Dialect on Trial: Raciolinguistic ideologies in perceptions of AAVE and MAE codeswitching

It is known that listeners map speakers’ voices to racial categories and that such identification can have harmful social, political, and economic consequences for African American Vernacular English (AAVE) speakers (Baugh 2003, Grogger 2009, Rickford and King 2016). While this work has focused on the production of linguistic cues used to perceive speakers’ race, recent research on the white listening subject (Flores and Rosa 2015) has advocated investigating listeners’ raciolinguistic ideologies, regardless of whether speakers command standardized or stigmatized varieties (Rosa and Flores 2017). This paper explores social perceptions of a bidialectal African American speaker when he uses African American Vernacular English (AAVE) compared to Mainstream American English (MAE). The speaker, a 32-year-old African American professor from California, recorded AAVE and MAE versions of a (2 minute) passage accounting his weekend activities, made to resemble an alibi in a criminal justice proceeding. Utilizing a matched-guise design, 116 undergraduate participants were randomly assigned to hear the account spoken in either AAVE or MAE, without background information about the speaker. A majority of participants identified the speaker as Black, as having less than a college degree, and as coming from a lower/working-class background, though listeners hearing the AAVE guise were more likely to perceive the speaker as Black and less educated than those in the MAE guise. Further, participants in the AAVE condition perceived the speaker as more likely to be involved in a gang compared to the MAE condition. That the speaker’s codeswitching resulted in racialized differences in some ratings (e.g., race, education, gang status), but not in others (e.g., class, credibility, trustworthiness) raises questions about whether codeswitching can ameliorate the well-established consequences of anti-Black stereotypes for AAVE speakers. Regardless of the presence or absence of AAVE features, ideologies attached to Black voices can still yield associations with legible Black tropes

Challenging Social Cognition Models of Adherence:Cycles of Discourse, Historical Bodies, and Interactional Order

Attempts to model individual beliefs as a means of predicting how people follow clinical advice have dominated adherence research, but with limited success. In this article, we challenge assumptions underlying this individualistic philosophy and propose an alternative formulation of context and its relationship with individual actions related to illness. Borrowing from Scollon and Scollon’s three elements of social action – “historical body,” “interaction order,” and “discourses in place” – we construct an alternative set of research methods and demonstrate their application with an example of a person talking about asthma management. We argue that talk- or illness-related behavior, both viewed as forms of social action, manifest themselves as an intersection of cycles of discourse, shifting as individuals move through these cycles across time and space. We finish by discussing how these dynamics of social action can be studied and how clinicians might use this understanding when negotiating treatment with patients

The Zero Resource Speech Challenge 2019: TTS without T

International audienceWe present the Zero Resource Speech Challenge 2019, which proposes to build a speech synthesizer without any text or pho-netic labels: hence, TTS without T (text-to-speech without text). We provide raw audio for a target voice in an unknown language (the Voice dataset), but no alignment, text or labels. Participants must discover subword units in an unsupervised way (using the Unit Discovery dataset) and align them to the voice recordings in a way that works best for the purpose of synthesizing novel utterances from novel speakers, similar to the target speaker's voice. We describe the metrics used for evaluation , a baseline system consisting of unsupervised subword unit discovery plus a standard TTS system, and a topline TTS using gold phoneme transcriptions. We present an overview of the 19 submitted systems from 10 teams and discuss the main results

Test-Retest Variability and Discriminatory Power of Measurements From Microperimetry and Dark Adaptation Assessment in People With Intermediate Age-Related Macular Degeneration – A MACUSTAR Study Report

Purpose: The purpose of this study was to assess test-retest variability and discriminatory power of measures from macular integrity assessment (S-MAIA) and AdaptDx. // Methods: This is a cross-sectional study of 167 people with intermediate age-related macular degeneration (iAMD), no AMD (controls; n = 54), early AMD (n = 28), and late AMD (n = 41), recruited across 18 European ophthalmology centers. Repeat measures of mesopic and scotopic S-MAIA average (mean) threshold (MMAT decibels [dB] and SMAT [dB]) and rod intercept time (RIT [mins]) at 2 visits 14 (±7) days apart were recorded. Repeat measures were assessed by Bland-Altman analysis, intra-class correlation coefficients (ICCs) and variability ratios. Secondary analysis assessed the area under the receiver operating characteristic curves (AUC) to determine the ability to distinguish people as having no AMD, early AMD, or iAMD. // Results: Data were available for 128, 131, and 103 iAMD participants for the mesopic and scotopic S-MAIA and AdaptDx, respectively. MMAT and SMAT demonstrate similar test-retest variability in iAMD (95% confidence interval [CI] ICC of 0.79–0.89 and 0.78–0.89, respectively). ICCs were worse in RIT (95% CI ICC = 0.55–0.77). All tests had equivalent AUCs (approximately 70%) distinguishing between subjects with iAMD and controls, whereas early AMD was indistinguishable from iAMD on all measures (AUC = <55%). A learning effect was not seen in these assessments under the operating procedures used. // Conclusions: MMAT, SMAT, and RIT have adequate test-retest variability and are all moderately good at separating people with iAMD from controls. // Translational Relevance: Expected levels of test-retest variability and discriminatory power of the AdaptDx and MAIA devices in a clinical study setting must be considered when designing future trials for people with AMD

