, and favorable trends in efficacy; and accelerated fractionation is not recommended for patients with locoregionally advanced NPC who receive chemoradiotherapy.postprin

Two-Dimensional Electronic Spectroscopy of Chlorophyll a: Solvent Dependent Spectral Evolution

The interaction of the monomeric chlorophyll Q-band electronic transition with solvents of differing physical-chemical properties is investigated through two-dimensional electronic spectroscopy (2DES). Chlorophyll constitutes the key chromophore molecule in light harvesting complexes. It is well-known that the surrounding protein in the light harvesting complex fine-tunes chlorophyll electronic transitions to optimize energy transfer. Therefore, an understanding of the influence of the environment on the monomeric chlorophyll electronic transitions is important. The Q-band 2DES is inhomogeneous at early times, particularly in hydrogen bonding polar solvents, but also in nonpolar solvents like cyclohexane. Interestingly this inhomogeneity persists for long times, even up to the nanosecond time scale in some solvents. The reshaping of the 2DES occurs over multiple time scales and was assigned mainly to spectral diffusion. At early times the reshaping is Gaussian-like, hinting at a strong solvent reorganization effect. The temporal evolution of the 2DES response was analyzed in terms of a Brownian oscillator model. The spectral densities underpinning the Brownian oscillator fitting were recovered for the different solvents. The absorption spectra and Stokes shift were also properly described by this model. The extent and nature of inhomogeneous broadening was a strong function of solvent, being larger in H-bonding and viscous media and smaller in nonpolar solvents. The fastest spectral reshaping components were assigned to solvent dynamics, modified by interactions with the solute