676 research outputs found
Unforgettable Ultimatums? Expectation Violations Promote Enhanced Social Memory Following Economic Bargaining
Recent work in the field of neuroeconomics has examined how people make decisions in interactive settings. However, less is currently known about how these social decisions influence subsequent memory for these interactions. We investigated this question by using functional magnetic resonance imaging to scan participants as they viewed photographs of people they had either recently played an Ultimatum Game with in the role of Responder, or that they had never seen before. Based on previous work that has investigated âcheater detectionâ, we were interested in whether participants demonstrated a relative enhanced memory for partners that made either fair or unfair proposals. We found no evidence, either behaviorally or neurally, supporting enhanced memory based on the amount of money offered by the Proposer. However, we did find that participantsâ initial expectations about the offers they would experience in the game influenced their memory. Participants demonstrated relatively enhanced subjective memory for partners that made proposals that were contradictory to their initial expectations. In addition, we observed two distinct brain systems that were associated with partners that either offered more or less than the participantsâ expectations. Viewing pictures of partners that exceeded initial expectations was associated with the bilateral anterior insula, anterior cingulate cortex/premotor area, striatum, and bilateral posterior hippocampi, while viewing partners that offered less than initial expectations was associated with bilateral temporal-parietal junction, right STS, bilateral posterior insula, and precuneus. These results suggest that memory for social interaction may not be guided by a specific cheater detection system, but rather a more general expectation violation system
Multivariate brain prediction of heart rate and skin conductance responses to social threat
Psychosocial stressors induce autonomic nervous system (ANS) responses in multiple body systems that are linked to health risks. Much work has focused on the common effects of stress, but ANS responses in different body systems are dissociable and may result from distinct patterns of corticalâsubcortical interactions. Here, we used machine learning to develop multivariate patterns of fMRI activity predictive of heart rate (HR) and skin conductance level (SCL) responses during social threat in humans (N = 18). Overall, brain patterns predicted both HR and SCL in cross-validated analyses successfully (r(HR) = 0.54, r(SCL) = 0.58, both p < 0.0001). These patterns partly reflected central stress mechanisms common to both responses because each pattern predicted the other signal to some degree (r(HRâSCL) = 0.21 and r(SCLâHR) = 0.22, both p < 0.01), but they were largely physiological response specific. Both patterns included positive predictive weights in dorsal anterior cingulate and cerebellum and negative weights in ventromedial PFC and local pattern similarity analyses within these regions suggested that they encode common central stress mechanisms. However, the predictive maps and searchlight analysis suggested that the patterns predictive of HR and SCL were substantially different across most of the brain, including significant differences in ventromedial PFC, insula, lateral PFC, pre-SMA, and dmPFC. Overall, the results indicate that specific patterns of cerebral activity track threat-induced autonomic responses in specific body systems. Physiological measures of threat are not interchangeable, but rather reflect specific interactions among brain systems. SIGNIFICANCE STATEMENT We show that threat-induced increases in heart rate and skin conductance share some common representations in the brain, located mainly in the vmPFC, temporal and parahippocampal cortices, thalamus, and brainstem. However, despite these similarities, the brain patterns that predict these two autonomic responses are largely distinct. This evidence for largely output-measure-specific regulation of autonomic responses argues against a common system hypothesis and provides evidence that different autonomic measures reflect distinct, measurable patterns of corticalâsubcortical interactions
Py-Feat: Python Facial Expression Analysis Toolbox
Studying facial expressions is a notoriously difficult endeavor. Recent
advances in the field of affective computing have yielded impressive progress
in automatically detecting facial expressions from pictures and videos.
However, much of this work has yet to be widely disseminated in social science
domains such as psychology. Current state of the art models require
considerable domain expertise that is not traditionally incorporated into
social science training programs. Furthermore, there is a notable absence of
user-friendly and open-source software that provides a comprehensive set of
tools and functions that support facial expression research. In this paper, we
introduce Py-Feat, an open-source Python toolbox that provides support for
detecting, preprocessing, analyzing, and visualizing facial expression data.
