Outcomes of subsequent neoplasms after umbilical cord blood transplantation in Europe

Subsequent neoplasms (SNs) compromise long-term survivors after hematopoietic cell transplantation. We performed a retrospective analysis of SNs in 10 358 recipients of umbilical cord blood transplantation (UCBT) from 1988 to 2018. SNs developed in 233 patients and 84 were of pediatric age. Indications for UCBT were malignant hematological diseases in 199 patients (85%). Three groups of SNs were observed. Posttransplant lymphoproliferative disorders (PTLD) were reported in 145 patients in a median of 4 months after UCBT. Of these, 9 patients died from relapse, 83 from PTLD, and 24 from transplant-related causes. At last follow-up, 29 were alive; 5-year overall survival (OS) after PTLD diagnosis was 21%. Acute leukemia/myelodysplasia (AL/MDS) was diagnosed in 23 patients in a median of 28 months after UCBT and included 3 donor-cell AL. Four of 23 patients died from relapse of primary disease, 8 from progression of SNs, and 4 from TRM. Seven patients remain alive; the 5-year OS after AL/MDS diagnosis was 36%. Solid tumors (ST) were reported in 65 patients in a median of 54 months after UCBT. Most common tumor sites were lung, thyroid, bone, and soft tissue. A total of 33 patients died (26 owing to ST, 6 to relapse of primary disease, and 1 cause missing). At last follow-up, 32 of 65 patients were alive; the 5-year OS after the diagnosis of ST was 51%. In conclusion, despite their poor outcomes, SNs that occur after UCBT are extremely rare. Identification of risk factors and early detection may help to improve OS

Common germline polymorphisms associated with breast cancer-specific survival

Abstract Introduction Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect. Results Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease. Conclusions Although no variants reached genome-wide significance (P <5 x 10−8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels

Qualitative tests of remote eyetracker recovery and performance during head rotation

What are the decision criteria for choosing an eyetracker? Often the choice is based on specifications by the manufacturer of the validity (accuracy) and reliability (precision) of measurements that can be achieved using a particular eyetracker. These specifications are mostly achieved under optimal conditions-for example, by using an artificial eye or trained participants fixed in a chinrest. Research, however, does not always take place in optimal conditions: For instance, when investigating eye movements in infants, school children, and patient groups with disorders such as attention-deficit hyperactivity disorder, it is practically impossible to restrict movement. We modeled movements often seen in infant research in two behaviors: (1) looking away from and back to the screen, to investigate eyetracker recovery, and (2) head orientations, to investigate eyetracker performance with nonoptimal orientations of the eyes. We investigated how eight eyetracking setups by three manufacturers (SMI, Tobii, and LC Technologies) coped with these modeled behaviors in adults. We report that the tested SMI eyetrackers dropped in sampling frequency when the eyes were not visible to the eyetracker, whereas the other systems did not, and discuss the potential consequences thereof. Furthermore, we report that the tested eyetrackers varied in their rates of data loss and systematic offsets during shifted head orientations. We conclude that (prospective) eye-movement researchers who cannot restrict movement or nonoptimal head orientations in their participants might benefit from testing their eyetracker in nonoptimal conditions. Additionally, researchers should be aware of the data loss and inaccuracies that might result from nonoptimal head orientations

Qualitative tests of remote eyetracker recovery and performance during head rotation

What are the decision criteria for choosing an eyetracker? Often the choice is based on specifications by the manufacturer of the validity (accuracy) and reliability (precision) of measurements that can be achieved using a particular eyetracker. These specifications are mostly achieved under optimal conditions-for example, by using an artificial eye or trained participants fixed in a chinrest. Research, however, does not always take place in optimal conditions: For instance, when investigating eye movements in infants, school children, and patient groups with disorders such as attention-deficit hyperactivity disorder, it is practically impossible to restrict movement. We modeled movements often seen in infant research in two behaviors: (1) looking away from and back to the screen, to investigate eyetracker recovery, and (2) head orientations, to investigate eyetracker performance with nonoptimal orientations of the eyes. We investigated how eight eyetracking setups by three manufacturers (SMI, Tobii, and LC Technologies) coped with these modeled behaviors in adults. We report that the tested SMI eyetrackers dropped in sampling frequency when the eyes were not visible to the eyetracker, whereas the other systems did not, and discuss the potential consequences thereof. Furthermore, we report that the tested eyetrackers varied in their rates of data loss and systematic offsets during shifted head orientations. We conclude that (prospective) eye-movement researchers who cannot restrict movement or nonoptimal head orientations in their participants might benefit from testing their eyetracker in nonoptimal conditions. Additionally, researchers should be aware of the data loss and inaccuracies that might result from nonoptimal head orientations

Eye contact takes two – autistic and social anxiety traits predict gaze behavior in dyadic interaction

Research on social impairments in psychopathology has relied heavily on the face processing literature. However, although many sub-systems of facial information processing are described, recent evidence suggests that generalizability of these findings to social settings may be limited. The main argument is that in social interaction, the content of faces is more dynamic and dependent on the interplay between interaction partners, than the content of a non-responsive face (e.g. pictures or videos) as portrayed in a typical experiment. The question beckons whether gaze atypicalities to non-responsive faces in certain disorders generalize to faces in interaction. In the present study, a dual eye-tracking setup capable of recording gaze with high resolution was used to investigate how gaze behavior in interaction is related to traits of Autism Spectrum Disorder (ASD), and Social Anxiety Disorder (SAD). As clinical ASD and SAD groups have exhibited deficiencies in reciprocal social behavior, traits of these two conditions were assessed in a general population. We report that gaze behavior in interaction of individuals scoring high on ASD and SAD traits corroborates hypotheses posed in typical face-processing research using non-responsive stimuli. Moreover, our findings on the relation between paired gaze states (when and how often pairs look at each other’s eyes simultaneously or alternately) and ASD and SAD traits bear resemblance to prevailing models in the ASD literature (the ‘gaze aversion’ model) and SAD literature (the ‘vigilant-avoidance’ model). Pair-based analyses of gaze may reveal behavioral patterns crucial to our understanding of ASD and SAD, and more general to our understanding of eye movements as social signals in interaction

Eye contact takes two – autistic and social anxiety traits predict gaze behavior in dyadic interaction

Research on social impairments in psychopathology has relied heavily on the face processing literature. However, although many sub-systems of facial information processing are described, recent evidence suggests that generalizability of these findings to social settings may be limited. The main argument is that in social interaction, the content of faces is more dynamic and dependent on the interplay between interaction partners, than the content of a non-responsive face (e.g. pictures or videos) as portrayed in a typical experiment. The question beckons whether gaze atypicalities to non-responsive faces in certain disorders generalize to faces in interaction. In the present study, a dual eye-tracking setup capable of recording gaze with high resolution was used to investigate how gaze behavior in interaction is related to traits of Autism Spectrum Disorder (ASD), and Social Anxiety Disorder (SAD). As clinical ASD and SAD groups have exhibited deficiencies in reciprocal social behavior, traits of these two conditions were assessed in a general population. We report that gaze behavior in interaction of individuals scoring high on ASD and SAD traits corroborates hypotheses posed in typical face-processing research using non-responsive stimuli. Moreover, our findings on the relation between paired gaze states (when and how often pairs look at each other’s eyes simultaneously or alternately) and ASD and SAD traits bear resemblance to prevailing models in the ASD literature (the ‘gaze aversion’ model) and SAD literature (the ‘vigilant-avoidance’ model). Pair-based analyses of gaze may reveal behavioral patterns crucial to our understanding of ASD and SAD, and more general to our understanding of eye movements as social signals in interaction