Brain connectivity Patterns Dissociate action of specific Acupressure Treatments in Fatigued Breast cancer survivors

Funding This work was supported by grants R01 CA151445 and 2UL1 TR000433-06 from the National Institutes of Health. The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. We thank the expert assistance by Dr. Bradley Foerster in acquisition of 1H-MRS and fMRI data.Peer reviewedPublisher PD

Ensuring Safe Exploration: Ares Launch Vehicle Integrated Vehicle Ground Vibration Testing

Ground vibration testing has been an integral tool for developing new launch vehicles throughout the space age. Several launch vehicles have been lost due to problems that would have been detected by early vibration testing, including Ariane 5, Delta III, and Falcon 1. NASA will leverage experience and testing hardware developed during the Saturn and Shuttle programs to perform ground vibration testing (GVT) on the Ares I crew launch vehicle and Ares V cargo launch vehicle stacks. NASA performed dynamic vehicle testing (DVT) for Saturn and mated vehicle ground vibration testing (MVGVT) for Shuttle at the Dynamic Test Stand (Test Stand 4550) at Marshall Space Flight Center (MSFC) in Huntsville, Alabama, and is now modifying that facility to support Ares I integrated vehicle ground vibration testing (IVGVT) beginning in 2012. The Ares IVGVT schedule shows most of its work being completed between 2010 and 2014. Integrated 2nd Stage Ares IVGVT will begin in 2012 and IVGVT of the entire Ares launch stack will begin in 2013. The IVGVT data is needed for the human-rated Orion launch vehicle's Design Certification Review (DCR) in early 2015. During the Apollo program, GVT detected several serious design concerns, which NASA was able to address before Saturn V flew, eliminating costly failures and potential losses of mission or crew. During the late 1970s, Test Stand 4550 was modified to support the four-body structure of the Space Shuttle. Vibration testing confirmed that the vehicle's mode shapes and frequencies were better than analytical models suggested, however, the testing also identified challenges with the rate gyro assemblies, which could have created flight instability and possibly resulted in loss of the vehicle. Today, NASA has begun modifying Test Stand 4550 to accommodate Ares I, including removing platforms needed for Shuttle testing and upgrading the dynamic test facilities to characterize the mode shapes and resonant frequencies of the vehicle. The IVGVT team expects to collect important information about the new launch vehicles, greatly increasing astronaut safety as NASA prepares to explore the Moon and beyond

Multi‐system repeatability and reproducibility of apparent diffusion coefficient measurement using an ice‐water phantom

Purpose: To determine quantitative quality control procedures to evaluate technical variability in multi‐center measurements of the diffusion coefficient of water as a prerequisite to use of the biomarker apparent diffusion coefficient (ADC) in multi‐center clinical trials. Materials and Methods: A uniform data acquisition protocol was developed and shared with 18 participating test sites along with a temperature‐controlled diffusion phantom delivered to each site. Usable diffusion weighted imaging data of ice water at five b‐values were collected on 35 clinical MRI systems from three vendors at two field strengths (1.5 and 3 Tesla [T]) and analyzed at a central processing site. Results: Standard deviation of bore‐center ADCs measured across 35 scanners was 10%) vendor‐specific and system‐specific spatial nonuniformity ADC bias was detected for the off‐center measurement that was consistent with gradient nonlinearity. Conclusion: Standardization of DWI protocol has improved reproducibility of ADC measurements and allowed identifying spatial ADC nonuniformity as a source of error in multi‐site clinical studies. J. Magn. Reson. Imaging 2013;37:1238–1246. © 2012 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97442/1/23825_ftp.pd

Perceptions of high involvement work practices, person-organization fit and burnout: a time lagged study of health care employees

Previous research demonstrates that high involvement work practices (HIWPs) may be associated with burnout (emotional exhaustion and depersonalization); however, to date, the process through which HIWPs influence burnout is not clear. This article examined the impact of HIWPs on long term burnout (emotional exhaustion and depersonalization) by considering the mediating role of person-organization fit (P-O fit) in this relationship. The study used a time lagged design and was conducted in a Canadian general hospital amongst health care personnel. Findings from structural equation modeling (N = 185) revealed that perceived HIWPs were positively associated with P-O fit. There was no direct effect of HIWPs on burnout; rather, P-O fit fully mediated the relationship between employee perceptions of HIWPs and burnout. This study fills a void in the HR and burnout literature by demonstrating the role that P-O fit has in explaining how HIWPs alleviates emotional exhaustion and depersonalization

