Optimization of energy efficiency in data and WEB hosting centers

Mención Internacional en el título de doctorThis thesis tackles the optimization of energy efficiency in data centers in terms of network and server utilization. For what concerns networking utilization the work focuses on Energy Efficient Ethernet (EEE) - IEEE 802.3az standard - which is the energy-aware alternative to legacy Ethernet, and an important component of current and future green data centers. More specifically the first contribution of this thesis consists in deriving and analytical model of gigabit EEE links with coalescing using M/G/1 queues with sleep and wake-up periods. Packet coalescing has been proposed to save energy by extending the sojourn in the Low Power Idle state of EEE. The model presented in this thesis approximates with a good accuracy both the energy saving and the average packet delay by using a few significant traffic descriptors. While coalescing improves by far the energy efficiency of EEE, it is still far from achieving energy consumption proportional to traffic. Moreover, coalescing can introduce high delays. To this extend, by using sensitivity analysis the thesis evaluates the impact of coalescing timers and buffer sizes, and sheds light on the delay incurred by adopting coalescing schemes. Accordingly, the design and study of a first family of dynamic algorithms, namely measurement-based coalescing control (MBCC), is proposed. MBCC schemes tune the coalescing parameters on-the-fly, according to the instantaneous load and the coalescing delay experienced by the packets. The thesis also discusses a second family of dynamic algorithms, namely NT-policy coalescing control (NTCC), that adjusts the coalescing parameters based on the sole occurrence of timeouts and buffer fill-ups. Furthermore, the performance of static as well as dynamic coalescing schemes is investigated using real traffic traces. The results reported in this work show that, by relying on run-time delay measurements, simple and practical MBCC adaptive coalescing schemes outperform traditional static and dynamic coalescing while the adoption of NTCC coalescing schemes has practically no advantages with respect to static coalescing when delay guarantees have to be provided. Notably, MBCC schemes double the energy saving benefit of legacy EEE coalescing and allow to control the coalescing delay. For what concerns server utilization, the thesis presents an exhaustive empirical characterization of the power requirements of multiple components of data center servers. The characterization is the second key contribution of this thesis, and is achieved by devising different experiments to stress server components, taking into account the multiple available CPU frequencies and the presence of multicore servers. The described experiments, allow to measure energy consumption of server components and identify their optimal operational points. The study proves that the curve defining the minimal CPU power utilization, as a function of the load expressed in Active Cycles Per Second, is neither concave nor purely convex. Instead, it definitively shows a superlinear dependence on the load. The results illustrate how to improve the efficiency of network cards and disks. Finally, the accuracy of the model derived from the server components consumption characterization is validated by comparing the real energy consumed by two Hadoop applications - PageRank and WordCount - with the estimation from the model, obtaining errors below 4:1%, on average.This work has been partially supported by IMDEA Networks Institute and the Greek State Scholarships FoundationPrograma Oficial de Doctorado en Ingeniería TelemáticaPresidente: Marco Giuseppe Ajmone Marsan.- Secretario: Jose Luis Ayala Rodrigo.- Vocal: Gianluca Antonio Rizz

A Measurement-based Analysis of the Energy Consumption of Data Center Servers

Energy consumption is a growing issue in data centers, impacting their economic viability and their public image. In this work we empirically characterize the power and energy consumed by different types of servers. In particular, in order to understand the behavior of their energy and power consumption, we perform measurements in different servers. In each of them, we exhaustively measure the power consumed by the CPU, the disk, and the network interface under different configurations, identifying the optimal operational levels. One interesting conclusion of our study is that the curve that defines the minimal CPU power as a function of the load is neither linear nor purely convex as has been previously assumed. Moreover, we find that the efficiency of the various server components can be maximized by tuning the CPU frequency and the number of active cores as a function of the system and network load, while the block size of I/O operations should be always maximized by applications. We also show how to estimate the energy consumed by an application as a function of some simple parameters, like the CPU load, and the disk and network activity. We validate the proposed approach by accurately estimating the energy of a map-reduce computation in a Hadoop platform

Placental Pathology and Blood Pressure's Level in Women with Hypertensive Disorders in Pregnancy