Py-Feat makes it easy for domain experts to disseminate and benchmark computer
vision models and also for end users to quickly process, analyze, and visualize
face expression data. We hope this platform will facilitate increased use of
facial expression data in human behavior research.Comment: 25 pages, 3 figures, 5 table
Medial Prefrontal Cortical Thinning Mediates Shifts in Other-Regarding Preferences during Adolescence
Adolescence is a time of significant cortical changes in the âsocial brainâ, a set of brain regions involved in sophisticated social inference. However, there is limited evidence linking the structural changes in social brain to development of social behavior. The present study investigated how cortical development of the social brain relates to other-regarding behavior, in the context of fairness concerns. Participants aged between 9 to 23 years old responded to multiple rounds of ultimatum game proposals. The degree to which each participant considers fairness of intention (i.e., intention-based reciprocity) vs. outcome (i.e., egalitarianism) was quantified using economic utility models. We observed a gradual shift in other-regarding preferences from simple rule-based egalitarianism to complex intention-based reciprocity from early childhood to young adulthood. The preference shift was associated with cortical thinning of the dorsomedial prefrontal cortex and posterior temporal cortex. Meta-analytic reverse-inference analysis showed that these regions were involved in social inference. Importantly, the other-regarding preference shift was statistically mediated by cortical thinning in the dorsomedial prefrontal cortex. Together these findings suggest that development of the ability to perform sophisticated other-regarding social inference is associated with the structural changes of specific social brain regions in late adolescence
The influence of tropospheric biennial oscillation on mid-tropospheric CO_2
Mid-tropospheric CO_2 retrieved from the Atmospheric Infrared Sounder (AIRS) was used to investigate CO_2 interannual variability over the Indo-Pacific region. A signal with periodicity around two years was found for the AIRS mid-tropospheric CO_2 for the first time, which is related to the Tropospheric Biennial Oscillation (TBO) associated with the strength of the monsoon. During a strong (weak) monsoon year, the Western Walker Circulation is strong (weak), resulting in enhanced (diminished) CO_2 transport from the surface to the mid-troposphere. As a result, there are positive (negative) CO2 anomalies at mid-troposphere over the Indo-Pacific region. We simulated the influence of the TBO on the mid-tropospheric CO_2 over the Indo-Pacific region using the MOZART-2 model, and results were consistent with observations, although we found the TBO signal in the model CO_2 is to be smaller than that in the AIRS observations
Flavour Changing Neutral Currents, Weak-Scale Scalars and Rare Top Decays
We examine the decays and in the Standard
Model with an extra scalar doublet and no discrete symmetry preventing
tree-level flavour changing neutral currents. The Yukawa couplings of the new
scalars are assumed to be proportional to fermion masses, evading bounds on
FCNC's from the light quark sector. These rare top decays may be visible at the
SSC.Comment: (some wording changed, and several references added) 13 pages, 2
figures included, uses harvmac.tex and epsf.tex, UCSD/PTH 93-0
FMDV replicons encoding green fluorescent protein are replication competent
The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by the replacement of sequences encoding chloramphenicol acetyl-transferase (CAT) with those encoding a functional L proteinase (Lpro) linked to a bi-functional fluorescent/antibiotic resistance fusion protein (green fluorescent protein/puromycin resistance, [GFP-PAC]). Cells were transfected with replicon-derived transcript RNA and GFP fluorescence quantified. Replication of transcript RNAs was readily detected by fluorescence, whilst the signal from replication-incompetent forms of the genome was >2-fold lower. Surprisingly, a form of the replicon lacking the Lpro showed a significantly stronger fluorescence signal, but appeared with slightly delayed kinetics. Replication can, therefore, be quantified simply by live-cell imaging and image analyses, providing a rapid and facile alternative to RT-qPCR or CAT assays
Electromagnetic field angular momentum in condensed matter systems
Various electromagnetic systems can carry an angular momentum in their {\bf
E} and {\bf B} fields. The electromagnetic field angular momentum (EMAM) of
these systems can combine with the spin angular momentum to give composite
fermions or composite bosons. In this paper we examine the possiblity that an
EMAM could provide an explanation of the fractional quantum Hall effect (FQHE)
which is complimentary to the Chern-Simons explanation. We also examine a toy
model of a non-BCS superconductor (e.g. high superconductors) in terms of
an EMAM. The models presented give a common, simple picture of these two
systems in terms of an EMAM. The presence of an EMAM in these systems might be
tested through the observation of the decay modes of a charged, spin zero
unstable particle inside one of these systems.Comment: 17 pages, no figures, to be published in Phys. Rev.
Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.
Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironments. Whether tumors exploit unique biophysical properties to metastasize remains unclear. Data show that invading mammary tumor cells, when cultured in a stiffened three-dimensional extracellular matrix that recapitulates the primary tumor stroma, adopt a basal-like phenotype. Metastatic tumor cells and basal-like tumor cells exert higher integrin-mediated traction forces at the bulk and molecular levels, consistent with a motor-clutch model in which motors and clutches are both increased. Basal-like nonmalignant mammary epithelial cells also display an altered integrin adhesion molecular organization at the nanoscale and recruit a suite of paxillin-associated proteins implicated in invasion and metastasis. Phosphorylation of paxillin by Src family kinases, which regulates adhesion turnover, is similarly enhanced in the metastatic and basal-like tumor cells, fostered by a stiff matrix, and critical for tumor cell invasion in our assays. Bioinformatics reveals an unappreciated relationship between Src kinases, paxillin, and survival of breast cancer patients. Thus adoption of the basal-like adhesion phenotype may favor the recruitment of molecules that facilitate tumor metastasis to integrin-based adhesions. Analysis of the physical properties of tumor cells and integrin adhesion composition in biopsies may be predictive of patient outcome
Probing flavor changing interactions in hadron collisions
The subprocess in the two-Higgs-doublet model with
flavor-changing scalar couplings is examined at the one loop level. With
perturbative QCD factorization theorem, the corresponding cross sections for
hadron-hadron collisions are computed numerically. The results are applicable
to the whole mass range of the weakly coupled Higgs bosons. In case we could
efficiently exclude the severe backgrounds of the
production signal, probing the flavor-changing top-charm-scalar vertex at
hadron colliders would be very promising and accessible experimentally.Comment: LaTex file, 14 pages, 8 EPS figure
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