Morphologic Change by Overwash: Establishing and Evaluating Predictors

The ability to predict cross-shore profile response to coastal overwash is important for both understanding how barrier islands respond to overwash and for disaster management on developed coastlines. This study establishes morphologic and hydrodynamic parameters for predicting the type of cross-shore profile response following overwash for given pre-storm profile and storm conditions. More than 50 data sets were categorised into 7 different types of cross-shore profile response to overwash. These responses are: 1) crest accumulation 2) landward translation of dunes/berms 3) dune lowering 4) dune destruction 5) barrier accretion 6) barrier rollover (short-term),and 7) barrier disintegration. Dimensionless parameters describing the pre-storm morphology and storm characteristics for these data sets were then plotted in two-dimensional space and trends for the different response types identified. For some responses it was possible to define criteria for their occurrence and for the others an approximate trend could be identified. Maximum surge level, maximum run-up level, storm overtopping duration, beach crest height, dune width and dune volume proved some of the most important parameters to distinguish responses. The criteria that are established and trends identified should allow the user to qualitatively predict the overwash response of a given cross-shore beach profile to a given set of storm conditions, using readily available data

Environmental Impact of a Tidal Bore on Tropical Rivers

A tidal bore impacts significantly on the estuarine ecosystem, although little is known on the flow field, mixing and sediment motion beneath tidal bores. In the absence of detailed field measurements, a quasi steady flow analogy was applied to investigate an undular tidal bore with inflow Froude numbers 1.6 and 1.25. Experimental results indicated that rapid flow redistributions occur beneath the free-surface undulations, with significant variations in bed shear stress between wave crests and troughs. Dynamic similarity was used to predict detailed flow characteristics of tidal bores with inflow Froude number between 1.3 and 1.6. The effects of periodic loading on river sediments, scour of the riverbed and flow mixing behind the bore were investigated. A better understanding of these processes will contribute to better management practices in tidal bore affected rivers, including the Styx, Daly and Ord rivers in tropical Australia

Impacts of climate change on European hydrology at 1.5, 2 and 3 degrees mean global warming above preindustrial level

Impacts of climate change at 1.5, 2 and 3 °C mean global warming above preindustrial level are investigated and compared for runoff, discharge and snowpack in Europe. Ensembles of climate projections representing each of the warming levels were assembled to describe the hydro-meteorological climate at 1.5, 2 and 3 °C. These ensembles were then used to force an ensemble of five hydrological models and changes to hydrological indicators were calculated. It is seen that there are clear changes in local impacts on evapotranspiration, mean, low and high runoff and snow water equivalent between a 1.5, 2 and 3 °C degree warmer world. In a warmer world, the hydrological impacts of climate change are more intense and spatially more extensive. Robust increases in runoff affect the Scandinavian mountains at 1.5 °C, but at 3 °C extend over most of Norway, Sweden and northern Poland. At 3 °C, Norway is affected by robust changes in all indicators. Decreases in mean annual runoff are seen only in Portugal at 1.5 °C warming, but at 3 °C warming, decreases to runoff are seen around the entire Iberian coast, the Balkan Coast and parts of the French coast. In affected parts of Europe, there is a distinct increase in the changes to mean, low and high runoff at 2 °C compared to 1.5 °C, strengthening the case for mitigation to lower levels of global warming. Between 2 and 3 °C, the changes in low and high runoff levels continue to increase, but the changes to mean runoff are less clear. Changes to discharge in Europe’s larger rivers are less distinct due to the lack of homogenous and robust changes across larger river catchments, with the exception of Scandinavia where discharges increase with warming level

Future socioeconomic conditions may have a larger impact than climate change on nutrient loads to the Baltic Sea

The Baltic Sea is suffering from eutrophication caused by nutrient discharges from land to sea, and these loads might change in a changing climate. We show that the impact from climate change by mid-century is probably less than the direct impact of changing socioeconomic factors such as land use, agricultural practices, atmospheric deposition, and wastewater emissions. We compare results from dynamic modelling of nutrient loads to the Baltic Sea under projections of climate change and scenarios for shared socioeconomic pathways. Average nutrient loads are projected to increase by 8% and 14% for nitrogen and phosphorus, respectively, in response to climate change scenarios. In contrast, changes in the socioeconomic drivers can lead to a decrease of 13% and 6% or an increase of 11% and 9% in nitrogen and phosphorus loads, respectively, depending on the pathway. This indicates that policy decisions still play a major role in climate adaptation and in managing eutrophication in the Baltic Sea region.Peer reviewe

18F-FDG PET/CT for diagnosing infectious complications in patients with severe neutropenia after intensive chemotherapy for haematological malignancy or stem cell transplantation

Item does not contain fulltextPURPOSE: Between 30 and 50% of febrile neutropenic episodes are accounted for by infection. C-reactive protein (CRP) is a nonspecific parameter for infection and inflammation but might be employed as a trigger for diagnosis. The aim of the study was to evaluate whether (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT can be used to detect inflammatory foci in neutropenic patients with elevated CRP and whether it helps to direct treatment. METHODS: Twenty-eight consecutive patients with neutropenia as a result of intensive chemotherapy for haematological malignancies or myeloablative therapy for haematopoietic stem cell transplantation were prospectively included. (18)F-FDG PET/CT was added to the regular diagnostic workup once the CRP level rose above 50 mg/l. RESULTS: Pathological FDG uptake was found in 26 of 28 cases despite peripheral neutrophil counts less than 0.1 x 10(-9)/l in 26 patients: in the digestive tract in 18 cases, around the tract of the central venous catheter (CVC) in 9 and in the lungs in 7 cases. FDG uptake in the CVC tract was associated with coagulase-negative staphylococcal bacteraemia (p < 0.001) and deep venous thrombosis (p = 0.002). The number of patients having Streptococcus mitis bacteraemia appeared to be higher in patients with grade 3 oesophageal FDG uptake (p = 0.08). Pulmonary FDG uptake was associated with the presence of invasive fungal disease (p = 0.04). CONCLUSION: (18)F-FDG PET/CT scanning during chemotherapy-induced febrile neutropenia and increased CRP is able to detect localized foci of infection and inflammation despite the absence of circulating neutrophils. Besides its potential role in detecting CVC-related infection during febrile neutropenia, the high negative predictive value of (18)F-FDG PET/CT is important for avoiding unnecessary diagnostic tests and therapy.1 januari 201

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility