ItD: Large Language Models Can Teach Themselves Induction through Deduction

Although Large Language Models (LLMs) are showing impressive performance on a wide range of Natural Language Processing tasks, researchers have found that they still have limited ability to conduct induction. Recent works mainly adopt ``post processes'' paradigms to improve the performance of LLMs on induction (e.g., the hypothesis search & refinement methods), but their performance is still constrained by the inherent inductive capability of the LLMs. In this paper, we propose a novel framework, Induction through Deduction (ItD), to enable the LLMs to teach themselves induction through deduction. The ItD framework is composed of two main components: a Deductive Data Generation module to generate induction data and a Naive Bayesian Induction module to optimize the fine-tuning and decoding of LLMs. Our empirical results showcase the effectiveness of ItD on two induction benchmarks, achieving relative performance improvement of 36% and 10% compared with previous state-of-the-art, respectively. Our ablation study verifies the effectiveness of two key modules of ItD. We also verify the effectiveness of ItD across different LLMs and deductors. The data and code of this paper can be found at https://anonymous.4open.science/r/ItD-E844

Precision excision of mandibular anterior compound odontoma using autonomous robotic guidance: a clinical case report

BackgroundManagement of compound odontomas in the pediatric anterior mandible poses significant surgical challenges due to proximity to developing tooth follicles and neurovascular structures. Conventional enucleation risks iatrogenic injury to adjacent dentoalveolar anatomy, while suboptimal bone preservation may impede permanent tooth eruption.Case descriptionAn 8-year-old patient presented with a compound odontoma adjacent to the unerupted permanent mandibular incisor. Utilizing an autonomous robotic guidance system independently developed by our research group, we performed minimally invasive enucleation featuring: (1) virtual osteotomy pathway planning, (2) sub-millimeter precision bone removal preserving the follicular space of tooth 31, and (3) capsule dissection under optical navigation. At the 2-week follow-up, the surgical site demonstrated complete mucosal healing without neurosensory complications, and CBCT confirmed absence of residual pathology.ConclusionRobotic-assisted enucleation enabled tissue-preserving removal of a high-risk odontoma while maintaining eruption potential. This approach represents a paradigm shift toward precision-targeted dentoalveoral surgery, particularly valuable for anatomically complex pediatric cases.Clinical Trial Registrationidentifier [ChiCTR2400092822]

Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review

Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug delivery systems (i.e., hydrogel, liposomes, electrospun fibers, nanoparticles and nanoemulsion) for phages and their encoded lysins in WI management has become a hot topic. To assess the current landscape of these emerging technologies, we conducted a comprehensive literature search across PubMed, Scopus and Web of Science up to July 2024, using terms such as “phage,” “lysin,” “wound,” “hydrogel,” “liposomes,” “fibers,” “nanoparticles,” and “nanoemulsion.” The criteria included original studies of five novel delivery systems for phages and lysins in WI management. The findings highlighted the positive effects of the five novel delivery systems for phages and lysins in WI management, significantly reducing wound bacterial populations, and accelerating healing at the injury site. However, the available literature on novel delivery systems for phages and lysins remains limited, particularly for lysins. In conclusion, the application of novel drug delivery systems for phages and lysins showed great potential in combating MDR bacterial WIs

Continued spread of HIV among injecting drug users in southern Sichuan Province, China

OBJECTIVE: To estimate HIV prevalence among injecting drug users (IDUs) in a drug trafficking city in southwest Sichuan Province, China. METHODS: A total of 314 IDUs was invited to participate in the cross-sectional survey in 2004 through community outreach recruitment and peer referrals. Blood sample was taken for HIV antibody testing and a structured questionnaire was administered to collect information on socio-demographics, drug using and sexual behaviors. RESULTS: HIV prevalence among IDUs was 17.8% (56/314), about one half higher than that in previous survey in 2002 (11.3%, 43/379). Yi and other minority ethnicity (Odds ratio [OR], 3.1; 95% confidence interval [CI], 1.7–5.8; P < 0.001), and total times of sharing injecting equipments 1–9 times versus none, OR, 2.7; 95% CI 1.2–6.2; P = 0.02; and ≥10 times versus none, OR, 7.5; 95% CI, 3.2–17.7; P < 0.001) were independent risk factors for HIV infection. CONCLUSION: IDUs with high prevalence rates of HIV and equipment sharing behavior in the drug trafficking city may serve a source for further spread of HIV to other areas in China. The increasing trend of HIV epidemic among IDUs underscores the urgency of scaling up interventions

Isolation and Characterization of 15 New Microsatellite Markers in Oncomelania hupensis, the Snail Intermediate Host of Schistosoma japonicum in Mainland China

Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which plays a key role during the transmission of schistosomiasis. It is mainly found in the Yangtze River valley and mountains or hills in southwest China. In this paper, we described 15 new microsatellite makers in O. hupensis. Polymorphism of each locus was assessed in 80 individuals from four wild populations (n = 20 per population). The number of alleles per locus ranged from 6 to 29, with an average of 15.8. The observed (HO) and expected (HE) heterozygosities varied from 0.397 to 0.851 and from 0.696 to 0.948, respectively. These microsatellite markers will be useful for population genetic studies and genome mapping in O. hupensis

Association Between Single Nucleotide Polymorphisms in PPARA and EPAS1 Genes and High-Altitude Appetite Loss in Chinese Young Men

Appetite loss is a common symptom that occurs in high altitude (HA) for lowlanders. Previous studies indicated that hypoxia is the initiating vital factor of HA appetite loss. PPARA, EPAS1, EGLN1, HIF1A, HIF1AN, and NFE2L2 play important roles in hypoxic responses. We aimed to explore the association of these hypoxia-related gene polymorphisms with HA appetite loss. In this study, we enrolled 416 young men who rapidly ascended to Lhasa (3700 m) from Chengdu (&lt;500m) by plane. PPARA, EPAS1, EGLN1, HIF1A, HIF1AN, and NFE2L2 were genotyped by MassARRAY. Appetite scores were measured to identify HA appetite loss. Logistic regression and multiple genetic models were tested to evaluate the association between the single nucleotide polymorphisms (SNPs) and risk of HA appetite loss in crude and adjusted (age and SaO2) analysis. Subsequently, Haploview software was used to analyze the linkage disequilibrium (LD), haplotype construction and the association of diverse haplotypes with the risk of HA appetite loss. Our results revealed that allele “A” in PPARA rs4253747 was significantly associated with the increased risk of HA appetite loss. Codominant, dominant, recessive, and log-additive models of PPARA rs4253747 showed the increased risk of HA appetite loss in the crude and adjusted analysis. However, only dominant, overdominant, and log-additive models of EPAS1 rs6756667 showed decreased risk of HA appetite loss in the crude and adjusted analysis. Moreover, the results from haplotype-based test showed that the rs7292407-rs6520015 haplotype “AC” was associated with HA appetite loss in the crude analysis rather than the adjusted analysis. In this study, we first established the association of SNPs in PPARA (rs4253747) and EPAS1 (rs6756667) genes with susceptibility to HA appetite loss in Han Chinese young men. These findings provide novel insights into understanding the mechanisms involved in HA appetite loss