Objective. The aim of this study was to investigate the extent of placental lesions associated with blood pressure (BP) levels in pregnancies complicated by hypertension. Methods. 55 singleton pregnancies complicated by mild hypertension were recruited and compared to 55 pregnancies complicated by severe hypertension. The histological assessment was carried out with regard to the following aspects: vessels number/field of vision, infarction, villous fibrinoid necrosis, villous hypermaturity, avascular villi, calcifications, lymphohistiocytic villitis, and thickened vessels. Statistical analysis was performed by SPSS. Results. All placental lesions were observed more often in the severe hypertension group. Vessels number was significantly decreased, and infarction and villous fibrinoid necrosis were significantly increased in the placentas of the severe hypertension group compared to the mild hypertension group (P < 0.001). Conclusion. This study supports that the extent of placental lesions in hypertensive pregnancies is correlated with hypertension level and so highlights blood pressure level as a mirror of placental function

Resolving data center power bill disputes: the energy-performance trade-offs of consolidation

This is the author accepted manuscript. The final version is available from ACM via http://dx.doi.org/10.1145/2768510.2770933In this paper we challenge the common evaluation practices used for Virtual Machine (VM) consolidation, such as simulation and small testbeds, which fail to capture the fundamental trade-off between energy consumption and performance. We identify a number of over-simplifying assumptions which are typically made about the energy consumption and performance characteristics of modern networked systems. In response, we describe how more accurate models for data-center systems can be designed and used in order to create an evaluation framework that allows the more reliable exploration of the energy-performance trade-off for VM consolidation strategies.This work was jointly supported by by MINECO (grant TEC2014- 55713-R), the EPSRC INTERNET Project EP / H040536/1, and the Defense Advanced Research Projects Agency (DARPA) and the Air Force Research Laboratory (AFRL), under contract FA8750-11-C-0249. The views, opinions, and/or findings contained in this article/presentation are those of the author/presenter and should not be interpreted as representing the official views or policies, either expressed or implied, of the Defense Advanced Research Projects Agency or the Department of Defense

Standardization and Validation of Brachytherapy Seeds'' Modelling Using GATE and GGEMS Monte Carlo Toolkits

Simple Summary:& nbsp;This study used GATE and GGEMS simulation toolkits, to estimate dose distribution on Brachytherapy procedures. Specific guidelines were followed as defined by the American Association of Physicists in Medicine (AAPM) as well as by the European SocieTy for Radiotherapy and Oncology (ESTRO). Several types of brachytherapy seeds were modelled and simulated, namely Low-Dose-Rate (LDR), High-Dose-Rate (HDR), and Pulsed-Dose-Rate (PDR). The basic difference between GATE and GGEMS is that GGEMS incorporates GPU capabilities, which makes the use of Monte Carlo (MC) simulations more accessible in clinical routine, by minimizing the computational time to obtain a dose map. During the validation procedure of both codes with protocol data, differences as well as uncertainties were measured within the margins defined by the guidelines. The study concluded that MC simulations may be utilized in clinical practice, to optimize dose distribution in real time, as well as to evaluate therapeutic plans.This study aims to validate GATE and GGEMS simulation toolkits for brachytherapy applications and to provide accurate models for six commercial brachytherapy seeds, which will be freely available for research purposes. The AAPM TG-43 guidelines were used for the validation of two Low Dose Rate (LDR), three High Dose Rate (HDR), and one Pulsed Dose Rate (PDR) brachytherapy seeds. Each seed was represented as a 3D model and then simulated in GATE to produce one single Phase-Space (PHSP) per seed. To test the validity of the simulations'' outcome, referenced data (provided by the TG-43) was compared with GATE results. Next, validation of the GGEMS toolkit was achieved by comparing its outcome with the GATE MC simulations, incorporating clinical data. The simulation outcomes on the radial dose function (RDF), anisotropy function (AF), and dose rate constant (DRC) for the six commercial seeds were compared with TG-43 values. The statistical uncertainty was limited to 1% for RDF, to 6% (maximum) for AF, and to 2.7% (maximum) for the DRC. GGEMS provided a good agreement with GATE when compared in different situations: (a) Homogeneous water sphere, (b) heterogeneous CT phantom, and (c) a realistic clinical case. In addition, GGEMS has the advantage of very fast simulations. For the clinical case, where TG-186 guidelines were considered, GATE required 1 h for the simulation while GGEMS needed 162 s to reach the same statistical uncertainty. This study produced accurate models and simulations of their emitted spectrum of commonly used commercial brachytherapy seeds which are freely available to the scientific community. Furthermore, GGEMS was validated as an MC GPU based tool for brachytherapy. More research is deemed necessary for the expansion of brachytherapy seed modeling

RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes

Context: The RANK/RANKL/OPG signalling pathway is important in the regulation of bone turnover, with single nucleotide polymorphisms (SNPs) in genes within this pathway associated with bone phenotypic adaptations. Objective: To determine whether four SNPs associated with genes in the RANK/RANKL/OPG signalling pathway were associated with stress fracture injury in elite athletes. Design, Participants, and Methods: Radiologically confirmed stress fracture history was reported in 518 elite athletes, forming the Stress Fracture Elite Athlete (SFEA) cohort. Data were analysed for the whole group, and were sub-stratified into male and cases of multiple stress fracture group. Genotypes were determined using proprietary fluorescence-based competitive allele-specific PCR assays. Results: SNPs rs3018362 (RANK) and rs1021188 (RANKL) were associated with stress fracture injury (p<0.05). 8.1% of stress fracture group and 2.8% of the non-stress fracture group were homozygote for the rare allele of rs1021188. Allele frequency, heterozygotes and homozygotes for the rare allele of rs3018362 were associated with stress fracture period prevalence (p<0.05). Analysis of the male only group showed 8.2% of rs1021188 rare allele homozygotes to have suffered a stress fracture while 2.5% of the non-stress fracture group were homozygous. In cases of multiple stress fractures, homozygotes for the rare allele of rs1021188, and individuals possessing at least one copy of the rare allele of rs4355801 (OPG) were shown to be associated with stress fracture injury (p<0.05). Conclusions: The data support an association between SNPs in the RANK/RANKL/OPG signalling pathway and the development of stress fracture injury. The association of rs3018362 (RANK) and rs1021188 (RANKL) with stress fracture injury susceptibility supports their role in the maintenance of bone health, and offers potential targets for therapeutic interventions

Clinical Study Placental Pathology and Blood Pressure&apos;s Level in Women with Hypertensive Disorders in Pregnancy

Objective. The aim of this study was to investigate the extent of placental lesions associated with blood pressure (BP) levels in pregnancies complicated by hypertension. Methods. 55 singleton pregnancies complicated by mild hypertension were recruited and compared to 55 pregnancies complicated by severe hypertension. The histological assessment was carried out with regard to the following aspects: vessels number/field of vision, infarction, villous fibrinoid necrosis, villous hypermaturity, avascular villi, calcifications, lymphohistiocytic villitis, and thickened vessels. Statistical analysis was performed by SPSS. Results. All placental lesions were observed more often in the severe hypertension group. Vessels number was significantly decreased, and infarction and villous fibrinoid necrosis were significantly increased in the placentas of the severe hypertension group compared to the mild hypertension group (P &lt; 0.001). Conclusion. This study supports that the extent of placental lesions in hypertensive pregnancies is correlated with hypertension level and so highlights blood pressure level as a mirror of placental function

Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury

Context: Military recruits and elite athletes are susceptible to stress fracture injuries. Genetic predisposition has been postulated to have a role in their development. The P2X7 receptor (P2X7R) gene, a key regulator of bone remodelling, is a genetic candidate that may contribute to stress fracture predisposition. Objective: To evaluate the putative contribution of P2X7R to stress fracture injury in two separate cohorts, military personnel and elite athletes. Methods: In 210 Israeli Defence Forces (IDF) military conscripts, stress fracture injury was diagnosed (n=43) based on symptoms and a positive bone scan. In a separate cohort of 518 elite athletes, self-reported medical imaging scan-certified stress fracture injuries were recorded (n=125). Non-stress fracture controls were identified from these cohorts who had a normal bone scan or no history or symptoms of stress fracture injury. Study participants were genotyped for functional SNPs within the P2X7R gene using proprietary fluorescence-based competitive allele-specific PCR assay. Pearson Chi-square (χ2) tests, corrected for multiple comparisons, were used to assess associations in genotype frequencies. Results: The variant allele of P2X7R SNP rs3751143 (Glu496Ala- loss of function) was associated with stress fracture injury, while the variant allele of rs1718119 (Ala348Thr- gain of function) was associated with a reduced occurrence of stress fracture injury in military conscripts (P<0.05). The association of the variant allele of rs3751143 with stress fractures was replicated in elite athletes (P<0.05), whereas the variant allele of rs1718119 was also associated with reduced multiple stress fracture cases in elite athletes (P<0.05). Conclusions: The association between independent P2X7R polymorphisms with stress fracture prevalence supports the role of a genetic predisposition in the development of stress fracture injury