Associations of Elements of Parental Social Integration with Migrant Children's Vaccination: An Epidemiological Analysis of National Survey Data in China.

Our study explored the effects of parental social integration on migrant children's vaccination status in China. Using data obtained from the 2014 China Migrants Dynamic Survey, a total of 4915 participants were included in this study. Social integration was measured by economic, social, cultural, and internal identity. Univariate chi-square testing was used to calculate associations between all variables and migrant children's vaccination status. Binary logistic regression was employed to calculate the impacts of social integration on migrant children's vaccination status. In total, 94.7% of migrant children had complete vaccinations for their age. Migrants who had medical insurance, spoke the native language when communicating with locals, lived mainly with locals, and did not perceive discrimination were more likely to have their children completely vaccinated. Social integration was positively associated with migrant children's vaccination status. Our study indicated that to improve vaccination coverage of migrant children, more policy support for migrant employment and housing, promotion of health services for migrants, and language support in health institutions is needed

A Modified Hyaluronic Acid–Based Dissolving Microneedle Loaded With Daphnetin Improved the Treatment of Psoriasis

Psoriasis is a common chronic immune-inflammatory disease. Challenges exist in the present treatment of psoriasis, such as difficulties in transdermal drug administration and severe side effects. We hope to achieve a better therapeutic outcome for psoriasis treatment. By using modified soluble microneedles (MNs) loaded with daphnetin, the psoriasis symptoms of mice, the abnormal proliferation of keratinocytes, and the secretion of inflammatory factors were significantly reduced. In vitro, daphnetin is proven to inhibit the NF-κB signaling pathway and to inhibit the proliferation of HaCaT cells and the release of inflammatory factors, especially CCL20. This research showed that the modified microneedle loaded with daphnetin optimized transdermal drug delivery and relieved the symptoms of psoriasis more effectively. The novel route of Daph administration provides a future research direction for the treatment of psoriasis

Research on the Perception of Historical District of Eight Great Passes in Qingdao Based on Online Travel Notes

In recent years, the protection mode of historical blocks has changed from simple material protection to comprehensive protection integrating various factors, and more and more attention has been paid to the role of human perception. How to pay attention to the practical experience of consumers while protecting has become the main problem. This paper studies the tourists' perception of historical district of Eight Great Passes in Qingdao by using the method of network text analysis, and carries out word frequency analysis, semantic network analysis and emotional analysis on the online travel notes by Rost CM6, so as to comprehend the current situation of tourists' perception of different dimensions of Eight Great Passes historical and Cultural District in Qingdao, and find out the problems in its development as well as put forward the sustainable development strategie

Water Retention Evaluation of Slab Trench on Rocky Desertification Slope in a Karst Area of Southwest China

Soil erosion and water loss are serious problems on the rocky desertification slopes in the karst dynamic system of southwest China. The lack of soil and shortage of water restrict the ecological restoration of the regional slopes and utility of water resources. Therefore, a new slab trench capable of storing soil and water in layers on rocky desertification slopes is introduced in this paper to promote vegetation restoration. To explore the water-storing and -holding capacity of the new type of vegetated slab trench, five groups of model experiments were carried out on the vegetated slab trench under different rainfall intensities and different numbers of plants. Under rainfall and then following dry conditions, the effects of rainfall intensity and the number of plants on the water-storing and -holding capacity of vegetated slab trench models were compared and analyzed. Water-storing and -holding capacity was further explored in three groups of models with single planting or combinations of plants including water stored only in succulent root plant, only in succulent stem plant, or in mixed plants. The test results show that the new type of vegetated slab trench can effectively help to store and hold water. In the rainfall period, due to the runoff of the rainfall not being considered, the greater the rainfall intensity, the higher the water storage efficiency; the more vegetation implanted, the greater the blocking effect of the plant canopy during falling rainwater, and the more reduction is induced on the water storage efficiency of the vegetated slab trench. In the following dry period, both the succulent root plant and succulent stem plant have strong water storage capacity, but the succulent root plant has a stronger capacity for water storage. The growth status of the mixed plants was better than that of single planting, which may be due to the water complementarities between the succulent root plant and succulent stem plant in a mixed planting manner. This study is important for solving the problem of soil erosion and water loss in rocky desertification slopes, and it helps to restore the ecological environment of the area

Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast

Objectives: Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in the process of wound healing. This research comprehensively studied the regulation of Hst 1 on the function of fibroblasts in the process of wound healing and preliminary mechanism about it. Materials and methods: The full-thickness skin wound model was made on the back of C57/BL6 mice. The wound healing, collagen deposition and fibroblast distribution were detected on days 3, 5 and 7 after injury. Fibroblast was cultured in vitro and stimulated with Hst 1, and then, their biological characteristics and functions were detected. Results: Histatin 1 can effectively promote wound healing, improve collagen deposition during and after healing and increase the number and function of fibroblasts. After healing, the mechanical properties of the skin also improved. In vitro, the migration ability of fibroblasts stimulated by Hst 1 was significantly improved, and the fibroblasts transformed more into myofibroblasts, which improved the function of contraction and collagen secretion. In fibroblasts, mTOR signalling pathway can be activated by Hst 1. Conclusions: Histatin 1 can accelerate wound healing and improve the mechanical properties of healed skin by promoting the function of fibroblasts. The intermolecular mechanisms need to be further studied, and this study provides a direction about mTOR signalling pathway