High apex predator biomass on remote Pacific islands

Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Coral Reefs 26 (2007): 47-51, doi:10.1007/s00338-006-0158-x.On coral reefs in Palmyra—a central Pacific atoll with limited fishing pressure—total fish biomass is 428 and 299% greater than on reefs in nearby Christmas and Fanning Islands. Large apex predators –groupers, sharks, snappers, and jacks larger than 50 cm in length- account for 56% of total fish biomass in Palmyra on average, but only 7% and 3% on Christmas and Fanning. These biomass proportions are remarkably similar to those previously reported for the remote and uninhabited Northwest Hawaiian Islands (NWHI) and densely populated Main Hawaiian Islands (MHI), although Palmyra’s reefs are dominated in biomass by sharks (44% of the total), whereas the NWHI by jacks (39%). Herbivorous fish biomass was also greater on Palmyra than on Christmas and Fanning (343% and 207%, respectively). These results and previous findings indicate that remote, uninhabited islands support high levels of consumers, and highlight the importance of healthy coral reef ecosystems as reference points for assessment of human impacts and establishment of restoration goals

Progress and challenges in predicting protein interfaces

*These authors contributed equally to this work. The majority of biological processes are mediated via protein–protein interactions. Determination of residues participating in such interactions improves our understanding of molecular mechanisms and facilitates the development of therapeutics. Experimental approaches to identifying interacting residues, such as mutagenesis, are costly and time-consuming and thus, computational methods for this purpose could streamline conventional pipelines. Here we review the field of computational protein interface prediction. We make a distinction between methods which address proteins in general and those targeted at antibodies, owing to the radically different binding mechanism of antibodies. We organize the multitude of currently available methods hierarchically based on required input and prediction principles to provide an overview of the field. Key words: protein–protein interaction; protein interface prediction; antibody antigen interaction Protein interfaces Proteins interact with other proteins, DNA, RNA and small mol-ecules to perform their cellular tasks. Knowledge of protein interfaces and the residues involved is vital to fully understand molecular mechanisms and to identify potential drug target

Memoria, remoción, olvido del estalinismo en la Rusia postsoviética

El estalinismo - aquí entendido como el sistema político y de gobierno instaurado por Stalin en la Unión Soviética y, cronológicamente, como el período de la historia soviética durante el cual Stalin ejerció un poder casi absoluto- ha representado una experiencia profundamente traumática para la sociedad rusa y soviética en general, así como para los países de Europa Central y Oriental incluidos después de 1945 en la esfera de influencia soviética. Para Rusia el estalinismo significó, por un lado, una transformación radical y violenta de la sociedad, por el otro, un terrorismo de Estado y un conjunto de represiones políticas que provocaron millones de víctimas. El recuerdo de este pasado permanece como un problema no resuelto de la memoria rusa. La sociedad rusa postsoviética continúa, de hecho, profundamente dividida a propósito de este “pasado que no pasa”, con el que no ha podido realmente lidiar: la división tiene que ver más con la interpretación que con los hechos, y qué sentido se le atribuye a ese pasado. Prevalece una actitud ambivalente, tanto en el gobierno cómo en la mayoría de la población. En estas páginas analizamos el recorrido de la memoria del estalinismo en Rusia desde la Perestroika hasta hoy, y los fenómenos de remoción, olvido y silencio que lo acompañaron.“Memoria, rimozione, oblio dello stalinismo nella Russia postsovietica” fue previamente publicado en italiano en el Giornale di Storia Contemporanea , año XIX, número 1, 2016, pp. 7-32.Facultad de Humanidades y Ciencias de la Educació

Use of composite endpoints in early and intermediate age-related macular degeneration clinical trials - state-of-the-art and future directions

The slow progression of early AMD stages to advanced AMD requires the use of surrogate endpoints in clinical trials. The use of combined endpoints may allow for shorter and smaller trials due to increased precision. We performed a literature search for the use of composite endpoints as primary outcome measures in clinical studies of early AMD stages. PubMed was searched for composite endpoints used in early/intermediate AMD studies published during the last 10 years. A total of 673 articles of interest were identified. After reviewing abstracts and applicable full-text articles, 33 articles were eligible and thus included in the qualitative synthesis. The main composite endpoint categories were: Combined structural and functional endpoints, combined structural endpoints, combined functional endpoints and combined multi-categorical endpoints. The majority of the studies included binary composite endpoints. There was a lack of sensitivity analyses of different endpoints against accepted outcomes (i.e. progression) in the literature. Various composite outcome measures have been used but there is a lack of standardization. To date no agreement on the optimal approach to implement combined endpoints in clinical studies of early stages of AMD exists and no surrogate endpoints have been accepted for AMD progression

Advancing the public health applications of Chlamydia trachomatis serology.

Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the leading infectious cause of blindness worldwide. New serological assays for C trachomatis could facilitate improved understanding of C trachomatis epidemiology and prevention. C trachomatis serology offers a means of investigating the incidence of chlamydia infection and might be developed as a biomarker of scarring sequelae, such as pelvic inflammatory disease. Therefore, serological assays have potential as epidemiological tools to quantify unmet need, inform service planning, evaluate interventions including screening and treatment, and to assess new vaccine candidates. However, questions about the performance characteristics and interpretation of C trachomatis serological assays remain, which must be addressed to advance development within this field. In this Personal View, we explore the available information about C trachomatis serology and propose several priority actions. These actions involve development of target product profiles to guide assay selection and assessment across multiple applications and populations, establishment of a serum bank to facilitate assay development and evaluation, and development of technical and statistical methods for assay evaluation and analysis of serological findings. The field of C trachomatis serology will benefit from collaboration across the public health community to align technological developments with their potential applications