Objectives and Progress on Ground Vibration Testing for the Ares Launch Vehicles

NASA has conducted dynamic tests on each of its major launch vehicles during the past 45 years. Each test has provided invaluable data to correlate and correct analytical models used to predict structural responses to differing dynamics for these vehicles. With both Saturn V and Space Shuttle, hardware changes were also required to the flight vehicles to ensure crew and vehicle safety. The Ares I IVGVT will undoubtedly provide similar valuable test data to support successful flights of the Constellation Program. The IVGVT will provide test determined natural frequencies, mode shapes and damping for the Ares I. This data will be used to support controls analysis by providing this test data to reduce uncertainty in the models. The value of this testing has been proven by past launch vehicle successes and failures. Performing dynamic testing on the Ares vehicles will provide confidence that the launch vehicles will be safe and successful in their missions. In addition, IVGVT will provide the following benefits for the Ares rockets: a) IVGVT data along with Ares development flights like Ares I-X, Ares I-Y, Ares I-X Prime, and Orion-1 or others will reduce the risk to the Orion-2 crew. IVGVT will permit anchoring the various analytical and operational models used in so many different aspects of Ares operations. b) IVGVT data will permit better understanding of the structural and GN&C margins of the spacecraft and may permit mass savings or expanded day-of-launch opportunities or fewer constraints to launch. c) Undoubtedly IVGVT will uncover some of the "unknown unknowns" so often seen in developing, launching, and flying new spacecraft vehicles and data from IVGVT may help prevent a loss of vehicle or crew. d) IVGVT also will be the first time Ares I flight-like hardware is transported, handled, rotated, mated, stacked, and integrated. e) Furthermore, handling and stacking the IVGVT launch vehicle stacks will be an opportunity to understand certain aspects of vehicle operability much better (for example, handling procedures, touch-labor time to accomplish tasks, access at interfaces, access to stage mating bolts, access to avionics boxes, access to the Interstage, GSE functionality, and many other important aspects of Ares I operability). All of these results will provide for better vehicle safety and better stewardship of national resources as NASA begins its next phase of human space exploration

F07RS SGB No. 2 (SG Surplus)

A BILL To allocate funds from the Student Government Surplus Accoun

A modelling approach towards Epidermal homoeostasis control

In order to grasp the features arising from cellular discreteness and individuality, in large parts of cell tissue modelling agent-based models are favoured. The subclass of off-lattice models allows for a physical motivation of the intercellular interaction rules. We apply an improved version of a previously introduced off-lattice agent-based model to the steady-state flow equilibrium of skin. The dynamics of cells is determined by conservative and drag forces,supplemented with delta-correlated random forces. Cellular adjacency is detected by a weighted Delaunay triangulation. The cell cycle time of keratinocytes is controlled by a diffusible substance provided by the dermis. Its concentration is calculated from a diffusion equation with time-dependent boundary conditions and varying diffusion coefficients. The dynamics of a nutrient is also taken into account by a reaction-diffusion equation. It turns out that the analysed control mechanism suffices to explain several characteristics of epidermal homoeostasis formation. In addition, we examine the question of how {\em in silico} melanoma with decreased basal adhesion manage to persist within the steady-state flow-equilibrium of the skin.Interestingly, even for melanocyte cell cycle times being substantially shorter than for keratinocytes, tiny stochastic effects can lead to completely different outcomes. The results demonstrate that the understanding of initial states of tumour growth can profit significantly from the application of off-lattice agent-based models in computer simulations.Comment: 23 pages, 7 figures, 1 table; version that is to appear in Journal of Theoretical Biolog

The sports appeal: are atheletics a viable academic marketing vehicle in higher education?

Universities are beginning to brand themselves. The days when the doors to higher-ed opened and students flooded into the classrooms are no more. Colleges have to find ways to separate themselves from each other in a noisy marketplace. Also there is a decline in newsroom resources for academic coverage, which leaves university marketers searching for ways to communicate their messages. However, universities have another available marketing outlet, which is not seeing declining media attention: sports. College sports are a big business, which generate national media attention. The Southeastern Conference had revenues of over $100 million from the marketing of its sports to television networks. The national reach of college sporting events is immense and university marketing officials have the opportunity to capitalize. This study examined a communications campaign launched by Louisiana State University\u27s Office of University Relations to see how it translated athletic coverage generated by its 2003 college football national championship appearance into academic promotion. This case study was used to determine if athletics are a viable academic marketing tool in higher education. It used student enrollment, licensing revenue, and movement in the U.S. News and World Report\u27s college rankings subsequent to the championship to evaluate the campaign and determine if sports are a viable academic marketing vehicle. Athletic success provided a Halo around the LSU brand and its Office of University Relations capitalized by launching a marketing campaign titled A Great Game Plan On and Off the Field. Since winning a football national championship LSU has realized a 208% increase in licensing royalties, student enrollment has reached record numbers, and its academic reputation ranking in U.S. News and World Report\u27s college rankings increased. The positive results realized by LSU after winning an athletic national championship are an indicator that sports are an effective academic marketing vehicle in higher education

A Transcriptomic Exploration of Hawaiian Drosophilid Development and Evolution

One in four known species of fruit flies inhabit the Hawaiian Islands. From a small number of colonizing flies, a wide range of species evolved, some of which managed to reverse-colonize other continental environments. In order to explore the developmental pathways, which separate the Hawaiian Drosophila proper and the Scaptomyza group that contains reverse-colonized species, the transcriptomes of two better-known species in each group, Scaptomyza anomala and Drosophila grimshawi, were analyzed to find changes in gene expression between the two groups. This study describes a novel transcriptome for S. anomala studies as well as unusual changes in gene expression in D. grimshawi relative to other species, revealing priorities of both species in early development

Comparison Of Air Displacement Plethysmography And Dual-Energy X-Ray Absorptiometry For Estimation Of Body Fat Percentage In National Collegiate Athletic Association Division I Athletes

The aim of this research is to study the Apple iOS and Android mobile frameworks from a developers\u27 perspective. The first chapter introduces a historical overview of operating systems for mobile devices as well the motivation and objectives of the research. The second chapter introduces basic principles of the iOS and Android mobile frameworks in order to evaluate the platforms. The third chapter evaluates and compares the main features of both frameworks. The fourth chapter discusses the implementation of several applications on the iOS and Android mobile frameworks, which are used to demonstrate the advantages and disadvantages of each platform. The final chapter contains a summary, which gives an outlook of the future of the platforms