171 research outputs found
SSE Spine Tango - content, workflow, set-up: www.eurospine.org - Spine Tango
The Spine Tango registry is now accessible via the SSE webpage under www.eurospine.org - Spine Tango. Links to the Swiss/International, German and Austrian modules are provided as well as information about the philosophy, methodology and content. Following the links, the users are taken to the respective national modules for registration or log-in and data entry. The Swiss/International module, also accessible under www.spinetango.com, is used by all Swiss and international users, who do not have a separate national module. The physician administered forms for surgery, staged surgery and follow-up can be downloaded as PDFs.The officially recommended Spine Tango patient forms are also available. All forms were implemented in an online version and as scannable optical mark reader forms which can be ordered from the corresponding autho
Cavitation pressure in liquid helium
Recent experiments have suggested that, at low enough temperature, the
homogeneous nucleation of bubbles occurs in liquid helium near the calculated
spinodal limit. This was done in pure superfluid helium 4 and in pure normal
liquid helium 3. However, in such experiments, where the negative pressure is
produced by focusing an acoustic wave in the bulk liquid, the local amplitude
of the instantaneous pressure or density is not directly measurable. In this
article, we present a series of measurements as a function of the static
pressure in the experimental cell. They allowed us to obtain an upper bound for
the cavitation pressure P_cav (at low temperature, P_cav < -2.4 bar in helium
3, P_cav < -8.0 bar in helium 4). From a more precise study of the acoustic
transducer characteristics, we also obtained a lower bound (at low temperature,
P_cav > -3.0 bar in helium 3, P_cav > - 10.4 bar in helium 4). In this article
we thus present quantitative evidence that cavitation occurs at low temperature
near the calculated spinodal limit (-3.1 bar in helium 3 and -9.5 bar in helium
4). Further information is also obtained on the comparison between the two
helium isotopes. We finally discuss the magnitude of nonlinear effects in the
focusing of a sound wave in liquid helium, where the pressure dependence of the
compressibility is large.Comment: 11 pages, 9 figure
3D infrared thermospectroscopic imaging
AbstractThis work reports a multispectral tomography technique in transmission mode (called 3DITI for 3D Infrared Thermospectroscopic Imaging) based on a middle wavelength infrared (MWIR) focal plane array. This technique relies on an MWIR camera (1.5 to 5.5 μm) used in combination with a multispectral IR monochromator (400 nm to 20 μm), and a sample mounted on a rotary stage for the measurement of its transmittance at several angular positions. Based on the projections expressed in terms of a sinogram, spatial three-dimensional (3D) cubes (proper emission and absorptivity) are reconstructed using a back-projection method based on inverse Radon transform. As a validation case, IR absorptivity tomography of a reflective metallic screw is performed within a very short time, i.e., shorter than 1 min, to monitor 72 angular positions of the sample. Then, the absorptivity and proper emission tomographies of a butane-propane-air burner flame and microfluidic perfluoroalkoxy (PFA) tubing filled with water and ethanol are obtained. These unique data evidence that 3D thermo-chemical information in complex semi-transparent media can be obtained using the proposed 3DITI method. Moreover, this measurement technique presents new problems in the acquisition, storage and processing of big data. In fact, the quantity of reconstructed data can reach several TB (a tomographic sample cube of 1.5 × 1.5 × 3 cm3 is composed of more than 1 million pixels per wavelength)
Cavitation of Electrons Bubbles in Liquid Helium Below saturation Pressure
We have used a Hartree-type electron-helium potential together with a density
functional description of liquid He and He to study the explosion of
electron bubbles submitted to a negative pressure. The critical pressure at
which bubbles explode has been determined as a function of temperature. It has
been found that this critical pressure is very close to the pressure at which
liquid helium becomes globally unstable in the presence of electrons. It is
shown that at high temperatures the capillary model overestimates the critical
pressures. We have checked that a commonly used and rather simple
electron-helium interaction yields results very similar to those obtained using
the more accurate Hartree-type interaction. We have estimated that the
crossover temperature for thermal to quantum nucleation of electron bubbles is
very low, of the order of 6 mK for He.Comment: 22 pages, 9 figure
Wall roughness induces asymptotic ultimate turbulence
Turbulence is omnipresent in Nature and technology, governing the transport
of heat, mass, and momentum on multiple scales. For real-world applications of
wall-bounded turbulence, the underlying surfaces are virtually always rough;
yet characterizing and understanding the effects of wall roughness for
turbulence remains a challenge, especially for rotating and thermally driven
turbulence. By combining extensive experiments and numerical simulations, here,
taking as example the paradigmatic Taylor-Couette system (the closed flow
between two independently rotating coaxial cylinders), we show how wall
roughness greatly enhances the overall transport properties and the
corresponding scaling exponents. If only one of the walls is rough, we reveal
that the bulk velocity is slaved to the rough side, due to the much stronger
coupling to that wall by the detaching flow structures. If both walls are
rough, the viscosity dependence is thoroughly eliminated in the boundary layers
and we thus achieve asymptotic ultimate turbulence, i.e. the upper limit of
transport, whose existence had been predicted by Robert Kraichnan in 1962
(Phys. Fluids {\bf 5}, 1374 (1962)) and in which the scalings laws can be
extrapolated to arbitrarily large Reynolds numbers
In vitro functional effects of XPC gene rare variants from bladder cancer patients
The XPC gene is involved in repair of bulky DNA adducts formed by carcinogenic metabolites and oxidative DNA damage, both known bladder cancer risk factors. Single nucleotide polymorphisms (SNPs) in XPC have been associated with increased bladder cancer risk. Recently, rarer genetic variants have been identified but it is difficult to ascertain which are of functional importance. During a mutation screen of XPC in DNA from 33 bladder tumour samples and matched blood samples, we identified five novel variants in the patients’ germ line DNA. In a case–control study of 771 bladder cancer cases and 800 controls, c.905T>C (Phe302Ser), c.1177C>T (Arg393Trp), c.*156G>A [3′ untranslated region (UTR)] and c.2251-37C>A (in an intronic C>G SNP site) were found to be rare variants, with a combined odds ratio of 3.1 (95% confidence interval 1.0–9.8, P = 0.048) for carriage of one variant. The fifth variant was a 2% minor allele frequency SNP not associated with bladder cancer. The two non-synonymous coding variants were predicted to have functional effects using analytical algorithms; a reduced recruitment of GFP-tagged XPC plasmids containing either c.905T>C or c.1177C>T to sites of 408 nm wavelength laser-induced oxidative DNA damage was found in vitro. c.*156G>A appeared to be associated with reduced messenger RNA stability in an in vitro plasmid-based assay. Although the laser microbeam assay is relevant to a range of DNA repair genes, our 3′ UTR assay based on Green fluorescent protein(GFP) has widespread applicability and could be used to assess any gene. These assays may be useful in determining which rare variants are functional, prior to large genotyping efforts
Reference Correlation of the Viscosity of Cyclohexane from the Triple Point to 700 K and up to 110 MPa
Cobalt, manganese, and iron near the Hawaiian Islands : a potential concentrating mechanism for cobalt within a cyclonic eddy and implications for the hybrid-type trace metals
Author Posting. © Elsevier B.V., 2008. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part II: Topical Studies in Oceanography 55 (2008): 1473-1490, doi:10.1016/j.dsr2.2008.02.010.The vertical distributions of cobalt, iron, and manganese in the water column were
studied during the E-Flux Program (E-Flux II and III), which focused on the
biogeochemistry of cold-core cyclonic eddies that form in the lee of the Hawaiian
Islands. During E-Flux II (January 2005) and E-Flux III (March 2005), 17 stations were
sampled for cobalt (n =147), all of which demonstrated nutrient-like depletion in surface
waters. During E-Flux III, two depth profiles collected from within a mesoscale coldcore
eddy, Cyclone Opal, revealed small distinct maxima in cobalt at ~100m depth and a
larger inventory of cobalt within the eddy. We hypothesize that this was due to a cobalt
concentrating effect within the eddy, where upwelled cobalt was subsequently associated
with sinking particulate organic carbon (POC) via biological activity and was released at
a depth coincident with nearly complete POC remineralization (Benitez-Nelson et al.
2007). There is also evidence for the formation of a correlation between cobalt and
soluble reactive phosphorus during E-Flux III relative to the E-Flux II cruise that we
suggest is due to increased productivity, implying a minimum threshold of primary
production below which cobalt-phosphate coupling does not occur. Dissolved iron was
measured in E-Flux II and found in somewhat elevated concentrations (~0.5nM) in
surface waters relative to the iron depleted waters of the surrounding Pacific (Fitzwater et
al. 1996), possibly due to island effects associated with the iron-rich volcanic soil from
the Hawaiian Islands and/or anthropogenic inputs. Distinct depth maxima in total
dissolved cobalt were observed at 400 to 600m depth, suggestive of the release of metals
from the shelf area of comparable depth that surrounds these islands.This research was supported by NSF Grants
OCE-0327225, OCE-0452883, OPP-0440840, the Office of Naval Research, the Center
for Environmental Bioinorganic Chemistry at Princeton, and the Center for Microbial
Oceanography and Education
Cellular responses to ionising radiation of AT heterozygotes: differences between missense and truncating mutation carriers
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